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CHEBI:16015
ChEBI
C10H14N5O7P
3'-AMP
347.06308
1.0
1.0
439153
PubChem-compound
16597-58-3
CAS
492-27-3
CAS
50
ChemSpider
HMDB01476
HMDB
HMDB00148
HMDB
HMDB01238
HMDB
1118
ChemSpider
910
PubChem-compound
HMDB00142
HMDB
1.13.11.52
false
1.13.11.52
L-Tryptophan + Oxygen → N'-Formylkynurenine
LEFT_TO_RIGHT
N-ACETYL-5-METHOXY-TRYPTAMINE
BioCyc
559142
ChemSpider
HMDB01200
HMDB
HMDB01206
HMDB
5742
ChemSpider
C03722
KEGG Compound
NADH
PW000163
PathWhiz
5-Hydroxyindoleacetaldehyde
CHEBI:16474
ChEBI
CHEBI:995
ChEBI
Transport138
false
L-Tryptophan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
C02406
KEGG Compound
5735
ChemSpider
L-Kynurenine
PW000151
PathWhiz
SMILES
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS
C10H12N2O4
L-3-Hydroxykynurenine
224.07971
708-23-6
CAS
37610
ChemSpider
1.0
HMDB01423
HMDB
Tryptophan--tRNA ligase, mitochondrial
Serotonin N-acetyltransferase
1.0
979-92-0
CAS
1.0
CHEBI:5086
ChEBI
CHEBI:17380
ChEBI
CHEBI:48294
ChEBI
C00007
KEGG Compound
C7H7NO2
2-Aminobenzoic acid
137.04768
C00006
KEGG Compound
CHEBI:18009
ChEBI
C00001
KEGG Compound
L-ALPHA-ALANINE
BioCyc
56-41-7
CAS
C00005
KEGG Compound
C00004
KEGG Compound
NADPH
C00003
KEGG Compound
C00002
KEGG Compound
SMILES
N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O
1.0
Tryptophan--tRNA ligase, mitochondrial
1.0
1.0
Q9UGM6
UniProt
84
ChemSpider
67261
ChemSpider
SubPathwayInteraction461
SubPathway461Reaction
SubPathwayReaction
C00019
KEGG Compound
Coenzyme A
C00011
KEGG Compound
C00010
KEGG Compound
tRNA(Ala)
C10H9NO3
5-Hydroxyindoleacetic acid
191.05824
C00013
KEGG Compound
903
PubChem-compound
59-00-7
CAS
56-65-5
CAS
C00021
KEGG Compound
53-84-9
CAS
L-Glutamic acid
C00026
KEGG Compound
CHEBI:50157
ChEBI
Q8N5Z0
UniProt
C00025
KEGG Compound
C01598
KEGG Compound
C00024
KEGG Compound
C00272
KEGG Compound
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
NADP
1022-31-7
CAS
4a-Hydroxytetrahydrobiopterin
CHEBI:29170
ChEBI
CL:0000000
CELL TYPE ONTOLOGY
1760
ChemSpider
C01367
KEGG Compound
1.0
Formic acid
Tryptophan--tRNA ligase, cytoplasmic
2-Aminomuconic acid semialdehyde
C00041
KEGG Compound
SMILES
N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O
TETRA-H-BIOPTERIN
BioCyc
SMILES
NCCC1=CNC2=CC=C(O)C=C12
SMILES
COC1=CC(C(=O)CCNC(C)=O)=C(NC=O)C=C1
C15522
KEGG Compound
3,4-Dihydroxyphenylacetaldehyde
P04798
UniProt
6-Hydroxymelatonin
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
HMDB00303
HMDB
C04409
KEGG Compound
1.0
606-59-7
CAS
Kynureninase
886
ChemSpider
C02470
KEGG Compound
52450-38-1
CAS
1.0
1.0
tRNA(Tyr)
HMDB00538
HMDB
2-AMINO-3-CARBOXYMUCONATE_SEMIAL
BioCyc
L-tryptophyl-tRNA(Trp)
Xanthurenic acid
C00058
KEGG Compound
CHEBI:29159
ChEBI
SMILES
OC(=O)C1=CC=CN=C1C(O)=O
FORMATE
BioCyc
C10H12N2O3
Formyl-5-hydroxykynurenamine
208.0848
3712
ChemSpider
HMDB00763
HMDB
C10H16N5O13P3
Adenosine triphosphate
506.99576
1.0
Kynurenine formamidase
Indolethylamine N-methyltransferase
41211
PubChem-compound
962
PubChem-compound
31983
ChemSpider
Kynureninase
17528-72-2
CAS
L-Alanine
C00078
KEGG Compound
114908
ChemSpider
HMDB04096
HMDB
CO2
Carbon dioxide
43.98983
SMILES
O=O
Melatonin
54-16-0
CAS
HMDB11631
HMDB
BiologicalState2
1794
ChemSpider
HMDB12948
HMDB
Aldehyde dehydrogenase, mitochondrial
CHEBI:18086
ChEBI
1892-21-3
CAS
1.0
Catalase
1.0
2-AMINOMUCONATE_SEMIALDEHYDE
BioCyc
HMDB00978
HMDB
SMILES
COC1=CC2=C(NC=C2CCNC(C)=O)C=C1
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
C10H12N2
Tryptamine
160.10005
644102
PubChem-compound
Kynurenine formamidase
HMDB04076
HMDB
HMDB04077
HMDB
64-18-6
CAS
879
ChemSpider
HMDB04078
HMDB
872
ChemSpider
C9H15N5O4
4a-Hydroxytetrahydrobiopterin
257.1124
HMDB04073
HMDB
SMILES
CNCCC1=CNC2=C1C=C(O)C=C2
SMILES
CNCCC1=CNC2=CC=CC=C12
NADH
BioCyc
29908-03-0
CAS
3517-61-1
CAS
141580
ChemSpider
977
PubChem-compound
CHEBI:29182
ChEBI
HMDB04086
HMDB
HMDB04089
HMDB
Tryptophan--tRNA ligase, cytoplasmic
HMDB04083
HMDB
HMDB04081
HMDB
HMDB00715
HMDB
30572
ChemSpider
17215925
ChemSpider
144400
ChemSpider
SMILES
NCCC1=CNC2=CC=CC=C12
SMILES
CC(O)C(O)C1CNC2=NC(N)=NC(=O)C2(O)N1
101399
PubChem-compound
1.0
1125
PubChem-compound
Cytochrome P450 1A1
CHEBI:2065
ChEBI
6816
PubChem-compound
51
PubChem-compound
CHEBI:235589
ChEBI
1.0
1150
PubChem-compound
144
PubChem-compound
278
ChemSpider
274
ChemSpider
86
PubChem-compound
tRNA(Tyr)
C9H15N5O3
Tetrahydrobiopterin
241.1175
Pyrophosphate
C06212
KEGG Compound
1.0
NADPH
BioCyc
Reaction1619
false
L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
LEFT_TO_RIGHT
3.7.1.3
false
3.7.1.3
L-3-Hydroxykynurenine + Water → 3-Hydroxyanthranilic acid + L-Alanine
LEFT_TO_RIGHT
1.11.1.6
false
1.11.1.6
2 3-Hydroxyanthranilic acid + Oxygen → Cinnavalininate + 2 Water
LEFT_TO_RIGHT
Reaction1615
false
4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid
LEFT_TO_RIGHT
1.14.13.9
false
1.14.13.9
L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
LEFT_TO_RIGHT
Carbon dioxide
Cinnavalininate
CPD-6641
BioCyc
440745
PubChem-compound
Catalase
440744
PubChem-compound
459
ChemSpider
440743
PubChem-compound
C06213
KEGG Compound
440741
PubChem-compound
58-68-4
CAS
HMDB04370
HMDB
3.7.1.3
false
3.7.1.3
L-Kynurenine + Water → 2-Aminobenzoic acid + L-Alanine
LEFT_TO_RIGHT
Reaction1614
false
L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
LEFT_TO_RIGHT
CHEBI:30915
ChEBI
3.5.1.9
false
3.5.1.9
N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
LEFT_TO_RIGHT
3.5.1.9
false
3.5.1.9
Formylanthranilic acid + Water → 2-Aminobenzoic acid + Formic acid
LEFT_TO_RIGHT
3.7.1.3
false
3.7.1.3
N'-Formylkynurenine + Water → Formylanthranilic acid + L-Alanine
LEFT_TO_RIGHT
6.1.1.2
false
6.1.1.2
Adenosine triphosphate + L-Tryptophan + tRNA(Tyr) → 3'-AMP + L-tryptophyl-tRNA(Trp) + Pyrophosphate
LEFT_TO_RIGHT
1.13.11.11
false
1.13.11.11
L-Tryptophan + Oxygen → N'-Formylkynurenine
LEFT_TO_RIGHT
6.1.1.2
false
6.1.1.2
Adenosine triphosphate + L-Tryptophan + tRNA(Ala) → 3'-AMP + L-tryptophyl-tRNA(Trp) + Pyrophosphate
LEFT_TO_RIGHT
SMILES
CC(O)C(O)C1CNC2=C(N1)C(=O)N=C(N)N2
440738
PubChem-compound
548-93-6
CAS
Reduced flavoprotein
5280673
PubChem-compound
2591-98-2
CAS
INDOLE_ACETALDEHYDE
BioCyc
Oxoglutaric acid
1.13.11.52
false
1.13.11.52
Melatonin + Oxygen → Acetyl-N-formyl-5-methoxykynurenamine
LEFT_TO_RIGHT
2.1.1.4
false
2.1.1.4
N-Acetylserotonin + S-Adenosylmethionine → Melatonin + S-Adenosylhomocysteine
LEFT_TO_RIGHT
CHEBI:15745
ChEBI
1.14.14.1
false
1.14.14.1
Melatonin + Oxygen + Reduced flavoprotein → 6-Hydroxymelatonin + Oxidized flavoprotein + Water
LEFT_TO_RIGHT
C7H7NO3
3-Hydroxyanthranilic acid
153.04259
SMILES
O=C=O
5950
PubChem-compound
N-ACETYL-SEROTONIN
BioCyc
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
C21H29N7O14P2
NADH
665.12476
5957
PubChem-compound
1.14.13.9
false
1.14.13.9
5-Hydroxykynurenamine + NADPH + Oxygen → 4,6-Dihydroxyquinoline + NADP + Water
LEFT_TO_RIGHT
2.3.1.87
false
2.3.1.87
Acetyl-CoA + Serotonin → Coenzyme A + N-Acetylserotonin
LEFT_TO_RIGHT
CHEBI:16828
ChEBI
3.5.1.9
false
3.5.1.9
5-Hydroxy-N-formylkynurenine + Water → 5-Hydroxykynurenine + Formic acid
LEFT_TO_RIGHT
4,6-Dihydroxyquinoline
4.1.1.28
false
4.1.1.28
5-Hydroxykynurenine → 5-Hydroxykynurenamine + Carbon dioxide
LEFT_TO_RIGHT
1.13.11.52
false
1.13.11.52
5-Hydroxy-L-tryptophan + Oxygen → 5-Hydroxy-N-formylkynurenine
LEFT_TO_RIGHT
2.1.1.4
false
2.1.1.4
5-Hydroxyindoleacetic acid + S-Adenosylmethionine → 5-Methoxyindoleacetate + S-Adenosylhomocysteine
LEFT_TO_RIGHT
1.0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
1.0
HMDB04369
HMDB
1.2.1.3
false
1.2.1.3
5-Hydroxyindoleacetaldehyde + NAD + Water → 5-Hydroxyindoleacetic acid + NADH
LEFT_TO_RIGHT
3-hydroxyanthranilate 3,4-dioxygenase
1.14.13.9
false
1.14.13.9
NADPH + Oxygen + Serotonin → 5-Hydroxyindoleacetaldehyde + NADP + Water
LEFT_TO_RIGHT
222
ChemSpider
1.14.16.4
false
1.14.16.4
L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
LEFT_TO_RIGHT
Reaction1622
false
2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid
LEFT_TO_RIGHT
4.1.1.45
false
4.1.1.45
2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + Carbon dioxide
LEFT_TO_RIGHT
Reaction1620
false
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid → Xanthurenic acid
LEFT_TO_RIGHT
1.13.11.6
false
1.13.11.6
3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde
LEFT_TO_RIGHT
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
CHEBI:16411
ChEBI
SMILES
OC(=O)CC1=CNC2=CC=C(O)C=C12
C00954
KEGG Compound
1.0
5682
ChemSpider
C10H9NO5
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
223.04807
87-51-4
CAS
C11H12N2O5
5-Hydroxy-N-formylkynurenine
252.07462
L-Tryptophan
C8H7NO3
Formylanthranilic acid
165.04259
C14H8N2O6
Cinnavalininate
300.03824
14000-31-8
CAS
C13H16N2O3
6-Hydroxymelatonin
248.11609
1.0
CO-A
BioCyc
1.0
P05091
UniProt
5675
ChemSpider
Catalase
72-89-9
CAS
N'-Formylkynurenine
1.0
Reaction1646
false
S-Adenosylmethionine + Tryptamine → N-Methyltryptamine + S-Adenosylhomocysteine
LEFT_TO_RIGHT
Q16719
UniProt
2.0
1.14.13.9
false
1.14.13.9
NADPH + Oxygen + Tryptamine → Indoleacetaldehyde + NADP + Water
LEFT_TO_RIGHT
1.2.1.3
false
1.2.1.3
Indoleacetaldehyde + NAD + Water → Indoleacetic acid + NADH
LEFT_TO_RIGHT
1.0
C11H11NO3
5-Methoxyindoleacetate
205.0739
4.1.1.28
false
4.1.1.28
L-Tryptophan → Carbon dioxide + Tryptamine
LEFT_TO_RIGHT
Reaction1640
false
S-Adenosylmethionine + Serotonin → N-Methylserotonin + S-Adenosylhomocysteine
LEFT_TO_RIGHT
Cell
1.13.11.52
false
1.13.11.52
Oxygen + Serotonin → Formyl-5-hydroxykynurenamine
LEFT_TO_RIGHT
SMILES
NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O)C2=NC=N1
6557
ChemSpider
C00978
KEGG Compound
HMDB01280
HMDB
HMDB00197
HMDB
18986
PubChem-compound
CH2O2
Formic acid
46.005478
3-hydroxyanthranilate 3,4-dioxygenase
Water
C5H9NO4
L-Glutamic acid
147.05316
33032
PubChem-compound
L-3-Hydroxykynurenine
1.0
3-HYDROXY-L-KYNURENINE
BioCyc
1.0
5-Hydroxy-N-formylkynurenine
1093
ChemSpider
1.0
CHEBI:15793
ChEBI
7782-44-7
CAS
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
C10H9NO2
5-Hydroxyindoleacetaldehyde
175.06332
C9H12N2O2
5-Hydroxykynurenamine
180.08987
L-Tryptophan
C9H7NO2
4,6-Dihydroxyquinoline
161.04768
9606
TAXONOMY
2-KETOGLUTARATE
BioCyc
392413
ChemSpider
HMDB02111
HMDB
L-KYNURENINE
BioCyc
CHEBI:30754
ChEBI
CHEBI:30751
ChEBI
SMILES
NCCC(=O)C1=C(NC=O)C=CC(O)=C1
Indoleamine 2,3-dioxygenase 1
Acetyl-N-formyl-5-methoxykynurenamine
CHEBI:15377
ChEBI
CHEBI:15379
ChEBI
1.0
Quinolinic acid
SubPathwayInput
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
CHEBI:15372
ChEBI
CHEBI:15374
ChEBI
Oxygen
CHEBI:16675
ChEBI
HMDB01487
HMDB
164719
PubChem-compound
N-FORMYLKYNURENINE
BioCyc
1.0
Tryptamine
3342-77-6
CAS
2.0
5280625
PubChem-compound
56-69-9
CAS
Acetylserotonin O-methyltransferase
SMILES
NC1=CC=CC=C1C(O)=O
5497
ChemSpider
5013
ChemSpider
C00780
KEGG Compound
CHEBI:16680
ChEBI
HMDB00161
HMDB
CHEBI:15351
ChEBI
85-61-0
CAS
Aromatic-L-amino-acid decarboxylase
C10H7NO4
Xanthurenic acid
205.0375
Tryptophan Metabolism
61-54-1
CAS
C03824
KEGG Compound
HMDB00259
HMDB
802
PubChem-compound
C23H38N7O17P3S
Acetyl-CoA
809.1258
800
PubChem-compound
937
ChemSpider
HMDB00250
HMDB
114918
PubChem-compound
1.0
C00328
KEGG Compound
C12H14N2O2
N-Acetylserotonin
218.10553
HMDB00027
HMDB
ATP
BioCyc
P04040
UniProt
Aromatic-L-amino-acid decarboxylase
17924
ChemSpider
1.0
HMDB00232
HMDB
C15H23N6O5S
S-Adenosylmethionine
399.14505
4.0
1.0
5863
ChemSpider
CHEBI:17442
ChEBI
HMDB00472
HMDB
C10H9NO
Indoleacetaldehyde
159.06842
952
ChemSpider
1.0
Aldehyde dehydrogenase, mitochondrial
SMILES
NC(CC(=O)C1=C(NC=O)C=CC(O)=C1)C(O)=O
SMILES
OC(=O)C1=CC=CC=C1NC=O
SMILES
NC1=C(C(O)=O)C2=NC3=C(C=CC=C3OC2=CC1=O)C(O)=O
5-Hydroxykynurenine
SMILES
COC1=C(O)C=C2NC=C(CCNC(C)=O)C2=C1
SMILES
NC1=C(C=CC=C1O)C(=O)CC(=O)C(O)=O
SMP00048
SMPDB
C11H12N2O4
N'-Formylkynurenine
236.07971
C00108
KEGG Compound
CHEBI:17697
ChEBI
HMDB01330
HMDB
1134-01-6
CAS
2.0
73-22-3
CAS
1826
PubChem-compound
PPI
BioCyc
SMILES
COC1=CC2=C(NC=C2CC(O)=O)C=C1
SMILES
O=CCC1=CNC2=CC=CC=C12
1.0
1.0
C11H12N2O2
L-Tryptophan
204.08987
HMDB00217
HMDB
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12
Cytosol
1.0
C14H20N6O5S
S-Adenosylhomocysteine
384.12158
HMDB00208
HMDB
C6H7NO3
2-Aminomuconic acid semialdehyde
141.04259
ReactionCatalysis2059
ACTIVATION
HMDB00221
HMDB
1037
ChemSpider
Serotonin N-acetyltransferase
CHEBI:18361
ChEBI
SMILES
NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O
1.0
P20711
UniProt
Kynurenine 3-monooxygenase
Tetrahydrobiopterin
C21H28N7O14P2
NAD
664.11694
102864
ChemSpider
Indoleacetaldehyde
Extracellular Space
QUINOLINATE
BioCyc
74688
PubChem-compound
NAD(P)
BioCyc
HMDB00684
HMDB
388301
ChemSpider
1.0
CHEBI:18344
ChEBI
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
CHEBI:28136
ChEBI
4.0
Indoleamine 2,3-dioxygenase 1
1.0
778
ChemSpider
C00398
KEGG Compound
328-50-7
CAS
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
389609
ChemSpider
389612
ChemSpider
389616
ChemSpider
389615
ChemSpider
389614
ChemSpider
C01252
KEGG Compound
C01017
KEGG Compound
1.0
P17752
UniProt
1.0
3-Hydroxyanthranilic acid
TRP
BioCyc
CHEBI:217069
ChEBI
CPD-476
BioCyc
CHEBI:18377
ChEBI
7732-18-5
CAS
56-86-0
CAS
N-Acetylserotonin
O95050
UniProt
HMDB00881
HMDB
896
PubChem-compound
Indoleacetic acid
C10H12N2O3
L-Kynurenine
208.0848
NAD
Acetylserotonin O-methyltransferase
C10H9NO4
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
207.05316
C05639
KEGG Compound
C05638
KEGG Compound
CHEBI:28171
ChEBI
C05635
KEGG Compound
C05634
KEGG Compound
N-Methylserotonin
606-14-4
CAS
Tryptophan 5-hydroxylase 1
S-Adenosylhomocysteine
C05640
KEGG Compound
3845
PubChem-compound
SMILES
NC1=C(O)C=CC=C1C(O)=O
L-tryptophyl-tRNA(Trp)
780
ChemSpider
245128-91-0
CAS
HMDB01967
HMDB
C3H7NO2
L-Alanine
89.047676
1.0
C05645
KEGG Compound
C03227
KEGG Compound
C05648
KEGG Compound
Serotonin
C05647
KEGG Compound
C05642
KEGG Compound
Reduced flavoprotein
C05643
KEGG Compound
Oxidized flavoprotein
C05651
KEGG Compound
SMILES
N[C@@H](CCC(O)=O)C(O)=O
2922-83-0
CAS
SMILES
OC=O
C11H12N2O3
5-Hydroxy-L-tryptophan
220.0848
132989
ChemSpider
2208-41-5
CAS
C05653
KEGG Compound
P23381
UniProt
SMILES
OC1=CC2=C(NC=C2CC=O)C=C1
C05660
KEGG Compound
SMILES
NCCC(=O)C1=C(N)C=CC(O)=C1
SMILES
OC1=CC2=C(O)C=CN=C2C=C1
HMDB12819
HMDB
6088
PubChem-compound
444493
PubChem-compound
C10H7NO3
Kynurenic acid
189.04259
Indolethylamine N-methyltransferase
73-31-4
CAS
22833512
PubChem-compound
25246222
PubChem-compound
CHEBI:2076
ChEBI
ACETYL-COA
BioCyc
H2O
Water
18.010565
1.0
NAD
BioCyc
Formylanthranilic acid
1.0
5-Hydroxy-L-tryptophan
1864
PubChem-compound
118-92-3
CAS
Nicotinate and Nicotinamide Metabolism
SubPathway
2.0
P48775
UniProt
SMILES
OC(=O)C1=CC(=O)C2=CC=CC=C2N1
P46597
UniProt
1.0
1.0
1.0
SMILES
O
C7H5NO4
Quinolinic acid
167.02185
Acetyl-CoA
1.0
Q8TDX5
UniProt
HMDB00929
HMDB
4444266
ChemSpider
Cytochrome P450 1A1
171161
PubChem-compound
N-Methyltryptamine
1.0
472
PubChem-compound
CHEBI:27823
ChEBI
CHEBI:15846
ChEBI
91624
ChemSpider
HMDB00939
HMDB
53-59-8
CAS
C10H9NO2
Indoleacetic acid
175.06332
C10H12N2O4
5-Hydroxykynurenine
224.07971
2-Amino-3-carboxymuconic acid semialdehyde
1.0
GO:0005829
GENE ONTOLOGY
ReactionCatalysis1349
ACTIVATION
C5H6O5
Oxoglutaric acid
146.02153
HMDB00902
HMDB
CHEBI:16908
ChEBI
Tryptophan 2,3-dioxygenase
BUFOTENINE
BioCyc
50-67-9
CAS
ADENOSYL-HOMO-CYS
BioCyc
ReactionCatalysis1357
ACTIVATION
5-Methoxyindoleacetate
ReactionCatalysis1356
ACTIVATION
ReactionCatalysis1359
ACTIVATION
ReactionCatalysis1358
ACTIVATION
C21H30N7O17P3
NADPH
745.0911
141
ChemSpider
ReactionCatalysis1351
ACTIVATION
ReactionCatalysis1350
ACTIVATION
C21H29N7O17P3
NADP
744.08325
ReactionCatalysis1353
ACTIVATION
ReactionCatalysis1352
ACTIVATION
ReactionCatalysis1355
ACTIVATION
ReactionCatalysis1354
ACTIVATION
SMILES
NC(CC(=O)C1=C(N)C=CC(O)=C1)C(O)=O
HMDB04259
HMDB
1.0
CHEBI:16977
ChEBI
3-HYDROXY-ANTHRANILATE
BioCyc
SMILES
OC(=O)CC1=CNC2=C1C=CC=C2
11811
PubChem-compound
1.0
C11H14N2O
N-Methylserotonin
190.11061
C11H14N2
N-Methyltryptamine
174.11569
SMILES
OC(=O)CCC(=O)C(O)=O
Formyl-5-hydroxykynurenamine
124-38-9
CAS
CHEBI:15414
ChEBI
1.0
Tryptophan 2,3-dioxygenase
1.0
CHEBI:36575
ChEBI
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
CHEBI:28715
ChEBI
GLT
BioCyc
53-57-6
CAS
5-Hydroxyindoleacetic acid
227
PubChem-compound
S-ADENOSYLMETHIONINE
BioCyc
SMILES
C[C@H](N)C(O)=O
1210-83-9
CAS
161166
PubChem-compound
O7P2
Pyrophosphate
173.91193
C13H16N2O4
Acetyl-N-formyl-5-methoxykynurenamine
264.111
C7H7NO5
2-Amino-3-carboxymuconic acid semialdehyde
185.03242
CHEBI:16946
ChEBI
5-HYDROXY-TRYPTOPHAN
BioCyc
C10H12N2O
Serotonin
176.09496
720-00-3
CAS
SMILES
NC(CC1=CNC2=C1C=C(O)C=C2)C(O)=O
6066
ChemSpider
Adenosine triphosphate
CHEBI:28931
ChEBI
GO:0005615
GENE ONTOLOGY
3471-31-6
CAS
5699
PubChem-compound
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
6305
PubChem-compound
HMDB01185
HMDB
Oxidized flavoprotein
CHEBI:1146900
ChEBI
1.0
3'-AMP
HMDB02281
HMDB
Kynurenine 3-monooxygenase
5202
PubChem-compound
S-Adenosylmethionine
C21H36N7O16P3S
Coenzyme A
767.11523
SMILES
N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O
HMDB01190
HMDB
18971002
PubChem-compound
84-21-9
CAS
1.0
CHEBI:15422
ChEBI
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
388299
ChemSpider
SMILES
OC(=O)C1=NC2=C(O)C=CC=C2C(O)=C1
89-00-9
CAS
O2
Oxygen
31.98983
CHEBI:308079
ChEBI
CHEBI:16765
ChEBI
C01717
KEGG Compound
1.0
CHEBI:16526
ChEBI
129803
PubChem-compound
SMILES
CC(=O)NCCC1=CNC2=C1C=C(O)C=C2
C13H16N2O2
Melatonin
232.12119
Tryptophan 5-hydroxylase 1
CHEBI:28736
ChEBI
1.0
4444230
ChemSpider
HMDB01389
HMDB
70110-58-6
CAS
1.0
C00637
KEGG Compound
5-Hydroxykynurenamine
ANTHRANILATE
BioCyc
C00632
KEGG Compound
Aldehyde dehydrogenase, mitochondrial
5893
PubChem-compound
ReactionCatalysis1367
ACTIVATION
5-HYDROXYINDOLE_ACETATE
BioCyc
XANTHURENATE
BioCyc
P46952
UniProt
ReactionCatalysis1360
ACTIVATION
ReactionCatalysis1362
ACTIVATION
ReactionCatalysis1361
ACTIVATION
SMP00063
SMPDB
ReactionCatalysis1363
ACTIVATION
ReactionCatalysis1366
ACTIVATION
Q63HM1
UniProt
SMILES
NC1=C(C=CC=C1)C(=O)CC(=O)C(O)=O
61-49-4
CAS
5886
PubChem-compound
SMILES
N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O
ReactionCatalysis1379
ACTIVATION
ReactionCatalysis1378
ACTIVATION
CHEBI:28799
ChEBI
280
PubChem-compound
Kynurenic acid
ReactionCatalysis1371
ACTIVATION
CHEBI:28790
ChEBI
ReactionCatalysis1373
ACTIVATION
150885
PubChem-compound
ReactionCatalysis1375
ACTIVATION
ReactionCatalysis1374
ACTIVATION
ReactionCatalysis1377
ACTIVATION
ReactionCatalysis1376
ACTIVATION
CHEBI:16796
ChEBI
HMDB01123
HMDB
11318
ChemSpider
149637
ChemSpider
tRNA(Ala)
ReactionCatalysis1380
ACTIVATION
SMILES
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O
HMDB03540
HMDB
O15229
UniProt
2-Aminobenzoic acid
SMILES
N\C(=C\C=C/C=O)C(O)=O
ReactionCatalysis1382
ACTIVATION
ReactionCatalysis1381
ACTIVATION
ReactionCatalysis1384
ACTIVATION
ReactionCatalysis1383
ACTIVATION
TRYPTAMINE
BioCyc
ReactionCatalysis1386
ACTIVATION
ReactionCatalysis1385
ACTIVATION
HMDB01377
HMDB
1066
PubChem-compound
P14902
UniProt
24762165
PubChem-compound
Q16613
UniProt