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Sodium/potassium-transporting ATPase subunit alpha-3 6022 PubChem-compound 923 PubChem-compound Sodium/potassium-transporting ATPase subunit beta-1 937 ChemSpider CPD-8587 BioCyc C00031 KEGG Compound Transport191 false D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Cell LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit beta-2 1.0 B7ZKV8 UniProt 899 ChemSpider 76293 ChemSpider Sodium ReactionCatalysis1202 ACTIVATION Water Sodium/potassium-transporting ATPase subunit gamma 63-42-3 CAS LACTOSE BioCyc TransportCatalysis95 ACTIVATION SMILES O TransportCatalysis94 ACTIVATION Adenosine triphosphate P09848 UniProt HMDB0001341 HMDB Transport121 false D-Glucose (→), Sodium (→) Transport: Homo sapiens, Intestine to Homo sapiens, Intestine, Epithelial Cell LEFT_TO_RIGHT Transport122 false D-Galactose (→), Sodium (→) Transport: Homo sapiens, Intestine to Homo sapiens, Intestine, Epithelial Cell LEFT_TO_RIGHT HMDB0000538 HMDB SMILES [Na+] 388480 ChemSpider SMILES [K+] ATP BioCyc K%2b BioCyc Water P54709 UniProt 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Reaction1481 false Alpha-Lactose + Water → D-Galactose + D-Glucose LEFT_TO_RIGHT ADP BioCyc Lactase-phlorizin hydrolase Lactose Synthesis SubPathway HMDB0000143 HMDB 17341-25-2 CAS P05023 UniProt GALACTOSE BioCyc ATPase, (Na+)/K+ transporting, beta 4 polypeptide CHEBI:15422 ChEBI 5589 ChemSpider Sodium/glucose cotransporter 1 Sodium/potassium-transporting ATPase subunit alpha-4 PW000049 PathWhiz P05026 UniProt CHEBI:28061 ChEBI 1.0 Homo sapiens CL:0000066 CELL TYPE ONTOLOGY 5742 ChemSpider P14415 UniProt 7732-18-5 CAS Sodium/potassium-transporting ATPase subunit alpha-1 Sodium/potassium-transporting ATPase subunit alpha-3 C6H12O6 D-Galactose 180.06339 2280-44-6 CAS Sodium 791 ChemSpider BTO:0000648 BRENDA TISSUE ONTOLOGY Lactose Degradation ATPase, (Na+)/K+ transporting, beta 4 polypeptide Phosphate PW000153 PathWhiz 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 813 PubChem-compound O4P Phosphate 94.95342 1.0 C00984 KEGG Compound Sodium/potassium-transporting ATPase subunit beta-1 CHEBI:16761 ChEBI 1.0 Sodium/potassium-transporting ATPase subunit beta-3 Epithelial Cell 9606 TAXONOMY 962 PubChem-compound Solute carrier family 2, facilitated glucose transporter member 2 C00238 KEGG Compound 3.0 P11168 UniProt 5800 ChemSpider Sodium/potassium-transporting ATPase subunit gamma P13866 UniProt 439357 PubChem-compound 2.0 SMILES [O-]P([O-])([O-])=O CHEBI:36219 ChEBI GO:0005886 GENE ONTOLOGY BiologicalState75 Homo sapiens, Intestine, Epithelial Cell SMP0000444 SMPDB C6H12O6 D-Glucose 180.06339 HMDB0002111 HMDB D-Galactose SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O CHEBI:15377 ChEBI Cell Membrane C00009 KEGG Compound C00008 KEGG Compound C12H22O11 Alpha-Lactose 342.1162 Sodium/potassium-transporting ATPase subunit alpha-2 14265-44-2 CAS Sodium/potassium-transporting ATPase subunit beta-3 SMP0000457 SMPDB C00243 KEGG Compound C00001 KEGG Compound GLC BioCyc 24203-36-9 CAS 58-64-0 CAS HMDB0001429 HMDB Sodium/glucose cotransporter 1 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 C01330 KEGG Compound 3.6.3.9 false 3.6.3.9 Adenosine triphosphate + 2 Potassium + 3 Sodium + Water → Adenosine diphosphate + Phosphate + 2 Potassium + 3 Sodium LEFT_TO_RIGHT Lactase-phlorizin hydrolase CHEBI:18367 ChEBI P13637 UniProt 1032 ChemSpider C00002 KEGG Compound 1.0 HMDB0000586 HMDB HMDB0000588 HMDB Intestine CHEBI:4167 ChEBI Potassium HMDB0000186 HMDB TransportCatalysis143 ACTIVATION 5793 PubChem-compound TransportCatalysis142 ACTIVATION 84571 PubChem-compound P54710 UniProt Alpha-Lactose SubPathwayOutput SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O H2O Water 18.010565 D-Glucose Sodium/potassium ATPase 5957 PubChem-compound P50993 UniProt Sodium/potassium-transporting ATPase subunit beta-2 Q13733 UniProt Transport187 false D-Glucose (→) Transport: Homo sapiens, Intestine, Epithelial Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 1061 PubChem-compound Transport188 false D-Galactose (→) Transport: Homo sapiens, Intestine, Epithelial Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 ReactionCoupledTransportCatalysis39 ACTIVATION K Potassium 38.963707 59-23-4 CAS Sodium/potassium-transporting ATPase subunit alpha-4 56-65-5 CAS SubPathwayInteraction649 SubPathwayReaction SubPathway649Reaction Solute carrier family 2, facilitated glucose transporter member 2 SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O HMDB0000122 HMDB Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 BiologicalState60 Homo sapiens, Intestine CHEBI:29101 ChEBI Sodium/potassium-transporting ATPase subunit alpha-1 CHEBI:29103 ChEBI Sodium/glucose cotransporter 1 Sodium/glucose cotransporter 1 Solute carrier family 2, facilitated glucose transporter member 2 Solute carrier family 2, facilitated glucose transporter member 2 Lactase- phlorizin hydrolase Sodium/potassium- transporting ATPase subunit alpha-1 Alpha-Lactose D-Glucose D-Glucose Na + Na + D-Galactose D-Galactose Na + Na + D-Galactose D-Glucose D-Glucose H 2 O ATP K + Na + ADP K + Lactose Synthesis Intestinal microvillus Intestinal Epithelial Cell Intestinal Epithelial Cell Capillary Bed Lacteal Intestinal Epithelial Cell Capillary Capillary Bed Liver Intestinal Lumen
Sodium/potassium-transporting ATPase subunit alpha-3 6022 PubChem-compound 923 PubChem-compound Sodium/potassium-transporting ATPase subunit beta-1 937 ChemSpider CPD-8587 BioCyc C00031 KEGG Compound Transport191 false D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Cell LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit beta-2 1.0 B7ZKV8 UniProt 899 ChemSpider 76293 ChemSpider Sodium ReactionCatalysis1202 ACTIVATION Water Sodium/potassium-transporting ATPase subunit gamma 63-42-3 CAS LACTOSE BioCyc TransportCatalysis95 ACTIVATION SMILES O TransportCatalysis94 ACTIVATION Adenosine triphosphate P09848 UniProt HMDB0001341 HMDB Transport121 false D-Glucose (→), Sodium (→) Transport: Homo sapiens, Intestine to Homo sapiens, Intestine, Epithelial Cell LEFT_TO_RIGHT Transport122 false D-Galactose (→), Sodium (→) Transport: Homo sapiens, Intestine to Homo sapiens, Intestine, Epithelial Cell LEFT_TO_RIGHT HMDB0000538 HMDB SMILES [Na+] 388480 ChemSpider SMILES [K+] ATP BioCyc K%2b BioCyc Water P54709 UniProt 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Reaction1481 false Alpha-Lactose + Water → D-Galactose + D-Glucose LEFT_TO_RIGHT ADP BioCyc Lactase-phlorizin hydrolase Lactose Synthesis SubPathway HMDB0000143 HMDB 17341-25-2 CAS P05023 UniProt GALACTOSE BioCyc ATPase, (Na+)/K+ transporting, beta 4 polypeptide CHEBI:15422 ChEBI 5589 ChemSpider Sodium/glucose cotransporter 1 Sodium/potassium-transporting ATPase subunit alpha-4 PW000049 PathWhiz P05026 UniProt CHEBI:28061 ChEBI 1.0 Homo sapiens CL:0000066 CELL TYPE ONTOLOGY 5742 ChemSpider P14415 UniProt 7732-18-5 CAS Sodium/potassium-transporting ATPase subunit alpha-1 Sodium/potassium-transporting ATPase subunit alpha-3 C6H12O6 D-Galactose 180.06339 2280-44-6 CAS Sodium 791 ChemSpider BTO:0000648 BRENDA TISSUE ONTOLOGY Lactose Degradation ATPase, (Na+)/K+ transporting, beta 4 polypeptide Phosphate PW000153 PathWhiz 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 813 PubChem-compound O4P Phosphate 94.95342 1.0 C00984 KEGG Compound Sodium/potassium-transporting ATPase subunit beta-1 CHEBI:16761 ChEBI 1.0 Sodium/potassium-transporting ATPase subunit beta-3 Epithelial Cell 9606 TAXONOMY 962 PubChem-compound Solute carrier family 2, facilitated glucose transporter member 2 C00238 KEGG Compound 3.0 P11168 UniProt 5800 ChemSpider Sodium/potassium-transporting ATPase subunit gamma P13866 UniProt 439357 PubChem-compound 2.0 SMILES [O-]P([O-])([O-])=O CHEBI:36219 ChEBI GO:0005886 GENE ONTOLOGY BiologicalState75 Homo sapiens, Intestine, Epithelial Cell SMP0000444 SMPDB C6H12O6 D-Glucose 180.06339 HMDB0002111 HMDB D-Galactose SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O CHEBI:15377 ChEBI Cell Membrane C00009 KEGG Compound C00008 KEGG Compound C12H22O11 Alpha-Lactose 342.1162 Sodium/potassium-transporting ATPase subunit alpha-2 14265-44-2 CAS Sodium/potassium-transporting ATPase subunit beta-3 SMP0000457 SMPDB C00243 KEGG Compound C00001 KEGG Compound GLC BioCyc 24203-36-9 CAS 58-64-0 CAS HMDB0001429 HMDB Sodium/glucose cotransporter 1 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 C01330 KEGG Compound 3.6.3.9 false 3.6.3.9 Adenosine triphosphate + 2 Potassium + 3 Sodium + Water → Adenosine diphosphate + Phosphate + 2 Potassium + 3 Sodium LEFT_TO_RIGHT Lactase-phlorizin hydrolase CHEBI:18367 ChEBI P13637 UniProt 1032 ChemSpider C00002 KEGG Compound 1.0 HMDB0000586 HMDB HMDB0000588 HMDB Intestine CHEBI:4167 ChEBI Potassium HMDB0000186 HMDB TransportCatalysis143 ACTIVATION 5793 PubChem-compound TransportCatalysis142 ACTIVATION 84571 PubChem-compound P54710 UniProt Alpha-Lactose SubPathwayOutput SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O H2O Water 18.010565 D-Glucose Sodium/potassium ATPase 5957 PubChem-compound P50993 UniProt Sodium/potassium-transporting ATPase subunit beta-2 Q13733 UniProt Transport187 false D-Glucose (→) Transport: Homo sapiens, Intestine, Epithelial Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 1061 PubChem-compound Transport188 false D-Galactose (→) Transport: Homo sapiens, Intestine, Epithelial Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 ReactionCoupledTransportCatalysis39 ACTIVATION K Potassium 38.963707 59-23-4 CAS Sodium/potassium-transporting ATPase subunit alpha-4 56-65-5 CAS SubPathwayInteraction649 SubPathwayReaction SubPathway649Reaction Solute carrier family 2, facilitated glucose transporter member 2 SMILES OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O HMDB0000122 HMDB Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 BiologicalState60 Homo sapiens, Intestine CHEBI:29101 ChEBI Sodium/potassium-transporting ATPase subunit alpha-1 CHEBI:29103 ChEBI SLC5A1 SLC5A1 SLC2A2 SLC2A2 LCT ATP1A1 Alpha-Lactose D-Glucose D-Glucose Sodium Sodium D-Galactose D-Galactose Sodium Sodium D-Galactose D-Glucose D-Glucose Water Adenosine triphosphate Potassium Sodium Adenosine diphosphate Potassium Lactose Synthesis