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Prostaglandin G/H synthase 2 Prostaglandin G/H synthase 1 Solute carrier family 22 member 6 Solute carrier family 22 member 8 Cytochrome P450 3A4 Cytochrome P450 2C8 Cytochrome P450 2C19 Cytochrome P450 2C9 Cytochrome P450 2C9 Cytochrome P450 2C19 Cytochrome P450 2C8 UDP- glucuronosyltransferase 2B7 UDP- glucuronosyltransferase 2B4 UDP- glucuronosyltransferase 1-1 UDP- glucuronosyltransferase 1-3 UDP- glucuronosyltransferase 1-9 UDP- glucuronosyltransferase 1-10 Cytochrome P450 2C9 Ibuprofen Ibuprofen 1-Hydroxyibuprofen O2 NADPH H+ 2-Hydroxyibuprofen H2O NADP O2 NADPH H+ 3-Hydroxyibuprofen H2O NADP Uridine diphosphate glucuronic acid Ibuprofen glucuronide Uridine 5'-diphosphate H2O O2 Carboxy-ibuprofen H2O2 Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Endoplasmic Reticulum Membrane
Endoplasmic Reticulum PTGS2 PTGS1 SLC22A6 SLC22A8 CYP3A4 CYP2C8 CYP2C19 CYP2C9 CYP2C9 CYP2C19 CYP2C8 UGT2B7 UGT2B4 UGT1A1 UGT1A3 UGT1A9 UGT1A10 CYP2C9 Ibuprofen Ibuprofen 1- Hydroxyibuprofen Oxygen NADPH Hydrogen Ion 2- Hydroxyibuprofen Water NADP Oxygen NADPH Hydrogen Ion 3- Hydroxyibuprofen Water NADP Uridine diphosphate glucuronic acid Ibuprofen glucuronide Uridine 5'-diphosphate Water Oxygen Carboxy- ibuprofen Hydrogen peroxide
PTGS2 PTGS1 SLC22A6 SLC22A8 CYP3A4 CYP2C8 CYP2C19 CYP2C9 CYP2C9 CYP2C19 CYP2C8 UGT2B7 UGT2B4 UGT1A1 UGT1A3 UGT1A9 UGT1A10 CYP2C9 Ibuprfn Ibuprfn 1Hibupf O2 NADPH H+ IbuOH H2O NADP O2 NADPH H+ 3-HIbup H2O NADP UDPGlcA Ibuprof UDP H2O O2 C-ibupf H2O2 Heme Heme Heme Heme Heme Heme Heme Heme Heme Heme Endoplasmic Reticulum Membrane