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3548 ChemSpider DG(14:0/14:1(9Z)/0:0) 1.0 923 PubChem-compound Voltage-gated slow delayed rectifying potassium channel (IK5) HMDB60679 HMDB Voltage-gated ultra rapid delayed rectifying potassium channel Disks large homolog 1 P62158 UniProt 937 ChemSpider HMDB60678 HMDB Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto) ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Acetylcholine-activated potassium channel (IKACh) SubPathwayActivation Inward rectifier potassium channel (IK1) Potassium voltage-gated channel subfamily A member 5 HMDB60677 HMDB HMDB60681 HMDB 70478 ChemSpider HMDB14426 HMDB 439153 PubChem-compound HMDB60680 HMDB Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SubPathwayInhibition C07073 KEGG Compound Transport119 false Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT CHEBI:222828 ChEBI O00180 UniProt Transport116 false Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Transport120 false Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT 87833 PubChem-compound Transport123 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT P30556 UniProt Voltage-gated T-type calcium channel (ICaT) NADPH Calcium SubPathwayActivator Voltage-gated sodium channel (INa) Voltage-depenent L-type calcium channel P63252 UniProt Voltage-depenent L-type calcium channel SubPathwayActivation ATP-sensitive inward rectifier potassium channel (IKATP) Voltage-gated rapid delayed rectifying potassium channel (IKr) Ryanodine receptor 2 2-Amino-3-methylbenzoate Voltage-dependent calcium channel subunit alpha-2/delta-2 1.0 Lidocaine 1.0 34604-56-3 CAS 1.0 P05023 UniProt 2283781 ChemSpider BTO:0000759 BRENDA TISSUE ONTOLOGY P05026 UniProt 1.0 24765843 ChemSpider 1.0 P19429 UniProt 1.0 CHEBI:16474 ChEBI Hydrogen Ion CHEBI:16595 ChEBI 952 ChemSpider HMDB10042 HMDB Sodium channel protein type 5 subunit alpha Q9NQ66 UniProt HMDB59597 HMDB 69010 ChemSpider BTO:0000887 BRENDA TISSUE ONTOLOGY Q13936 UniProt Transport266 false Lidocaine (→) Transport: Homo sapiens, Liver, Cell, Endoplasmic Reticulum Membrane to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 813 PubChem-compound 1.0 Sodium/potassium ATPase Inositol 1,4,5-trisphosphate receptor type 1 1010 ChemSpider Beta-1-syntrophin CL:0000746 CELL TYPE ONTOLOGY Troponin, slow skeletal muscle SubPathwayActivation Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-1 24767919 ChemSpider Voltage-gated sodium channel (INa) SubPathwayInhibition P48050 UniProt C00238 KEGG Compound FORMALDEHYDE BioCyc Q92736 UniProt 4.0 161824 PubChem-compound HMDB00217 HMDB HMDB01426 HMDB 1.0 Cytosol 79241 ChemSpider 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayActivation Tropomyosin beta chain Beta-2-syntrophin 1.0 Alpha-1-syntrophin 1.0 inositol_1,4,5-trisphosphate BioCyc C11004 KEGG Compound HMDB00221 HMDB HMDB00464 HMDB C00007 KEGG Compound Q13884 UniProt HMDB00586 HMDB cAMP-dependent protein kinase type I-alpha regulatory subunit SubPathwayActivation C00006 KEGG Compound Phosphatidylinositols BioCyc HMDB00588 HMDB CHEBI:18009 ChEBI Tropomyosin SubPathwayActivation C00001 KEGG Compound 24203-36-9 CAS Sodium/potassium-transporting ATPase subunit alpha-4 C01330 KEGG Compound Troponin I, cardiac muscle C00005 KEGG Compound Transport53 false Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT C00004 KEGG Compound C00003 KEGG Compound 388562 ChemSpider Cytochrome P450 1A2 Sodium/potassium-transporting ATPase subunit alpha-1 Transport62 false Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Monoethylglycinexylidide Inward rectifier potassium channel 2 BiologicalState47 P54710 UniProt BiologicalState46 C21H28N7O14P2 NAD 664.11694 BiologicalState45 1.0 6630 ChemSpider 1.0 CHEBI:357241 ChEBI Extracellular Space 1.0 NAD(P) BioCyc ATP-sensitive inward rectifier potassium channel 11 14127-61-8 CAS BiologicalState52 Q9NS61 UniProt P15382 UniProt SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCC 1.0 Q13733 UniProt Q9UK17 UniProt SMILES CCN(CC)CC(=O)NC1=C(C)C=CC(O)=C1C H Hydrogen Ion 1.007825 SMILES CC1=CC=CC(C)=C1NC(=O)CN Calcium SMILES CCNCC(=O)NC1=C(C)C=CC=C1C SMILES CCNCC(=O)NC1=C(C)C=CC(O)=C1C Type-1 angiotensin II receptor P63316 UniProt 1.0 1.0 53-84-9 CAS Calmodulin SubPathwayActivator Sodium Troponin T, fast skeletal muscle 3015693 PubChem-compound CHEBI:29108 ChEBI 1.0 CHEBI:29101 ChEBI 34604-55-2 CAS 24415 PubChem-compound SMILES CC1=CC(O)=CC(C)=C1N SMILES CC1=C(N)C(=CC=C1)C(O)=O CHEBI:29103 ChEBI SMILES CC1=CC=CC(C)=C1N 7728-40-7 CAS CL:0000000 CELL TYPE ONTOLOGY 899 ChemSpider C01245 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O P51787 UniProt 53477948 PubChem-compound Potassium Ryanodine receptor 2 PIP2(16:0/20:3(8Z,11Z,14Z)) P07951 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Potassium voltage-gated channel subfamily H member 2 3096-70-6 CAS K%2b BioCyc P54709 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 3-Hydroxylidocaine 4.0 17341-25-2 CAS SMP00328 SMPDB Potassium voltage-gated channel subfamily KQT member 1 1.0 SubPathwayControl320 ActivatingSubPathwayControl SubPathway320Control SubPathwayControl321 SubPathway321Control ActivatingSubPathwayControl SubPathwayControl684 SubPathway684Control ActivatingSubPathwayControl SubPathwayControl322 ActivatingSubPathwayControl SubPathway322Control SubPathwayControl323 SubPathway323Control ActivatingSubPathwayControl SubPathwayControl324 ActivatingSubPathwayControl SubPathway324Control Potassium SubPathwayControl325 SubPathway325Control ActivatingSubPathwayControl SubPathwayControl326 ActivatingSubPathwayControl SubPathway326Control SubPathwayControl327 ActivatingSubPathwayControl SubPathway327Control 7732-18-5 CAS 1.0 Water 1.0 76543 PubChem-compound 791 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent T-type calcium channel subunit alpha-1G BiologicalState10 C00067 KEGG Compound SubPathwayControl318 SubPathway318Control ActivatingSubPathwayControl SubPathwayControl319 SubPathway319Control InhibitorySubPathwayControl 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 BiologicalState18 18865-38-8 CAS O95180 UniProt Inositol 1,4,5-trisphosphate receptor type 1 C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 Voltage-dependent T-type calcium channel subunit alpha-1H Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase 962 PubChem-compound G-protein signalling cascade ActivatingSubPathway Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 InhibitorySubPathway Voltage-dependent L-type calcium channel subunit beta-1 HMDB07009 HMDB SubPathwayControl586 SubPathway586Control InhibitorySubPathwayControl Beta-1 adrenergic receptor cAMP-dependent protein kinase type I-alpha regulatory subunit C00076 KEGG Compound P16615 UniProt Sodium 1.0 C00080 KEGG Compound SMILES O=O CHEBI:6456 ChEBI 1.0 Ca Calcium 39.96259 1.0 Q9Y3Q4 UniProt Potassium voltage-gated channel subfamily E member 1 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 ActivatingSubPathway 712 PubChem-compound P02585 UniProt Kv channel-interacting protein 2 SMILES CCN(CC)CC(=O)NC1=C(C)C=CC=C1C Q09428 UniProt CHEBI:55545 ChEBI Ryanodine receptor 2 Q12959 UniProt 1.0 G-protein signalling cascade ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel ActivatingSubPathway Calcium activates Troponin ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2 ActivatingSubPathway Potassium voltage-gated channel subfamily E member 2 Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle ActivatingSubPathway Muscle Contraction ActivatingSubPathway Calcium activates Ryanodine receptor 2 ActivatingSubPathway G-protein signalling cascade ActivatingSubPathway C16560 KEGG Compound G protein-activated inward rectifier potassium channel 1 C16561 KEGG Compound G protein-activated inward rectifier potassium channel 4 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 22833512 PubChem-compound Q12809 UniProt Sodium channel protein type 5 subunit alpha H2O Water 18.010565 P50993 UniProt NADH BioCyc Potassium channel subfamily K member 1 NAD BioCyc C16571 KEGG Compound C16572 KEGG Compound 977 PubChem-compound Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 K Potassium 38.963707 Voltage-dependent L-type calcium channel subunit alpha-1C C16570 KEGG Compound Cardiomyocyte Troponin I, slow skeletal muscle ATP-sensitive inward rectifier potassium channel 8 50-00-0 CAS Troponin I, fast skeletal muscle P17612 UniProt P26678 UniProt Inositol 1,4,5-trisphosphate SubPathwayActivator C16569 KEGG Compound Lidocaine inhibition of Voltage-gated sodium channel (INa) InhibitorySubPathway 2.0 Sodium/potassium-transporting ATPase subunit alpha-3 Myosin light chain kinase, smooth muscle Reaction1938 false Monoethylglycinexylidide → Glycinexylidide LEFT_TO_RIGHT 17215925 ChemSpider Reaction1936 false Monoethylglycinexylidide → 3-Hydroxymonoethylglycinexylidide LEFT_TO_RIGHT Reaction1934 false 3-Hydroxylidocaine → 3-Hydroxymonoethylglycinexylidide LEFT_TO_RIGHT 1.0 1.0 3676 PubChem-compound TransportCatalysis93 ACTIVATION TransportCatalysis92 ACTIVATION TransportCatalysis91 ACTIVATION TransportCatalysis90 ACTIVATION TransportCatalysis96 ACTIVATION SMILES O 2,6-Dimethylaniline 1.14.14.1 false 1.14.14.1 Hydrogen Ion + Lidocaine + NADPH + Oxygen → 3-Hydroxylidocaine + NADP + Water LEFT_TO_RIGHT Cytochrome P450 3A4 Reaction1930 false Monoethylglycinexylidide → 2,6-Dimethylaniline LEFT_TO_RIGHT Cytochrome P450 1A2 TransportCatalysis9 ACTIVATION 1.14.14.1 false 1.14.14.1 Lidocaine + NADH + Oxygen → Formaldehyde + Monoethylglycinexylidide + NAD + Water LEFT_TO_RIGHT Reaction1926 false Lidocaine → 2,6-Dimethylaniline LEFT_TO_RIGHT Cytochrome P450 3A4 SMILES [Na+] SMILES [K+] P48544 UniProt Troponin C, skeletal muscle Inward rectifier potassium channel 2 Ryanodine receptor 2 SubPathwayActivation P48549 UniProt 22824 ChemSpider Q5I7T1 UniProt P48788 UniProt CHEBI:15846 ChEBI GO:0016529 GENE ONTOLOGY 53-59-8 CAS CL:0000187 CELL TYPE ONTOLOGY 142125 ChemSpider O60706 UniProt 1038 PubChem-compound P14415 UniProt ATP-binding cassette sub-family C member 8 4-Hydroxy-2,6-dimethylaniline GO:0005829 GENE ONTOLOGY Type-1 angiotensin II receptor SubPathwayActivator Monoethylglycinexylidide Tropomyosin alpha-1 chain CH2O Formaldehyde 30.010565 1.0 1.0 HMDB00902 HMDB 85166-31-0 CAS CHEBI:16908 ChEBI O43497 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide P45379 UniProt P45378 UniProt 266 ChemSpider Troponin T, slow skeletal muscle C21H30N7O17P3 NADPH 745.0911 Reaction1943 false 2,6-Dimethylaniline → 2-Amino-3-methylbenzoate LEFT_TO_RIGHT Reaction1944 false 2,6-Dimethylaniline → 4-Hydroxy-2,6-dimethylaniline LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Reaction1942 false Glycinexylidide → 2,6-Dimethylaniline LEFT_TO_RIGHT 4.0 Voltage-dependent L-type calcium channel subunit beta-1 NADPH BioCyc Sodium/potassium-transporting ATPase subunit gamma P22460 UniProt Potassium voltage-gated channel subfamily H member 2 CPD-6641 BioCyc 1.0 Calmodulin Beta-1-syntrophin Voltage-dependent L-type calcium channel subunit alpha-1C Sodium channel protein type 5 subunit alpha 58-68-4 CAS ReactionCatalysis1768 ACTIVATION SMILES C=O 692 ChemSpider ReactionCatalysis1769 ACTIVATION sarcoplasmic reticulum 78101 PubChem-compound GO:0005886 GENE ONTOLOGY 1.0 53480233 PubChem-compound NADH Voltage-dependent calcium channel subunit alpha-2/delta-2 Oxygen ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Formaldehyde Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 1.0 1.0 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/calcium exchanger 1 1.0 Potassium voltage-gated channel subfamily KQT member 1 P13637 UniProt Q9NY47 UniProt Liver P09493 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Myocyte SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Calcium Muscle 53-57-6 CAS Voltage-dependent T-type calcium channel subunit alpha-1G Voltage-dependent T-type calcium channel subunit alpha-1H Cardiac phospholamban Muscarinic acetylcholine receptor M2 P08172 UniProt ReactionCatalysis1786 ACTIVATION ReactionCatalysis1785 ACTIVATION Lidocaine SubPathwayInhibitor C21H29N7O14P2 NADH 665.12476 SMILES [Ca++] Glycinexylidide 1.0 1.0 CHEBI:16842 ChEBI Voltage-dependent L-type calcium channel subunit beta-1 cAMP-dependent protein kinase catalytic subunit alpha GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY 1.0 137-58-6 CAS 3.0 Potassium voltage-gated channel subfamily E member 2 Q14643 UniProt Inositol 1,4,5-trisphosphate receptor type 1 3.1.4.11 false 3.1.4.11 PIP2(16:0/20:3(8Z,11Z,14Z)) → DG(14:0/14:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Endoplasmic Reticulum Endoplasmic Reticulum Membrane Sodium/potassium-transporting ATPase subunit beta-1 Kv channel-interacting protein 2 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O TransportCatalysis10 ACTIVATION Sodium/potassium-transporting ATPase subunit beta-2 B7ZKV8 UniProt Potassium voltage-gated channel subfamily E member 1 5682 ChemSpider Q14524 UniProt Potassium channel subfamily K member 1 G protein-activated inward rectifier potassium channel 4 Q14654 UniProt C14H22N2O2 3-Hydroxylidocaine 250.16812 C12H18N2O2 3-Hydroxymonoethylglycinexylidide 222.13683 3.0 1.0 C12H18N2O Monoethylglycinexylidide 206.1419 2.0 C10H14N2O Glycinexylidide 178.11061 1.0 Beta-2-syntrophin TransportCatalysis23 ACTIVATION 5675 ChemSpider Potassium voltage-gated channel subfamily D member 3 6896 PubChem-compound Alpha-1-syntrophin Inward rectifier potassium channel 4 G protein-activated inward rectifier potassium channel 1 Q02641 UniProt NAD Cytoplasm Q15746 UniProt Troponin, cardiac muscle SubPathwayActivation C8H11N 2,6-Dimethylaniline 121.08915 Troponin T, cardiac muscle C8H9NO2 2-Amino-3-methylbenzoate 151.06332 Cell C8H11NO 4-Hydroxy-2,6-dimethylaniline 137.08406 Sodium/potassium-transporting ATPase subunit alpha-4 Lidocaine CHEBI:28738 ChEBI Sodium/potassium-transporting ATPase subunit alpha-2 Cardiac phospholamban Ryanodine receptor 2 388299 ChemSpider Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Sodium/potassium-transporting ATPase subunit alpha-1 Troponin C, slow skeletal and cardiac muscles O2 Oxygen 31.98983 439456 PubChem-compound GO:0005789 GENE ONTOLOGY ATP-sensitive inward rectifier potassium channel 8 GO:0005783 GENE ONTOLOGY Beta-1 adrenergic receptor SubPathwayActivator Q15842 UniProt C00626 KEGG Compound Transport35 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT C14H22N2O Lidocaine 234.17322 ATP-sensitive inward rectifier potassium channel 11 Transport36 false Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit alpha-3 7782-44-7 CAS Q9Y6J6 UniProt cAMP-dependent protein kinase catalytic subunit alpha SubPathwayActivation SubPathwayActivator Myosin light chain kinase, smooth muscle SubPathwayActivation SubPathwayActivator 87-62-7 CAS Q13424 UniProt Q13425 UniProt 9606 TAXONOMY 1.0 1.0 PW000381 PathWhiz 5893 PubChem-compound HMDB02111 HMDB 3-Hydroxymonoethylglycinexylidide CA%2b2 BioCyc C31H58O5 DG(14:0/14:1(9Z)/0:0) 510.42844 CHEBI:15377 ChEBI 4389-45-1 CAS Cell Membrane P05177 UniProt CHEBI:15379 ChEBI P10644 UniProt CHEBI:15378 ChEBI SMILES [H+] P08684 UniProt 1.0 5886 PubChem-compound 271 PubChem-compound P32418 UniProt ATP-binding cassette sub-family C member 8 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC HMDB01487 HMDB P13805 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide Alpha-1-syntrophin Troponin C, skeletal muscle HMDB60656 HMDB Troponin C, slow skeletal and cardiac muscles Troponin I, slow skeletal muscle Lidocaine (Antiarrhythmic) Action Pathway HMDB60655 HMDB ReactionCatalysis1269 ACTIVATION Troponin I, cardiac muscle Troponin I, fast skeletal muscle Troponin T, cardiac muscle Troponin T, slow skeletal muscle 1.0 NADP HMDB01377 HMDB HMDB01498 HMDB 1.0 Calcium P08588 UniProt TransportCatalysis89 ACTIVATION TransportCatalysis88 ACTIVATION Inositol 1,4,5-trisphosphate receptor type 1 SubPathwayActivation 3-Hydroxylidocaine Beta-2-syntrophin TransportCatalysis87 ACTIVATION 1.0 Troponin T, fast skeletal muscle TransportCatalysis82 ACTIVATION Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Beta-1-syntrophin Tropomyosin beta chain TransportCatalysis86 ACTIVATION Muscarinic acetylcholine receptor M2 SubPathwayActivator TransportCatalysis85 ACTIVATION Sodium/potassium-transporting ATPase subunit gamma TransportCatalysis84 ACTIVATION Tropomyosin alpha-1 chain TransportCatalysis83 ACTIVATION P19237 UniProt 5.0 Troponin, fast skeletal muscle SubPathwayActivation Cardiac phospholamban SubPathwayInhibitor Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Muscarinic acetylcholine receptor M2 Cardiac phospholamban Beta-1 adrenergic receptor cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit Calmodulin Myosin light chain kinase, smooth muscle Type-1 angiotensin II receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Inositol 1,4,5- trisphosphate receptor type 1 Troponin C, skeletal muscle Troponin I, slow skeletal muscle Troponin T, slow skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, cardiac muscle Troponin T, cardiac muscle Troponin C, skeletal muscle Troponin I, fast skeletal muscle Troponin T, fast skeletal muscle Tropomyosin alpha-1 chain Tropomyosin beta chain Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Ryanodine receptor 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Lidocaine 3-Hydroxylidocaine 3- Hydroxymonoethylglycinexylidide Monoethylglycinexylidide 2,6-Dimethylaniline Glycinexylidide 2-Amino-3-methylbenzoate 4-Hydroxy-2,6-dimethylaniline O 2 NADPH H + H 2 O NADP O 2 NADH H 2 O Formaldehyde NAD Lidocaine Heme Heme Heme Heme Ca + Na + Na + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + Ca + Ca + Na + Na + Na + Na + K + K + Na + Na + Ca + Ca + Ca + Ca + Ca + PIP2(16:0/20:3(8Z,11Z,14Z)) Inositol 1,4,5- trisphosphate DG(14:0/14:1(9Z)/0:0) ATP H 2 O Ca + ADP P i Ca + Magnesium Calcium Calcium G-protein signalling cascade G-protein signalling cascade Muscle Contraction G-protein signalling cascade Cardiac Myocyte Voltage-gated sodium channel (INa) MYOCYTE SARCOPLASMIC RETICULUM In smooth muscle In striated muscle
3548 ChemSpider DG(14:0/14:1(9Z)/0:0) 1.0 923 PubChem-compound Voltage-gated slow delayed rectifying potassium channel (IK5) HMDB60679 HMDB Voltage-gated ultra rapid delayed rectifying potassium channel Disks large homolog 1 P62158 UniProt 937 ChemSpider HMDB60678 HMDB Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto) ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Acetylcholine-activated potassium channel (IKACh) SubPathwayActivation Inward rectifier potassium channel (IK1) Potassium voltage-gated channel subfamily A member 5 HMDB60677 HMDB HMDB60681 HMDB 70478 ChemSpider HMDB14426 HMDB 439153 PubChem-compound HMDB60680 HMDB Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SubPathwayInhibition C07073 KEGG Compound Transport119 false Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT CHEBI:222828 ChEBI O00180 UniProt Transport116 false Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Transport120 false Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT 87833 PubChem-compound Transport123 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT P30556 UniProt Voltage-gated T-type calcium channel (ICaT) NADPH Calcium SubPathwayActivator Voltage-gated sodium channel (INa) Voltage-depenent L-type calcium channel P63252 UniProt Voltage-depenent L-type calcium channel SubPathwayActivation ATP-sensitive inward rectifier potassium channel (IKATP) Voltage-gated rapid delayed rectifying potassium channel (IKr) Ryanodine receptor 2 2-Amino-3-methylbenzoate Voltage-dependent calcium channel subunit alpha-2/delta-2 1.0 Lidocaine 1.0 34604-56-3 CAS 1.0 P05023 UniProt 2283781 ChemSpider BTO:0000759 BRENDA TISSUE ONTOLOGY P05026 UniProt 1.0 24765843 ChemSpider 1.0 P19429 UniProt 1.0 CHEBI:16474 ChEBI Hydrogen Ion CHEBI:16595 ChEBI 952 ChemSpider HMDB10042 HMDB Sodium channel protein type 5 subunit alpha Q9NQ66 UniProt HMDB59597 HMDB 69010 ChemSpider BTO:0000887 BRENDA TISSUE ONTOLOGY Q13936 UniProt Transport266 false Lidocaine (→) Transport: Homo sapiens, Liver, Cell, Endoplasmic Reticulum Membrane to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 813 PubChem-compound 1.0 Sodium/potassium ATPase Inositol 1,4,5-trisphosphate receptor type 1 1010 ChemSpider Beta-1-syntrophin CL:0000746 CELL TYPE ONTOLOGY Troponin, slow skeletal muscle SubPathwayActivation Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-1 24767919 ChemSpider Voltage-gated sodium channel (INa) SubPathwayInhibition P48050 UniProt C00238 KEGG Compound FORMALDEHYDE BioCyc Q92736 UniProt 4.0 161824 PubChem-compound HMDB00217 HMDB HMDB01426 HMDB 1.0 Cytosol 79241 ChemSpider 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayActivation Tropomyosin beta chain Beta-2-syntrophin 1.0 Alpha-1-syntrophin 1.0 inositol_1,4,5-trisphosphate BioCyc C11004 KEGG Compound HMDB00221 HMDB HMDB00464 HMDB C00007 KEGG Compound Q13884 UniProt HMDB00586 HMDB cAMP-dependent protein kinase type I-alpha regulatory subunit SubPathwayActivation C00006 KEGG Compound Phosphatidylinositols BioCyc HMDB00588 HMDB CHEBI:18009 ChEBI Tropomyosin SubPathwayActivation C00001 KEGG Compound 24203-36-9 CAS Sodium/potassium-transporting ATPase subunit alpha-4 C01330 KEGG Compound Troponin I, cardiac muscle C00005 KEGG Compound Transport53 false Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT C00004 KEGG Compound C00003 KEGG Compound 388562 ChemSpider Cytochrome P450 1A2 Sodium/potassium-transporting ATPase subunit alpha-1 Transport62 false Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Monoethylglycinexylidide Inward rectifier potassium channel 2 BiologicalState47 Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum P54710 UniProt BiologicalState46 Homo sapiens, Cardiomyocyte , Cytosol C21H28N7O14P2 NAD 664.11694 BiologicalState45 Homo sapiens, Cardiomyocyte , Cell Membrane 1.0 6630 ChemSpider 1.0 CHEBI:357241 ChEBI Extracellular Space 1.0 NAD(P) BioCyc ATP-sensitive inward rectifier potassium channel 11 14127-61-8 CAS BiologicalState52 Homo sapiens, Muscle, Myocyte, Cell Membrane Q9NS61 UniProt P15382 UniProt SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCC 1.0 Q13733 UniProt Q9UK17 UniProt SMILES CCN(CC)CC(=O)NC1=C(C)C=CC(O)=C1C H Hydrogen Ion 1.007825 SMILES CC1=CC=CC(C)=C1NC(=O)CN Calcium SMILES CCNCC(=O)NC1=C(C)C=CC=C1C SMILES CCNCC(=O)NC1=C(C)C=CC(O)=C1C Type-1 angiotensin II receptor P63316 UniProt 1.0 1.0 53-84-9 CAS Calmodulin SubPathwayActivator Sodium Troponin T, fast skeletal muscle 3015693 PubChem-compound CHEBI:29108 ChEBI 1.0 CHEBI:29101 ChEBI 34604-55-2 CAS 24415 PubChem-compound SMILES CC1=CC(O)=CC(C)=C1N SMILES CC1=C(N)C(=CC=C1)C(O)=O CHEBI:29103 ChEBI SMILES CC1=CC=CC(C)=C1N 7728-40-7 CAS CL:0000000 CELL TYPE ONTOLOGY 899 ChemSpider C01245 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O P51787 UniProt 53477948 PubChem-compound Potassium Ryanodine receptor 2 PIP2(16:0/20:3(8Z,11Z,14Z)) P07951 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Potassium voltage-gated channel subfamily H member 2 3096-70-6 CAS K%2b BioCyc P54709 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 3-