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Glutathione synthetase CHEBI:16015 ChEBI 30572 ChemSpider 6022 PubChem-compound 7722-84-1 CAS 17215925 ChemSpider SMILES N[C@@H](CS)C(O)=O 937 ChemSpider 2.0 1.0 1.0 CYS BioCyc 32980411 ChemSpider 388596 ChemSpider (5-L-Glutamyl)-L-amino acid C8H14N2O5S Gamma-Glutamylcysteine 250.06235 HMDB01341 HMDB Methyl-S-cystein Glutathione Glutathione reductase, mitochondrial 2.0 255 ChemSpider SMILES OO SMILES O 2.0 Pyroglutamic acid SMP00021 SMPDB ReactionCatalysis28 ACTIVATION CHEBI:50619 ChEBI 1.0 HMDB00267 HMDB ReactionCatalysis26 ACTIVATION HMDB00148 HMDB Caspase-7 C01419 KEGG Compound 1004 PubChem-compound ATP BioCyc 1.0 Cysteinylglycine Water Caspase-7 ADP BioCyc 2.0 P07203 UniProt Glycine Glutathione reductase, mitochondrial 53-59-8 CAS Gamma-glutamyltransferase 6 7127 ChemSpider 5742 ChemSpider CHEBI:17561 ChEBI CHEBI:16474 ChEBI P48637 UniProt GO:0005829 GENE ONTOLOGY C11347 KEGG Compound 950 ChemSpider C13645 KEGG Compound HMDB00123 HMDB Glutathione S-transferase omega-2 HMDB00125 HMDB 2.0 PW000038 PathWhiz 5735 ChemSpider Glutathione synthetase 1.0 CHEBI:16240 ChEBI 5862 PubChem-compound Hydrogen bromide 1.0 C21H30N7O17P3 NADPH 745.0911 6.3.2.2 false 6.3.2.2 Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate + Gamma-Glutamylcysteine + Phosphoric acid LEFT_TO_RIGHT 6.3.2.3 false 6.3.2.3 Adenosine triphosphate + Gamma-Glutamylcysteine + Glycine → Adenosine diphosphate + Glutathione + Phosphoric acid LEFT_TO_RIGHT Mitochondrion C21H29N7O17P3 NADP 744.08325 5-oxoprolinase 3.5.2.9 false 3.5.2.9 Adenosine triphosphate + Pyroglutamic acid + 2 Water → Adenosine diphosphate + L-Glutamic acid + Phosphoric acid LEFT_TO_RIGHT HMDB00574 HMDB GLY BioCyc NADPH BioCyc ReactionCatalysis58 ACTIVATION Gamma-glutamylcyclotransferase 1.0 CHEBI:16856 ChEBI HMDB00217 HMDB CHEBI:16977 ChEBI 124886 PubChem-compound L-Glutamic acid SubPathwayOutput Cytosol ReactionCatalysis56 ACTIVATION ReactionCatalysis57 ACTIVATION C03740 KEGG Compound ReactionCatalysis54 ACTIVATION ReactionCatalysis55 ACTIVATION 7664-38-2 CAS GO:0005886 GENE ONTOLOGY 1.0 C2H5NO2 Glycine 75.03203 1.0 3.4.11.2 false 3.4.11.2 Methyl-S-Cysteinylglycine + Water → Glycine + Methyl-S-cystein LEFT_TO_RIGHT Reaction2268 false S-(methyl)glutathione + Water → L-Glutamic acid + Methyl-S-Cysteinylglycine LEFT_TO_RIGHT C00009 KEGG Compound HMDB00221 HMDB Glutathione C00008 KEGG Compound 1.0 CPD-589 BioCyc C00127 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI 2.0 C00001 KEGG Compound 1.0 56-41-7 CAS C00005 KEGG Compound C20H32N6O12S2 Oxidized glutathione 612.152 C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 2.0 P48506 UniProt P48507 UniProt 5257127 PubChem-compound C10H17N3O6S Glutathione 307.0838 55290163 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLT BioCyc Gamma-Glutamylcysteine 1.0 C18447 KEGG Compound 53-57-6 CAS CHEBI:39275 ChEBI SMILES Br Gamma-glutamylcyclotransferase Adenosine triphosphate 1.0 5950 PubChem-compound 2.0 5-oxoprolinase SMILES OP(O)(O)=O 6083 ChemSpider P15144 UniProt Hydrogen peroxide NAD(P) BioCyc 5957 PubChem-compound C5H10N2O3S Cysteinylglycine 178.04121 1.0 10035-10-6 CAS SMILES C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O SMILES CSC(N)C(O)=O CH3Br Bromomethane 93.94181 SMILES CS[C@@H](N)CNCC(O)=O 1.0 SMILES CSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O 1.0 SMILES C[C@H](N)C(O)=O SubPathwayInteraction800 SubPathway800Reaction SubPathwayReaction Gamma-glutamyltransferase 6 1.0 56-65-5 CAS 5653 ChemSpider C00027 KEGG Compound L-Glutamic acid C00025 KEGG Compound CHEBI:26078 ChEBI C5H7NO3 Pyroglutamic acid 129.04259 Aminopeptidase N GO:0005739 GENE ONTOLOGY Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 2.3.2.4 false 2.3.2.4 Gamma-Glutamylcysteine → L-Cysteine + Pyroglutamic acid LEFT_TO_RIGHT GO:0005737 GENE ONTOLOGY Glutamate--cysteine ligase regulatory subunit Reaction2270 false Glutathione + L-amino acid → (5-L-Glutamyl)-L-amino acid + Cysteinylglycine LEFT_TO_RIGHT 2.3.2.4 false 2.3.2.4 (5-L-Glutamyl)-L-amino acid → L-amino acid + Pyroglutamic acid LEFT_TO_RIGHT SMP00013 SMPDB Glutamate--cysteine ligase catalytic subunit SMP00015 SMPDB 1.0 1.0 70-18-8 CAS HMDB03125 HMDB OXIDIZED-GLUTATHIONE BioCyc SubPathwayInteraction798 SubPathway798Reaction SubPathwayReaction BrH Hydrogen bromide 79.92616 SubPathwayInteraction799 SubPathwayReaction SubPathway799Reaction CL:0000000 CELL TYPE ONTOLOGY 52-90-4 CAS Gamma-glutamylcyclotransferase 98-79-3 CAS 1.0 2.0 HMDB61368 HMDB O75223 UniProt C00037 KEGG Compound HMDB61367 HMDB HMDB61369 HMDB ReactionCatalysis2138 ACTIVATION SMILES N[C@@H](CS)C(=O)NCC(O)=O 1.0 ReactionCatalysis2137 ACTIVATION 5255796 PubChem-compound ReactionCatalysis2139 ACTIVATION C00041 KEGG Compound HMDB61370 HMDB 110467 ChemSpider HYDROGEN-PEROXIDE BioCyc SMILES CBr C11H19N3O6S S-(methyl)glutathione 321.09946 Glutathione peroxidase 1 ReactionCatalysis2136 ACTIVATION C5H12N2O2S Methyl-S-Cysteinylglycine 164.06195 1.0 C3H7NO2S Methyl-S-cystein 121.01975 C8H14N2O5 (5-L-Glutamyl)-L-amino acid 218.09027 Taurine and Hypotaurine Metabolism SubPathway C3H7NO2 L-amino acid 89.047676 103128 ChemSpider Glutamate--cysteine ligase catalytic subunit CHEBI:17515 ChEBI Glutathione peroxidase 1 Cysteinylglycine 5675 ChemSpider Aminopeptidase N SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 763 ChemSpider HMDB61366 HMDB HMDB61365 HMDB Adenosine diphosphate C00051 KEGG Compound 4.0 ReactionCatalysis2141 ACTIVATION Cytoplasm HMDB00538 HMDB ReactionCatalysis2140 ACTIVATION 2.0 ReactionCatalysis2142 ACTIVATION SMILES OC(=O)[C@@H]1CCC(=O)N1 Cell Gamma-glutamyltransferase 6 HMDB00078 HMDB Glutathione S-transferase omega-2 5-oxoprolinase HMDB01049 HMDB 784 PubChem-compound CHEBI:15422 ChEBI 2922-56-7 CAS SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O 1.0 7732-18-5 CAS 1.0 6323 PubChem-compound Gamma-glutamyltransferase 6 123938 PubChem-compound 19246-18-5 CAS (5-L-Glutamyl)-L-amino acid 56-86-0 CAS 115260 PubChem-compound Adenosine diphosphate Water C5H9NO4 L-Glutamic acid 147.05316 1.8.1.7 false 1.8.1.7 NADPH + Oxidized glutathione ↔ 2 Glutathione + NADP REVERSIBLE 33032 PubChem-compound BiologicalState14 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17858 ChEBI Phosphoric acid 1.11.1.9 false 1.11.1.9 2 Glutathione + Hydrogen peroxide → Oxidized glutathione + 2 Water LEFT_TO_RIGHT 1.0 56-40-6 CAS 7405 PubChem-compound Glutathione Phosphoric acid HMDB02142 HMDB CHEBI:16761 ChEBI 1.0 Oxidized glutathione Gamma-Glutamylcysteine O14841 UniProt 2.0 CHEBI:15428 ChEBI Q9H4Y5 UniProt S-(methyl)glutathione Aminopeptidase N 1.0 3.4.11.2 false 3.4.11.2 Cysteinylglycine + Water → Glycine + L-Cysteine LEFT_TO_RIGHT Glutamate--cysteine ligase Oxidized glutathione P55210 UniProt 9606 TAXONOMY 1.0 962 PubChem-compound P00390 UniProt Glutathione Metabolism 5800 ChemSpider 74-83-9 CAS 636-58-8 CAS 979 ChemSpider 1.0 HMDB02111 HMDB 440103 PubChem-compound 730 ChemSpider H3O4P Phosphoric acid 97.9769 BiologicalState8 L-amino acid PW000018 PathWhiz Glutathione BiologicalState3 1.0 SMILES N[C@@H](CCC(O)=O)C(O)=O Glutamate Metabolism SubPathway BiologicalState2 Gamma-glutamyltransferase 6 Cysteine Metabolism SubPathway CHEBI:15377 ChEBI Cell Membrane L-Cysteine SubPathwayInput HMDB03337 HMDB HMDB31524 HMDB GLUTATHIONE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O L-amino acid 5886 PubChem-compound 1.0 1.0 NADP SMP00072 SMPDB Methyl-S-Cysteinylglycine 2.0 CHEBI:4047 ChEBI Glutathione reductase, mitochondrial 1.0 111188 ChemSpider Glutathione synthetase Bromomethane 389104 ChemSpider C3H7NO2S L-Cysteine 121.01975 27025-41-8 CAS PW000004 PathWhiz PW000003 PathWhiz C00097 KEGG Compound 5875-41-2 CAS 22833512 PubChem-compound Glycine 439498 PubChem-compound 1.0 H2O2 Hydrogen peroxide 34.005478 H2O Water 18.010565 SMILES NCC(O)=O 22169024 PubChem-compound CHEBI:47266 ChEBI C00669 KEGG Compound C01879 KEGG Compound Glutamate--cysteine ligase regulatory subunit NADPH Glutathione S-transferase omega-2 L-GAMMA-GLUTAMYLCYSTEINE BioCyc SMILES NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O Glutathione peroxidase 1 CHEBI:18183 ChEBI Q6P531 UniProt 1.0 SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O Reaction587 false Bromomethane + Glutathione → Hydrogen bromide + S-(methyl)glutathione LEFT_TO_RIGHT Glutathione synthetase Glutathione peroxidase 1 Glutathione reductase, mitochondrial Glutathione S-transferase omega-2 Gamma- glutamyltransferase 6 Aminopeptidase N Caspase-7 Gamma- glutamyltransferase 6 Aminopeptidase N Caspase-7 Glutamate-- cysteine ligase catalytic subunit Glutamate-- cysteine ligase regulatory subunit 5-oxoprolinase Gamma- glutamylcyclotransferase Gamma- glutamylcyclotransferase L-Glutamic acid L-Cysteine ATP Gamma-Glutamylcysteine Glycine ADP P i Glutathione H 2 O 2 Oxidized glutathione H 2 O NADPH NADP Bromomethane Hydrogen bromide S-(methyl)glutathione H 2 O Methyl-S-Cysteinylglycine H 2 O Methyl-S- cystein Glycine L-amino acid (5-L-Glutamyl)-L-amino acid Cysteinylglycine H 2 O ATP L-Glutamic acid ADP P i ATP Pyroglutamic acid H 2 O ADP P i L-Cysteine L-amino acid FAD Zinc (II) ion Zinc Zinc (II) ion Zinc Glutamate Metabolism Cysteine Metabolism Taurine and Hypotaurine Metabolism Extracellular Space Intracellular Space Gamma Glutamyl cycle Intracellular Space Extracellular Space
Glutathione synthetase CHEBI:16015 ChEBI 30572 ChemSpider 6022 PubChem-compound 7722-84-1 CAS 17215925 ChemSpider SMILES N[C@@H](CS)C(O)=O 937 ChemSpider 2.0 1.0 1.0 CYS BioCyc 32980411 ChemSpider 388596 ChemSpider (5-L-Glutamyl)-L-amino acid C8H14N2O5S Gamma-Glutamylcysteine 250.06235 HMDB01341 HMDB Methyl-S-cystein Glutathione Glutathione reductase, mitochondrial 2.0 255 ChemSpider SMILES OO SMILES O 2.0 Pyroglutamic acid http://identifiers.org/smpdb/SMP00021 SMPDB ReactionCatalysis28 ACTIVATION CHEBI:50619 ChEBI 1.0 HMDB00267 HMDB ReactionCatalysis26 ACTIVATION HMDB00148 HMDB Caspase-7 C01419 KEGG Compound 1004 PubChem-compound ATP BioCyc 1.0 Cysteinylglycine Water Caspase-7 ADP BioCyc 2.0 P07203 UniProt Glycine Glutathione reductase, mitochondrial 53-59-8 CAS Gamma-glutamyltransferase 6 7127 ChemSpider 5742 ChemSpider CHEBI:17561 ChEBI CHEBI:16474 ChEBI P48637 UniProt GO:0005829 GENE ONTOLOGY C11347 KEGG Compound 950 ChemSpider C13645 KEGG Compound HMDB00123 HMDB Glutathione S-transferase omega-2 HMDB00125 HMDB 2.0 PW000038 PathWhiz 5735 ChemSpider Glutathione synthetase 1.0 CHEBI:16240 ChEBI 5862 PubChem-compound Hydrogen bromide 1.0 C21H30N7O17P3 NADPH 745.0911 6.3.2.2 false 6.3.2.2 Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate + Gamma-Glutamylcysteine + Phosphoric acid LEFT_TO_RIGHT 6.3.2.3 false 6.3.2.3 Adenosine triphosphate + Gamma-Glutamylcysteine + Glycine → Adenosine diphosphate + Glutathione + Phosphoric acid LEFT_TO_RIGHT Mitochondrion C21H29N7O17P3 NADP 744.08325 5-oxoprolinase 3.5.2.9 false 3.5.2.9 Adenosine triphosphate + Pyroglutamic acid + 2 Water → Adenosine diphosphate + L-Glutamic acid + Phosphoric acid LEFT_TO_RIGHT HMDB00574 HMDB GLY BioCyc NADPH BioCyc ReactionCatalysis58 ACTIVATION Gamma-glutamylcyclotransferase 1.0 CHEBI:16856 ChEBI HMDB00217 HMDB CHEBI:16977 ChEBI 124886 PubChem-compound L-Glutamic acid SubPathwayOutput Cytosol ReactionCatalysis56 ACTIVATION ReactionCatalysis57 ACTIVATION C03740 KEGG Compound ReactionCatalysis54 ACTIVATION ReactionCatalysis55 ACTIVATION 7664-38-2 CAS GO:0005886 GENE ONTOLOGY 1.0 C2H5NO2 Glycine 75.03203 1.0 3.4.11.2 false 3.4.11.2 Methyl-S-Cysteinylglycine + Water → Glycine + Methyl-S-cystein LEFT_TO_RIGHT Reaction2268 false S-(methyl)glutathione + Water → L-Glutamic acid + Methyl-S-Cysteinylglycine LEFT_TO_RIGHT C00009 KEGG Compound HMDB00221 HMDB Glutathione C00008 KEGG Compound 1.0 CPD-589 BioCyc C00127 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI 2.0 C00001 KEGG Compound 1.0 56-41-7 CAS C00005 KEGG Compound C20H32N6O12S2 Oxidized glutathione 612.152 C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 2.0 P48506 UniProt P48507 UniProt 5257127 PubChem-compound C10H17N3O6S Glutathione 307.0838 55290163 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLT BioCyc Gamma-Glutamylcysteine 1.0 C18447 KEGG Compound 53-57-6 CAS CHEBI:39275 ChEBI SMILES Br Gamma-glutamylcyclotransferase Adenosine triphosphate 1.0 5950 PubChem-compound 2.0 5-oxoprolinase SMILES OP(O)(O)=O 6083 ChemSpider P15144 UniProt Hydrogen peroxide NAD(P) BioCyc 5957 PubChem-compound C5H10N2O3S Cysteinylglycine 178.04121 1.0 10035-10-6 CAS SMILES C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O SMILES CSC(N)C(O)=O CH3Br Bromomethane 93.94181 SMILES CS[C@@H](N)CNCC(O)=O 1.0 SMILES CSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O 1.0 SMILES C[C@H](N)C(O)=O SubPathwayInteraction800 SubPathway800Reaction SubPathwayReaction Gamma-glutamyltransferase 6 1.0 56-65-5 CAS 5653 ChemSpider C00027 KEGG Compound L-Glutamic acid C00025 KEGG Compound CHEBI:26078 ChEBI C5H7NO3 Pyroglutamic acid 129.04259 Aminopeptidase N GO:0005739 GENE ONTOLOGY Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 2.3.2.4 false 2.3.2.4 Gamma-Glutamylcysteine → L-Cysteine + Pyroglutamic acid LEFT_TO_RIGHT GO:0005737 GENE ONTOLOGY Glutamate--cysteine ligase regulatory subunit Reaction2270 false Glutathione + L-amino acid → (5-L-Glutamyl)-L-amino acid + Cysteinylglycine LEFT_TO_RIGHT 2.3.2.4 false 2.3.2.4 (5-L-Glutamyl)-L-amino acid → L-amino acid + Pyroglutamic acid LEFT_TO_RIGHT http://identifiers.org/smpdb/SMP00013 SMPDB Glutamate--cysteine ligase catalytic subunit http://identifiers.org/smpdb/SMP00015 SMPDB 1.0 1.0 70-18-8 CAS HMDB03125 HMDB OXIDIZED-GLUTATHIONE BioCyc SubPathwayInteraction798 SubPathway798Reaction SubPathwayReaction BrH Hydrogen bromide 79.92616 SubPathwayInteraction799 SubPathwayReaction SubPathway799Reaction CL:0000000 CELL TYPE ONTOLOGY 52-90-4 CAS Gamma-glutamylcyclotransferase 98-79-3 CAS 1.0 2.0 HMDB61368 HMDB O75223 UniProt C00037 KEGG Compound HMDB61367 HMDB HMDB61369 HMDB ReactionCatalysis2138 ACTIVATION SMILES N[C@@H](CS)C(=O)NCC(O)=O 1.0 ReactionCatalysis2137 ACTIVATION 5255796 PubChem-compound ReactionCatalysis2139 ACTIVATION C00041 KEGG Compound HMDB61370 HMDB 110467 ChemSpider HYDROGEN-PEROXIDE BioCyc SMILES CBr C11H19N3O6S S-(methyl)glutathione 321.09946 Glutathione peroxidase 1 ReactionCatalysis2136 ACTIVATION C5H12N2O2S Methyl-S-Cysteinylglycine 164.06195 1.0 C3H7NO2S Methyl-S-cystein 121.01975 C8H14N2O5 (5-L-Glutamyl)-L-amino acid 218.09027 Taurine and Hypotaurine Metabolism SubPathway C3H7NO2 L-amino acid 89.047676 103128 ChemSpider Glutamate--cysteine ligase catalytic subunit CHEBI:17515 ChEBI Glutathione peroxidase 1 Cysteinylglycine 5675 ChemSpider Aminopeptidase N SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 763 ChemSpider HMDB61366 HMDB HMDB61365 HMDB Adenosine diphosphate C00051 KEGG Compound 4.0 ReactionCatalysis2141 ACTIVATION Cytoplasm HMDB00538 HMDB ReactionCatalysis2140 ACTIVATION 2.0 ReactionCatalysis2142 ACTIVATION SMILES OC(=O)[C@@H]1CCC(=O)N1 Cell Gamma-glutamyltransferase 6 HMDB00078 HMDB Glutathione S-transferase omega-2 5-oxoprolinase HMDB01049 HMDB 784 PubChem-compound CHEBI:15422 ChEBI 2922-56-7 CAS SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O 1.0 7732-18-5 CAS 1.0 6323 PubChem-compound Gamma-glutamyltransferase 6 123938 PubChem-compound 19246-18-5 CAS (5-L-Glutamyl)-L-amino acid 56-86-0 CAS 115260 PubChem-compound Adenosine diphosphate Water C5H9NO4 L-Glutamic acid 147.05316 1.8.1.7 false 1.8.1.7 NADPH + Oxidized glutathione ↔ 2 Glutathione + NADP REVERSIBLE 33032 PubChem-compound BiologicalState14 Homo sapiens, Cell Membrane C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17858 ChEBI Phosphoric acid 1.11.1.9 false 1.11.1.9 2 Glutathione + Hydrogen peroxide → Oxidized glutathione + 2 Water LEFT_TO_RIGHT 1.0 56-40-6 CAS 7405 PubChem-compound Glutathione Phosphoric acid HMDB02142 HMDB CHEBI:16761 ChEBI 1.0 Oxidized glutathione Gamma-Glutamylcysteine O14841 UniProt 2.0 CHEBI:15428 ChEBI Q9H4Y5 UniProt S-(methyl)glutathione Aminopeptidase N 1.0 3.4.11.2 false 3.4.11.2 Cysteinylglycine + Water → Glycine + L-Cysteine LEFT_TO_RIGHT Glutamate--cysteine ligase Oxidized glutathione P55210 UniProt 9606 TAXONOMY 1.0 962 PubChem-compound P00390 UniProt Glutathione Metabolism 5800 ChemSpider 74-83-9 CAS 636-58-8 CAS 979 ChemSpider 1.0 HMDB02111 HMDB 440103 PubChem-compound 730 ChemSpider H3O4P Phosphoric acid 97.9769 BiologicalState8 Homo sapiens, Cell, Cytoplasm L-amino acid PW000018 PathWhiz Glutathione BiologicalState3 Homo sapiens, Cell, Mitochondrion 1.0 SMILES N[C@@H](CCC(O)=O)C(O)=O Glutamate Metabolism SubPathway BiologicalState2 Homo sapiens, Cell, Cytosol Gamma-glutamyltransferase 6 Cysteine Metabolism SubPathway CHEBI:15377 ChEBI Cell Membrane L-Cysteine SubPathwayInput HMDB03337 HMDB HMDB31524 HMDB GLUTATHIONE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O L-amino acid 5886 PubChem-compound 1.0 1.0 NADP http://identifiers.org/smpdb/SMP00072 SMPDB Methyl-S-Cysteinylglycine 2.0 CHEBI:4047 ChEBI Glutathione reductase, mitochondrial 1.0 111188 ChemSpider Glutathione synthetase Bromomethane 389104 ChemSpider C3H7NO2S L-Cysteine 121.01975 27025-41-8 CAS PW000004 PathWhiz PW000003 PathWhiz C00097 KEGG Compound 5875-41-2 CAS 22833512 PubChem-compound Glycine 439498 PubChem-compound 1.0 H2O2 Hydrogen peroxide 34.005478 H2O Water 18.010565 SMILES NCC(O)=O 22169024 PubChem-compound CHEBI:47266 ChEBI C00669 KEGG Compound C01879 KEGG Compound Glutamate--cysteine ligase regulatory subunit NADPH Glutathione S-transferase omega-2 L-GAMMA-GLUTAMYLCYSTEINE BioCyc SMILES NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O Glutathione peroxidase 1 CHEBI:18183 ChEBI Q6P531 UniProt 1.0 SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O Reaction587 false Bromomethane + Glutathione → Hydrogen bromide + S-(methyl)glutathione LEFT_TO_RIGHT GSS GPX1 GSR GSTO2 GGT6 ANPEP CASP7 GGT6 ANPEP CASP7 GCLC GCLM OPLAH GGCT GGCT L-Glutamic acid L-Cysteine Adenosine triphosphate Gamma- Glutamylcysteine Glycine Adenosine diphosphate Phosphoric acid Glutathione Hydrogen peroxide Oxidized glutathione Water NADPH NADP Bromomethane Hydrogen bromide S- (methyl)glutathione Water Methyl-S- Cysteinylglycine Water Methyl-S- cystein Glycine L-amino acid (5-L- Glutamyl)-L- amino acid Cysteinylglycine Water Adenosine triphosphate L-Glutamic acid Adenosine diphosphate Phosphoric acid Adenosine triphosphate Pyroglutamic acid Water Adenosine diphosphate Phosphoric acid L-Cysteine L-amino acid Glutamate Metabolism Cysteine Metabolism Taurine and Hypotaurine Metabolism