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1.0 Mitochondrial Outer Membrane 1-acyl-sn-glycerol 3-phosphate  Glycerol 3-phosphate Endoplasmic Reticulum Membrane 937 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 439162 PubChem-compound 3.1.3.4 false 3.1.3.4 1,2-diacyl-sn-glycerol 3-phosphate + Water → 1,2-diacyl-sn-glycerol + Phosphate LEFT_TO_RIGHT 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Dihydroxyacetone phosphate SubPathwayOutput Glycerol-3-phosphate acyltransferase 1, mitochondrial Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:1146900 ChEBI P21695 UniProt 439153 PubChem-compound Coenzyme A 1,2-diacyl-sn-glycerol 3-phosphate 1.0 SMILES O De Novo Triacylglycerol Biosynthesis CO-A BioCyc 648 ChemSpider Glycolysis SubPathway long-chain fatty acyl-CoA 1.0 C21H36N7O16P3S Coenzyme A 767.11523 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Reaction55814 false Dihydroxyacetone phosphate + Hydrogen Ion + NADH → Glycerol 3-phosphate + NAD LEFT_TO_RIGHT CHEBI:15846 ChEBI 2.3.1.20 false 2.3.1.20 1,2-diacyl-sn-glycerol + long-chain fatty acyl-CoA → Coenzyme A + triglyceride LEFT_TO_RIGHT 2.0 HMDB0001473 HMDB ReactionCatalysis45606 ACTIVATION Phosphate Transport1196 true 1-acyl-sn-glycerol 3-phosphate  (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Endoplasmic Reticulum Membrane REVERSIBLE 6557 ChemSpider ReactionCatalysis45567 ACTIVATION 668 PubChem-compound Homo sapiens NADH 1.0 1038 PubChem-compound 388299 ChemSpider 7732-18-5 CAS 1.0 HMDB0001487 HMDB Water GO:0005829 GENE ONTOLOGY SubPathwayInteraction7446 SubPathwayReaction SubPathway7446Reaction GO:0005789 GENE ONTOLOGY CHEBI:16908 ChEBI NAD DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha O4P Phosphate 94.95342 triglyceride 1010 ChemSpider Glycerol 3-phosphate SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS SMILES OCC(=O)COP(O)(O)=O Diacylglycerol O-acyltransferase 1 O75907 UniProt 9606 TAXONOMY 962 PubChem-compound 2.3.1.51 false 2.3.1.51 1-acyl-sn-glycerol 3-phosphate  + long-chain fatty acyl-CoA → 1,2-diacyl-sn-glycerol 3-phosphate + Coenzyme A LEFT_TO_RIGHT C00111 KEGG Compound Cytosol 1.0 5893 PubChem-compound 58-68-4 CAS C00080 KEGG Compound 1-acyl-sn-glycerol 3-phosphate  HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O 1.0 long-chain fatty acyl-CoA HMDB0002111 HMDB 1,2-diacyl-sn-glycerol CHEBI:15377 ChEBI C00009 KEGG Compound Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS Hydrogen Ion 1.0 CHEBI:16108 ChEBI 17989-41-2 CAS long-chain fatty acyl-CoA Q14693 UniProt C00001 KEGG Compound HMDB0001429 HMDB 1.0 SMP0015896 SMPDB Diacylglycerol O-acyltransferase 1 C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1.0 1032 ChemSpider C00641 KEGG Compound Q9HCL2 UniProt Phosphatidate phosphatase LPIN1 C3H9O6P Glycerol 3-phosphate 172.01367 1.0 GLYCEROL-3P BioCyc Glycerol-3-phosphate acyltransferase 1, mitochondrial Q99943 UniProt C00093 KEGG Compound 1,2-diacyl-sn-glycerol 57-04-5 CAS 1-acyl-sn-glycerol 3-phosphate  1.0 C21H28N7O14P2 NAD 664.11694 ReactionCatalysis45523 ACTIVATION 1.0 1.0 C00010 KEGG Compound HMDB0000902 HMDB C21H29N7O14P2 NADH 665.12476 H2O Water 18.010565 CHEBI:15978 ChEBI GO:0005741 GENE ONTOLOGY NADH BioCyc 1.0 NAD BioCyc 1,2-diacyl-sn-glycerol 3-phosphate H Hydrogen Ion 1.007825 1061 PubChem-compound HMDB0059597 HMDB 388308 ChemSpider 2.3.1.15 false 2.3.1.15 Glycerol 3-phosphate + long-chain fatty acyl-CoA → 1-acyl-sn-glycerol 3-phosphate  + Coenzyme A LEFT_TO_RIGHT triglyceride Coenzyme A 53-84-9 CAS 1.0 C00422 KEGG Compound Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic Phosphatidate phosphatase LPIN1 ReactionCatalysis45939 ACTIVATION PW016768 PathWhiz 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha HMDB0000126 HMDB ReactionCatalysis45664 ACTIVATION 85-61-0 CAS SMILES OC[C@@H](O)COP(O)(O)=O Glycerol-3- phosphate dehydrogenase [NAD(+)], cytoplasmic glycerol-3- phosphate acyltransferase phosphatidate phosphatase diacylglycerol O- acyltransferase 1-acyl-sn- glycerol-3- phosphate acyltransferase Dihydroxyacetone phosphate NADH H + NAD Glycerol 3-phosphate CoA H 2 O P i CoA CoA Magnesium 1-acyl-sn- glycerol 3-phosphate 1-acyl-sn- glycerol 3-phosphate long-chain fatty acyl-CoA 1,2-diacyl- sn-glycerol 3-phosphate 1,2-diacyl- sn-glycerol long-chain fatty acyl-CoA triglyceride long-chain fatty acyl-CoA Glycolysis Mitochondria Outer Membrane Endoplasmic Reticulum Membrane Cytosol
1.0 Mitochondrial Outer Membrane 1-acyl-sn-glycerol 3-phosphate  Glycerol 3-phosphate Endoplasmic Reticulum Membrane 937 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 439162 PubChem-compound 3.1.3.4 false 3.1.3.4 1,2-diacyl-sn-glycerol 3-phosphate + Water → 1,2-diacyl-sn-glycerol + Phosphate LEFT_TO_RIGHT 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Dihydroxyacetone phosphate SubPathwayOutput Glycerol-3-phosphate acyltransferase 1, mitochondrial Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:1146900 ChEBI P21695 UniProt 439153 PubChem-compound Coenzyme A 1,2-diacyl-sn-glycerol 3-phosphate 1.0 SMILES O De Novo Triacylglycerol Biosynthesis CO-A BioCyc 648 ChemSpider Glycolysis SubPathway long-chain fatty acyl-CoA 1.0 C21H36N7O16P3S Coenzyme A 767.11523 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 Reaction55814 false Dihydroxyacetone phosphate + Hydrogen Ion + NADH → Glycerol 3-phosphate + NAD LEFT_TO_RIGHT CHEBI:15846 ChEBI 2.3.1.20 false 2.3.1.20 1,2-diacyl-sn-glycerol + long-chain fatty acyl-CoA → Coenzyme A + triglyceride LEFT_TO_RIGHT 2.0 HMDB0001473 HMDB ReactionCatalysis45606 ACTIVATION Phosphate Transport1196 true 1-acyl-sn-glycerol 3-phosphate  (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Endoplasmic Reticulum Membrane REVERSIBLE 6557 ChemSpider ReactionCatalysis45567 ACTIVATION 668 PubChem-compound Homo sapiens NADH 1.0 1038 PubChem-compound 388299 ChemSpider 7732-18-5 CAS 1.0 HMDB0001487 HMDB Water GO:0005829 GENE ONTOLOGY SubPathwayInteraction7446 SubPathwayReaction SubPathway7446Reaction GO:0005789 GENE ONTOLOGY CHEBI:16908 ChEBI NAD DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha O4P Phosphate 94.95342 triglyceride 1010 ChemSpider Glycerol 3-phosphate SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS SMILES OCC(=O)COP(O)(O)=O Diacylglycerol O-acyltransferase 1 O75907 UniProt 9606 TAXONOMY 962 PubChem-compound 2.3.1.51 false 2.3.1.51 1-acyl-sn-glycerol 3-phosphate  + long-chain fatty acyl-CoA → 1,2-diacyl-sn-glycerol 3-phosphate + Coenzyme A LEFT_TO_RIGHT C00111 KEGG Compound Cytosol 1.0 5893 PubChem-compound 58-68-4 CAS C00080 KEGG Compound 1-acyl-sn-glycerol 3-phosphate  HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O 1.0 long-chain fatty acyl-CoA HMDB0002111 HMDB 1,2-diacyl-sn-glycerol CHEBI:15377 ChEBI C00009 KEGG Compound Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS Hydrogen Ion 1.0 CHEBI:16108 ChEBI 17989-41-2 CAS long-chain fatty acyl-CoA Q14693 UniProt C00001 KEGG Compound HMDB0001429 HMDB 1.0 SMP0015896 SMPDB Diacylglycerol O-acyltransferase 1 C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1.0 1032 ChemSpider C00641 KEGG Compound Q9HCL2 UniProt Phosphatidate phosphatase LPIN1 C3H9O6P Glycerol 3-phosphate 172.01367 1.0 GLYCEROL-3P BioCyc Glycerol-3-phosphate acyltransferase 1, mitochondrial Q99943 UniProt C00093 KEGG Compound 1,2-diacyl-sn-glycerol 57-04-5 CAS 1-acyl-sn-glycerol 3-phosphate  1.0 C21H28N7O14P2 NAD 664.11694 ReactionCatalysis45523 ACTIVATION 1.0 1.0 C00010 KEGG Compound HMDB0000902 HMDB C21H29N7O14P2 NADH 665.12476 H2O Water 18.010565 CHEBI:15978 ChEBI GO:0005741 GENE ONTOLOGY NADH BioCyc 1.0 NAD BioCyc 1,2-diacyl-sn-glycerol 3-phosphate H Hydrogen Ion 1.007825 1061 PubChem-compound HMDB0059597 HMDB 388308 ChemSpider 2.3.1.15 false 2.3.1.15 Glycerol 3-phosphate + long-chain fatty acyl-CoA → 1-acyl-sn-glycerol 3-phosphate  + Coenzyme A LEFT_TO_RIGHT triglyceride Coenzyme A 53-84-9 CAS 1.0 C00422 KEGG Compound Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic Phosphatidate phosphatase LPIN1 ReactionCatalysis45939 ACTIVATION PW016768 PathWhiz 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha HMDB0000126 HMDB ReactionCatalysis45664 ACTIVATION 85-61-0 CAS SMILES OC[C@@H](O)COP(O)(O)=O Mitochondria Endoplasmic Reticulum GPD1 GPAM LPIN1 DGAT1 AGPAT1 Dihydroxyacetone phosphate NADH Hydrogen Ion NAD Glycerol 3-phosphate Coenzyme A Water Phosphate Coenzyme A Coenzyme A 1-acyl-sn- glycerol 3-phosphate 1-acyl-sn- glycerol 3-phosphate long-chain fatty acyl-CoA 1,2-diacyl- sn-glycerol 3-phosphate 1,2-diacyl- sn-glycerol long-chain fatty acyl-CoA triglyceride long-chain fatty acyl-CoA Glycolysis