SMPDB

Pathway Description

Roxithromycin Action Pathway

Homo sapiens

Drug Action Pathway

Created: 2013-08-22

Last Updated: 2025-01-29

A member of the semi-synthetic macrolide class of antibiotics, roxithromycin is employed in infections of the respiratory tract, urinary, and soft tissue infections. Its macrocyclic lactone ring and deoxy sugars, defining features of macrolide antibiotics, mediates its mechanism of action as it inhibits peptide translocation by binding to the 50S subunit of the bacterial ribosome. Protein synthesis is thus inhibited by ribosomal binding. It has been demonstrated to have a longer half-life compared to other macrolide antibiotics such as erythromycin and is effective against certain Gram-negative bacteria.

References

Roxithromycin Pathway References

Bertho G, Gharbi-Benarous J, Delaforge M, Girault JP: Transferred nuclear Overhauser effect study of macrolide-ribosome interactions: correlation between antibiotic activities and bound conformations. Bioorg Med Chem. 1998 Feb;6(2):209-21.

Pubmed: 9547944

Fournet MP, Barre J, Zini R, Deforges L, Duval J, Tillement JP: Binding parameters and microbiological activity of macrolides, lincosamides and streptogramins against Staphylococcus aureus. J Pharm Pharmacol. 1987 Apr;39(4):319-22.

Pubmed: 2884302

Gentry LO: Roxithromycin, a new macrolide antibiotic, in the treatment of infections in the lower respiratory tract: an overview. J Antimicrob Chemother. 1987 Nov;20 Suppl B:145-52. doi: 10.1093/jac/20.suppl_b.145.

Pubmed: 3323166

Song, K.S. Ribosomal protein synthesis inhibitors. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology. (2004) p. 827-833. Berlin, Germany: Springer.

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Highlighted elements will appear in red.

Highlight Compounds

Roxithromycin

Highlight Proteins

No Proteins Present

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

Roxithromycin

Visualize Protein Data

No Proteins Present

Downloads

SVG Image

Simple SVG Image

Large Font SVG Image

Simple Large Font SVG Image

Greyscale SVG Image

BioPAX

SBGN