Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.

Loading Pathway...

Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha 6022 PubChem-compound Phosphatidylinositol 4-kinase alpha 937 ChemSpider Inositol 1,4,5-trisphosphate Synaptojanin-1 CHEBI:75466 ChEBI C43H82O16P2 PIP(18:1(9Z)/16:0) 916.5078 Polyphosphoinositide phosphatase SMILES O O15327 UniProt C13861 KEGG Compound HMDB0000095 HMDB 3123-73-7 CAS 6131 PubChem-compound 1.0 CDP-diacylglycerol--inositol 3-phosphatidyltransferase HMDB0000538 HMDB ATP BioCyc 1.0 Type II inositol 3,4-bisphosphate 4-phosphatase Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform P48426 UniProt 1.0 ADP BioCyc PIP2(16:0/18:1(9Z)) PIP2(16:0/18:1(9Z)) PW000168 PathWhiz 1.0 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5742 ChemSpider CHEBI:16595 ChEBI GO:0005829 GENE ONTOLOGY Q9Y2I7 UniProt Q9NQ66 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H](C(O)[C@H]1O)N1C=CC(N)=NC1=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MYO-INOSITOL BioCyc 85166-31-0 CAS Phosphatidylinositol 3-kinase regulatory subunit alpha SubPathwayInteraction297 SubPathway297Reaction SubPathwayReaction Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SubPathwayInteraction296 SubPathway296Reaction SubPathwayReaction PW000156 PathWhiz Phosphate 24767914 ChemSpider C6H12O6 myo-Inositol 180.06339 4445454 ChemSpider O4P Phosphate 94.95342 72 kDa inositol polyphosphate 5-phosphatase 1.0 72 kDa inositol polyphosphate 5-phosphatase Synaptojanin-1 C43H81O13P PI(16:0/18:1(9Z)) 836.5415 87-89-8 CAS 53480165 PubChem-compound SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC 63-37-6 CAS P04626 UniProt Activating molecule in BECN1-regulated autophagy protein 1 Polyphosphoinositide phosphatase Type II inositol 3,4-bisphosphate 4-phosphatase CHEBI:17268 ChEBI EGFR protein 10239179 ChemSpider Beclin-1 1.0 1.0 Cytosol myo-Inositol SubPathwayOutput Phosphoinositide 3-kinase regulatory subunit 4 HMDB0000211 HMDB PIP[4'](16:0/18:1(9Z)) SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY inositol_1,4,5-trisphosphate BioCyc C00009 KEGG Compound Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha C00008 KEGG Compound 53480228 PubChem-compound Phosphatidylinositols BioCyc Receptor tyrosine-protein kinase erbB-2 C00001 KEGG Compound HMDB0001429 HMDB Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1.0 SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O Protein VAC14 homolog CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 388562 ChemSpider SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC Polyphosphoinositide phosphatase HMDB0010150 HMDB 24767668 ChemSpider CHEBI:17361 ChEBI HMDB0010037 HMDB C00137 KEGG Compound 5957 PubChem-compound DG(16:0/18:1(9Z)/0:0) Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha Q504U8 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(O)(O)=O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)[O](C(OP(O)(O)=O)C1O)P(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC 24765811 ChemSpider SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)C(O)C(OP(O)(O)=O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC PIP[5'](16:0/18:1(9Z)) 56-65-5 CAS C00269 KEGG Compound 1.0 Phosphatidylinositol 3-kinase catalytic subunit type 3 Q9C0C7 UniProt Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 PIP2[4,5](16:0/18:1(9Z)) C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN C9H14N3O8P Cytidine monophosphate 323.05185 HMDB0009970 HMDB 1.0 DIACYLGLYCEROL BioCyc CPD-8587 BioCyc Q99570 UniProt Cytidine monophosphate C01245 KEGG Compound C46H83N3O15P2 CDP-DG(16:0/18:1(9Z)) 979.52997 1.0 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 1-phosphatidylinositol 3-phosphate 5-kinase Adenosine triphosphate 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0) LEFT_TO_RIGHT HMDB0001341 HMDB 1.0 3.1.3.36 false 3.1.3.36 PIP(18:1(9Z)/16:0) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 1.0 C43H82O16P2 PIP[5'](16:0/18:1(9Z)) 916.5078 2.7.8.11 false 2.7.8.11 CDP-DG(16:0/18:1(9Z)) + myo-Inositol → Cytidine monophosphate + PI(16:0/18:1(9Z)) LEFT_TO_RIGHT C42H82O19P3 PIP2[4,5](16:0/18:1(9Z)) 983.4663 C43H82O16P2 PIP[4'](16:0/18:1(9Z)) 916.5078 Receptor tyrosine-protein kinase erbB-2 24767851 ChemSpider Water 24768027 ChemSpider Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O C37H70O5 DG(16:0/18:1(9Z)/0:0) 594.52234 CDP-diacylglycerol--inositol 3-phosphatidyltransferase SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O Adenosine diphosphate Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha ReactionCatalysis1175 ACTIVATION 1.0 ReactionCatalysis1177 ACTIVATION ReactionCatalysis1176 ACTIVATION ReactionCatalysis1179 ACTIVATION Q8NEB9 UniProt ReactionCatalysis1178 ACTIVATION 5901 ChemSpider PIP(18:1(9Z)/16:0) HMDB0061187 HMDB CHEBI:17962 ChEBI CHEBI:15422 ChEBI Q92835 UniProt HMDB0061188 HMDB ReactionCatalysis1180 ACTIVATION C43H84O22P4 PIP3(16:0/18:1(9Z)) 1076.4404 HMDB0061186 HMDB O00443 UniProt ReactionCatalysis1182 ACTIVATION ReactionCatalysis1181 ACTIVATION Homo sapiens C00055 KEGG Compound Phosphatidylinositol 3-kinase regulatory subunit alpha 7732-18-5 CAS 5282283 PubChem-compound O00329 UniProt 1.0 O14735 UniProt Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 439456 PubChem-compound 1.0 SMILES CCCCCCCCCCCCCCCC(=O)O[C@]([H])(COC(=O)CCCCCCC\C=C/CCCCCCCC)COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](OP(=O)(O)O)C1O myo-Inositol CDPDIACYLGLYCEROL BioCyc 3.1.3.36 false 3.1.3.36 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1184 ACTIVATION ReactionCatalysis1183 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP2(16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z)) LEFT_TO_RIGHT ReactionCatalysis1186 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1185 ACTIVATION 3.1.3.86 false 3.1.3.86 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1188 ACTIVATION C43H83O19P3 PIP2(16:0/18:1(9Z)) 996.4741 Water HMDB0007102 HMDB ReactionCatalysis1189 ACTIVATION C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 ReactionCatalysis1190 ACTIVATION 2.7.1.149 false 2.7.1.149 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT C00626 KEGG Compound 1.0 ReactionCatalysis1192 ACTIVATION P60484 UniProt 892 PubChem-compound Protein VAC14 homolog CHEBI:16761 ChEBI 1-phosphatidylinositol-3-phosphate 5-kinase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Phosphatidylinositol Phosphate Metabolism HMDB0001498 HMDB Inositol Phosphate Metabolism SubPathway Q9NRR6 UniProt O43426 UniProt 3.1.3.66 false 3.1.3.66 PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate LEFT_TO_RIGHT PIP3(16:0/18:1(9Z)) 1.0 3.1.3.36 false 3.1.3.36 PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate LEFT_TO_RIGHT 1.0 2.7.1.150 false 2.7.1.150 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.137 false 2.7.1.137 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0) LEFT_TO_RIGHT 9606 TAXONOMY 962 PubChem-compound SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(OP(=O)(O)O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC 5800 ChemSpider PIP(18:1(9Z)/16:0) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1-phosphatidylinositol-3-phosphate 5-kinase 1.0 CMP BioCyc ReactionCatalysis1128 ACTIVATION ReactionCatalysis1127 ACTIVATION Phosphatidylinositol 3-kinase catalytic subunit type 3 P42356 UniProt 3.1.3.36 false 3.1.3.36 PIP[4'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC HMDB0002111 HMDB 1.0 HMDB0009783 HMDB Cell Membrane CHEBI:15377 ChEBI 1.0 14265-44-2 CAS Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha 58-64-0 CAS Q92562 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PI(16:0/18:1(9Z)) Phosphate 1.0 1.0 P27986 UniProt CDP-DG(16:0/18:1(9Z)) ReactionCatalysis1132 ACTIVATION Q14457 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 EGFR protein 1.0 1.0 1.0 ReactionCatalysis1148 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP[5'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1147 ACTIVATION 3.1.3.- false 3.1.3.- Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.149 false 2.7.1.149 Adenosine triphosphate + PIP[5'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z)) LEFT_TO_RIGHT Q99755 UniProt H2O Water 18.010565 3.1.3.86 false 3.1.3.86 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[5'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT HMDB0006971 HMDB SMP0000463 SMPDB ReactionCatalysis1142 ACTIVATION ReactionCatalysis1141 ACTIVATION ReactionCatalysis1143 ACTIVATION SMP0000462 SMPDB Q08AM6 UniProt ReactionCatalysis1145 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z)) LEFT_TO_RIGHT 1.0 1.0 1061 PubChem-compound Beclin-1 1.0 Phosphatidylinositol 4-kinase alpha 1.0 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT Reaction1463 false PIP3(16:0/18:1(9Z)) + Water → PIP2[4,5](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT Adenosine diphosphate 2.7.1.67 false 2.7.1.67 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[4'](16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.154 false 2.7.1.154 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT Activating molecule in BECN1-regulated autophagy protein 1 1.0 Inositol 1,4,5-trisphosphate SubPathwayInput 3.1.3.36 false 3.1.3.36 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 53477915 PubChem-compound ReactionCatalysis1152 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1155 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z)) LEFT_TO_RIGHT ReactionCatalysis1154 ACTIVATION 3.1.3.86 false 3.1.3.86 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PIP2[4,5](16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z)) LEFT_TO_RIGHT 1.0 ReactionCatalysis1156 ACTIVATION 3.1.4.11 false 3.1.4.11 PIP2[4,5](16:0/18:1(9Z)) + Water → DG(16:0/18:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT CDP- diacylglycerol- -inositol 3- phosphatidyltransferase Synaptojanin-1 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Beclin-1 Activating molecule in BECN1-regulated autophagy protein 1 1- phosphatidylinositol- 3-phosphate 5-kinase Polyphosphoinositide phosphatase Protein VAC14 homolog Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Synaptojanin-1 Type II inositol 3,4- bisphosphate 4-phosphatase Phosphatidylinositol- 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 3,4,5- trisphosphate 5-phosphatase 1 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 72 kDa inositol polyphosphate 5-phosphatase Synaptojanin-1 Synaptojanin-1 Phosphatidylinositol 4-kinase alpha Phosphatidylinositol 4-phosphate 3-kinase C2 domain- containing subunit alpha Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3,4,5- trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 3,4,5- trisphosphate 5-phosphatase 1 72 kDa inositol polyphosphate 5-phosphatase Synaptojanin-1 Phosphatidylinositol 3,4,5- trisphosphate 5-phosphatase 1 Phosphatidylinositol- 5-phosphate 4-kinase type-2 alpha Synaptojanin-1 Polyphosphoinositide phosphatase Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha myo-Inositol Inositol 1,4,5- trisphosphate CDP-DG(16:0/18:1(9Z)) PI(16:0/18:1(9Z)) Cytidine monophosphate PIP(18:1(9Z)/16:0) H 2 O P i ATP ADP ATP ADP ATP PIP2(16:0/18:1(9Z)) ADP ATP ADP ATP PIP2(16:0/18:1(9Z)) ADP H 2 O P i H 2 O P i ATP ADP PIP3(16:0/18:1(9Z)) H 2 O P i ATP ADP H 2 O P i H 2 O P i PIP[4'](16:0/18:1(9Z)) H 2 O P i ATP ADP ATP ADP ATP ADP H 2 O PIP2[4,5](16:0/18:1(9Z)) P i ATP ADP H 2 O DG(16:0/18:1(9Z)/0:0) ATP ADP H 2 O P i H 2 O P i H 2 O P i H 2 O PIP[5'](16:0/18:1(9Z)) P i ATP ADP H 2 O P i ATP ADP ATP ADP Magnesium Manganese Manganese Calcium Magnesium Calcium Inositol Phosphate Metabolism Inositol Phosphate Metabolism
Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha 6022 PubChem-compound Phosphatidylinositol 4-kinase alpha 937 ChemSpider Inositol 1,4,5-trisphosphate Synaptojanin-1 CHEBI:75466 ChEBI C43H82O16P2 PIP(18:1(9Z)/16:0) 916.5078 Polyphosphoinositide phosphatase SMILES O O15327 UniProt C13861 KEGG Compound HMDB0000095 HMDB 3123-73-7 CAS 6131 PubChem-compound 1.0 CDP-diacylglycerol--inositol 3-phosphatidyltransferase HMDB0000538 HMDB ATP BioCyc 1.0 Type II inositol 3,4-bisphosphate 4-phosphatase Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform P48426 UniProt 1.0 ADP BioCyc PIP2(16:0/18:1(9Z)) PIP2(16:0/18:1(9Z)) PW000168 PathWhiz 1.0 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5742 ChemSpider CHEBI:16595 ChEBI GO:0005829 GENE ONTOLOGY Q9Y2I7 UniProt Q9NQ66 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H](C(O)[C@H]1O)N1C=CC(N)=NC1=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MYO-INOSITOL BioCyc 85166-31-0 CAS Phosphatidylinositol 3-kinase regulatory subunit alpha SubPathwayInteraction297 SubPathway297Reaction SubPathwayReaction Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SubPathwayInteraction296 SubPathway296Reaction SubPathwayReaction PW000156 PathWhiz Phosphate 24767914 ChemSpider C6H12O6 myo-Inositol 180.06339 4445454 ChemSpider O4P Phosphate 94.95342 72 kDa inositol polyphosphate 5-phosphatase 1.0 72 kDa inositol polyphosphate 5-phosphatase Synaptojanin-1 C43H81O13P PI(16:0/18:1(9Z)) 836.5415 87-89-8 CAS 53480165 PubChem-compound SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC 63-37-6 CAS P04626 UniProt Activating molecule in BECN1-regulated autophagy protein 1 Polyphosphoinositide phosphatase Type II inositol 3,4-bisphosphate 4-phosphatase CHEBI:17268 ChEBI EGFR protein 10239179 ChemSpider Beclin-1 1.0 1.0 Cytosol myo-Inositol SubPathwayOutput Phosphoinositide 3-kinase regulatory subunit 4 HMDB0000211 HMDB PIP[4'](16:0/18:1(9Z)) SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY inositol_1,4,5-trisphosphate BioCyc C00009 KEGG Compound Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha C00008 KEGG Compound 53480228 PubChem-compound Phosphatidylinositols BioCyc Receptor tyrosine-protein kinase erbB-2 C00001 KEGG Compound HMDB0001429 HMDB Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1.0 SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O Protein VAC14 homolog CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 388562 ChemSpider SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC Polyphosphoinositide phosphatase HMDB0010150 HMDB 24767668 ChemSpider CHEBI:17361 ChEBI HMDB0010037 HMDB C00137 KEGG Compound 5957 PubChem-compound DG(16:0/18:1(9Z)/0:0) Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha Q504U8 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(O)(O)=O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)[O](C(OP(O)(O)=O)C1O)P(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC 24765811 ChemSpider SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)C(O)C(OP(O)(O)=O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC PIP[5'](16:0/18:1(9Z)) 56-65-5 CAS C00269 KEGG Compound 1.0 Phosphatidylinositol 3-kinase catalytic subunit type 3 Q9C0C7 UniProt Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 PIP2[4,5](16:0/18:1(9Z)) C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN C9H14N3O8P Cytidine monophosphate 323.05185 HMDB0009970 HMDB 1.0 DIACYLGLYCEROL BioCyc CPD-8587 BioCyc Q99570 UniProt Cytidine monophosphate C01245 KEGG Compound C46H83N3O15P2 CDP-DG(16:0/18:1(9Z)) 979.52997 1.0 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 1-phosphatidylinositol 3-phosphate 5-kinase Adenosine triphosphate 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0) LEFT_TO_RIGHT HMDB0001341 HMDB 1.0 3.1.3.36 false 3.1.3.36 PIP(18:1(9Z)/16:0) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 1.0 C43H82O16P2 PIP[5'](16:0/18:1(9Z)) 916.5078 2.7.8.11 false 2.7.8.11 CDP-DG(16:0/18:1(9Z)) + myo-Inositol → Cytidine monophosphate + PI(16:0/18:1(9Z)) LEFT_TO_RIGHT C42H82O19P3 PIP2[4,5](16:0/18:1(9Z)) 983.4663 C43H82O16P2 PIP[4'](16:0/18:1(9Z)) 916.5078 Receptor tyrosine-protein kinase erbB-2 24767851 ChemSpider Water 24768027 ChemSpider Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O C37H70O5 DG(16:0/18:1(9Z)/0:0) 594.52234 CDP-diacylglycerol--inositol 3-phosphatidyltransferase SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O Adenosine diphosphate Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha ReactionCatalysis1175 ACTIVATION 1.0 ReactionCatalysis1177 ACTIVATION ReactionCatalysis1176 ACTIVATION ReactionCatalysis1179 ACTIVATION Q8NEB9 UniProt ReactionCatalysis1178 ACTIVATION 5901 ChemSpider PIP(18:1(9Z)/16:0) HMDB0061187 HMDB CHEBI:17962 ChEBI CHEBI:15422 ChEBI Q92835 UniProt HMDB0061188 HMDB ReactionCatalysis1180 ACTIVATION C43H84O22P4 PIP3(16:0/18:1(9Z)) 1076.4404 HMDB0061186 HMDB O00443 UniProt ReactionCatalysis1182 ACTIVATION ReactionCatalysis1181 ACTIVATION Homo sapiens C00055 KEGG Compound Phosphatidylinositol 3-kinase regulatory subunit alpha 7732-18-5 CAS 5282283 PubChem-compound O00329 UniProt 1.0 O14735 UniProt Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 439456 PubChem-compound 1.0 SMILES CCCCCCCCCCCCCCCC(=O)O[C@]([H])(COC(=O)CCCCCCC\C=C/CCCCCCCC)COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](OP(=O)(O)O)C1O myo-Inositol CDPDIACYLGLYCEROL BioCyc 3.1.3.36 false 3.1.3.36 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1184 ACTIVATION ReactionCatalysis1183 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP2(16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z)) LEFT_TO_RIGHT ReactionCatalysis1186 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1185 ACTIVATION 3.1.3.86 false 3.1.3.86 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1188 ACTIVATION C43H83O19P3 PIP2(16:0/18:1(9Z)) 996.4741 Water HMDB0007102 HMDB ReactionCatalysis1189 ACTIVATION C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 ReactionCatalysis1190 ACTIVATION 2.7.1.149 false 2.7.1.149 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT C00626 KEGG Compound 1.0 ReactionCatalysis1192 ACTIVATION P60484 UniProt 892 PubChem-compound Protein VAC14 homolog CHEBI:16761 ChEBI 1-phosphatidylinositol-3-phosphate 5-kinase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Phosphatidylinositol Phosphate Metabolism HMDB0001498 HMDB Inositol Phosphate Metabolism SubPathway Q9NRR6 UniProt O43426 UniProt 3.1.3.66 false 3.1.3.66 PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate LEFT_TO_RIGHT PIP3(16:0/18:1(9Z)) 1.0 3.1.3.36 false 3.1.3.36 PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate LEFT_TO_RIGHT 1.0 2.7.1.150 false 2.7.1.150 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.137 false 2.7.1.137 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0) LEFT_TO_RIGHT 9606 TAXONOMY 962 PubChem-compound SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(OP(=O)(O)O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC 5800 ChemSpider PIP(18:1(9Z)/16:0) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1-phosphatidylinositol-3-phosphate 5-kinase 1.0 CMP BioCyc ReactionCatalysis1128 ACTIVATION ReactionCatalysis1127 ACTIVATION Phosphatidylinositol 3-kinase catalytic subunit type 3 P42356 UniProt 3.1.3.36 false 3.1.3.36 PIP[4'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC HMDB0002111 HMDB 1.0 HMDB0009783 HMDB Cell Membrane CHEBI:15377 ChEBI 1.0 14265-44-2 CAS Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha 58-64-0 CAS Q92562 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PI(16:0/18:1(9Z)) Phosphate 1.0 1.0 P27986 UniProt CDP-DG(16:0/18:1(9Z)) ReactionCatalysis1132 ACTIVATION Q14457 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 EGFR protein 1.0 1.0 1.0 ReactionCatalysis1148 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP[5'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1147 ACTIVATION 3.1.3.- false 3.1.3.- Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.149 false 2.7.1.149 Adenosine triphosphate + PIP[5'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z)) LEFT_TO_RIGHT Q99755 UniProt H2O Water 18.010565 3.1.3.86 false 3.1.3.86 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[5'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT HMDB0006971 HMDB SMP0000463 SMPDB ReactionCatalysis1142 ACTIVATION ReactionCatalysis1141 ACTIVATION ReactionCatalysis1143 ACTIVATION SMP0000462 SMPDB Q08AM6 UniProt ReactionCatalysis1145 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z)) LEFT_TO_RIGHT 1.0 1.0 1061 PubChem-compound Beclin-1 1.0 Phosphatidylinositol 4-kinase alpha 1.0 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT Reaction1463 false PIP3(16:0/18:1(9Z)) + Water → PIP2[4,5](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT Adenosine diphosphate 2.7.1.67 false 2.7.1.67 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[4'](16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.154 false 2.7.1.154 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT Activating molecule in BECN1-regulated autophagy protein 1 1.0 Inositol 1,4,5-trisphosphate SubPathwayInput 3.1.3.36 false 3.1.3.36 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 53477915 PubChem-compound ReactionCatalysis1152 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1155 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z)) LEFT_TO_RIGHT ReactionCatalysis1154 ACTIVATION 3.1.3.86 false 3.1.3.86 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PIP2[4,5](16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z)) LEFT_TO_RIGHT 1.0 ReactionCatalysis1156 ACTIVATION 3.1.4.11 false 3.1.4.11 PIP2[4,5](16:0/18:1(9Z)) + Water → DG(16:0/18:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT CDIPT SYNJ1 PIK3CA PIK3R1 PIK3C3 PIK3R4 Unknown AMBRA1 PIKFYVE FIG4 VAC14 PIP5K1A PIP5K1A SYNJ1 INPP4B PIP4K2A INPP5D PIP5K1A INPP5E SYNJ1 SYNJ1 PI4KA PIK3C2A ERBB2 Unknown PIK3CD PIK3R1 PTEN PIK3CD PIK3R1 PLCB1 PIP5K1A INPP5D INPP5E SYNJ1 INPP5D PIP4K2A SYNJ1 FIG4 VAC14 PIKFYVE PIP5K1A myo-Inositol Inositol 1,4,5- trisphosphate CDP- DG(16:0/18:1(9Z)) PI(16:0/18:1(9Z)) Cytidine monophosphate PIP(18:1(9Z)/16:0) Water Phosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate PIP2(16:0/18:1(9Z)) Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate PIP2(16:0/18:1(9Z)) Adenosine diphosphate Water Phosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate PIP3(16:0/18:1(9Z)) Water Phosphate Adenosine triphosphate Adenosine diphosphate Water Phosphate Water Phosphate PIP[4'](16:0/18:1(9Z)) Water Phosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Water PIP2[4,5](16:0/18:1(9Z)) Phosphate Adenosine triphosphate Adenosine diphosphate Water DG(16:0/18:1(9Z)/0:0) Adenosine triphosphate Adenosine diphosphate Water Phosphate Water Phosphate Water Phosphate Water PIP[5'](16:0/18:1(9Z)) Phosphate Adenosine triphosphate Adenosine diphosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Inositol Phosphate Metabolism Inositol Phosphate Metabolism