Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Small Molecule Pathway Database.
Loading Pathway...
CHEBI:16015 ChEBI HMDB03406 HMDB HMDB00139 HMDB 439161 PubChem-compound C00430 KEGG Compound L-Arginine CHEBI:30314 ChEBI Ammonia 439153 PubChem-compound 50 ChemSpider 53481912 PubChem-compound CHEBI:20506 ChEBI CHEBI:17115 ChEBI CHEBI:16027 ChEBI HMDB00148 HMDB Sarcosine 1.0 Glycine N-methyltransferase 559142 ChemSpider 1.0 1.0 P09622 UniProt HMDB01206 HMDB CHEBI:15380 ChEBI 5742 ChemSpider NADH C25H40N7O19P3S Succinyl-CoA 867.1312 C00213 KEGG Compound CHEBI:17561 ChEBI 1.0 439175 PubChem-compound Amine oxidase [flavin-containing] A Glycyl-tRNA(Gly) HMDB00123 HMDB 5736 ChemSpider C3H5O7P Phosphohydroxypyruvic acid 183.9773 5735 ChemSpider HMDB00128 HMDB PW000157 PathWhiz CHEBI:16240 ChEBI PW000152 PathWhiz HMDB01451 HMDB SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS HMDB00119 HMDB 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Glycerate kinase Serine hydroxymethyltransferase, cytosolic C03508 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O HMDB00574 HMDB HMDB01423 HMDB 3913-50-6 CAS HMDB01426 HMDB 979-92-0 CAS 1.0 Serine racemase 1.0 C00009 KEGG Compound C00008 KEGG Compound 1.0 C00007 KEGG Compound CHEBI:17158 ChEBI C00001 KEGG Compound L-ALPHA-ALANINE BioCyc 439194 PubChem-compound HMDB13639 HMDB SMILES OC(=O)C(=O)COP(O)(O)=O 56-41-7 CAS C00004 KEGG Compound Pyruvic acid C00003 KEGG Compound 135-16-0 CAS L-Seryl-tRNA(Ser) C00002 KEGG Compound Coenzyme A 1.0 Mitochondrial Inner Membrane HMDB01429 HMDB C00019 KEGG Compound Oxygen 352-97-6 CAS SMP00128 SMPDB 1.0 C00011 KEGG Compound C00010 KEGG Compound C00258 KEGG Compound C00014 KEGG Compound C01103 KEGG Compound C00013 KEGG Compound 1.0 6112 PubChem-compound C00022 KEGG Compound C00021 KEGG Compound 56-65-5 CAS 53-84-9 CAS C00020 KEGG Compound C00027 KEGG Compound L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound SMILES NCSCCC(S)CCCCC(O)=O 3432-99-3 CAS 298-12-4 CAS 1118-68-9 CAS Carbon dioxide Q9UL12 UniProt BiologicalState22 CL:0000000 CELL TYPE ONTOLOGY D-3-phosphoglycerate dehydrogenase 52-90-4 CAS 760 PubChem-compound C00037 KEGG Compound Glyoxylic acid 653 ChemSpider C00041 KEGG Compound 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Hydroxypyruvic acid 408 ChemSpider CHEBI:18047 ChEBI C00048 KEGG Compound 107-97-1 CAS Orotidylic acid SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O L-serine dehydratase/L-threonine deaminase SMILES N[C@@H](COP(O)(O)=O)C(O)=O SMILES CNCC(O)=O Phosphoserine aminotransferase 604-98-8 CAS 1.0 HMDB00538 HMDB CHEBI:29162 ChEBI L-Seryl-tRNA(Ser) Glycyl-tRNA L-Seryl-tRNA Glycyl-tRNA(Gly) 784 PubChem-compound C3H7O7P 3-Phosphoglyceric acid 185.99294 GLYOX BioCyc SMILES N[C@@H](CCCNC(N)=N)C(O)=O C00062 KEGG Compound Pyruvic acid 1.0 C5H9NO3 5-Aminolevulinic acid 131.05824 5,10-Methylene-THF CHEBI:29156 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 C00067 KEGG Compound C00065 KEGG Compound 1.0 NAD 1.0 SMILES CC(=O)C(O)=O ReactionCatalysis1513 ACTIVATION ReactionCatalysis1515 ACTIVATION ReactionCatalysis1514 ACTIVATION ReactionCatalysis1516 ACTIVATION HMDB01846 HMDB HMDB00517 HMDB P50440 UniProt 3-Phosphoglyceric acid SubPathwayOutput 962 PubChem-compound DIMETHYL-GLYCINE BioCyc Serine--pyruvate aminotransferase 31983 ChemSpider 724 PubChem-compound 964 PubChem-compound Dimethylglycine CO2 Carbon dioxide 43.98983 857 ChemSpider SMILES O=O Glycine dehydrogenase [decarboxylating], mitochondrial BiologicalState3 BiologicalState4 BiologicalState2 SubPathwayInteraction621 SubPathway621Reaction SubPathwayReaction Glycerate kinase 1.0 14265-44-2 CAS SubPathwayInteraction624 SubPathwayReaction SubPathway624Reaction PYRUVATE BioCyc 712 PubChem-compound CHEBI:15811 ChEBI SubPathwayInteraction623 SubPathwayReaction SubPathway623Reaction SubPathwayInteraction629 SubPathway629Reaction SubPathwayReaction C00091 KEGG Compound G3P BioCyc 644102 PubChem-compound C3H7NO2S L-Cysteine 121.01975 C00097 KEGG Compound 1.0 SMILES OCC(=O)C(O)=O 1.0 H2O2 Hydrogen peroxide 34.005478 6-S-ACETYL-DIHYDROLIPOATE BioCyc Glycine NADH BioCyc CREATINE BioCyc Pyruvaldehyde 29908-03-0 CAS 977 PubChem-compound Sarcosine dehydrogenase, mitochondrial 1.0 50-00-0 CAS 1.0 Glycine--tRNA ligase Acetyl-CoA 820-11-1 CAS 1.0 30572 ChemSpider SMILES N[C@@H](CS)C(O)=O C8H14O2S2 (R)-lipoic acid 206.04352 Adenosine monophosphate SMILES OO H3N Ammonia 17.026548 C10H14N5O7P Adenosine monophosphate 347.06308 HMDB00807 HMDB 4.0 1.0 1.0 Phosphoserine phosphatase Ammonia Serines BioCyc 6816 PubChem-compound 1.0 51 PubChem-compound CHEBI:17906 ChEBI C4H9N3O2 Creatine 131.06947 C16241 KEGG Compound CH2O Formaldehyde 30.010565 274 ChemSpider P23378 UniProt 137 PubChem-compound 141140 ChemSpider Q14353 UniProt Pyrophosphate O4P Phosphate 94.95342 L-2-Amino-3-oxobutanoic acid SER BioCyc 1.0 Serine--tRNA ligase, cytoplasmic SubPathwayInteraction609 SubPathwayReaction SubPathway609Reaction Q9Y617 UniProt Amine oxidase [flavin-containing] A AMINO-ACETONE BioCyc CPD-6641 BioCyc 217 ChemSpider 58-68-4 CAS 1.0 SMILES [O-]P([O-])([O-])=O 210 ChemSpider (R)-lipoic acid SMILES C=O 692 ChemSpider CHEBI:30915 ChEBI C2H5NO2 Glycine 75.03203 C2H2O3 Glyoxylic acid 74.0004 298-08-8 CAS C3H7N3O2 Guanidoacetic acid 117.053825 1.0 GO:0005759 GENE ONTOLOGY C20H23N7O6 5,10-Methylene-THF 457.171 1.0 105 PubChem-compound 586 PubChem-compound O43175 UniProt Oxoglutaric acid SMILES O=C=O Glycine dehydrogenase [decarboxylating], mitochondrial 5950 PubChem-compound 5951 PubChem-compound C21H29N7O14P2 NADH 665.12476 P21397 UniProt Glycine amidinotransferase, mitochondrial 5957 PubChem-compound GO:0005743 GENE ONTOLOGY GO:0005741 GENE ONTOLOGY CHEBI:16842 ChEBI 3-P-HYDROXYPYRUVATE BioCyc GO:0005739 GENE ONTOLOGY 1.0 1.0 1.0 C4H9NO2 Dimethylglycine 103.06333 OROTIDINE-5-PHOSPHATE BioCyc CHEBI:16891 ChEBI 389046 ChemSpider 5682 ChemSpider 5,10-Methylene-THF Glycyl-tRNA METHYL-GLYOXAL BioCyc 1.0 false Aminoacetone + Oxygen + Water → Ammonia + Hydrogen peroxide + Pyruvaldehyde LEFT_TO_RIGHT Mitochondrial Matrix Formaldehyde 14000-31-8 CAS L-2-Amino-3-oxobutanoic acid CO-A BioCyc P05091 UniProt Dimethylglycine dehydrogenase, mitochondrial Guanidinoacetate N-methyltransferase 72-89-9 CAS Carbon dioxide 1.0 C8H16O2S2 Dihydrolipoate 208.05917 5,10-Methylene-THF Q8IVS8 UniProt Cell 6557 ChemSpider CHEBI:17724 ChEBI 106-60-5 CAS HMDB02134 HMDB 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial false Acetyl-CoA + Glycine → Coenzyme A + L-2-Amino-3-oxobutanoic acid LEFT_TO_RIGHT 127-17-3 CAS C3H6O4 Glyceric acid 106.02661 CHEBI:30933 ChEBI 28782 PubChem-compound Hydrogen peroxide false (R)-lipoic acid + Glycine → 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid + Carbon dioxide LEFT_TO_RIGHT 312-84-5 CAS Q14749 UniProt 1.0 false Sarcosine + Water → Formaldehyde + Glycine LEFT_TO_RIGHT false Dimethylglycine + Water → Formaldehyde + Sarcosine LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound Dihydrolipoyl dehydrogenase, mitochondrial P34897 UniProt Reaction1429 false L-2-Amino-3-oxobutanoic acid → Aminoacetone + Carbon dioxide LEFT_TO_RIGHT P34896 UniProt Phosphoserine C00740 KEGG Compound 7782-44-7 CAS 1.0 false NAD + Pyruvaldehyde → NADH + Pyruvic acid + Water LEFT_TO_RIGHT NADH 9606 TAXONOMY HMDB01024 HMDB CHEBI:17549 ChEBI 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES OC(COP(O)(O)=O)C(O)=O C3H4O2 Pyruvaldehyde 72.021126 HMDB02111 HMDB HMDB01022 HMDB SMILES NCC(=O)CCC(O)=O PW000018 PathWhiz false 5,10-Methylene-THF + Glycine + Water ↔ L-Serine + Tetrahydrofolic acid REVERSIBLE CHEBI:15377 ChEBI L-Cysteine SubPathwayInput CHEBI:15379 ChEBI CHEBI:16467 ChEBI 56-45-1 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB00187 HMDB Serine hydroxymethyltransferase, cytosolic Dimethylglycine dehydrogenase, mitochondrial AMINO-OXOBUT BioCyc false 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid + Tetrahydrofolic acid → 5,10-Methylene-THF + Ammonia + Dihydrolipoate LEFT_TO_RIGHT ReactionCatalysis1498 ACTIVATION HMDB01487 HMDB L-Alanine 5-aminolevulinate synthase, nonspecific, mitochondrial O75600 UniProt Glycine dehydrogenase [decarboxylating], mitochondrial 3-METHYLBENZYLSUCCINYL-COA BioCyc C00546 KEGG Compound 74-79-3 CAS 1.0 CHEBI:16680 ChEBI HMDB00161 HMDB CHEBI:15351 ChEBI C00300 KEGG Compound 85-61-0 CAS 1.0 P21549 UniProt C01888 KEGG Compound 7722-84-1 CAS 6022 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 939 ChemSpider L-Serine 937 ChemSpider CYS BioCyc HMDB00250 HMDB CHEBI:16134 ChEBI HMDB01341 HMDB 1.0 Serine--pyruvate aminotransferase PW000054 PathWhiz Glycine and Serine Metabolism ATP BioCyc HMDB01352 HMDB 18714427 ChemSpider SMP00034 SMPDB Tetrahydrofolic acid Tetrahydrofolic acid 388334 ChemSpider C15H23N6O5S S-Adenosylmethionine 399.14505 1.0 952 ChemSpider Glycine--tRNA ligase Aldehyde dehydrogenase, mitochondrial SMP00040 SMPDB Q9UI17 UniProt HMDB00243 HMDB ARG BioCyc 5858 ChemSpider METHYLENE-THF BioCyc C00581 KEGG Compound 704 ChemSpider Aminoacetone 1.0 C00101 KEGG Compound 1.0 HMDB12210 HMDB SMILES OC(=O)CCCCC(S)CCS 440033 PubChem-compound PPI BioCyc 160617 PubChem-compound 5-aminolevulinate synthase, nonspecific, mitochondrial FORMALDEHYDE BioCyc 1.0 5886 ChemSpider SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 Cytosol 1.0 C00597 KEGG Compound C14H20N6O5S S-Adenosylhomocysteine 384.12158 SARCOSINE BioCyc 1.0 HMDB00208 HMDB 1.0 CHEBI:18361 ChEBI NADH CHEBI:18367 ChEBI 1032 ChemSpider 1031 ChemSpider 388320 ChemSpider P13196 UniProt HMDB00218 HMDB 1.0 SMILES CC(=O)C=O Pyruvic acid SubPathwayInput C21H28N7O14P2 NAD 664.11694 Succinyl-CoA SMP00004 SMPDB HMDB01533 HMDB 388301 ChemSpider 1057 ChemSpider 388307 ChemSpider C00143 KEGG Compound 5653 ChemSpider Pyruvaldehyde 57689797 PubChem-compound SMP00013 SMPDB Guanidoacetic acid 2.0 C3H7NO3 D-Serine 105.042595 C01005 KEGG Compound 880 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 328-50-7 CAS AMP BioCyc GUANIDOACETIC_ACID BioCyc Serine--tRNA ligase, cytoplasmic 1.0 HYDROGEN-PEROXIDE BioCyc Glycine amidinotransferase, mitochondrial P49591 UniProt LIPOIC-ACID BioCyc Phosphoserine phosphatase C00168 KEGG Compound 763 ChemSpider SMILES CN(C)CC(O)=O 1.0 421 PubChem-compound 78-98-8 CAS 7732-18-5 CAS C01026 KEGG Compound Glycine amidinotransferase, mitochondrial NAD 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES OC(=O)CCCC[C@@H]1CCSS1 AMMONIA BioCyc SMILES N 56-86-0 CAS L-Serine NAD 56-40-6 CAS Sarcosine S-Adenosylhomocysteine 1.0 1.0 CHEBI:17050 ChEBI SMILES CN(CC(O)=O)C(N)=N HMDB01967 HMDB Formaldehyde C3H7NO2 L-Alanine 89.047676 2.0 5800 ChemSpider C3H7NO Aminoacetone 73.052765 D-3-phosphoglycerate dehydrogenase 730 ChemSpider Water Aldehyde dehydrogenase, mitochondrial SMILES OC[C@@H](O)C(O)=O Phosphoserine aminotransferase SMILES N[C@@H](CCC(O)=O)C(O)=O C02147 KEGG Compound 58-64-0 CAS 1.0 C03232 KEGG Compound L-serine dehydratase/L-threonine deaminase Q9GZT4 UniProt 1.0 C3H7NO3 L-Serine 105.042595 Aldehyde dehydrogenase, mitochondrial 444493 PubChem-compound 57-00-1 CAS 6083 PubChem-compound C4H7NO3 L-2-Amino-3-oxobutanoic acid 117.042595 2-PG BioCyc 25246222 PubChem-compound Glycine SMILES OC(=O)C=O ACETYL-COA BioCyc H2O Water 18.010565 Dihydrolipoyl dehydrogenase, mitochondrial SMILES NCC(O)=O NAD BioCyc Guanidinoacetate N-methyltransferase 743 ChemSpider 5-AMINO-LEVULINATE BioCyc Aminomethyltransferase, mitochondrial 740 ChemSpider 3-P-SERINE BioCyc SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O Aminoacetone SMILES NC(=N)NCC(O)=O 2149-82-8 CAS CHEBI:15842 ChEBI 1.0 Aminomethyltransferase, mitochondrial 5-Aminolevulinic acid SMILES CC(=O)[C@H](N)C(O)=O 1.0 134 ChemSpider SMILES O C6H14N4O2 L-Arginine 174.11168 D-Serine 1.0 473-81-4 CAS CHEBI:15611 ChEBI 62-46-4 CAS 64231 ChemSpider CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 HMDB00939 HMDB 2.0 Glycine N-methyltransferase SMILES N[C@H](CO)C(O)=O HMDB06454 HMDB GO:0005829 GENE ONTOLOGY C19H23N7O6 Tetrahydrofolic acid 445.171 C5H6O5 Oxoglutaric acid 146.02153 HMDB00902 HMDB CHEBI:16908 ChEBI Ammonia ADENOSYL-HOMO-CYS BioCyc Serine hydroxymethyltransferase, cytosolic CHEBI:32398 ChEBI Sarcosine dehydrogenase, mitochondrial Serine hydroxymethyltransferase, mitochondrial 5862 PubChem-compound Serine--pyruvate aminotransferase 1.0 62074 ChemSpider C10H13N2O11P Orotidylic acid 368.0257 Mitochondrion THF BioCyc Phosphohydroxypyruvic acid CHEBI:16919 ChEBI 1.0 GLY BioCyc CHEBI:16977 ChEBI Guanidoacetic acid ReactionCatalysis1518 ACTIVATION Glyceric acid SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 ReactionCatalysis1522 ACTIVATION ReactionCatalysis1521 ACTIVATION Water C3H4O4 Hydroxypyruvic acid 104.010956 ReactionCatalysis1524 ACTIVATION ReactionCatalysis1523 ACTIVATION ReactionCatalysis1526 ACTIVATION ReactionCatalysis1525 ACTIVATION SMILES OC(=O)CCC(=O)C(O)=O ReactionCatalysis1528 ACTIVATION ReactionCatalysis1527 ACTIVATION 124-38-9 CAS ReactionCatalysis1520 ACTIVATION CHEBI:15414 ChEBI Cysteine Metabolism SubPathway 6857549 PubChem-compound ReactionCatalysis1529 ACTIVATION 1.0 673 PubChem-compound 566 ChemSpider 1.0 5257127 PubChem-compound 1113-60-6 CAS SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C(=O)NC(=O)C=C1C(O)=O 7664-41-7 CAS 1.0 GLT BioCyc L-serine dehydratase/L-threonine deaminase Serine hydroxymethyltransferase, mitochondrial Serine racemase 462-20-4 CAS false Dihydrolipoate + NAD → (R)-lipoic acid + NADH LEFT_TO_RIGHT S-ADENOSYLMETHIONINE BioCyc SMILES C[C@H](N)C(O)=O SMILES CC(=O)CN 222 PubChem-compound 1.0 O7P2 Pyrophosphate 173.91193 OH-PYR BioCyc 6082 ChemSpider Creatine Glycolysis SubPathway 215 PubChem-compound Sphingolipid Metabolism SubPathway CHEBI:15636 ChEBI SMILES N[C@@H](CO)C(O)=O 1.0 103 ChemSpider P48728 UniProt Adenosine triphosphate 1.0 1.0 C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 1.0 C3H8NO6P Phosphoserine 185.00893 1.0 C3H7NO2 Sarcosine 89.047676 Pyruvate Metabolism SubPathway Gluconeogenesis SubPathway Mitochondrial Outer Membrane HMDB03125 HMDB ReactionCatalysis1160 ACTIVATION 1.0 1.0 HMDB00092 HMDB 4.0 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc HMDB01185 HMDB Reaction1770 false Glycine + Pyruvic acid ↔ Glyoxylic acid + L-Alanine REVERSIBLE CHEBI:1146900 ChEBI false Glycine + Succinyl-CoA → 5-Aminolevulinic acid + Coenzyme A LEFT_TO_RIGHT false Guanidoacetic acid + S-Adenosylhomocysteine → Creatine + S-Adenosylmethionine LEFT_TO_RIGHT false Glycine + L-Arginine ↔ Guanidoacetic acid + Orotidylic acid REVERSIBLE P78330 UniProt Water Reaction1769 false L-Serine + Pyruvic acid ↔ Hydroxypyruvic acid + L-Alanine REVERSIBLE 1088 PubChem-compound S-Adenosylmethionine C21H36N7O16P3S Coenzyme A 767.11523 Adenosine diphosphate ReactionCatalysis1174 ACTIVATION 1.0 HMDB01167 HMDB Glycine CHEBI:15422 ChEBI Coenzyme A 1.0 SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 1.0 false Adenosine triphosphate + Glycine + Glycyl-tRNA → Adenosine monophosphate + Glycyl-tRNA(Gly) + Pyrophosphate LEFT_TO_RIGHT Reaction1793 false L-Serine → D-Serine LEFT_TO_RIGHT O2 Oxygen 31.98983 false Adenosine triphosphate + L-Serine + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphate LEFT_TO_RIGHT false L-Serine + Tetrahydrofolic acid ↔ 5,10-Methylene-THF + Glycine + Water REVERSIBLE 1.0 CHEBI:40673 ChEBI CHEBI:16523 ChEBI CHEBI:16526 ChEBI 1.0 CHEBI:16761 ChEBI false S-Adenosylhomocysteine + Sarcosine ↔ Glycine + S-Adenosylmethionine REVERSIBLE P20132 UniProt Reaction1789 false L-Serine ↔ Ammonia + Pyruvic acid REVERSIBLE CHEBI:15428 ChEBI false L-Glutamic acid + Phosphohydroxypyruvic acid ↔ Oxoglutaric acid + Phosphoserine REVERSIBLE false Phosphoserine + Water → L-Serine + Phosphate LEFT_TO_RIGHT 1.0 false 3-Phosphoglyceric acid + NAD ↔ NADH + Phosphohydroxypyruvic acid REVERSIBLE false Adenosine triphosphate + Glyceric acid ↔ 3-Phosphoglyceric acid + Adenosine diphosphate REVERSIBLE HMDB01149 HMDB PW000148 PathWhiz PW000146 PathWhiz HMDB00051 HMDB 5893 PubChem-compound 1.0 SMP00060 SMPDB Dihydrolipoate 1.0 CHEBI:32816 ChEBI L-Serine SubPathwayInput 1.0 CHEBI:16344 ChEBI 2.0 Sarcosine HMDB00064 HMDB Phosphate 280 PubChem-compound C9H19NO2S2 8-[(Aminomethyl)sulfanyl]-6-sulfanyloctanoic acid 237.08572 ReactionCatalysis1135 ACTIVATION HMDB00271 HMDB SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O HMDB00272 HMDB ReactionCatalysis1149 ACTIVATION L-Seryl-tRNA 407-41-0 CAS ReactionCatalysis1146 ACTIVATION 3946848 PubChem-compound HMDB01377 HMDB 1060 PubChem-compound HMDB00045 HMDB 1061 PubChem-compound Tetrahydrofolic acid P41250 UniProt 24762165 PubChem-compound CHEBI:30841 ChEBI ReactionCatalysis1151 ACTIVATION 13781857 PubChem-compound ReactionCatalysis1153 ACTIVATION ReactionCatalysis1157 ACTIVATION Amine oxidase [flavin- containing] A Aldehyde dehydrogenase, mitochondrial 2-amino-3- ketobutyrate coenzyme A ligase, mitochondrial Dimethylglycine dehydrogenase, mitochondrial Sarcosine dehydrogenase, mitochondrial Glycine dehydrogenase [decarboxylating], mitochondrial Aminomethyltransferase, mitochondrial Serine hydroxymethyltransferase, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial Serine-- pyruvate aminotransferase Serine-- pyruvate aminotransferase Glycine amidinotransferase, mitochondrial Guanidinoacetate N- methyltransferase 5- aminolevulinate synthase, nonspecific, mitochondrial Betaine-- homocysteine S- methyltransferase 1 Glycine N- methyltransferase Glycerate kinase D-3- phosphoglycerate dehydrogenase Phosphoserine aminotransferase Phosphoserine phosphatase L-serine dehydratase/L- threonine deaminase Serine--tRNA ligase, cytoplasmic Serine hydroxymethyltransferase, cytosolic Glycine--tRNA ligase Serine racemase Cystathionine beta-synthase Cystathionine gamma-lyase L-Cysteine 3- Phosphoglyceric acid Pyruvic acid Pyruvic acid Pyruvic acid L-Serine Aminoacetone O 2 H 2 O NH 3 H 2 O 2 Pyruvaldehyde NAD NADH H 2 O L-2-Amino-3- oxobutanoic acid CO 2 Acetyl-CoA Glycine CoA Dimethylglycine H 2 O Formaldehyde Sarcosine