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Pathway Description
Clarithromycin Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2013-08-22
Last Updated: 2025-01-29
Clarithromycin, is a macrolide antibiotic. It is used to treat many bacterial infections, from sinusitis to AIDS-related infections, and can be used along with anti-ulcer medications to treat stomach ulcers. The way this antibiotic works is by halting bacteria growth. It stops bacteria growth by binding to 50S ribosomal subunits or the 70S ribosome located on the bacteria, inhibits the movement of aminoacyl transfer-RNA and makes sure that the elongation of peptide chain does not occur. This ensures that RNA-mediated bacterial protein creation is blocked. This drug also blocks the isoenzyme CYP3A4, found in the liver, and P-glycoprotein.
References
Clarithromycin Pathway References
Biaxin/Biaxin BID/Biaxin XL . (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved July 17, 2009.
Song, K.S. Ribosomal protein synthesis inhibitors. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology. (2004) p. 827-833. Berlin, Germany: Springer.
Clarithromycin. Tuberculosis (Edinb). 2008 Mar;88(2):92-5. doi: 10.1016/S1472-9792(08)70005-2.
Pubmed: 18486039
Westphal JF: Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin. Br J Clin Pharmacol. 2000 Oct;50(4):285-95.
Pubmed: 11012550
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