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CHEBI:16015 ChEBI HMDB00134 HMDB Urea Cycle 6022 PubChem-compound O75746 UniProt Q9UI32 UniProt 6262 PubChem-compound Citrulline SMP00029 SMPDB 937 ChemSpider 1.0 Ornithine carbamoyltransferase, mitochondrial HMDB00250 HMDB CHEBI:16134 ChEBI HMDB01341 HMDB 2.0 L-Aspartic acid SubPathwayOutput 439153 PubChem-compound 110-17-8 CAS SMP00024 SMPDB Arginase-1 50 ChemSpider SMP00020 SMPDB C00327 KEGG Compound CHEBI:16027 ChEBI HMDB00148 HMDB 1.0 OXALACETIC_ACID BioCyc ATP BioCyc PW000052 PathWhiz Aspartate aminotransferase, mitochondrial 559142 ChemSpider SMP00036 SMPDB PW000046 PathWhiz PW000043 PathWhiz 5746 ChemSpider 5745 ChemSpider 5742 ChemSpider Ornithine carbamoyltransferase, mitochondrial PW000162 PathWhiz 1.0 L-ASPARTATE BioCyc 1143 ChemSpider PW000160 PathWhiz UREA BioCyc Transport139 false L-Glutamine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT SMP00046 SMPDB 1.0 SMP00044 SMPDB HMDB00243 HMDB L-Glutamic acid ARG BioCyc 5858 ChemSpider Adenosine monophosphate Carbon dioxide Transport141 false L-Alanine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 5735 ChemSpider 1.0 L-CITRULLINE BioCyc PW000158 PathWhiz 945 ChemSpider PW000152 PathWhiz 16950 PubChem-compound PW000030 PathWhiz 1.0 SMP00050 SMPDB L-Aspartic acid PPI BioCyc SMP00057 SMPDB SMP00059 SMPDB Arginase-1 1.0 SMP00055 SMPDB HMDB00214 HMDB C5H10N2O3 L-Glutamine 146.06914 CH4NO5P Carbamoyl phosphate 140.98271 Neutral amino acid transporter A L-Alanine SubPathwayInput Alanine aminotransferase 1 7664-38-2 CAS 1.0 HMDB00208 HMDB 6.0 1.0 C00009 KEGG Compound C00008 KEGG Compound HMDB00223 HMDB L-ALPHA-ALANINE BioCyc C00001 KEGG Compound 1.0 C00122 KEGG Compound 56-41-7 CAS CHEBI:18361 ChEBI NADH C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider 1031 ChemSpider C00002 KEGG Compound 1.0 Fumaric acid SubPathwayInput Carbamoyl-phosphate synthase [ammonia], mitochondrial HMDB01429 HMDB false L-Arginine + Water → Ornithine + Urea LEFT_TO_RIGHT SMP00009 SMPDB C6H13N3O3 Citrulline 175.09569 372-75-8 CAS C21H28N7O14P2 NAD 664.11694 1.0 C03406 KEGG Compound 1.0 SMP00127 SMPDB SMP00128 SMPDB 44367445 PubChem-compound SMP00129 SMPDB Adenosine triphosphate C00011 KEGG Compound 1.0 2.0 C00014 KEGG Compound Extracellular Space C00013 KEGG Compound Calcium-binding mitochondrial carrier protein Aralar1 Neutral amino acid transporter B(0) Phosphate C00022 KEGG Compound 56-65-5 CAS 53-84-9 CAS C00020 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound CHEBI:26078 ChEBI SMP00015 SMPDB L-Glutamic acid SubPathwayOutput SubPathwayInput SubPathwayInteraction675 SubPathway675Reaction SubPathwayReaction SubPathwayInteraction676 SubPathway676Reaction SubPathwayReaction SubPathwayInteraction674 SubPathwayReaction SubPathway674Reaction SubPathwayInteraction679 SubPathway679Reaction SubPathwayReaction SubPathwayInteraction677 SubPathwayReaction SubPathway677Reaction false L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid LEFT_TO_RIGHT SubPathwayInteraction678 SubPathwayReaction SubPathway678Reaction CL:0000000 CELL TYPE ONTOLOGY 9367 ChemSpider C00036 KEGG Compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Argininosuccinate lyase AMP BioCyc 1.0 C00041 KEGG Compound SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Argininosuccinate synthase 1.0 L-Glutamine C00049 KEGG Compound false L-Glutamine + Water → Ammonia + L-Glutamic acid LEFT_TO_RIGHT C00169 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Alanine aminotransferase 1 Argininosuccinate lyase HMDB00538 HMDB CH4N2O Urea 60.032364 1.0 SubPathwayInteraction698 SubPathway698Reaction SubPathwayReaction 10197150 ChemSpider false 2 Argininosuccinic acid → Fumaric acid + L-Arginine LEFT_TO_RIGHT SubPathwayInteraction699 SubPathway699Reaction SubPathwayReaction Ammonia SubPathwayOutput SubPathwayInput FUM BioCyc SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS false Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Argininosuccinic acid + Pyrophosphate LEFT_TO_RIGHT Aspartate aminotransferase, mitochondrial CHEBI:18012 ChEBI CHEBI:16199 ChEBI SMILES N[C@@H](CCCNC(N)=N)C(O)=O 61-19-8 CAS 1.0 SMILES