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DG(14:0/14:1(9Z)/0:0) 1.0 1.0 923 PubChem-compound Voltage-gated slow delayed rectifying potassium channel (IK5) Voltage-gated ultra rapid delayed rectifying potassium channel Disks large homolog 1 P62158 UniProt 937 ChemSpider Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto) ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Acetylcholine-activated potassium channel (IKACh) SubPathwayActivation Inward rectifier potassium channel (IK1) Potassium voltage-gated channel subfamily A member 5 Catechol O-methyltransferase Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SubPathwayInhibition 1.0 1.0 Transport119 false Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT O00180 UniProt C15H12N2O2 Phenytoin 252.08987 Transport116 false Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Transport120 false Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Transport123 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT P30556 UniProt Voltage-gated T-type calcium channel (ICaT) NADPH Calcium SubPathwayActivator Voltage-gated sodium channel (INa) Voltage-depenent L-type calcium channel P63252 UniProt Voltage-depenent L-type calcium channel SubPathwayActivation ATP-sensitive inward rectifier potassium channel (IKATP) Voltage-gated rapid delayed rectifying potassium channel (IKr) Ryanodine receptor 2 P21964 UniProt Voltage-dependent calcium channel subunit alpha-2/delta-2 1.0 1.0 P05023 UniProt C15H23N6O5S S-Adenosylmethionine 399.14505 BTO:0000759 BRENDA TISSUE ONTOLOGY P05026 UniProt 24765843 ChemSpider 1.0 2.0 P19429 UniProt CHEBI:17200 ChEBI 1.0 CHEBI:16474 ChEBI Hydrogen Ion CHEBI:16595 ChEBI 952 ChemSpider HMDB10042 HMDB Sodium channel protein type 5 subunit alpha Q9NQ66 UniProt HMDB59597 HMDB Q13936 UniProt P11712 UniProt UDP-GLUCURONATE BioCyc 6031 PubChem-compound 813 PubChem-compound Q6IN67 UniProt Sodium/potassium ATPase Inositol 1,4,5-trisphosphate receptor type 1 1010 ChemSpider Beta-1-syntrophin CL:0000746 CELL TYPE ONTOLOGY Troponin, slow skeletal muscle SubPathwayActivation Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-1 Q9HCN8 UniProt 24767919 ChemSpider 1.0 Phenytoin catechol Voltage-gated sodium channel (INa) SubPathwayInhibition P48050 UniProt C15H22N2O18P2 Uridine diphosphate glucuronic acid 580.0343 C00238 KEGG Compound Q92736 UniProt 4.0 57-41-0 CAS HMDB00217 HMDB ReactionCatalysis2171 ACTIVATION 1.0 SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 979-92-0 CAS 1.0 Cytosol HMDB60598 HMDB 1.0 C14H20N6O5S S-Adenosylhomocysteine 384.12158 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayActivation UDP-glucuronosyltransferase 1-9 UDP-glucuronosyltransferase 1-1 Tropomyosin beta chain UDP-glucuronosyltransferase 1-4 Beta-2-syntrophin 1.0 Alpha-1-syntrophin ReactionCatalysis2173 ACTIVATION ReactionCatalysis2175 ACTIVATION ReactionCatalysis2178 ACTIVATION inositol_1,4,5-trisphosphate BioCyc ReactionCatalysis2177 ACTIVATION 1.0 HMDB00221 HMDB HMDB00464 HMDB C00007 KEGG Compound Q13884 UniProt HMDB00586 HMDB cAMP-dependent protein kinase type I-alpha regulatory subunit SubPathwayActivation C00006 KEGG Compound Phosphatidylinositols BioCyc HMDB00588 HMDB ReactionCatalysis2180 ACTIVATION CHEBI:18009 ChEBI ReactionCatalysis2183 ACTIVATION Tropomyosin SubPathwayActivation C00001 KEGG Compound 24203-36-9 CAS Sodium/potassium-transporting ATPase subunit alpha-4 C01330 KEGG Compound Troponin I, cardiac muscle C00005 KEGG Compound Transport53 false Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT NADP 388562 ChemSpider Cytochrome P450 1A2 2784-27-2 CAS Sodium/potassium-transporting ATPase subunit alpha-1 Transport62 false Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 UDP-glucuronosyltransferase 1-6 16756 ChemSpider ReactionCatalysis2185 ACTIVATION ReactionCatalysis2184 ACTIVATION ReactionCatalysis2187 ACTIVATION ReactionCatalysis2186 ACTIVATION ReactionCatalysis2188 ACTIVATION C00019 KEGG Compound Inward rectifier potassium channel 2 BiologicalState47 P54710 UniProt BiologicalState46 BiologicalState45 1.0 5.3.4.1 false 5.3.4.1 Hydroxyphenytoin + Uridine diphosphate glucuronic acid → 4-Hydroxyphenytoin glucuronide + Uridine 5'-diphosphate LEFT_TO_RIGHT 2.1.1.6 false 2.1.1.6 Phenytoin catechol + S-Adenosylmethionine → Phenytoin methylcatechol + S-Adenosylhomocysteine LEFT_TO_RIGHT 78 kDa glucose-regulated protein C00015 KEGG Compound 1.0 Extracellular Space Reaction2287 false Phenytoin arene-oxide → Hydroxyphenytoin LEFT_TO_RIGHT Reaction2288 false Phenytoin dihydrodiol → Phenytoin catechol LEFT_TO_RIGHT 1.0 Reaction2285 false Hydrogen Ion + NADPH + Oxygen + Phenytoin → NADP + Phenytoin arene-oxide + Water LEFT_TO_RIGHT 1.14.14.1 false 1.14.14.1 Phenytoin arene-oxide + Water → Phenytoin dihydrodiol LEFT_TO_RIGHT NAD(P) BioCyc Cytochrome P450 2E1 ATP-sensitive inward rectifier potassium channel 11 14127-61-8 CAS Q9NS61 UniProt Reaction2289 false Hydrogen Ion + Hydroxyphenytoin + NADPH + Oxygen → NADP + Phenytoin catechol + Water LEFT_TO_RIGHT P15382 UniProt SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCC 1.0 Q13733 UniProt Q9UK17 UniProt SMILES O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC2OC2C=C1 H Hydrogen Ion 1.007825 388301 ChemSpider Calcium SMILES OC1=NC(C(O)=N1)(C1=CC=CC=C1)C1=CC=C(O)C=C1 SMILES OC1C=CC(=CC1O)C1(NC(=O)NC1=O)C1=CC=CC=C1 Type-1 angiotensin II receptor P63316 UniProt 1.0 C00021 KEGG Compound 1.0 Calmodulin SubPathwayActivator Protein disulfide-isomerase A2 Sodium Troponin T, fast skeletal muscle CHEBI:8107 ChEBI CHEBI:29108 ChEBI HYOU1 protein CHEBI:29101 ChEBI CHEBI:29103 ChEBI CL:0000000 CELL TYPE ONTOLOGY UDP-glucuronosyltransferase 1-6 1775 PubChem-compound 899 ChemSpider C01245 KEGG Compound Phenytoin methylcatechol P51787 UniProt BiologicalState31 53477948 PubChem-compound Potassium Ryanodine receptor 2 PIP2(16:0/20:3(8Z,11Z,14Z)) P07951 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C 119152 ChemSpider Potassium voltage-gated channel subfamily H member 2 K%2b BioCyc P54709 UniProt C00167 KEGG Compound SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 4.0 S-Adenosylmethionine 1.6.5.2 false 1.6.5.2 NADP + Phenytoin catechol ↔ NADPH + Phenytoin quinone REVERSIBLE C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 17341-25-2 CAS Potassium voltage-gated channel subfamily KQT member 1 SubPathwayControl320 ActivatingSubPathwayControl SubPathway320Control Epoxide hydrolase 1 SubPathwayControl321 SubPathway321Control ActivatingSubPathwayControl SubPathwayControl684 SubPathway684Control ActivatingSubPathwayControl SubPathwayControl322 ActivatingSubPathwayControl SubPathway322Control SMP00327 SMPDB SubPathwayControl323 SubPathway323Control ActivatingSubPathwayControl SubPathwayControl324 ActivatingSubPathwayControl SubPathway324Control Potassium SubPathwayControl325 SubPathway325Control ActivatingSubPathwayControl SubPathwayControl326 ActivatingSubPathwayControl SubPathway326Control SubPathwayControl327 ActivatingSubPathwayControl SubPathway327Control 7732-18-5 CAS 1.0 4-Hydroxyphenytoin glucuronide Water Hydroxyphenytoin 791 ChemSpider 16522 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent T-type calcium channel subunit alpha-1G BiologicalState14 BiologicalState10 SubPathwayControl318 SubPathway318Control ActivatingSubPathwayControl SubPathwayControl319 SubPathway319Control InhibitorySubPathwayControl 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 BiologicalState18 1.0 O95180 UniProt Inositol 1,4,5-trisphosphate receptor type 1 C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 Voltage-dependent T-type calcium channel subunit alpha-1H Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase 962 PubChem-compound 31983 ChemSpider SubPathwayControl582 InhibitorySubPathwayControl SubPathway582Control G-protein signalling cascade ActivatingSubPathway Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 InhibitorySubPathway SMILES O[C@@H]1[C@@H](O)C(OC2=CC=C(C=C2)C2(NC(=O)NC2=O)C2=CC=CC=C2)O[C@@H]([C@H]1O)C(O)=O Phenytoin dihydrodiol SMILES OC1=C(O)C=C(C=C1)C1(NC(=O)NC1=O)C1=CC=CC=C1 Voltage-dependent L-type calcium channel subunit beta-1 HMDB07009 HMDB Beta-1 adrenergic receptor 1.0 58-98-0 CAS cAMP-dependent protein kinase type I-alpha regulatory subunit SMILES O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC(=O)C(=O)C=C1 C00076 KEGG Compound P16615 UniProt SMILES OC1=C(C=O)C=C(C=C1)C1(NC(=O)NC1=O)C1=CC=CC=C1 Sodium Phenytoin 1.0 C00080 KEGG Compound SMILES O=O 1.0 Ca Calcium 39.96259 1.0 Q9Y3Q4 UniProt 5809 ChemSpider Potassium voltage-gated channel subfamily E member 1 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 ActivatingSubPathway 1.0 NAD(P)H dehydrogenase [quinone] 1 P02585 UniProt Kv channel-interacting protein 2 134809 ChemSpider Q09428 UniProt Ryanodine receptor 2 Q12959 UniProt 1.0 G-protein signalling cascade ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel ActivatingSubPathway Calcium activates Troponin ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2 ActivatingSubPathway Potassium voltage-gated channel subfamily E member 2 Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle ActivatingSubPathway Muscle Contraction ActivatingSubPathway Calcium activates Ryanodine receptor 2 ActivatingSubPathway G-protein signalling cascade ActivatingSubPathway G protein-activated inward rectifier potassium channel 1 Phenytoin SubPathwayInhibitor G protein-activated inward rectifier potassium channel 4 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 22833512 PubChem-compound 25246222 PubChem-compound Q12809 UniProt Sodium channel protein type 5 subunit alpha H2O Water 18.010565 P50993 UniProt Uridine 5'-diphosphate Potassium channel subfamily K member 1 29908-03-0 CAS 977 PubChem-compound NAD(P)H dehydrogenase [quinone] 1 Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 K Potassium 38.963707 Voltage-dependent L-type calcium channel subunit alpha-1C 1.0 Cardiomyocyte Troponin I, slow skeletal muscle P15559 UniProt Q15084 UniProt ATP-sensitive inward rectifier potassium channel 8 P23284 UniProt Troponin I, fast skeletal muscle 169703 PubChem-compound P17612 UniProt P26678 UniProt Drug inhibition of Sodium channel protein type 5 subunit alpha InhibitorySubPathway Catechol O-methyltransferase Inositol 1,4,5-trisphosphate SubPathwayActivator 2.0 Sodium/potassium-transporting ATPase subunit alpha-3 Myosin light chain kinase, smooth muscle 17215925 ChemSpider 1.0 Cytochrome P450 2E1 P13667 UniProt TransportCatalysis93 ACTIVATION TransportCatalysis92 ACTIVATION TransportCatalysis91 ACTIVATION TransportCatalysis90 ACTIVATION TransportCatalysis96 ACTIVATION SMILES O Cytochrome P450 3A4 Cytochrome P450 1A2 Stromal cell-derived factor 2-like protein 1 1.0 TransportCatalysis9 ACTIVATION 2616-64-0 CAS Cytochrome P450 3A4 SMILES [Na+] SMILES [K+] P48544 UniProt Troponin C, skeletal muscle Inward rectifier potassium channel 2 Ryanodine receptor 2 SubPathwayActivation P48549 UniProt Uridine diphosphate glucuronic acid Phenytoin arene-oxide Q5I7T1 UniProt P48788 UniProt CHEBI:63804 ChEBI HMDB00935 HMDB HMDB00939 HMDB P33261 UniProt GO:0016529 GENE ONTOLOGY 53-59-8 CAS Phenytoin quinone O60706 UniProt 1038 PubChem-compound P14415 UniProt ATP-binding cassette sub-family C member 8 Endoplasmic reticulum resident protein 29 GO:0005829 GENE ONTOLOGY Type-1 angiotensin II receptor SubPathwayActivator Tropomyosin alpha-1 chain 1.0 P11021 UniProt 85166-31-0 CAS O43497 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide ADENOSYL-HOMO-CYS BioCyc 1.0 Cytochrome P450 2C9 Cytochrome P450 2C19 P45379 UniProt P45378 UniProt 266 ChemSpider SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O Troponin T, slow skeletal muscle C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 4.0 Voltage-dependent L-type calcium channel subunit beta-1 NADPH BioCyc Sodium/potassium-transporting ATPase subunit gamma P22460 UniProt Potassium voltage-gated channel subfamily H member 2 CPD-6641 BioCyc 1.0 Calmodulin Beta-1-syntrophin Voltage-dependent L-type calcium channel subunit alpha-1C Sodium channel protein type 5 subunit alpha 1.0 sarcoplasmic reticulum GO:0005886 GENE ONTOLOGY 1.0 53480233 PubChem-compound Q96GW1 UniProt 1.0 1710 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 Oxygen CHEBI:15414 ChEBI ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Potassium voltage-gated channel subfamily A member 5 Q13087 UniProt Disks large homolog 1 1.0 1.0 Q9UBS4 UniProt Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/calcium exchanger 1 Potassium voltage-gated channel subfamily KQT member 1 P13637 UniProt Q9NY47 UniProt Liver P09493 UniProt C07443 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Protein disulfide-isomerase A6 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 17473 PubChem-compound Calcium 53-57-6 CAS Voltage-dependent T-type calcium channel subunit alpha-1G Voltage-dependent T-type calcium channel subunit alpha-1H DnaJ homolog subfamily B member 11 Protein disulfide-isomerase A4 HSP90B1 protein Cardiac phospholamban Muscarinic acetylcholine receptor M2 C15H12N2O4 Phenytoin catechol 284.0797 C21H20N2O9 4-Hydroxyphenytoin glucuronide 444.11688 S-ADENOSYLMETHIONINE BioCyc C16H12N2O4 Phenytoin methylcatechol 296.0797 C15H10N2O4 Phenytoin quinone 282.06406 P08172 UniProt SMILES [Ca++] 1.0 1.0 UDP-glucuronosyltransferase 1-1 Stromal cell-derived factor 2-like protein 1 Endoplasmic reticulum resident protein 29 Protein disulfide-isomerase A4 Protein disulfide-isomerase A6 Peptidyl-prolyl cis-trans isomerase B Voltage-dependent L-type calcium channel subunit beta-1 HYOU1 protein P07099 UniProt Protein disulfide-isomerase A2 78 kDa glucose-regulated protein cAMP-dependent protein kinase catalytic subunit alpha GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY 1.0 HMDB14397 HMDB 3.0 Potassium voltage-gated channel subfamily E member 2 Q14643 UniProt DnaJ homolog subfamily B member 11 Inositol 1,4,5-trisphosphate receptor type 1 3.1.4.11 false 3.1.4.11 PIP2(16:0/20:3(8Z,11Z,14Z)) → DG(14:0/14:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Endoplasmic Reticulum Endoplasmic Reticulum Membrane Sodium/potassium-transporting ATPase subunit beta-1 Kv channel-interacting protein 2 1.0 TransportCatalysis10 ACTIVATION Sodium/potassium-transporting ATPase subunit beta-2 HMDB01185 HMDB B7ZKV8 UniProt Potassium voltage-gated channel subfamily E member 1 UDP BioCyc O60656 UniProt 1.0 Q14524 UniProt P30040 UniProt P22309 UniProt Potassium channel subfamily K member 1 G protein-activated inward rectifier potassium channel 4 UDP-glucuronosyltransferase 1-4 Q14654 UniProt C15H12N2O3 Phenytoin arene-oxide 268.08478 C15H14N2O4 Phenytoin dihydrodiol 286.09537 3.0 1.0 C15H12N2O3 Hydroxyphenytoin 268.08478 2.0 1.0 Beta-2-syntrophin TransportCatalysis23 ACTIVATION 5675 ChemSpider Potassium voltage-gated channel subfamily D member 3 NAD(P)H dehydrogenase [quinone] 1 Alpha-1-syntrophin Inward rectifier potassium channel 4 G protein-activated inward rectifier potassium channel 1 Q02641 UniProt Cytoplasm Q15746 UniProt Troponin, cardiac muscle SubPathwayActivation Troponin T, cardiac muscle NADPH Cell Sodium/potassium-transporting ATPase subunit alpha-4 Sodium/potassium-transporting ATPase subunit alpha-2 Cardiac phospholamban Ryanodine receptor 2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Sodium/potassium-transporting ATPase subunit alpha-1 Troponin C, slow skeletal and cardiac muscles Cytochrome P450 2C9 O2 Oxygen 31.98983 HSP90B1 protein 439456 PubChem-compound GO:0005789 GENE ONTOLOGY ATP-sensitive inward rectifier potassium channel 8 Phenytoin catechol SMILES O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC=CC=C1 GO:0005783 GENE ONTOLOGY Beta-1 adrenergic receptor SubPathwayActivator Q15842 UniProt 1.0 C00626 KEGG Compound Transport35 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT ATP-sensitive inward rectifier potassium channel 11 Transport36 false Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit alpha-3 7782-44-7 CAS Q9Y6J6 UniProt cAMP-dependent protein kinase catalytic subunit alpha SubPathwayActivation SubPathwayActivator Myosin light chain kinase, smooth muscle SubPathwayActivation SubPathwayActivator Cytochrome P450 2C19 P22310 UniProt ReactionCatalysis2165 ACTIVATION ReactionCatalysis2167 ACTIVATION Q13424 UniProt ReactionCatalysis2166 ACTIVATION UDP-glucuronosyltransferase 1-9 Q13425 UniProt 9606 TAXONOMY 152954 PubChem-compound UDP-glucuronosyltransferase 1-1 1.0 1.0 HMDB00295 HMDB PW000380 PathWhiz HMDB02111 HMDB 135250 PubChem-compound 1.0 CA%2b2 BioCyc C31H58O5 DG(14:0/14:1(9Z)/0:0) 510.42844 1.0 CHEBI:15377 ChEBI Cell Membrane P05177 UniProt CHEBI:15379 ChEBI P10644 UniProt CHEBI:15378 ChEBI SMILES [H+] 1.0 P08684 UniProt HMDB60866 HMDB HMDB60865 HMDB 5886 PubChem-compound HMDB60868 HMDB HMDB60867 HMDB 271 PubChem-compound HMDB60864 HMDB P32418 UniProt 1.0 ATP-binding cassette sub-family C member 8 Epoxide hydrolase 1 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC Peptidyl-prolyl cis-trans isomerase B P13805 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide Alpha-1-syntrophin 1.0 P05181 UniProt Troponin C, skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, slow skeletal muscle 17732 PubChem-compound SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O Phenytoin (Antiarrhythmic) Action Pathway SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)O[C@H]([C@@H]1O)N1C=CC(=O)NC1=O ReactionCatalysis1269 ACTIVATION Troponin I, cardiac muscle P19224 UniProt Troponin I, fast skeletal muscle Troponin T, cardiac muscle Troponin T, slow skeletal muscle NADP HMDB01377 HMDB HMDB01498 HMDB S-Adenosylhomocysteine CHEBI:17659 ChEBI 1.0 Calcium P08588 UniProt 1.0 TransportCatalysis89 ACTIVATION HMDB60769 HMDB CHEBI:16680 ChEBI TransportCatalysis88 ACTIVATION Inositol 1,4,5-trisphosphate receptor type 1 SubPathwayActivation Beta-2-syntrophin TransportCatalysis87 ACTIVATION 1.0 Troponin T, fast skeletal muscle 148411 ChemSpider 24762165 PubChem-compound TransportCatalysis82 ACTIVATION Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Beta-1-syntrophin Tropomyosin beta chain TransportCatalysis86 ACTIVATION Muscarinic acetylcholine receptor M2 SubPathwayActivator TransportCatalysis85 ACTIVATION Sodium/potassium-transporting ATPase subunit gamma TransportCatalysis84 ACTIVATION Tropomyosin alpha-1 chain TransportCatalysis83 ACTIVATION P19237 UniProt 5.0 Troponin, fast skeletal muscle SubPathwayActivation Cardiac phospholamban SubPathwayInhibitor Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Cytochrome P450 2C19 Cytochrome P450 2C9 Cytochrome P450 1A2 Cytochrome P450 2C19 Cytochrome P450 2E1 Epoxide hydrolase 1 Cytochrome P450 2C9 Cytochrome P450 2C19 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-1 UDP- glucuronosyltransferase 1-4 UDP- glucuronosyltransferase 1-6 UDP- glucuronosyltransferase 1-9 Catechol O- methyltransferase NAD(P)H dehydrogenase [quinone] 1 Muscarinic acetylcholine receptor M2 Cardiac phospholamban Beta-1 adrenergic receptor cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit Calmodulin Myosin light chain kinase, smooth muscle Type-1 angiotensin II receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Inositol 1,4,5- trisphosphate receptor type 1 Troponin C, skeletal muscle Troponin I, slow skeletal muscle Troponin T, slow skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, cardiac muscle Troponin T, cardiac muscle Troponin C, skeletal muscle Troponin I, fast skeletal muscle Troponin T, fast skeletal muscle Tropomyosin alpha-1 chain Tropomyosin beta chain Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Ryanodine receptor 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Phenytoin Phenytoin O 2 NADPH H + Phenytoin arene-oxide H 2 O NADP H 2 O Phenytoin dihydrodiol Hydroxyphenytoin Phenytoin catechol O 2 NADPH H + H 2 O NADP Uridine diphosphate glucuronic acid 4-Hydroxyphenytoin glucuronide Uridine 5'-diphosphate S- Adenosylmethionine Phenytoin methylcatechol S- Adenosylhomocysteine NADP Phenytoin quinone NADPH Heme Heme Heme Heme Heme Heme Heme Heme Magnesium FAD Ca + Na + Na + K +