Paromomycin (also known as Aminosidin) is an antimicrobial that can be used for treatment of various parasitic infections. By binding to the A site of ribosomal RNA complexes, paramomycin can lead to production of incorrect polypeptide chain in bacteria, which cause incorrect protein production and eventually, the death of bacteria. Therefore, paramomycin can kill bacteria by inhibiting their protein synthesis that lead to bacterial death.
References
Paromomycin Pathway References
Lando D, Cousin MA, Ojasoo T, Raymond JP: Paromomycin and dihydrostreptomycin binding to Escherichia coli ribosomes. Eur J Biochem. 1976 Jul 15;66(3):597-606.
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