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CHEBI:16015 ChEBI C10H14N5O7P 3'-AMP 347.06308 1.0 1.0 439153 PubChem-compound 16597-58-3 CAS 492-27-3 CAS 50 ChemSpider HMDB01476 HMDB HMDB00148 HMDB HMDB01238 HMDB 1118 ChemSpider 910 PubChem-compound HMDB00142 HMDB 1.13.11.52 false 1.13.11.52 L-Tryptophan + Oxygen → N'-Formylkynurenine LEFT_TO_RIGHT N-ACETYL-5-METHOXY-TRYPTAMINE BioCyc 559142 ChemSpider HMDB01200 HMDB HMDB01206 HMDB 5742 ChemSpider C03722 KEGG Compound NADH PW000163 PathWhiz 5-Hydroxyindoleacetaldehyde CHEBI:16474 ChEBI CHEBI:995 ChEBI Transport138 false L-Tryptophan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT C02406 KEGG Compound 5735 ChemSpider L-Kynurenine PW000151 PathWhiz SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS C10H12N2O4 L-3-Hydroxykynurenine 224.07971 708-23-6 CAS 37610 ChemSpider 1.0 HMDB01423 HMDB Tryptophan--tRNA ligase, mitochondrial Serotonin N-acetyltransferase 1.0 979-92-0 CAS 1.0 CHEBI:5086 ChEBI CHEBI:17380 ChEBI CHEBI:48294 ChEBI C00007 KEGG Compound C7H7NO2 2-Aminobenzoic acid 137.04768 C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound L-ALPHA-ALANINE BioCyc 56-41-7 CAS C00005 KEGG Compound C00004 KEGG Compound NADPH C00003 KEGG Compound C00002 KEGG Compound SMILES N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O 1.0 Tryptophan--tRNA ligase, mitochondrial 1.0 1.0 Q9UGM6 UniProt 84 ChemSpider 67261 ChemSpider SubPathwayInteraction461 SubPathway461Reaction SubPathwayReaction C00019 KEGG Compound Coenzyme A C00011 KEGG Compound C00010 KEGG Compound tRNA(Ala) C10H9NO3 5-Hydroxyindoleacetic acid 191.05824 C00013 KEGG Compound 903 PubChem-compound 59-00-7 CAS 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS L-Glutamic acid C00026 KEGG Compound CHEBI:50157 ChEBI Q8N5Z0 UniProt C00025 KEGG Compound C01598 KEGG Compound C00024 KEGG Compound C00272 KEGG Compound Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial NADP 1022-31-7 CAS 4a-Hydroxytetrahydrobiopterin CHEBI:29170 ChEBI CL:0000000 CELL TYPE ONTOLOGY 1760 ChemSpider C01367 KEGG Compound 1.0 Formic acid Tryptophan--tRNA ligase, cytoplasmic 2-Aminomuconic acid semialdehyde C00041 KEGG Compound SMILES N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O TETRA-H-BIOPTERIN BioCyc SMILES NCCC1=CNC2=CC=C(O)C=C12 SMILES COC1=CC(C(=O)CCNC(C)=O)=C(NC=O)C=C1 C15522 KEGG Compound 3,4-Dihydroxyphenylacetaldehyde P04798 UniProt 6-Hydroxymelatonin SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB00303 HMDB C04409 KEGG Compound 1.0 606-59-7 CAS Kynureninase 886 ChemSpider C02470 KEGG Compound 52450-38-1 CAS 1.0 1.0 tRNA(Tyr) HMDB00538 HMDB 2-AMINO-3-CARBOXYMUCONATE_SEMIAL BioCyc L-tryptophyl-tRNA(Trp) Xanthurenic acid C00058 KEGG Compound CHEBI:29159 ChEBI SMILES OC(=O)C1=CC=CN=C1C(O)=O FORMATE BioCyc C10H12N2O3 Formyl-5-hydroxykynurenamine 208.0848 3712 ChemSpider HMDB00763 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 Kynurenine formamidase Indolethylamine N-methyltransferase 41211 PubChem-compound 962 PubChem-compound 31983 ChemSpider Kynureninase 17528-72-2 CAS L-Alanine C00078 KEGG Compound 114908 ChemSpider HMDB04096 HMDB CO2 Carbon dioxide 43.98983 SMILES O=O Melatonin 54-16-0 CAS HMDB11631 HMDB BiologicalState2 1794 ChemSpider HMDB12948 HMDB Aldehyde dehydrogenase, mitochondrial CHEBI:18086 ChEBI 1892-21-3 CAS 1.0 Catalase 1.0 2-AMINOMUCONATE_SEMIALDEHYDE BioCyc HMDB00978 HMDB SMILES COC1=CC2=C(NC=C2CCNC(C)=O)C=C1 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial C10H12N2 Tryptamine 160.10005 644102 PubChem-compound Kynurenine formamidase HMDB04076 HMDB HMDB04077 HMDB 64-18-6 CAS 879 ChemSpider HMDB04078 HMDB 872 ChemSpider C9H15N5O4 4a-Hydroxytetrahydrobiopterin 257.1124 HMDB04073 HMDB SMILES CNCCC1=CNC2=C1C=C(O)C=C2 SMILES CNCCC1=CNC2=CC=CC=C12 NADH BioCyc 29908-03-0 CAS 3517-61-1 CAS 141580 ChemSpider 977 PubChem-compound CHEBI:29182 ChEBI HMDB04086 HMDB HMDB04089 HMDB Tryptophan--tRNA ligase, cytoplasmic HMDB04083 HMDB HMDB04081 HMDB HMDB00715 HMDB 30572 ChemSpider 17215925 ChemSpider 144400 ChemSpider SMILES NCCC1=CNC2=CC=CC=C12 SMILES CC(O)C(O)C1CNC2=NC(N)=NC(=O)C2(O)N1 101399 PubChem-compound 1.0 1125 PubChem-compound Cytochrome P450 1A1 CHEBI:2065 ChEBI 6816 PubChem-compound 51 PubChem-compound CHEBI:235589 ChEBI 1.0 1150 PubChem-compound 144 PubChem-compound 278 ChemSpider 274 ChemSpider 86 PubChem-compound tRNA(Tyr) C9H15N5O3 Tetrahydrobiopterin 241.1175 Pyrophosphate C06212 KEGG Compound 1.0 NADPH BioCyc Reaction1619 false L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid LEFT_TO_RIGHT 3.7.1.3 false 3.7.1.3 L-3-Hydroxykynurenine + Water → 3-Hydroxyanthranilic acid + L-Alanine LEFT_TO_RIGHT 1.11.1.6 false 1.11.1.6 2 3-Hydroxyanthranilic acid + Oxygen → Cinnavalininate + 2 Water LEFT_TO_RIGHT Reaction1615 false 4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid LEFT_TO_RIGHT 1.14.13.9 false 1.14.13.9 L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water LEFT_TO_RIGHT Carbon dioxide Cinnavalininate CPD-6641 BioCyc 440745 PubChem-compound Catalase 440744 PubChem-compound 459 ChemSpider 440743 PubChem-compound C06213 KEGG Compound 440741 PubChem-compound 58-68-4 CAS HMDB04370 HMDB 3.7.1.3 false 3.7.1.3 L-Kynurenine + Water → 2-Aminobenzoic acid + L-Alanine LEFT_TO_RIGHT Reaction1614 false L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid LEFT_TO_RIGHT CHEBI:30915 ChEBI 3.5.1.9 false 3.5.1.9 N'-Formylkynurenine + Water → Formic acid + L-Kynurenine LEFT_TO_RIGHT 3.5.1.9 false 3.5.1.9 Formylanthranilic acid + Water → 2-Aminobenzoic acid + Formic acid LEFT_TO_RIGHT 3.7.1.3 false 3.7.1.3 N'-Formylkynurenine + Water → Formylanthranilic acid + L-Alanine LEFT_TO_RIGHT 6.1.1.2 false 6.1.1.2 Adenosine triphosphate + L-Tryptophan + tRNA(Tyr) → 3'-AMP + L-tryptophyl-tRNA(Trp) + Pyrophosphate LEFT_TO_RIGHT 1.13.11.11 false 1.13.11.11 L-Tryptophan + Oxygen → N'-Formylkynurenine LEFT_TO_RIGHT 6.1.1.2 false 6.1.1.2 Adenosine triphosphate + L-Tryptophan + tRNA(Ala) → 3'-AMP + L-tryptophyl-tRNA(Trp) + Pyrophosphate LEFT_TO_RIGHT SMILES CC(O)C(O)C1CNC2=C(N1)C(=O)N=C(N)N2 440738 PubChem-compound 548-93-6 CAS Reduced flavoprotein 5280673 PubChem-compound 2591-98-2 CAS INDOLE_ACETALDEHYDE BioCyc Oxoglutaric acid 1.13.11.52 false 1.13.11.52 Melatonin + Oxygen → Acetyl-N-formyl-5-methoxykynurenamine LEFT_TO_RIGHT 2.1.1.4 false 2.1.1.4 N-Acetylserotonin + S-Adenosylmethionine → Melatonin + S-Adenosylhomocysteine LEFT_TO_RIGHT CHEBI:15745 ChEBI 1.14.14.1 false 1.14.14.1 Melatonin + Oxygen + Reduced flavoprotein → 6-Hydroxymelatonin + Oxidized flavoprotein + Water LEFT_TO_RIGHT C7H7NO3 3-Hydroxyanthranilic acid 153.04259 SMILES O=C=O 5950 PubChem-compound N-ACETYL-SEROTONIN BioCyc 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound 1.14.13.9 false 1.14.13.9 5-Hydroxykynurenamine + NADPH + Oxygen → 4,6-Dihydroxyquinoline + NADP + Water LEFT_TO_RIGHT 2.3.1.87 false 2.3.1.87 Acetyl-CoA + Serotonin → Coenzyme A + N-Acetylserotonin LEFT_TO_RIGHT CHEBI:16828 ChEBI 3.5.1.9 false 3.5.1.9 5-Hydroxy-N-formylkynurenine + Water → 5-Hydroxykynurenine + Formic acid LEFT_TO_RIGHT 4,6-Dihydroxyquinoline 4.1.1.28 false 4.1.1.28 5-Hydroxykynurenine → 5-Hydroxykynurenamine + Carbon dioxide LEFT_TO_RIGHT 1.13.11.52 false 1.13.11.52 5-Hydroxy-L-tryptophan + Oxygen → 5-Hydroxy-N-formylkynurenine LEFT_TO_RIGHT 2.1.1.4 false 2.1.1.4 5-Hydroxyindoleacetic acid + S-Adenosylmethionine → 5-Methoxyindoleacetate + S-Adenosylhomocysteine LEFT_TO_RIGHT 1.0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 1.0 HMDB04369 HMDB 1.2.1.3 false 1.2.1.3 5-Hydroxyindoleacetaldehyde + NAD + Water → 5-Hydroxyindoleacetic acid + NADH LEFT_TO_RIGHT 3-hydroxyanthranilate 3,4-dioxygenase 1.14.13.9 false 1.14.13.9 NADPH + Oxygen + Serotonin → 5-Hydroxyindoleacetaldehyde + NADP + Water LEFT_TO_RIGHT 222 ChemSpider 1.14.16.4 false 1.14.16.4 L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan LEFT_TO_RIGHT Reaction1622 false 2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid LEFT_TO_RIGHT 4.1.1.45 false 4.1.1.45 2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + Carbon dioxide LEFT_TO_RIGHT Reaction1620 false 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid → Xanthurenic acid LEFT_TO_RIGHT 1.13.11.6 false 1.13.11.6 3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde LEFT_TO_RIGHT 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase CHEBI:16411 ChEBI SMILES OC(=O)CC1=CNC2=CC=C(O)C=C12 C00954 KEGG Compound 1.0 5682 ChemSpider C10H9NO5 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid 223.04807 87-51-4 CAS C11H12N2O5 5-Hydroxy-N-formylkynurenine 252.07462 L-Tryptophan C8H7NO3 Formylanthranilic acid 165.04259 C14H8N2O6 Cinnavalininate 300.03824 14000-31-8 CAS C13H16N2O3 6-Hydroxymelatonin 248.11609 1.0 CO-A BioCyc 1.0 P05091 UniProt 5675 ChemSpider Catalase 72-89-9 CAS N'-Formylkynurenine 1.0 Reaction1646 false S-Adenosylmethionine + Tryptamine → N-Methyltryptamine + S-Adenosylhomocysteine LEFT_TO_RIGHT Q16719 UniProt 2.0 1.14.13.9 false 1.14.13.9 NADPH + Oxygen + Tryptamine → Indoleacetaldehyde + NADP + Water LEFT_TO_RIGHT 1.2.1.3 false 1.2.1.3 Indoleacetaldehyde + NAD + Water → Indoleacetic acid + NADH LEFT_TO_RIGHT 1.0 C11H11NO3 5-Methoxyindoleacetate 205.0739 4.1.1.28 false 4.1.1.28 L-Tryptophan → Carbon dioxide + Tryptamine LEFT_TO_RIGHT Reaction1640 false S-Adenosylmethionine + Serotonin → N-Methylserotonin + S-Adenosylhomocysteine LEFT_TO_RIGHT Cell 1.13.11.52 false 1.13.11.52 Oxygen + Serotonin → Formyl-5-hydroxykynurenamine LEFT_TO_RIGHT SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1 6557 ChemSpider C00978 KEGG Compound HMDB01280 HMDB HMDB00197 HMDB 18986 PubChem-compound CH2O2 Formic acid 46.005478 3-hydroxyanthranilate 3,4-dioxygenase Water C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound L-3-Hydroxykynurenine 1.0 3-HYDROXY-L-KYNURENINE BioCyc 1.0 5-Hydroxy-N-formylkynurenine 1093 ChemSpider 1.0 CHEBI:15793 ChEBI 7782-44-7 CAS 4-(2-Aminophenyl)-2,4-dioxobutanoic acid C10H9NO2 5-Hydroxyindoleacetaldehyde 175.06332 C9H12N2O2 5-Hydroxykynurenamine 180.08987 L-Tryptophan C9H7NO2 4,6-Dihydroxyquinoline 161.04768 9606 TAXONOMY 2-KETOGLUTARATE BioCyc 392413 ChemSpider HMDB02111 HMDB L-KYNURENINE BioCyc CHEBI:30754 ChEBI CHEBI:30751 ChEBI SMILES NCCC(=O)C1=C(NC=O)C=CC(O)=C1 Indoleamine 2,3-dioxygenase 1 Acetyl-N-formyl-5-methoxykynurenamine CHEBI:15377 ChEBI CHEBI:15379 ChEBI 1.0 Quinolinic acid SubPathwayInput SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O CHEBI:15372 ChEBI CHEBI:15374 ChEBI Oxygen CHEBI:16675 ChEBI HMDB01487 HMDB 164719 PubChem-compound N-FORMYLKYNURENINE BioCyc 1.0 Tryptamine 3342-77-6 CAS 2.0 5280625 PubChem-compound 56-69-9 CAS Acetylserotonin O-methyltransferase SMILES NC1=CC=CC=C1C(O)=O 5497 ChemSpider 5013 ChemSpider C00780 KEGG Compound CHEBI:16680 ChEBI HMDB00161 HMDB CHEBI:15351 ChEBI 85-61-0 CAS Aromatic-L-amino-acid decarboxylase C10H7NO4 Xanthurenic acid 205.0375 Tryptophan Metabolism 61-54-1 CAS C03824 KEGG Compound HMDB00259 HMDB 802 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 800 PubChem-compound 937 ChemSpider HMDB00250 HMDB 114918 PubChem-compound 1.0 C00328 KEGG Compound C12H14N2O2 N-Acetylserotonin 218.10553 HMDB00027 HMDB ATP BioCyc P04040 UniProt Aromatic-L-amino-acid decarboxylase 17924 ChemSpider 1.0 HMDB00232 HMDB C15H23N6O5S S-Adenosylmethionine 399.14505 4.0 1.0 5863 ChemSpider CHEBI:17442 ChEBI HMDB00472 HMDB C10H9NO Indoleacetaldehyde 159.06842 952 ChemSpider 1.0 Aldehyde dehydrogenase, mitochondrial SMILES NC(CC(=O)C1=C(NC=O)C=CC(O)=C1)C(O)=O SMILES OC(=O)C1=CC=CC=C1NC=O SMILES NC1=C(C(O)=O)C2=NC3=C(C=CC=C3OC2=CC1=O)C(O)=O 5-Hydroxykynurenine SMILES COC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C1 SMILES NC1=C(C=CC=C1O)C(=O)CC(=O)C(O)=O SMP00048 SMPDB C11H12N2O4 N'-Formylkynurenine 236.07971 C00108 KEGG Compound CHEBI:17697 ChEBI HMDB01330 HMDB 1134-01-6 CAS 2.0 73-22-3 CAS 1826 PubChem-compound PPI BioCyc SMILES COC1=CC2=C(NC=C2CC(O)=O)C=C1 SMILES O=CCC1=CNC2=CC=CC=C12 1.0 1.0 C11H12N2O2 L-Tryptophan 204.08987 HMDB00217 HMDB SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 Cytosol 1.0 C14H20N6O5S S-Adenosylhomocysteine 384.12158 HMDB00208 HMDB C6H7NO3 2-Aminomuconic acid semialdehyde 141.04259 ReactionCatalysis2059 ACTIVATION HMDB00221 HMDB 1037 ChemSpider Serotonin N-acetyltransferase CHEBI:18361 ChEBI SMILES NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O 1.0 P20711 UniProt Kynurenine 3-monooxygenase Tetrahydrobiopterin C21H28N7O14P2 NAD 664.11694 102864 ChemSpider Indoleacetaldehyde Extracellular Space QUINOLINATE BioCyc 74688 PubChem-compound NAD(P) BioCyc HMDB00684 HMDB 388301 ChemSpider 1.0 CHEBI:18344 ChEBI 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase CHEBI:28136 ChEBI 4.0 Indoleamine 2,3-dioxygenase 1 1.0 778 ChemSpider C00398 KEGG Compound 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 389609 ChemSpider 389612 ChemSpider 389616 ChemSpider 389615 ChemSpider 389614 ChemSpider C01252 KEGG Compound C01017 KEGG Compound 1.0 P17752 UniProt 1.0 3-Hydroxyanthranilic acid TRP BioCyc CHEBI:217069 ChEBI CPD-476 BioCyc CHEBI:18377 ChEBI 7732-18-5 CAS 56-86-0 CAS N-Acetylserotonin O95050 UniProt HMDB00881 HMDB 896 PubChem-compound Indoleacetic acid C10H12N2O3 L-Kynurenine 208.0848 NAD Acetylserotonin O-methyltransferase C10H9NO4 4-(2-Aminophenyl)-2,4-dioxobutanoic acid 207.05316 C05639 KEGG Compound C05638 KEGG Compound CHEBI:28171 ChEBI C05635 KEGG Compound C05634 KEGG Compound N-Methylserotonin 606-14-4 CAS Tryptophan 5-hydroxylase 1 S-Adenosylhomocysteine C05640 KEGG Compound 3845 PubChem-compound SMILES NC1=C(O)C=CC=C1C(O)=O L-tryptophyl-tRNA(Trp) 780 ChemSpider 245128-91-0 CAS HMDB01967 HMDB C3H7NO2 L-Alanine 89.047676 1.0 C05645 KEGG Compound C03227 KEGG Compound C05648 KEGG Compound Serotonin C05647 KEGG Compound C05642 KEGG Compound Reduced flavoprotein C05643 KEGG Compound Oxidized flavoprotein C05651 KEGG Compound SMILES N[C@@H](CCC(O)=O)C(O)=O 2922-83-0 CAS SMILES OC=O C11H12N2O3 5-Hydroxy-L-tryptophan 220.0848 132989 ChemSpider 2208-41-5 CAS C05653 KEGG Compound P23381 UniProt SMILES OC1=CC2=C(NC=C2CC=O)C=C1 C05660 KEGG Compound SMILES NCCC(=O)C1=C(N)C=CC(O)=C1 SMILES OC1=CC2=C(O)C=CN=C2C=C1 HMDB12819 HMDB 6088 PubChem-compound 444493 PubChem-compound C10H7NO3 Kynurenic acid 189.04259 Indolethylamine N-methyltransferase 73-31-4 CAS 22833512 PubChem-compound 25246222 PubChem-compound CHEBI:2076 ChEBI ACETYL-COA BioCyc H2O Water 18.010565 1.0 NAD BioCyc Formylanthranilic acid 1.0 5-Hydroxy-L-tryptophan 1864 PubChem-compound 118-92-3 CAS Nicotinate and Nicotinamide Metabolism SubPathway 2.0 P48775 UniProt SMILES OC(=O)C1=CC(=O)C2=CC=CC=C2N1 P46597 UniProt 1.0 1.0 1.0 SMILES O C7H5NO4 Quinolinic acid 167.02185 Acetyl-CoA 1.0 Q8TDX5 UniProt HMDB00929 HMDB 4444266 ChemSpider Cytochrome P450 1A1 171161 PubChem-compound N-Methyltryptamine 1.0 472 PubChem-compound CHEBI:27823 ChEBI CHEBI:15846 ChEBI 91624 ChemSpider HMDB00939 HMDB 53-59-8 CAS C10H9NO2 Indoleacetic acid 175.06332 C10H12N2O4 5-Hydroxykynurenine 224.07971 2-Amino-3-carboxymuconic acid semialdehyde 1.0 GO:0005829 GENE ONTOLOGY ReactionCatalysis1349 ACTIVATION C5H6O5 Oxoglutaric acid 146.02153 HMDB00902 HMDB CHEBI:16908 ChEBI Tryptophan 2,3-dioxygenase BUFOTENINE BioCyc 50-67-9 CAS ADENOSYL-HOMO-CYS BioCyc ReactionCatalysis1357 ACTIVATION 5-Methoxyindoleacetate ReactionCatalysis1356 ACTIVATION ReactionCatalysis1359 ACTIVATION ReactionCatalysis1358 ACTIVATION C21H30N7O17P3 NADPH 745.0911 141 ChemSpider ReactionCatalysis1351 ACTIVATION ReactionCatalysis1350 ACTIVATION C21H29N7O17P3 NADP 744.08325 ReactionCatalysis1353 ACTIVATION ReactionCatalysis1352 ACTIVATION ReactionCatalysis1355 ACTIVATION ReactionCatalysis1354 ACTIVATION SMILES NC(CC(=O)C1=C(N)C=CC(O)=C1)C(O)=O HMDB04259 HMDB 1.0 CHEBI:16977 ChEBI 3-HYDROXY-ANTHRANILATE BioCyc SMILES OC(=O)CC1=CNC2=C1C=CC=C2 11811 PubChem-compound 1.0 C11H14N2O N-Methylserotonin 190.11061 C11H14N2 N-Methyltryptamine 174.11569 SMILES OC(=O)CCC(=O)C(O)=O Formyl-5-hydroxykynurenamine 124-38-9 CAS CHEBI:15414 ChEBI 1.0 Tryptophan 2,3-dioxygenase 1.0 CHEBI:36575 ChEBI SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O CHEBI:28715 ChEBI GLT BioCyc 53-57-6 CAS 5-Hydroxyindoleacetic acid 227 PubChem-compound S-ADENOSYLMETHIONINE BioCyc SMILES C[C@H](N)C(O)=O 1210-83-9 CAS 161166 PubChem-compound O7P2 Pyrophosphate 173.91193 C13H16N2O4 Acetyl-N-formyl-5-methoxykynurenamine 264.111 C7H7NO5 2-Amino-3-carboxymuconic acid semialdehyde 185.03242 CHEBI:16946 ChEBI 5-HYDROXY-TRYPTOPHAN BioCyc C10H12N2O Serotonin 176.09496 720-00-3 CAS SMILES NC(CC1=CNC2=C1C=C(O)C=C2)C(O)=O 6066 ChemSpider Adenosine triphosphate CHEBI:28931 ChEBI GO:0005615 GENE ONTOLOGY 3471-31-6 CAS 5699 PubChem-compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 6305 PubChem-compound HMDB01185 HMDB Oxidized flavoprotein CHEBI:1146900 ChEBI 1.0 3'-AMP HMDB02281 HMDB Kynurenine 3-monooxygenase 5202 PubChem-compound S-Adenosylmethionine C21H36N7O16P3S Coenzyme A 767.11523 SMILES N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O HMDB01190 HMDB 18971002 PubChem-compound 84-21-9 CAS 1.0 CHEBI:15422 ChEBI SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider SMILES OC(=O)C1=NC2=C(O)C=CC=C2C(O)=C1 89-00-9 CAS O2 Oxygen 31.98983 CHEBI:308079 ChEBI CHEBI:16765 ChEBI C01717 KEGG Compound 1.0 CHEBI:16526 ChEBI 129803 PubChem-compound SMILES CC(=O)NCCC1=CNC2=C1C=C(O)C=C2 C13H16N2O2 Melatonin 232.12119 Tryptophan 5-hydroxylase 1 CHEBI:28736 ChEBI 1.0 4444230 ChemSpider HMDB01389 HMDB 70110-58-6 CAS 1.0 C00637 KEGG Compound 5-Hydroxykynurenamine ANTHRANILATE BioCyc C00632 KEGG Compound Aldehyde dehydrogenase, mitochondrial 5893 PubChem-compound ReactionCatalysis1367 ACTIVATION 5-HYDROXYINDOLE_ACETATE BioCyc XANTHURENATE BioCyc P46952 UniProt ReactionCatalysis1360 ACTIVATION ReactionCatalysis1362 ACTIVATION ReactionCatalysis1361 ACTIVATION SMP00063 SMPDB ReactionCatalysis1363 ACTIVATION ReactionCatalysis1366 ACTIVATION Q63HM1 UniProt SMILES NC1=C(C=CC=C1)C(=O)CC(=O)C(O)=O 61-49-4 CAS 5886 PubChem-compound SMILES N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O ReactionCatalysis1379 ACTIVATION ReactionCatalysis1378 ACTIVATION CHEBI:28799 ChEBI 280 PubChem-compound Kynurenic acid ReactionCatalysis1371 ACTIVATION CHEBI:28790 ChEBI ReactionCatalysis1373 ACTIVATION 150885 PubChem-compound ReactionCatalysis1375 ACTIVATION ReactionCatalysis1374 ACTIVATION ReactionCatalysis1377 ACTIVATION ReactionCatalysis1376 ACTIVATION CHEBI:16796 ChEBI HMDB01123 HMDB 11318 ChemSpider 149637 ChemSpider tRNA(Ala) ReactionCatalysis1380 ACTIVATION SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O HMDB03540 HMDB O15229 UniProt 2-Aminobenzoic acid SMILES N\C(=C\C=C/C=O)C(O)=O ReactionCatalysis1382 ACTIVATION ReactionCatalysis1381 ACTIVATION ReactionCatalysis1384 ACTIVATION ReactionCatalysis1383 ACTIVATION TRYPTAMINE BioCyc ReactionCatalysis1386 ACTIVATION ReactionCatalysis1385 ACTIVATION HMDB01377 HMDB 1066 PubChem-compound P14902 UniProt 24762165 PubChem-compound Q16613 UniProt