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Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha 6022 PubChem-compound Phosphatidylinositol 4-kinase alpha 937 ChemSpider Inositol 1,4,5-trisphosphate Synaptojanin-1 CHEBI:75466 ChEBI C43H82O16P2 PIP(18:1(9Z)/16:0) 916.5078 Polyphosphoinositide phosphatase SMILES O O15327 UniProt C13861 KEGG Compound HMDB0000095 HMDB 3123-73-7 CAS 6131 PubChem-compound 1.0 CDP-diacylglycerol--inositol 3-phosphatidyltransferase HMDB0000538 HMDB ATP BioCyc 1.0 Type II inositol 3,4-bisphosphate 4-phosphatase Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform P48426 UniProt 1.0 ADP BioCyc PIP2(16:0/18:1(9Z)) PIP2(16:0/18:1(9Z)) 1.0 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5742 ChemSpider CHEBI:16595 ChEBI GO:0005829 GENE ONTOLOGY Q9Y2I7 UniProt Q9NQ66 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H](C(O)[C@H]1O)N1C=CC(N)=NC1=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MYO-INOSITOL BioCyc 85166-31-0 CAS Phosphatidylinositol 3-kinase regulatory subunit alpha SubPathwayInteraction297 SubPathway297Reaction SubPathwayReaction Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform SubPathwayInteraction296 SubPathway296Reaction SubPathwayReaction PW000156 PathWhiz Phosphate 24767914 ChemSpider C6H12O6 myo-Inositol 180.06339 4445454 ChemSpider O4P Phosphate 94.95342 72 kDa inositol polyphosphate 5-phosphatase 1.0 72 kDa inositol polyphosphate 5-phosphatase Synaptojanin-1 C43H81O13P PI(16:0/18:1(9Z)) 836.5415 87-89-8 CAS 53480165 PubChem-compound SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC 63-37-6 CAS P04626 UniProt Activating molecule in BECN1-regulated autophagy protein 1 Polyphosphoinositide phosphatase Type II inositol 3,4-bisphosphate 4-phosphatase CHEBI:17268 ChEBI EGFR protein 10239179 ChemSpider Beclin-1 1.0 1.0 Cytosol myo-Inositol SubPathwayOutput Phosphoinositide 3-kinase regulatory subunit 4 HMDB0000211 HMDB PIP[4'](16:0/18:1(9Z)) SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY inositol_1,4,5-trisphosphate BioCyc C00009 KEGG Compound Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha C00008 KEGG Compound 53480228 PubChem-compound Phosphatidylinositols BioCyc Receptor tyrosine-protein kinase erbB-2 C00001 KEGG Compound HMDB0001429 HMDB Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1.0 SMILES O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O Protein VAC14 homolog CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 388562 ChemSpider SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC Polyphosphoinositide phosphatase HMDB0010150 HMDB 24767668 ChemSpider CHEBI:17361 ChEBI HMDB0010037 HMDB C00137 KEGG Compound 5957 PubChem-compound DG(16:0/18:1(9Z)/0:0) Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha Q504U8 UniProt SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(O)(O)=O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)[O](C(OP(O)(O)=O)C1O)P(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC 24765811 ChemSpider SMILES [H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(=O)O[C@@H]1C(O)[C@H](O)C(O)C(OP(O)(O)=O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC PIP[5'](16:0/18:1(9Z)) 56-65-5 CAS C00269 KEGG Compound 1.0 Phosphatidylinositol 3-kinase catalytic subunit type 3 Q9C0C7 UniProt Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 PIP2[4,5](16:0/18:1(9Z)) C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN C9H14N3O8P Cytidine monophosphate 323.05185 HMDB0009970 HMDB 1.0 DIACYLGLYCEROL BioCyc CPD-8587 BioCyc Q99570 UniProt Cytidine monophosphate C01245 KEGG Compound C46H83N3O15P2 CDP-DG(16:0/18:1(9Z)) 979.52997 1.0 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 1-phosphatidylinositol 3-phosphate 5-kinase Adenosine triphosphate 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0) LEFT_TO_RIGHT HMDB0001341 HMDB 1.0 3.1.3.36 false 3.1.3.36 PIP(18:1(9Z)/16:0) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 1.0 C43H82O16P2 PIP[5'](16:0/18:1(9Z)) 916.5078 2.7.8.11 false 2.7.8.11 CDP-DG(16:0/18:1(9Z)) + myo-Inositol → Cytidine monophosphate + PI(16:0/18:1(9Z)) LEFT_TO_RIGHT C42H82O19P3 PIP2[4,5](16:0/18:1(9Z)) 983.4663 C43H82O16P2 PIP[4'](16:0/18:1(9Z)) 916.5078 Receptor tyrosine-protein kinase erbB-2 24767851 ChemSpider Water 24768027 ChemSpider Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O C37H70O5 DG(16:0/18:1(9Z)/0:0) 594.52234 CDP-diacylglycerol--inositol 3-phosphatidyltransferase SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O Adenosine diphosphate Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha ReactionCatalysis1175 ACTIVATION 1.0 ReactionCatalysis1177 ACTIVATION ReactionCatalysis1176 ACTIVATION ReactionCatalysis1179 ACTIVATION Q8NEB9 UniProt ReactionCatalysis1178 ACTIVATION 5901 ChemSpider PIP(18:1(9Z)/16:0) HMDB0061187 HMDB CHEBI:17962 ChEBI CHEBI:15422 ChEBI Q92835 UniProt HMDB0061188 HMDB ReactionCatalysis1180 ACTIVATION C43H84O22P4 PIP3(16:0/18:1(9Z)) 1076.4404 HMDB0061186 HMDB O00443 UniProt ReactionCatalysis1182 ACTIVATION ReactionCatalysis1181 ACTIVATION Homo sapiens C00055 KEGG Compound Phosphatidylinositol 3-kinase regulatory subunit alpha 7732-18-5 CAS 5282283 PubChem-compound O00329 UniProt 1.0 O14735 UniProt Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 439456 PubChem-compound 1.0 SMILES CCCCCCCCCCCCCCCC(=O)O[C@]([H])(COC(=O)CCCCCCC\C=C/CCCCCCCC)COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](OP(=O)(O)O)C1O myo-Inositol CDPDIACYLGLYCEROL BioCyc 3.1.3.36 false 3.1.3.36 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1184 ACTIVATION ReactionCatalysis1183 ACTIVATION PW000558 PathWhiz 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP2(16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z)) LEFT_TO_RIGHT ReactionCatalysis1186 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1185 ACTIVATION 3.1.3.86 false 3.1.3.86 PIP3(16:0/18:1(9Z)) + Water → PIP2(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1188 ACTIVATION C43H83O19P3 PIP2(16:0/18:1(9Z)) 996.4741 Water HMDB0007102 HMDB ReactionCatalysis1189 ACTIVATION C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 ReactionCatalysis1190 ACTIVATION 2.7.1.149 false 2.7.1.149 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT C00626 KEGG Compound 1.0 ReactionCatalysis1192 ACTIVATION P60484 UniProt 892 PubChem-compound Protein VAC14 homolog CHEBI:16761 ChEBI 1-phosphatidylinositol-3-phosphate 5-kinase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 HMDB0001498 HMDB Inositol Phosphate Metabolism SubPathway Joubert Syndrome Q9NRR6 UniProt O43426 UniProt 3.1.3.66 false 3.1.3.66 PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate LEFT_TO_RIGHT PIP3(16:0/18:1(9Z)) 1.0 3.1.3.36 false 3.1.3.36 PIP2(16:0/18:1(9Z)) + Water → PIP(18:1(9Z)/16:0) + Phosphate LEFT_TO_RIGHT 1.0 2.7.1.150 false 2.7.1.150 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP(18:1(9Z)/16:0) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.137 false 2.7.1.137 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP(18:1(9Z)/16:0) LEFT_TO_RIGHT 9606 TAXONOMY 962 PubChem-compound SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(OP(=O)(O)O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC 5800 ChemSpider PIP(18:1(9Z)/16:0) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1-phosphatidylinositol-3-phosphate 5-kinase 1.0 CMP BioCyc ReactionCatalysis1128 ACTIVATION ReactionCatalysis1127 ACTIVATION Phosphatidylinositol 3-kinase catalytic subunit type 3 P42356 UniProt 3.1.3.36 false 3.1.3.36 PIP[4'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC HMDB0002111 HMDB 1.0 HMDB0009783 HMDB Cell Membrane CHEBI:15377 ChEBI 1.0 14265-44-2 CAS Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha 58-64-0 CAS Q92562 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PI(16:0/18:1(9Z)) Phosphate 1.0 1.0 P27986 UniProt CDP-DG(16:0/18:1(9Z)) ReactionCatalysis1132 ACTIVATION Q14457 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 EGFR protein 1.0 1.0 1.0 ReactionCatalysis1148 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP[5'](16:0/18:1(9Z)) + Water → PI(16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1147 ACTIVATION 3.1.3.- false 3.1.3.- Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.149 false 2.7.1.149 Adenosine triphosphate + PIP[5'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z)) LEFT_TO_RIGHT Q99755 UniProt H2O Water 18.010565 3.1.3.86 false 3.1.3.86 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[5'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT HMDB0006971 HMDB ReactionCatalysis1142 ACTIVATION ReactionCatalysis1141 ACTIVATION SMP0000582 SMPDB ReactionCatalysis1143 ACTIVATION SMP0000462 SMPDB Q08AM6 UniProt ReactionCatalysis1145 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[5'](16:0/18:1(9Z)) LEFT_TO_RIGHT 1.0 1.0 1061 PubChem-compound Beclin-1 1.0 Phosphatidylinositol 4-kinase alpha 1.0 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT Reaction1463 false PIP3(16:0/18:1(9Z)) + Water → PIP2[4,5](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT Adenosine diphosphate 2.7.1.67 false 2.7.1.67 Adenosine triphosphate + PI(16:0/18:1(9Z)) → Adenosine diphosphate + PIP[4'](16:0/18:1(9Z)) LEFT_TO_RIGHT 2.7.1.154 false 2.7.1.154 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2(16:0/18:1(9Z)) LEFT_TO_RIGHT Activating molecule in BECN1-regulated autophagy protein 1 1.0 Inositol 1,4,5-trisphosphate SubPathwayInput 3.1.3.36 false 3.1.3.36 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 53477915 PubChem-compound ReactionCatalysis1152 ACTIVATION 3.1.3.36 false 3.1.3.36 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT ReactionCatalysis1155 ACTIVATION 2.7.1.68 false 2.7.1.68 Adenosine triphosphate + PIP[4'](16:0/18:1(9Z)) → Adenosine diphosphate + PIP2[4,5](16:0/18:1(9Z)) LEFT_TO_RIGHT ReactionCatalysis1154 ACTIVATION 3.1.3.86 false 3.1.3.86 PIP2[4,5](16:0/18:1(9Z)) + Water → PIP[4'](16:0/18:1(9Z)) + Phosphate LEFT_TO_RIGHT 2.7.1.153 false 2.7.1.153 Adenosine triphosphate + PIP2[4,5](16:0/18:1(9Z)) → Adenosine diphosphate + PIP3(16:0/18:1(9Z)) LEFT_TO_RIGHT 1.0 ReactionCatalysis1156 ACTIVATION 3.1.4.11 false 3.1.4.11 PIP2[4,5](16:0/18:1(9Z)) + Water → DG(16:0/18:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT CDP- diacylglycerol- -inositol 3- phosphatidyltransferase Synaptojanin-1 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Beclin-1 Activating molecule in BECN1-regulated autophagy protein 1 1- phosphatidylinositol- 3-phosphate 5-kinase Polyphosphoinositide phosphatase Protein VAC14 homolog Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha Synaptojanin-1 Type II inositol 3,4- bisphosphate 4-phosphatase Phosphatidylinositol- 5-phosphate 4-kinase type-2 alpha Phosphatidylinositol 3,4,5- trisphosphate 5-phosphatase 1 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 72 kDa inositol polyphosphate 5-phosphatase Synaptojanin-1 Synaptojanin-1 Phosphatidylinositol 4-kinase alpha Phosphatidylinositol 4-phosphate 3-kinase C2 domain- containing subunit alpha Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3,4,5- trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN Phosphatidylinositol 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1