SMPDB

Pathway Description

Tirofiban Action Pathway

Homo sapiens

Drug Action Pathway

Created: 2013-08-22

Last Updated: 2025-01-29

Tirofiban is a platelet aggregation inhibitor drug sold under the name Aggrastat. It is specifically a small molecule that inhibits the glycoprotein IIb/IIIa receptor of platelets. It is administered intravenously, and can act to decrease platelet aggregation by over 90% after the infusion, and can help prevent aggregation for up to two days after administration. In the vein, tirofiban causes a conformational change in the integrins on the surface of activated platelets. This prevents the binding of fibrinogen to these integrins, which in turn prevents the platelets from being held together by these fibrinogen fibres. The conformational change also prevents the binding of von Willebrand factor to the platelets, which also prevents aggregation and adhesion.

References

Tirofiban Pathway References

Ciccone A, Abraha I, Santilli I: Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD005208. doi: 10.1002/14651858.CD005208.pub2.

Pubmed: 17054247

Jennings LK, Saucedo JF: Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes. Curr Opin Cardiol. 2008 Jul;23(4):302-8. doi: 10.1097/HCO.0b013e3283021ad9.

Pubmed: 18520712

Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS: Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors. J Biol Chem. 1987 Jun 25;262(18):8476-82.

Pubmed: 2439501

Frachet P, Uzan G, Thevenon D, Denarier E, Prandini MH, Marguerie G: GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs. Mol Biol Rep. 1990 Feb;14(1):27-33.

Pubmed: 2345548

Heidenreich R, Eisman R, Surrey S, Delgrosso K, Bennett JS, Schwartz E, Poncz M: Organization of the gene for platelet glycoprotein IIb. Biochemistry. 1990 Feb 6;29(5):1232-44. doi: 10.1021/bi00457a020.

Pubmed: 2322558

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Tirofiban

Highlight Proteins

	Integrin alpha-IIb
	Integrin beta-3

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Tirofiban

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