SMPDB

Pathway Description

Tigecycline Action Pathway

Homo sapiens

Drug Action Pathway

Created: 2014-04-26

Last Updated: 2025-01-29

Tigecycline is a glycylcycline, a class of antibiotics derived from tetracycline. Tigecycline has broad spectrum antibacterial abilities and is not susceptible to traditional tetracycline resistance mechanisms such as ribosomal protection and efflux by tetracycline-specific pumps. Tigecycline inhibits bacterial protein synthesis by binding to the A site of the 16s rRNA on the 30S ribosomal subunit. By binding to the A site, tigecycline prevents tRNA from docking onto the 16S rRNA with it’s codon ultimately halting the addition of amino acids to elongate peptide chains used in protein structures.

References

Tigecycline Pathway References

Skrtic M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, Datti A, Ketela T, Moffat J, Robinson BH, Cameron JH, Wrana J, Eaves CJ, Minden MD, Wang JC, Dick JE, Humphries K, Nislow C, Giaever G, Schimmer AD: Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 2011 Nov 15;20(5):674-88. doi: 10.1016/j.ccr.2011.10.015.

Pubmed: 22094260

Olson MW, Ruzin A, Feyfant E, Rush TS 3rd, O'Connell J, Bradford PA: Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. doi: 10.1128/AAC.01499-05.

Pubmed: 16723578

Bauer G, Berens C, Projan SJ, Hillen W: Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. J Antimicrob Chemother. 2004 Apr;53(4):592-9. doi: 10.1093/jac/dkh125. Epub 2004 Feb 25.

Pubmed: 14985271

Highlighted elements will appear in red.

Highlight Compounds

Tigecycline

Highlight Proteins

No Proteins Present

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

Tigecycline

Visualize Protein Data

No Proteins Present

Downloads

SVG Image

Simple SVG Image

Large Font SVG Image

Simple Large Font SVG Image

Greyscale SVG Image

BioPAX

SBGN