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2457-80-9 CAS C00315 KEGG Compound 2.5.1.22 false 2.5.1.22 S-Adenosylmethioninamine + Spermidine → 5'-Methylthioadenosine + Spermine LEFT_TO_RIGHT 71-44-3 CAS 1.0 2.5.1.16 false 2.5.1.16 Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Spermidine LEFT_TO_RIGHT 6262 PubChem-compound 937 ChemSpider P11926 UniProt S-adenosylmethionine synthase isoform type-2 S-Adenosylmethioninamine SMILES O 13837702 ChemSpider HMDB0001185 HMDB HMDB0000538 HMDB ATP BioCyc 6137 PubChem-compound S-ADENOSYLMETHIONINAMINE BioCyc S-adenosylmethionine synthase isoform type-2 Water 124-20-9 CAS 559142 ChemSpider CHEBI:15729 ChEBI S-adenosylmethionine decarboxylase proenzyme C15H23N6O5S S-Adenosylmethionine 399.14505 1.0 5742 ChemSpider 1038 PubChem-compound SMILES CSCC[C@H](N)C(O)=O GO:0005829 GENE ONTOLOGY Carbon dioxide 439176 PubChem-compound 274 ChemSpider Ornithine 1.0 ReactionCatalysis168 ACTIVATION 70-26-8 CAS PW000037 PathWhiz 485-80-3 CAS O4P Phosphate 94.95342 6026 ChemSpider 1.0 1010 ChemSpider Ornithine SubPathwayOutput 1.0 Ornithine decarboxylase HMDB0001414 HMDB Putrescine PPI BioCyc SMILES NCCCCN S-Adenosylmethioninamine C5H12N2O2 Ornithine 132.08987 CHEBI:17148 ChEBI CHEBI:16610 ChEBI SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N Carbon dioxide Cytosol HMDB0000696 HMDB SMILES [O-]P([O-])([O-])=O HMDB0000214 HMDB 124-38-9 CAS C00009 KEGG Compound 110-60-1 CAS CHEBI:15414 ChEBI Hydrogen Ion C00001 KEGG Compound HMDB0001429 HMDB Spermidine CHEBI:18361 ChEBI 388321 ChemSpider CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound SMILES NCCC[C@H](N)C(O)=O ReactionCatalysis410 ACTIVATION C00019 KEGG Compound 1.0 1.0 CHEBI:15625 ChEBI CHEBI:15746 ChEBI Adenosine triphosphate S-ADENOSYLMETHIONINE BioCyc C00011 KEGG Compound SMILES O=C=O C00013 KEGG Compound C00134 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 P19623 UniProt ReactionCatalysis409 ACTIVATION 5957 PubChem-compound C7H19N3 Spermidine 145.1579 ReactionCatalysis407 ACTIVATION ReactionCatalysis408 ACTIVATION C10H26N4 Spermine 202.21574 439415 PubChem-compound 1.0 H Hydrogen Ion 1.007825 22365-13-5 CAS SMILES CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N P52788 UniProt 1102 PubChem-compound 56-65-5 CAS MET BioCyc 1103 PubChem-compound Arginine and Proline Metabolism SubPathway GO:0005737 GENE ONTOLOGY Methionine adenosyltransferase 2 subunit beta C5H11NO2S L-Methionine 149.05106 PUTRESCINE BioCyc CPD-8587 BioCyc Spermine synthase SMILES NCCCCNCCCN SMILES NCCCNCCCCNCCCN 1.0 1.0 5-METHYLTHIOADENOSINE BioCyc HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Spermidine synthase 1072 ChemSpider 1071 ChemSpider C01137 KEGG Compound S-Adenosylmethionine SPERMINE BioCyc C00170 KEGG Compound CHEBI:17509 ChEBI Cytoplasm 388529 ChemSpider Spermidine and Spermine Biosynthesis C4H12N2 Putrescine 88.10005 CHEBI:15422 ChEBI Homo sapiens Methionine adenosyltransferase 2 subunit beta 4.0 7732-18-5 CAS 5'-Methylthioadenosine Spermine L-Methionine 63-68-3 CAS P31153 UniProt 5907 ChemSpider SMP0000020 SMPDB Spermine synthase CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:16526 ChEBI Ornithine decarboxylase Pyrophosphate Spermine synthase HMDB0001256 HMDB Spermidine synthase HMDB0001257 HMDB C00073 KEGG Compound 2.0 C14H23N6O3S S-Adenosylmethioninamine 355.15524 S-adenosylmethionine synthase 9606 TAXONOMY 962 PubChem-compound 31983 ChemSpider 2.0 1.0 SMP0000445 SMPDB SubPathwayInteraction755 SubPathway755Reaction SubPathwayReaction C00077 KEGG Compound S-adenosylmethionine decarboxylase proenzyme CO2 Carbon dioxide 43.98983 P17707 UniProt C00750 KEGG Compound C00080 KEGG Compound HMDB0002111 HMDB 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT CHEBI:15377 ChEBI 14265-44-2 CAS C11H15N5O3S 5'-Methylthioadenosine 297.08957 CHEBI:15378 ChEBI SMILES [H+] PW000010 PathWhiz SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Phosphate 1045 PubChem-compound 280 PubChem-compound SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N Spermidine synthase 644102 PubChem-compound Q9NZL9 UniProt HMDB0000988 HMDB 2.0 H2O Water 18.010565 4.1.1.17 false 4.1.1.17 Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 4.1.1.50 false 4.1.1.50 Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine LEFT_TO_RIGHT 1061 PubChem-compound Ornithine decarboxylase HMDB0059597 HMDB SPERMIDINE BioCyc 1.0 1.0 2.0 HMDB0001967 HMDB 1.0 24762165 PubChem-compound S-adenosylmethionine decarboxylase proenzyme 1.0 1.0 S-Adenosylmethionine HMDB0001173 HMDB L-ORNITHINE BioCyc S- adenosylmethionine synthase isoform type-2 Methionine adenosyltransferase 2 subunit beta Spermidine synthase Spermine synthase Ornithine decarboxylase S- adenosylmethionine decarboxylase proenzyme Ornithine ATP L-Methionine H 2 O S-Adenosylmethionine P i PP i S-Adenosylmethioninamine Putrescine 5'-Methylthioadenosine Spermidine Spermine CO 2 H + CO 2 Magnesium Potassium Pyridoxal 5'-phosphate Pyruvoyl group Arginine and Proline Metabolism Intracellular Space
2457-80-9 CAS C00315 KEGG Compound 2.5.1.22 false 2.5.1.22 S-Adenosylmethioninamine + Spermidine → 5'-Methylthioadenosine + Spermine LEFT_TO_RIGHT 71-44-3 CAS 1.0 2.5.1.16 false 2.5.1.16 Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Spermidine LEFT_TO_RIGHT 6262 PubChem-compound 937 ChemSpider P11926 UniProt S-adenosylmethionine synthase isoform type-2 S-Adenosylmethioninamine SMILES O 13837702 ChemSpider HMDB0001185 HMDB HMDB0000538 HMDB ATP BioCyc 6137 PubChem-compound S-ADENOSYLMETHIONINAMINE BioCyc S-adenosylmethionine synthase isoform type-2 Water 124-20-9 CAS 559142 ChemSpider CHEBI:15729 ChEBI S-adenosylmethionine decarboxylase proenzyme C15H23N6O5S S-Adenosylmethionine 399.14505 1.0 5742 ChemSpider 1038 PubChem-compound SMILES CSCC[C@H](N)C(O)=O GO:0005829 GENE ONTOLOGY Carbon dioxide 439176 PubChem-compound 274 ChemSpider Ornithine 1.0 ReactionCatalysis168 ACTIVATION 70-26-8 CAS PW000037 PathWhiz 485-80-3 CAS O4P Phosphate 94.95342 6026 ChemSpider 1.0 1010 ChemSpider Ornithine SubPathwayOutput 1.0 Ornithine decarboxylase HMDB0001414 HMDB Putrescine PPI BioCyc SMILES NCCCCN S-Adenosylmethioninamine C5H12N2O2 Ornithine 132.08987 CHEBI:17148 ChEBI CHEBI:16610 ChEBI SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N Carbon dioxide Cytosol HMDB0000696 HMDB SMILES [O-]P([O-])([O-])=O HMDB0000214 HMDB 124-38-9 CAS C00009 KEGG Compound 110-60-1 CAS CHEBI:15414 ChEBI Hydrogen Ion C00001 KEGG Compound HMDB0001429 HMDB Spermidine CHEBI:18361 ChEBI 388321 ChemSpider CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound SMILES NCCC[C@H](N)C(O)=O ReactionCatalysis410 ACTIVATION C00019 KEGG Compound 1.0 1.0 CHEBI:15625 ChEBI CHEBI:15746 ChEBI Adenosine triphosphate S-ADENOSYLMETHIONINE BioCyc C00011 KEGG Compound SMILES O=C=O C00013 KEGG Compound C00134 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 P19623 UniProt ReactionCatalysis409 ACTIVATION 5957 PubChem-compound C7H19N3 Spermidine 145.1579 ReactionCatalysis407 ACTIVATION ReactionCatalysis408 ACTIVATION C10H26N4 Spermine 202.21574 439415 PubChem-compound 1.0 H Hydrogen Ion 1.007825 22365-13-5 CAS SMILES CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N P52788 UniProt 1102 PubChem-compound 56-65-5 CAS MET BioCyc 1103 PubChem-compound Arginine and Proline Metabolism SubPathway GO:0005737 GENE ONTOLOGY Methionine adenosyltransferase 2 subunit beta C5H11NO2S L-Methionine 149.05106 PUTRESCINE BioCyc CPD-8587 BioCyc Spermine synthase SMILES NCCCCNCCCN SMILES NCCCNCCCCNCCCN 1.0 1.0 5-METHYLTHIOADENOSINE BioCyc HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Spermidine synthase 1072 ChemSpider 1071 ChemSpider C01137 KEGG Compound S-Adenosylmethionine SPERMINE BioCyc C00170 KEGG Compound CHEBI:17509 ChEBI Cytoplasm 388529 ChemSpider Spermidine and Spermine Biosynthesis C4H12N2 Putrescine 88.10005 CHEBI:15422 ChEBI Homo sapiens Methionine adenosyltransferase 2 subunit beta 4.0 7732-18-5 CAS 5'-Methylthioadenosine Spermine L-Methionine 63-68-3 CAS P31153 UniProt 5907 ChemSpider SMP0000020 SMPDB Spermine synthase CHEBI:16643 ChEBI C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:16526 ChEBI Ornithine decarboxylase Pyrophosphate Spermine synthase HMDB0001256 HMDB Spermidine synthase HMDB0001257 HMDB C00073 KEGG Compound 2.0 C14H23N6O3S S-Adenosylmethioninamine 355.15524 S-adenosylmethionine synthase 9606 TAXONOMY 962 PubChem-compound 31983 ChemSpider 2.0 1.0 SMP0000445 SMPDB SubPathwayInteraction755 SubPathway755Reaction SubPathwayReaction C00077 KEGG Compound S-adenosylmethionine decarboxylase proenzyme CO2 Carbon dioxide 43.98983 P17707 UniProt C00750 KEGG Compound C00080 KEGG Compound HMDB0002111 HMDB 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT CHEBI:15377 ChEBI 14265-44-2 CAS C11H15N5O3S 5'-Methylthioadenosine 297.08957 CHEBI:15378 ChEBI SMILES [H+] PW000010 PathWhiz SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Phosphate 1045 PubChem-compound 280 PubChem-compound SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N Spermidine synthase 644102 PubChem-compound Q9NZL9 UniProt HMDB0000988 HMDB 2.0 H2O Water 18.010565 4.1.1.17 false 4.1.1.17 Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 4.1.1.50 false 4.1.1.50 Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine LEFT_TO_RIGHT 1061 PubChem-compound Ornithine decarboxylase HMDB0059597 HMDB SPERMIDINE BioCyc 1.0 1.0 2.0 HMDB0001967 HMDB 1.0 24762165 PubChem-compound S-adenosylmethionine decarboxylase proenzyme 1.0 1.0 S-Adenosylmethionine HMDB0001173 HMDB L-ORNITHINE BioCyc MAT2A MAT2B SRM SMS ODC1 AMD1 Ornithine Adenosine triphosphate L-Methionine Water S- Adenosylmethionine Phosphate Pyrophosphate S- Adenosylmethioninamine Putrescine 5'- Methylthioadenosine Spermidine Spermine Carbon dioxide Hydrogen Ion Carbon dioxide Arginine and Proline Metabolism