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C00438 KEGG Compound C10H14N5O7P 3'-AMP 347.06308 HMDB01227 HMDB Guanine deaminase C00672 KEGG Compound 964-26-1 CAS 1.0 58580 ChemSpider 1.0 dUDP 4.0 6133 PubChem-compound 6131 PubChem-compound 6132 PubChem-compound C19H21N7O6 Dihydrofolic acid 443.15533 2905-86-4 CAS CHEBI:17594 ChEBI CHEBI:17111 ChEBI CHEBI:27389 ChEBI 13184-27-5 CAS 559142 ChemSpider L-Dihydroorotic acid Dihydroorotate dehydrogenase (quinone), mitochondrial 63-38-7 CAS HMDB00595 HMDB CHEBI:17568 ChEBI C00459 KEGG Compound C00458 KEGG Compound HMDB01202 HMDB 5746 ChemSpider HCO3 BioCyc 365-08-2 CAS 5742 ChemSpider 1.0 C00214 KEGG Compound PW000162 PathWhiz PW000160 PathWhiz CHEBI:17562 ChEBI 1141 ChemSpider CHEBI:16474 ChEBI SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O 7540-64-9 CAS 439175 PubChem-compound Thioredoxin 64968 PubChem-compound C02642 KEGG Compound C00460 KEGG Compound P04183 UniProt 1.0 Thymidine 5'-triphosphate SubPathwayInput Dihydroorotate dehydrogenase (quinone), mitochondrial 2.0 37610 ChemSpider thioredoxin 64956 PubChem-compound 1.0 C00239 KEGG Compound Ribonucleoside-diphosphate reductase subunit M2 CH4NO5P Carbamoyl phosphate 140.98271 Quinone C00472 KEGG Compound 1.0 Ribonucleoside-diphosphate reductase subunit M2 C00475 KEGG Compound Cytidine deaminase 1.0 7664-38-2 CAS C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound C00005 KEGG Compound NADPH C00002 KEGG Compound Inosine triphosphate pyrophosphatase Nucleoside diphosphate kinase 6 HMDB01429 HMDB 1.0 1.0 93072 PubChem-compound Q12882 UniProt 2.0 CHEBI:17361 ChEBI C00011 KEGG Compound C00015 KEGG Compound C01346 KEGG Compound C01103 KEGG Compound C00014 KEGG Compound C00013 KEGG Compound 1.0 58574 ChemSpider 1.0 56-65-5 CAS 388420 ChemSpider CHEBI:26078 ChEBI 3.5.1.6 false 3.5.1.6 Ureidoisobutyric acid + Water → 3-Aminoisobutanoic acid + Ammonia + Carbon dioxide LEFT_TO_RIGHT 3432-99-3 CAS HMDB01409 HMDB 1.0 NADP 769 PubChem-compound CL:0000000 CELL TYPE ONTOLOGY 504-07-4 CAS Dihydropyrimidinase C01367 KEGG Compound 128553 ChemSpider GTP:AMP phosphotransferase, mitochondrial SMILES CC1=CNC(=O)NC1=O 98792 PubChem-compound SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB00300 HMDB 56-85-9 CAS C00288 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O DIHYDROFOLATE BioCyc 7062 ChemSpider SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 HMDB00538 HMDB 1.0 UTP BioCyc 5902 ChemSpider 5901 ChemSpider 5903 ChemSpider HMDB00998 HMDB C00055 KEGG Compound C00295 KEGG Compound C00299 KEGG Compound 1.0 SMILES OC(=O)C1=CC(=O)NC(=O)N1 C00063 KEGG Compound 145729 PubChem-compound Q9UIJ7 UniProt 5,10-Methylene-THF DUDP BioCyc C10H16N5O13P3 Adenosine triphosphate 506.99576 Phosphoric acid CHEBI:18261 ChEBI C00064 KEGG Compound 4033-27-6 CAS Uridine monophosphate synthetase isoform A 65-47-4 CAS Ureidopropionic acid 58-96-8 CAS C4H9NO2 3-Aminoisobutanoic acid 103.06333 C5H8N2O5 Ureidosuccinic acid 176.04332 41211 PubChem-compound Uridine-cytidine kinase-like 1 962 PubChem-compound 1.0 967 PubChem-compound 58-98-0 CAS CHEBI:18077 ChEBI C00075 KEGG Compound CO2 Carbon dioxide 43.98983 CHEBI:18075 ChEBI 13712 PubChem-compound 13711 PubChem-compound 951-77-9 CAS Q7LG56 UniProt BiologicalState2 DNA reaction SubPathway 6175 PubChem-compound Alanine Metabolism SubPathway 14265-44-2 CAS 6176 PubChem-compound Beta-ureidopropionase Dihydropyrimidinase 13945 PubChem-compound THYMINE BioCyc Q9NWZ5 UniProt UMP-CMP kinase 2, mitochondrial Phosphoribosyl pyrophosphate SubPathwayInput 1103 ChemSpider 644102 PubChem-compound 84456 ChemSpider 5941 ChemSpider C4H4N2O2 Uracil 112.027275 C9H12N2O6 Uridine 244.06953 C00099 KEGG Compound 5940 ChemSpider Carbamoyl phosphate SubPathwayOutput SMILES OC[C@H]1OC(C[C@@H]1O)OP(O)(O)=O CHEBI:18050 ChEBI SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O RNA reaction SubPathway SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O DEOXYCYTIDINE BioCyc UMP-CMP kinase 2, mitochondrial UMP BioCyc Uridine-cytidine kinase-like 1 629 ChemSpider Ribonucleoside-diphosphate reductase subunit M2 B 1.0 Glutamate Metabolism SubPathway CHO3 Hydrogen carbonate 60.99257 Urea Cycle SubPathway Pentose Phosphate Pathway SubPathway Valine, Leucine and Isoleucine Degradation SubPathway Valine, Leucine and Isoleucine Degradation SubPathway 17215925 ChemSpider 1032-65-1 CAS 1.0 CTP synthase 1 1135 PubChem-compound SMILES O=C1NC=CC(=O)N1 Deoxycytidylate deaminase 1.0 C5H10N2O3 Ureidoisobutyric acid 146.06914 ReactionCatalysis1209 ACTIVATION ReactionCatalysis1208 ACTIVATION H3N Ammonia 17.026548 5961 PubChem-compound 111 PubChem-compound Q02127 UniProt P27708 UniProt ReactionCatalysis1214 ACTIVATION ReactionCatalysis1213 ACTIVATION ReactionCatalysis1215 ACTIVATION C05100 KEGG Compound ReactionCatalysis1218 ACTIVATION ReactionCatalysis1217 ACTIVATION SMILES OC([O-])=O ReactionCatalysis1219 ACTIVATION ReactionCatalysis1210 ACTIVATION ReactionCatalysis1212 ACTIVATION ReactionCatalysis1211 ACTIVATION C3H7NO2 Beta-Alanine 89.047676 C9H13N3O4 Deoxycytidine 227.0906 C9H12N2O5 Deoxyuridine 228.07462 696-04-8 CAS 4.0 Uridine 5'-monophosphate ReactionCatalysis1225 ACTIVATION ReactionCatalysis1224 ACTIVATION ReactionCatalysis1227 ACTIVATION ReactionCatalysis1226 ACTIVATION ReactionCatalysis1229 ACTIVATION 274 ChemSpider Nucleoside diphosphate kinase 6 272 ChemSpider 4208-67-7 CAS DUMP BioCyc ReactionCatalysis1221 ACTIVATION ReactionCatalysis1220 ACTIVATION 1.0 141140 ChemSpider C4H8N2O3 Ureidopropionic acid 132.0535 1.0 CHEBI:15713 ChEBI Pyrophosphate O4P Phosphate 94.95342 DI-H-URACIL BioCyc 4650 PubChem-compound Cytidine monophosphate ReactionCatalysis1236 ACTIVATION ReactionCatalysis1235 ACTIVATION ReactionCatalysis1238 ACTIVATION ReactionCatalysis1237 ACTIVATION SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O ReactionCatalysis1239 ACTIVATION ReactionCatalysis1230 ACTIVATION C00906 KEGG Compound ReactionCatalysis1232 ACTIVATION Q14117 UniProt ReactionCatalysis1231 ACTIVATION ReactionCatalysis1234 ACTIVATION ReactionCatalysis1233 ACTIVATION 141172 ChemSpider NADPH BioCyc 1.0 SMILES NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](CO)O1 Carbon dioxide SMILES OC[C@H]1O[C@H](C[C@@H]1O)N1C=CC(=O)NC1=O 1.0 Dihydrothymine 217 ChemSpider Q9UBR1 UniProt SMILES [O-]P([O-])([O-])=O CHEBI:28846 ChEBI CYTIDINE BioCyc dUMP 1.0 1.0 CAD protein SMILES NC(=O)NCCC(O)=O 3-UREIDO-PROPIONATE BioCyc C05145 KEGG Compound 3-AMINO-ISOBUTYRATE BioCyc C20H23N7O6 5,10-Methylene-THF 457.171 GTP:AMP phosphotransferase, mitochondrial thioredoxin disulfide 1.0 Dihydrouracil 1.0 SMILES O=C=O 234 ChemSpider P04818 UniProt C5H11O8P Ribose 1-phosphate 230.01915 5957 PubChem-compound C9H16N3O14P3 Cytidine triphosphate 482.9845 C5H8N2O2 Dihydrothymine 128.05858 C4H6N2O2 Dihydrouracil 114.04293 C00705 KEGG Compound HMDB01096 HMDB CARBAMYUL-L-ASPARTATE BioCyc C9H13N3O5 Cytidine 243.08553 C9H14N3O8P Cytidine monophosphate 323.05185 OROTIDINE-5-PHOSPHATE BioCyc P33316 UniProt Cytosolic purine 5'-nucleotidase CHEBI:17748 ChEBI Q9BY32 UniProt UDP BioCyc P49902 UniProt 14000-31-8 CAS DIHYDRO-THYMINE BioCyc 93556 PubChem-compound 5675 ChemSpider B-ALANINE BioCyc Deoxyuridine 65063 PubChem-compound Thymidine kinase, cytosolic Thymidine phosphorylase 65070 PubChem-compound SMILES NC(=O)OP(O)(O)=O 1.0 Soluble calcium-activated nucleotidase 1 Uridine triphosphate SubPathwayInput Uridine Cell SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1 Dihydropyrimidinase CDP SubPathwayInput C9H15N3O11P2 CDP 403.0182 Water 9700 PubChem-compound SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1 HMDB02142 HMDB HMDB01056 HMDB 2.0 65091 PubChem-compound DUTP BioCyc 1.0 Beta-Alanine SubPathwayInput Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial CHEBI:28850 ChEBI 9606 TAXONOMY 1.0 CHEBI:17544 ChEBI dCTP SubPathwayInput 1.0 1174 PubChem-compound CHEBI:16450 ChEBI Deoxyuridine triphosphate CHEBI:16695 ChEBI HMDB02111 HMDB ReactionCatalysis1246 ACTIVATION ReactionCatalysis1249 ACTIVATION ReactionCatalysis1248 ACTIVATION Ureidoisobutyric acid 1.0 ReactionCatalysis1241 ACTIVATION ReactionCatalysis1240 ACTIVATION ReactionCatalysis1243 ACTIVATION ReactionCatalysis1242 ACTIVATION ReactionCatalysis1244 ACTIVATION CHEBI:15377 ChEBI C00526 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 HMDB01274 HMDB SMILES NC(=O)N[C@@H](CC(O)=O)C(O)=O SMILES CC(CN)C(O)=O ReactionCatalysis1250 ACTIVATION 3-UREIDO-ISOBUTYRATE BioCyc ReactionCatalysis1252 ACTIVATION ReactionCatalysis1251 ACTIVATION ReactionCatalysis1254 ACTIVATION HMDB01245 HMDB PW000001 PathWhiz HMDB01489 HMDB L-Glutamine SubPathwayInput PW000003 PathWhiz 89228 ChemSpider 388373 ChemSpider PRPP BioCyc HMDB01000 HMDB ReactionCatalysis1268 ACTIVATION Orotic acid ReactionCatalysis1261 ACTIVATION ReactionCatalysis1263 ACTIVATION ReactionCatalysis1262 ACTIVATION ReactionCatalysis1265 ACTIVATION P31350 UniProt ReactionCatalysis1264 ACTIVATION ReactionCatalysis1267 ACTIVATION Ribose 1-phosphate ReactionCatalysis1266 ACTIVATION 5789 PubChem-compound 106-51-4 CAS DEOXYURIDINE BioCyc ReactionCatalysis1271 ACTIVATION ReactionCatalysis1274 ACTIVATION HMDB00012 HMDB HMDB00014 HMDB 6022 PubChem-compound 365-07-1 CAS 937 ChemSpider 6029 PubChem-compound HMDB00250 HMDB Pyrimidine Metabolism 388355 ChemSpider CHEBI:16134 ChEBI HMDB01342 HMDB HMDB01341 HMDB 2.7.4.6 false 2.7.4.6 Adenosine diphosphate + Uridine triphosphate ↔ Adenosine triphosphate + Uridine 5'-diphosphate REVERSIBLE 3.6.1.6 false 3.6.1.6 Uridine 5'-diphosphate + Water → Phosphate + Uridine 5'-monophosphate LEFT_TO_RIGHT Reaction1494 false Adenosine triphosphate + Uridine 5'-monophosphate → Adenosine diphosphate + Uridine 5'-diphosphate LEFT_TO_RIGHT Reaction1491 false Orotic acid + Phosphoribosyl pyrophosphate ↔ Orotidylic acid REVERSIBLE Reaction1492 false Orotidylic acid → Uridine 5'-monophosphate LEFT_TO_RIGHT 1.3.5.2 false 1.3.5.2 L-Dihydroorotic acid + Quinone → Orotic acid + quinol LEFT_TO_RIGHT 6.3.4.2 false 6.3.4.2 Adenosine triphosphate + Uridine triphosphate → Adenosine diphosphate + Cytidine triphosphate + Phosphate + dCTP LEFT_TO_RIGHT 2.7.4.10 false 2.7.4.10 Adenosine diphosphate + Uridine 5'-diphosphate → 3'-AMP + Uridine triphosphate LEFT_TO_RIGHT 3.6.1.19 false 3.6.1.19 Uridine triphosphate + Water → Pyrophosphate + Uridine 5'-monophosphate LEFT_TO_RIGHT PW000055 PathWhiz HMDB00026 HMDB CHEBI:17239 ChEBI C10H15N2O8P 5-Thymidylic acid 322.0566 ATP BioCyc HMDB01351 HMDB HMDB00262 HMDB PW000051 PathWhiz 1.0 3-Aminoisobutanoic acid SubPathwayOutput Reaction1488 false Carbamoyl phosphate → Ureidosuccinic acid LEFT_TO_RIGHT Reaction1489 false Ureidosuccinic acid → L-Dihydroorotic acid LEFT_TO_RIGHT SMP00031 SMPDB SMP00032 SMPDB Reaction1487 false 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + Phosphate LEFT_TO_RIGHT Deoxycytidylate deaminase C00337 KEGG Compound C9H15N2O14P3 Deoxyuridine triphosphate 467.9736 58481 ChemSpider Thymidylate synthase SMP00046 SMPDB C00106 KEGG Compound C00105 KEGG Compound 6030 PubChem-compound 6031 PubChem-compound 800-73-7 CAS METHYLENE-THF BioCyc 58493 ChemSpider C9H14N3O7P dCMP 307.05695 942 ChemSpider CHEBI:15033 ChEBI Uridine 5'-diphosphate SubPathwayInput PPI BioCyc 439287 PubChem-compound SMP00059 SMPDB 63-37-6 CAS SMP00055 SMPDB C00119 KEGG Compound THYMIDINE BioCyc 160617 PubChem-compound SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O C10H16N2O11P2 dTDP 402.02292 1.0 HMDB01546 HMDB 1.0 C5H10N2O3 L-Glutamine 146.06914 HMDB00217 HMDB Cytosol CHEBI:17025 ChEBI 1.0 C00112 KEGG Compound Deoxyribose 1-phosphate dTDP 13118 ChemSpider 13117 ChemSpider 1.0 Ribonucleoside-diphosphate reductase large subunit O75414 UniProt HMDB00221 HMDB SubPathwayInteraction345 SubPathway345Reaction SubPathwayReaction O95045 UniProt SubPathwayInteraction346 SubPathway346Reaction SubPathwayReaction SubPathwayInteraction343 SubPathwayReaction SubPathway343Reaction SMILES NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 SubPathwayInteraction344 SubPathway344Reaction SubPathwayReaction HMDB00226 HMDB C00364 KEGG Compound CTP BioCyc C00363 KEGG Compound CHEBI:18361 ChEBI DEOXY-RIBOSE-1P BioCyc CHEBI:18367 ChEBI 1032 ChemSpider C00365 KEGG Compound 388320 ChemSpider Dihydropyrimidine dehydrogenase [NADP(+)] P19971 UniProt Ureidosuccinic acid HMDB00218 HMDB 65-86-1 CAS SubPathwayInteraction340 SubPathwayReaction SubPathway340Reaction C9H15N3O10P2 dCDP 387.02325 7339 PubChem-compound NAD(P) BioCyc HMDB01533 HMDB Cytosolic purine 5'-nucleotidase C00143 KEGG Compound 1.0 CHEBI:17013 ChEBI 5988-19-2 CAS 13343 ChemSpider 2.0 TTP BioCyc 462-88-4 CAS DCDP BioCyc Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Inosine triphosphate pyrophosphatase SMILES O=C1CCNC(=O)N1 SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H]1O SMILES CC1CNC(=O)NC1=O 649 PubChem-compound C9H14N2O11P2 dUDP 388.0073 C9H16N3O13P3 dCTP 466.9896 Q9Y2T3 UniProt 5-Thymidylic acid 1.0 C00169 KEGG Compound 58-97-9 CAS SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O dCDP 65-46-3 CAS SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O SubPathwayInteraction335 SubPathwayReaction SubPathway335Reaction DI-H-OROTATE BioCyc URACIL BioCyc C5H6N2O4 L-Dihydroorotic acid 158.03276 7732-18-5 CAS C00178 KEGG Compound SMILES CC(CNC(N)=O)C(O)=O C6H4O2 Quinone 108.021126 AMMONIA BioCyc SMILES N 590-55-6 CAS Thioredoxin HMDB00641 HMDB SubPathwayInteraction328 SubPathwayReaction SubPathway328Reaction HMDB03911 HMDB SubPathwayInteraction329 SubPathwayReaction SubPathway329Reaction Thioredoxin disulfide 132961 ChemSpider 1.0 Dihydropyrimidine dehydrogenase [NADP(+)] HMDB01967 HMDB SMILES NCCC(O)=O OROTATE BioCyc 5800 ChemSpider 979 ChemSpider CMP BioCyc CAD protein H3O4P Phosphoric acid 97.9769 CHEBI:18191 ChEBI 144-90-1 CAS SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5807 ChemSpider 5809 ChemSpider 5808 ChemSpider CHEBI:15918 ChEBI TMP BioCyc dCMP Uracil 58-64-0 CAS 1.0 951-78-0 CAS CTP synthase 1 1.0 22833512 PubChem-compound H2O Water 18.010565 HMDB00828 HMDB 1.0 1.0 749 ChemSpider 71-52-3 CAS Guanine deaminase CAD protein SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O CHEBI:15901 ChEBI 2149-82-8 CAS CHEBI:15842 ChEBI 66-22-8 CAS 1.0 RIBOSE-1P BioCyc Beta-ureidopropionase Dihydrofolic acid SMILES O 1.0 C5H4N2O4 Orotic acid 156.0171 Dihydropyrimidine dehydrogenase [NADP(+)] 1.0 1.0 239 PubChem-compound 1004 PubChem-compound Thymidylate synthase 1.0 Orotidylic acid ADP BioCyc Inosine triphosphate pyrophosphatase 53-59-8 CAS Guanine deaminase Thymidine kinase, cytosolic SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O GO:0005829 GENE ONTOLOGY SMILES NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 1.0 Cytidine Ammonia 164628 PubChem-compound P17812 UniProt Soluble calcium-activated nucleotidase 1 C21H30N7O17P3 NADPH 745.0911 C10H13N2O11P Orotidylic acid 368.0257 C21H29N7O17P3 NADP 744.08325 1.0 2056-98-6 CAS 144320 ChemSpider CHEBI:17821 ChEBI C9H15N2O15P3 Uridine triphosphate 483.96854 C5H11O7P Deoxyribose 1-phosphate 214.02425 C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 1.0 124-38-9 CAS Thioredoxin disulfide 6.0 C9H13N2O9P Uridine 5'-monophosphate 324.03586 CHEBI:16742 ChEBI Cytidine deaminase Uridine monophosphate synthetase isoform A 9319 ChemSpider 50-89-5 CAS URIDINE BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Q8WVQ1 UniProt SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C(=O)NC(=O)C=C1C(O)=O CDP BioCyc 7664-41-7 CAS 107-95-9 CAS 84022 ChemSpider Hydrogen carbonate 53-57-6 CAS 3.5.4.5 false 3.5.4.5 Deoxycytidine + Water → Ammonia + Deoxyuridine LEFT_TO_RIGHT 2.4.2.4 false 2.4.2.4 Deoxyuridine + Phosphate → Deoxyribose 1-phosphate + Uracil LEFT_TO_RIGHT 3.1.3.5 false 3.1.3.5 Water + dCMP → Deoxycytidine + Phosphate LEFT_TO_RIGHT 2.7.1.48 false 2.7.1.48 Adenosine triphosphate + Deoxycytidine → Adenosine diphosphate + dCMP LEFT_TO_RIGHT 222 PubChem-compound TDP BioCyc SMILES OP(O)(O)=O O7P2 Pyrophosphate 173.91193 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + dCDP → Adenosine diphosphate + dCTP LEFT_TO_RIGHT C5H6N2O2 Thymine 126.04293 Thymine CHEBI:16704 ChEBI Reaction1515 false Adenosine triphosphate + dCMP → Adenosine diphosphate + dCDP LEFT_TO_RIGHT 3.5.1.6 false 3.5.1.6 Ureidopropionic acid + Water → Ammonia + Beta-Alanine + Carbon dioxide LEFT_TO_RIGHT CHEBI:15859 ChEBI 1.17.4.1 false 1.17.4.1 CDP + Water + thioredoxin disulfide → dCDP + thioredoxin LEFT_TO_RIGHT 1.3.1.2 false 1.3.1.2 NADP + Uracil → Dihydrouracil + NADPH LEFT_TO_RIGHT 3.5.2.2 false 3.5.2.2 Dihydrouracil + Water → Ureidopropionic acid LEFT_TO_RIGHT 2.4.2.3 false 2.4.2.3 Phosphate + Uridine → Ribose 1-phosphate + Uracil LEFT_TO_RIGHT 3.5.4.3 false 3.5.4.3 Cytidine + Water → Ammonia + Uridine LEFT_TO_RIGHT DCMP BioCyc 3.1.3.5 false 3.1.3.5 Uridine 5'-monophosphate + Water → Phosphate + Uridine LEFT_TO_RIGHT CHEBI:15633 ChEBI Reaction1505 false Adenosine diphosphate + CDP ↔ Adenosine triphosphate + Cytidine monophosphate REVERSIBLE CHEBI:15636 ChEBI 1.0 109 ChemSpider 3.1.3.5 false 3.1.3.5 Cytidine monophosphate + Water → Cytidine + Phosphoric acid LEFT_TO_RIGHT Uridine phosphorylase 2 Adenosine triphosphate CHEBI:28931 ChEBI C10H15N5O10P2 Adenosine diphosphate 427.02942 C10H17N2O14P3 Thymidine 5'-triphosphate 481.98926 2.7.4.6 false 2.7.4.6 Adenosine diphosphate + Cytidine triphosphate ↔ Adenosine triphosphate + CDP REVERSIBLE CHEBI:16958 ChEBI 3.6.1.6 false 3.6.1.6 CDP + Water → Cytidine monophosphate + Phosphate LEFT_TO_RIGHT 3.6.1.6 false 3.6.1.6 Cytidine triphosphate + Water → CDP + Phosphate LEFT_TO_RIGHT C10H14N2O5 Thymidine 242.09027 1.0 CHEBI:17622 ChEBI CHEBI:17625 ChEBI CPD-8587 BioCyc HMDB02031 HMDB HMDB00095 HMDB SMILES NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1 HMDB03364 HMDB C9H13N2O8P dUMP 308.04095 150855 PubChem-compound 2.1.1.45 false 2.1.1.45 Adenosine triphosphate + dUMP ↔ Adenosine diphosphate + dUDP REVERSIBLE 1.17.4.1 false 1.17.4.1 Thioredoxin disulfide + Uridine 5'-diphosphate + Water → Thioredoxin + dUDP LEFT_TO_RIGHT 3.6.1.23 false 3.6.1.23 Deoxyuridine triphosphate + Water → Phosphate + dUMP LEFT_TO_RIGHT 2.7.4.6 false 2.7.4.6 Adenosine diphosphate + Deoxyuridine triphosphate → Adenosine triphosphate + dUDP LEFT_TO_RIGHT 3.5.2.2 false 3.5.2.2 Dihydrothymine + Water → Ureidoisobutyric acid LEFT_TO_RIGHT DCTP BioCyc 3.5.1.6 false 3.5.1.6 Ureidoisobutyric acid + Water → Ammonia + Carbon dioxide + Ureidoisobutyric acid LEFT_TO_RIGHT 3'-AMP 2.4.2.4 false 2.4.2.4 Phosphate + Thymidine → Deoxyribose 1-phosphate + Thymine LEFT_TO_RIGHT 1.3.1.2 false 1.3.1.2 NADP + Thymine → Dihydrothymine + NADPH LEFT_TO_RIGHT CHEBI:16300 ChEBI CHEBI:15698 ChEBI CARBAMOYL-P BioCyc 2.7.1.21 false 2.7.1.21 Adenosine triphosphate + Thymidine → 5-Thymidylic acid + Adenosine diphosphate LEFT_TO_RIGHT 3.6.1.6 false 3.6.1.6 Thymidine 5'-triphosphate + Water → Phosphate + dTDP LEFT_TO_RIGHT 3.1.3.5 false 3.1.3.5 5-Thymidylic acid + Water → Phosphate + Thymidine LEFT_TO_RIGHT Uridine phosphorylase 2 quinol thioredoxin thioredoxin disulfide Thymidine phosphorylase Adenosine diphosphate HMDB01191 HMDB 3.6.1.6 false 3.6.1.6 Water + dTDP → 5-Thymidylic acid + Phosphate LEFT_TO_RIGHT 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + dTDP ↔ Adenosine diphosphate + Thymidine 5'-triphosphate REVERSIBLE 2.1.1.45 false 2.1.1.45 5,10-Methylene-THF + dUMP → 5-Thymidylic acid + Dihydrofolic acid LEFT_TO_RIGHT 2.1.1.45 false 2.1.1.45 5-Thymidylic acid + Adenosine triphosphate ↔ Adenosine diphosphate + dTDP REVERSIBLE 84-21-9 CAS 2.7.1.21 false 2.7.1.21 Adenosine triphosphate + Deoxyuridine → Adenosine diphosphate + dUMP LEFT_TO_RIGHT Q5EBM0 UniProt 3.5.4.12 false 3.5.4.12 Water + dCMP → Ammonia + dUMP LEFT_TO_RIGHT 14075-00-4 CAS HMDB00079 HMDB CHEBI:15422 ChEBI HMDB03349 HMDB 5585 ChemSpider 1.0 HMDB00076 HMDB Ribonucleoside-diphosphate reductase subunit M2 B 3.6.1.6 false 3.6.1.6 Uridine triphosphate + Water → Phosphoric acid + Uridine 5'-diphosphate LEFT_TO_RIGHT SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(=O)NC1=O CHEBI:16509 ChEBI 439216 PubChem-compound HMDB00089 HMDB 1.0 4489 ChemSpider CHEBI:16526 ChEBI HMDB00082 HMDB CPD-8130 BioCyc C00620 KEGG Compound CHEBI:16761 ChEBI 160663 PubChem-compound 2.7.1.48 false 2.7.1.48 Adenosine triphosphate + Uridine → Adenosine diphosphate + Uridine 5'-monophosphate LEFT_TO_RIGHT 1.0 1173-82-6 CAS 1.0 HMDB00056 HMDB HMDB00051 HMDB HMDB00295 HMDB HMDB00296 HMDB 439236 PubChem-compound SMILES O=C1C=CC(=O)C=C1 CHEBI:17677 ChEBI 278 PubChem-compound Thymidine C00881 KEGG Compound 5886 PubChem-compound CHEBI:17672 ChEBI Phosphate SMP00072 SMPDB CHEBI:27468 ChEBI 280 PubChem-compound 491-97-4 CAS CHEBI:16311 ChEBI C00415 KEGG Compound 58601 ChemSpider P32320 UniProt P32321 UniProt Cytidine triphosphate SubPathwayInput SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O SMILES N[C@@H](CCC(N)=O)C(O)=O 17210-42-3 CAS 2.0 HMDB00273 HMDB HMDB03540 HMDB 1.0 Cytosolic purine 5'-nucleotidase CHEBI:28542 ChEBI 1061 PubChem-compound HMDB00288 HMDB 63-39-8 CAS CHEBI:17659 ChEBI 65-71-4 CAS C00429 KEGG Compound Deoxycytidine HMDB00280 HMDB HMDB00285 HMDB SMILES OC(=O)[C@@H]1CC(=O)NC(=O)N1 quinol CHEBI:1670 ChEBI