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Ca+ Na+ Ca+ Ca+ Na+ K+ K+ Sodium- dependent noradrenaline transporter Sodium- dependent serotonin transporter Cytochrome P450 2D6 Cytochrome P450 2C19 Cytochrome P450 1A2 Cytochrome P450 3A4 Alpha-1A adrenergic receptor 5- hydroxytryptamine receptor 1A D(1A) dopamine receptor Beta-endorphin Mu-type opioid receptor Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-4 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Beta-endorphin Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit 3A Sodium- dependent noradrenaline transporter Sodium- dependent serotonin transporter Sodium- dependent dopamine transporter Pro- opiomelanocortin Neuroendocrine convertase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Desipramine Desipramine 2-hydroxyimipramine 2-Hydroxy-imipramine glucuronide Imipramine O2 NADPH H+ H2O NADP O2 NADH H2O Formaldehyde NAD Heme Heme Heme Heme Norepinephrine Serotonin Dopamine Ca+ Na+ K+ Ca+ Ca+ Norepinephrine Serotonin Na+ Na+ Na+ Na+ Dopamine Na+ Na+ ATP H2O Na+ K+ ADP Pi Na+ K+ Sodium channel protein type 10 subunit alpha Neuronal acetylcholine receptor subunit alpha-4 Sodium channel subunit beta-1 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit gamma Neuronal acetylcholine receptor subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Desipramine Pathway Axon Terminal Synaptic Vesicle Presynaptic Neuron Postsynaptic Neuron Synaptic Cleft Neuron Neuron Axon Action Potential Membrane Potential (mV) Resting Potential -70 Time +40 0 Depolarization Peak Action Potential Repolarization Hyperpolarization
Chloroplast Vacuole Calcium Sodium Calcium Calcium Sodium Potassium Potassium SLC6A2 SLC6A4 CYP2D6 CYP2C19 CYP1A2 CYP3A4 ADRA1A HTR1A DRD1 Unknown OPRM1 Unknown Unknown Unknown Unknown CACNA1A CACNB1 CACNA2D2 KCND2 KCNIP2 Unknown GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 Unknown Unknown ATP1A1 Desipramine Desipramine 2- hydroxyimipramine 2-Hydroxy- imipramine glucuronide Imipramine Oxygen NADPH Hydrogen Ion Water NADP Oxygen NADH Water Formaldehyde NAD Norepinephrine Serotonin Dopamine Calcium Sodium Potassium Calcium Calcium Norepinephrine Serotonin Sodium Sodium Sodium Sodium Dopamine Sodium Sodium Adenosine triphosphate Water Sodium Potassium Adenosine diphosphate Phosphate Sodium Potassium SCN10A Unknown