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ReactionCatalysis155 ACTIVATION 1.0 Fibrinogen beta chain Coagulation factor V CHEBI:10033 ChEBI 5284607 PubChem-compound Fibrin (loose) 82688 ChemSpider ReactionCatalysis142 ACTIVATION 4447652 ChemSpider Fibrin (mesh) ReactionCatalysis381 ACTIVATION Prothrombin and coagulation factors VII, IX and X SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O P00488 UniProt Vitamin K-dependent gamma-carboxylase 10442445 ChemSpider BTO:0000759 BRENDA TISSUE ONTOLOGY P02671 UniProt Fibrinogen gamma chain C01541 KEGG Compound Tenase complex Coagulation factor VIII Coagulation factor IX ReactionCatalysis1103 ACTIVATION 2.3.2.13 false 2.3.2.13 Fibrin (loose) → Fibrin (mesh) LEFT_TO_RIGHT Coagulation factor VIII ReactionCatalysis1105 ACTIVATION HMDB0002972 HMDB 3.4.21.5 false 3.4.21.5 Fibrinogen → Fibrin (loose) LEFT_TO_RIGHT P02675 UniProt 1.1.4.1 false 1.1.4.1 Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT ReactionCatalysis1100 ACTIVATION P02679 UniProt 1.0 Tissue factor Collagen alpha-1(I) chain ReactionCatalysis1115 ACTIVATION 3.4.21.5 false 3.4.21.5 Coagulation factor V → Coagulation factor Va LEFT_TO_RIGHT 3.4.21.5 false 3.4.21.5 Coagulation factor VIII → Coagulation factor VIIIa LEFT_TO_RIGHT 3.4.21.22 false 3.4.21.22 Coagulation factor X → Coagulation factor Xa LEFT_TO_RIGHT 1.0 Precursors of Prothrombin and coagulation factors VII, IX, ad X Reaction1389 false Prothrombin → Thrombin LEFT_TO_RIGHT 3.4.21.38 false 3.4.21.38 Coagulation factor XI → Coagulation factor XIa LEFT_TO_RIGHT ReactionCatalysis1110 ACTIVATION SubPathwayControl184 ActivatingSubPathwayControl SubPathway184Control SubPathwayControl186 ActivatingSubPathwayControl SubPathway186Control SubPathwayControl188 ActivatingSubPathwayControl SubPathway188Control 3.4.21.27 false 3.4.21.27 Coagulation factor IX → Coagulation factor IXa LEFT_TO_RIGHT Prothrombin and coagulation factors VII, IX and X Vitamin K1 2,3-epoxide 84-80-0 CAS 91577 PubChem-compound Coagulation factor X Vitamin K epoxide reductase complex subunit 1 SubPathwayInhibition Coagulation factor VII SubPathwayActivator Liver Plasminogen C19H16O4 Warfarin 308.10486 25486-55-9 CAS Warfarin SubPathwayInhibitor Coagulation factor IX P03951 UniProt P03952 UniProt 54678486 PubChem-compound P00451 UniProt 1.0 Extracellular Space Blood Vessel BiologicalState51 Homo sapiens, Blood Vessel Coagulation factor XII GO:0005615 GENE ONTOLOGY XII activated to XIIa by Collagen ActivatingSubPathway Transport80 false Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT XII activated to XIIa by Plasma kallikrein ActivatingSubPathway 1.0 Coagulation factor X CHEBI:28371 ChEBI Plasma prekallikrein activated to Plasma kallikrein by XIIa ActivatingSubPathway Warfarin Action Pathway C05849 KEGG Compound BiologicalState29 Homo sapiens, Liver 1.0 Coagulation factor XIII B chain Tissue-type plasminogen activator P00750 UniProt 4.1.1.90 false 4.1.1.90 Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X LEFT_TO_RIGHT 1.0 Plasminogen Activate Coagulatin factor VII to VIIa by binding to Tissue Factor ActivatingSubPathway 4.1.1.90 false 4.1.1.90 Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide LEFT_TO_RIGHT 3.4.21.68 false 3.4.21.68 Plasminogen → Plasmin LEFT_TO_RIGHT Fibrinogen alpha chain Plasma kallikrein SubPathwayActivation C05850 KEGG Compound Fibrinogen gamma chain 1.0 Coagulation factor XIII B chain SubPathwayActivator 1.0 BTO:0001102 BRENDA TISSUE ONTOLOGY 1.0 3.4.21.7 false 3.4.21.7 Fibrin (mesh) → Fibrin degradation products LEFT_TO_RIGHT P38435 UniProt Coagulation factor XI Coagulation factor XIII A chain SubPathwayActivator Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Coagulation factor VII Homo sapiens 1.0 Vitamin K-dependent gamma-carboxylase P13726 UniProt HMDB0004198 HMDB SMP0000268 SMPDB Q9BQB6 UniProt PW000311 PathWhiz Fibrinogen 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc C31H46O3 Vitamin K1 2,3-epoxide 466.3447 1.0 81-81-2 CAS P08709 UniProt 9606 TAXONOMY Collagen alpha-1(I) chain SubPathwayActivator Coagulation factor XII P12259 UniProt P02452 UniProt Coagulation factor XIIIa SubPathwayActivation HMDB0001935 HMDB 1.0 P05160 UniProt ReactionCatalysis1126 ACTIVATION ReactionCatalysis1125 ACTIVATION ReactionCatalysis1129 ACTIVATION 1.0 Coagulation factor V ReactionCatalysis1124 ACTIVATION Fibrin degradation products SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC12OC1(C)C(=O)C1=C(C=CC=C1)C2=O SubPathwayControl457 SubPathway457Control InhibitorySubPathwayControl Coagulation factor XIII A chain Coagulation factor XIII A chain Tissue factor:Coagulation factor VIIa SubPathwayActivation Precursors of Prothrombin and coagulation factors VII, IX, ad X SubPathwayControl216 SubPathway216Control ActivatingSubPathwayControl Prothrombin and coagulation factors VII, IX and X 1.0 Coagulation factor XI Prothrombin ReactionCatalysis1134 ACTIVATION Plasma kallikrein Tissue-type plasminogen activator Coagulation factor XIIIa Tissue factor SubPathwayActivator Coagulation factor XIII B chain Fibrinogen alpha chain Fibrinogen beta chain 1.0 Prothrombin Warfarin inhibition of Coagulation factor VII InhibitorySubPathway P00734 UniProt Coagulation factor XIII A and B activate to Coagulation factor XIIIa ActivatingSubPathway Coagulation factor XII SubPathwayActivation SubPathwayActivator Vitamin K-dependent gamma-carboxylase SubPathwayControl235 SubPathway235Control ActivatingSubPathwayControl 1.0 Plasma kallikrein SubPathwayActivator CHEBI:18067 ChEBI P00747 UniProt Reduced Vitamin K (phylloquinone) P00748 UniProt Coagulation factor XI C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 P00740 UniProt P00742 UniProt SMILES CC(=O)CC(C1=CC=CC=C1)C1=C(O)C2=C(OC1=O)C=CC=C2 Vitamin K epoxide reductase complex subunit 1 Coagulation factor XII Collagen alpha-1(I) chain Coagulation factor XIIa Plasma kallikrein Coagulation factor XIII A chain Coagulation factor XIII B chain Coagulation factor VII Tissue factor Tissue factor:Coagulation factor VIIa Plasma prekallikrein Coagulation factor XIIa Coagulation factor XI Coagulation factor XIa Coagulation factor IX Coagulation factor IXa Coagulation factor VIII Coagulation factor VIIIa Prothrombin Coagulation factor V Coagulation factor Va Prothrombin Coagulation factor X Coagulation factor Xa Prothrombin Thrombin Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibrin (loose) Fibrin (mesh) Coagulation factor XIIIa Fibrin degradation products Plasmin Plasminogen Tissue-type plasminogen activator Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Vitamin K-dependent gamma- carboxylase Warfarin Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Cortexolone Calcium Calcium Cortexolone Calcium Cortexolone Calcium Calcium Calcium Calcium Calcium Calcium Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X Platelet Factor 3 Tenase complex Platelet factor 3 Prothrombinase complex ENDOTHELIAL CELL SUBENDOTHELIUM VASCULAR INJURY ENDOTHELIAL CELL SUBENDOTHELIUM COAGULATION
ReactionCatalysis155 ACTIVATION 1.0 Fibrinogen beta chain Coagulation factor V CHEBI:10033 ChEBI 5284607 PubChem-compound Fibrin (loose) 82688 ChemSpider ReactionCatalysis142 ACTIVATION 4447652 ChemSpider Fibrin (mesh) ReactionCatalysis381 ACTIVATION Prothrombin and coagulation factors VII, IX and X SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O P00488 UniProt Vitamin K-dependent gamma-carboxylase 10442445 ChemSpider BTO:0000759 BRENDA TISSUE ONTOLOGY P02671 UniProt Fibrinogen gamma chain C01541 KEGG Compound Tenase complex Coagulation factor VIII Coagulation factor IX ReactionCatalysis1103 ACTIVATION 2.3.2.13 false 2.3.2.13 Fibrin (loose) → Fibrin (mesh) LEFT_TO_RIGHT Coagulation factor VIII ReactionCatalysis1105 ACTIVATION HMDB0002972 HMDB 3.4.21.5 false 3.4.21.5 Fibrinogen → Fibrin (loose) LEFT_TO_RIGHT P02675 UniProt 1.1.4.1 false 1.1.4.1 Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT ReactionCatalysis1100 ACTIVATION P02679 UniProt 1.0 Tissue factor Collagen alpha-1(I) chain ReactionCatalysis1115 ACTIVATION 3.4.21.5 false 3.4.21.5 Coagulation factor V → Coagulation factor Va LEFT_TO_RIGHT 3.4.21.5 false 3.4.21.5 Coagulation factor VIII → Coagulation factor VIIIa LEFT_TO_RIGHT 3.4.21.22 false 3.4.21.22 Coagulation factor X → Coagulation factor Xa LEFT_TO_RIGHT 1.0 Precursors of Prothrombin and coagulation factors VII, IX, ad X Reaction1389 false Prothrombin → Thrombin LEFT_TO_RIGHT 3.4.21.38 false 3.4.21.38 Coagulation factor XI → Coagulation factor XIa LEFT_TO_RIGHT ReactionCatalysis1110 ACTIVATION SubPathwayControl184 ActivatingSubPathwayControl SubPathway184Control SubPathwayControl186 ActivatingSubPathwayControl SubPathway186Control SubPathwayControl188 ActivatingSubPathwayControl SubPathway188Control 3.4.21.27 false 3.4.21.27 Coagulation factor IX → Coagulation factor IXa LEFT_TO_RIGHT Prothrombin and coagulation factors VII, IX and X Vitamin K1 2,3-epoxide 84-80-0 CAS 91577 PubChem-compound Coagulation factor X Vitamin K epoxide reductase complex subunit 1 SubPathwayInhibition Coagulation factor VII SubPathwayActivator Liver Plasminogen C19H16O4 Warfarin 308.10486 25486-55-9 CAS Warfarin SubPathwayInhibitor Coagulation factor IX P03951 UniProt P03952 UniProt 54678486 PubChem-compound P00451 UniProt 1.0 Extracellular Space Blood Vessel BiologicalState51 Homo sapiens, Blood Vessel Coagulation factor XII GO:0005615 GENE ONTOLOGY XII activated to XIIa by Collagen ActivatingSubPathway Transport80 false Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT XII activated to XIIa by Plasma kallikrein ActivatingSubPathway 1.0 Coagulation factor X CHEBI:28371 ChEBI Plasma prekallikrein activated to Plasma kallikrein by XIIa ActivatingSubPathway Warfarin Action Pathway C05849 KEGG Compound BiologicalState29 Homo sapiens, Liver 1.0 Coagulation factor XIII B chain Tissue-type plasminogen activator P00750 UniProt 4.1.1.90 false 4.1.1.90 Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X LEFT_TO_RIGHT 1.0 Plasminogen Activate Coagulatin factor VII to VIIa by binding to Tissue Factor ActivatingSubPathway 4.1.1.90 false 4.1.1.90 Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide LEFT_TO_RIGHT 3.4.21.68 false 3.4.21.68 Plasminogen → Plasmin LEFT_TO_RIGHT Fibrinogen alpha chain Plasma kallikrein SubPathwayActivation C05850 KEGG Compound Fibrinogen gamma chain 1.0 Coagulation factor XIII B chain SubPathwayActivator 1.0 BTO:0001102 BRENDA TISSUE ONTOLOGY 1.0 3.4.21.7 false 3.4.21.7 Fibrin (mesh) → Fibrin degradation products LEFT_TO_RIGHT P38435 UniProt Coagulation factor XI Coagulation factor XIII A chain SubPathwayActivator Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Coagulation factor VII Homo sapiens 1.0 Vitamin K-dependent gamma-carboxylase P13726 UniProt HMDB0004198 HMDB SMP0000268 SMPDB Q9BQB6 UniProt PW000311 PathWhiz Fibrinogen 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc C31H46O3 Vitamin K1 2,3-epoxide 466.3447 1.0 81-81-2 CAS P08709 UniProt 9606 TAXONOMY Collagen alpha-1(I) chain SubPathwayActivator Coagulation factor XII P12259 UniProt P02452 UniProt Coagulation factor XIIIa SubPathwayActivation HMDB0001935 HMDB 1.0 P05160 UniProt ReactionCatalysis1126 ACTIVATION ReactionCatalysis1125 ACTIVATION ReactionCatalysis1129 ACTIVATION 1.0 Coagulation factor V ReactionCatalysis1124 ACTIVATION Fibrin degradation products SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC12OC1(C)C(=O)C1=C(C=CC=C1)C2=O SubPathwayControl457 SubPathway457Control InhibitorySubPathwayControl Coagulation factor XIII A chain Coagulation factor XIII A chain Tissue factor:Coagulation factor VIIa SubPathwayActivation Precursors of Prothrombin and coagulation factors VII, IX, ad X SubPathwayControl216 SubPathway216Control ActivatingSubPathwayControl Prothrombin and coagulation factors VII, IX and X 1.0 Coagulation factor XI Prothrombin ReactionCatalysis1134 ACTIVATION Plasma kallikrein Tissue-type plasminogen activator Coagulation factor XIIIa Tissue factor SubPathwayActivator Coagulation factor XIII B chain Fibrinogen alpha chain Fibrinogen beta chain 1.0 Prothrombin Warfarin inhibition of Coagulation factor VII InhibitorySubPathway P00734 UniProt Coagulation factor XIII A and B activate to Coagulation factor XIIIa ActivatingSubPathway Coagulation factor XII SubPathwayActivation SubPathwayActivator Vitamin K-dependent gamma-carboxylase SubPathwayControl235 SubPathway235Control ActivatingSubPathwayControl 1.0 Plasma kallikrein SubPathwayActivator CHEBI:18067 ChEBI P00747 UniProt Reduced Vitamin K (phylloquinone) P00748 UniProt Coagulation factor XI C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 P00740 UniProt P00742 UniProt SMILES CC(=O)CC(C1=CC=CC=C1)C1=C(O)C2=C(OC1=O)C=CC=C2 VKORC1 F12 COL1A1 F12 KLKB1 F13A1 Unknown F7 Unknown F7 KLKB1 F12 Unknown Unknown F9 F9 F8 F8 Unknown F5 F5 Unknown F10 F10 Unknown Unknown Unknown Unknown FGG Unknown Unknown F13A1 Unknown PLG PLG PLAT F10 VKORC1 GGCX Warfarin Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X Created with Snap