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1.0 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial 4.0 1.0 C20H32O2 Arachidonic acid 304.24023 CHEBI:15843 ChEBI Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Dual specificity mitogen-activated protein kinase kinase 7 Q06187 UniProt 1.0 1.0 Q9UQC2 UniProt 2.0 P28482 UniProt P63000 UniProt SMILES NCCC1=CNC=N1 Interleukin-13 SubPathwayOutput C23H37NO5S Leukotriene E4 439.23926 HMDB03080 HMDB Cytosolic phospholipase A2 P43405 UniProt 1.0 9005-49-6 CAS 1.0 GTPase KRas P04049 UniProt GTPase NRas LEUKOTRIENE-C4 BioCyc Tyrosine-protein kinase BTK Calcium SubPathwayInput 1.0 HMDB02200 HMDB 1.0 20-HYDROXY-LEUKOTRIENE-E4 BioCyc Leukotriene D4 SubPathwayOutput 1.0 CHEBI:1044940 ChEBI 1.0 RAC-alpha serine/threonine-protein kinase SubPathwayInput SubPathwayInteraction730 SubPathwayReaction SubPathway730Reaction 4444133 ChemSpider PW000044 PathWhiz 1.0 C00219 KEGG Compound SubPathwayControl720 InhibitorySubPathwayControl SubPathway720Control High affinity immunoglobulin epsilon receptor subunit gamma C00696 KEGG Compound CHEBI:16595 ChEBI GO:0005829 GENE ONTOLOGY Ras-related C3 botulinum toxin substrate 1 Immunoglobulin E SubPathwayActivation SubPathwayActivator 1.0 GTPase KRas 85166-31-0 CAS HMDB32436 HMDB 17216115 ChemSpider SMILES [H][C@](O)(CCCCC)\C=C\[C@@]1([H])C(=O)C[C@]([H])(O)[C@]1([H])C\C=C/CCCC(O)=O Protein kinase C alpha type Dual specificity mitogen-activated protein kinase kinase 4 C30H47N3O9S Leukotriene C4 625.3033 1.0 Q9UKW4 UniProt P35225 UniProt SubPathwayInteraction723 SubPathwayReaction SubPathway723Reaction P01112 UniProt P01111 UniProt SubPathwayInteraction722 SubPathwayReaction SubPathway722Reaction 5280493 PubChem-compound SubPathwayInteraction727 SubPathwayReaction SubPathway727Reaction GTPase HRas SubPathwayInteraction728 SubPathway728Reaction SubPathwayReaction [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial P06241 UniProt HEPARIN BioCyc SubPathwayInteraction729 SubPathway729Reaction SubPathwayReaction SubPathwayControl719 SubPathway719Control ActivatingSubPathwayControl SMILES CCCCCC=CCC=CC=CC=CC(SCC(N)C(=O)NCC(O)=O)C(O)CCCC(O)=O 266 ChemSpider C100H188O22 Mono- and diglycerides 1741.3593 4940074 ChemSpider P01116 UniProt P17252 UniProt Q16539 UniProt P36507 UniProt GTPase NRas Ras-related C3 botulinum toxin substrate 1 SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(C)=O.CCCCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(C)=O.CCCCCCCCCCCCCCCCCC(=O)OCC(COC(C)=O)OC(C)=O.CCCCCCCCCCCCCCCCCCCC(=O)OCC(COC(C)=O)OC(C)=O Tyrosine-protein kinase Fyn CHEBI:16978 ChEBI Phosphatidylinositol 3-kinase 1.0 Mitogen-activated protein kinase 1 Immunoglobulin Activation ActivatingSubPathway High affinity immunoglobulin epsilon receptor subunit beta Tyrosine-protein kinase SYK Cytosol 1.0 Growth factor receptor-bound protein 2 1.0 Reaction2144 true 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 → Inositol 1,4,5-trisphosphate + Mono- and diglycerides LEFT_TO_RIGHT 1.0 Tumor necrosis factor Reaction2145 true Mono- and diglycerides → Protein kinase C alpha type LEFT_TO_RIGHT Reaction2142 true Guanine nucleotide exchange factor VAV3 → Ras-related C3 botulinum toxin substrate 1 LEFT_TO_RIGHT Reaction2143 true Phosphatidylinositol 3-kinase → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Ras-related C3 botulinum toxin substrate 1 + [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial LEFT_TO_RIGHT Reaction2140 true GRB2-associated-binding protein 2 → Phosphatidylinositol 3-kinase LEFT_TO_RIGHT Reaction2141 true Lymphocyte cytosolic protein 2 → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Guanine nucleotide exchange factor VAV3 LEFT_TO_RIGHT Lymphocyte cytosolic protein 2 GO:0005886 GENE ONTOLOGY inositol_1,4,5-trisphosphate BioCyc Reaction2148 true Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 7 → Mitogen-activated protein kinase 8 LEFT_TO_RIGHT Reaction2149 true Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 6 → Mitogen-activated protein kinase 14 LEFT_TO_RIGHT Ig epsilon chain C region Reaction2146 true [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial → RAC-alpha serine/threonine-protein kinase LEFT_TO_RIGHT Reaction2147 true Ras-related C3 botulinum toxin substrate 1 → Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 6 + Dual specificity mitogen-activated protein kinase kinase 7 LEFT_TO_RIGHT 1.0 1.0 Generation of eicosanoids SubPathway HMDB00464 HMDB 1.0 P52564 UniProt Degranulation SubPathway SMP00358 SMPDB Phosphatidylinositol signaling system SubPathway MAPK signaling pathway SubPathway Dual specificity mitogen-activated protein kinase kinase 2 Guanine nucleotide exchange factor VAV3 Granulocyte-macrophage colony-stimulating factor SubPathwayOutput Leukotriene E4 SubPathwayOutput CHEBI:15650 ChEBI 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider Q07889 UniProt SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O 75715-89-8 CAS 6435286 PubChem-compound Reaction2139 true Tyrosine-protein kinase Fyn → GRB2-associated-binding protein 2 LEFT_TO_RIGHT CHEBI:16618 ChEBI Leukotriene C4 SubPathwayOutput Reaction2138 true Phosphatidylinositol-3,4,5-trisphosphate + Tyrosine-protein kinase BTK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Phosphatidylinositol-3,4,5-trisphosphate LEFT_TO_RIGHT Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 inhibition of Phosphatidylinositol-3,4,5-trisphosphate InhibitorySubPathway Reaction2135 true High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase Lyn → Tyrosine-protein kinase BTK + Tyrosine-protein kinase Fyn LEFT_TO_RIGHT BiologicalState80 Reaction2136 true High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase SYK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + GRB2-associated-binding protein 2 + Guanine nucleotide exchange factor VAV3 + Linker for activation of T-cells family member 1 + Lymphocyte cytosolic protein 2 + Phosphatidylinositol 3-kinase LEFT_TO_RIGHT P19174 UniProt Cytokine gene transcription SubPathway 22833565 PubChem-compound High affinity immunoglobulin epsilon receptor subunit alpha Arachidonic acid SubPathwayInput 1.0 HMDB01403 HMDB Son of sevenless homolog 1 1.0 Linker for activation of T-cells family member 1 Dual specificity mitogen-activated protein kinase kinase 2 C00374 KEGG Compound Dual specificity mitogen-activated protein kinase kinase 7 448457 PubChem-compound C12H24O22P4 Phosphatidylinositol-3,4,5-trisphosphate 643.97095 1.0 PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT BioCyc 444899 PubChem-compound P12319 UniProt Extracellular Space 2.0 Q02750 UniProt Interleukin-5 14127-61-8 CAS SMILES [Ca++] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 SubPathwayInhibitor Arachidonic Acid Metabolism SubPathway Q15118 UniProt HMDB04249 HMDB P05112 UniProt GTPase HRas P04141 UniProt 3.0 P05113 UniProt 1.0 Protein kinase C alpha type SubPathwayInput C05952 KEGG Compound C00388 KEGG Compound P31749 UniProt C05951 KEGG Compound Reaction2155 true Dual specificity mitogen-activated protein kinase kinase → Mitogen-activated protein kinase 1 LEFT_TO_RIGHT Reaction2156 true Mitogen-activated protein kinase 1 → Cytosolic phospholipase A2 LEFT_TO_RIGHT Reaction2153 true GTPase HRas + GTPase KRas + GTPase NRas → RAF proto-oncogene serine/threonine-protein kinase LEFT_TO_RIGHT Reaction2154 true RAF proto-oncogene serine/threonine-protein kinase → Dual specificity mitogen-activated protein kinase kinase LEFT_TO_RIGHT Tyrosine-protein kinase SYK C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 Reaction2151 true Growth factor receptor-bound protein 2 → Son of sevenless homolog 1 LEFT_TO_RIGHT GO:0005615 GENE ONTOLOGY Reaction2152 true Son of sevenless homolog 1 → GTPase HRas + GTPase KRas + GTPase NRas LEFT_TO_RIGHT CHEBI:29108 ChEBI Reaction2150 true Linker for activation of T-cells family member 1 → Growth factor receptor-bound protein 2 LEFT_TO_RIGHT 1.0 Heparin SubPathwayOutput 1.0 Reaction2157 true Cytosolic phospholipase A2 → Arachidonic acid LEFT_TO_RIGHT Interleukin-5 Tyrosine-protein kinase BTK Tyrosine-protein kinase Lyn CL:0000000 CELL TYPE ONTOLOGY Mitogen-activated protein kinase 1 SubPathwayInput 51-45-6 CAS SMILES CC(=O)OC(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(C)=O C01245 KEGG Compound Dual specificity mitogen-activated protein kinase kinase 4 1.0 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol-3,4,5-trisphosphate SubPathwayInhibition Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 2.0 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.0 2.0 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O BioCyc P07948 UniProt 392692 ChemSpider 1.0 C20H32O5 Prostaglandin D2 352.22498 PW000453 PathWhiz High affinity immunoglobulin epsilon receptor subunit gamma Tumor necrosis factor SubPathwayOutput 1.0 HMDB01198 HMDB SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O C05981 KEGG Compound RAC-alpha serine/threonine-protein kinase Mitogen-activated protein kinase 8 SubPathwayInput Growth factor receptor-bound protein 2 Histamine SubPathwayOutput P30273 UniProt Son of sevenless homolog 1 P01854 UniProt Cell Prostaglandin D2 SubPathwayOutput HMDB00870 HMDB Q92835 UniProt RAF proto-oncogene serine/threonine-protein kinase High affinity immunoglobulin epsilon receptor subunit alpha 1.0 SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O Phosphatidylinositol 3-kinase regulatory subunit alpha Q13094 UniProt HMDB01043 HMDB Dual specificity mitogen-activated protein kinase kinase 6 P46734 UniProt 1.0 SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SCC(N)C(O)=O)[C@@H](O)CCCC(O)=O High affinity immunoglobulin epsilon receptor subunit beta High affinity immunoglobulin epsilon receptor subunit alpha 439456 PubChem-compound 1.0 Interleukin-4 SubPathwayOutput High affinity immunoglobulin epsilon receptor O14733 UniProt Interleukin-5 SubPathwayOutput P08700 UniProt CHEBI:15555 ChEBI BiologicalState14 774 PubChem-compound Fc Epsilon Receptor I Signaling in Mast Cells Ig epsilon chain C region Granulocyte-macrophage colony-stimulating factor Dual specificity mitogen-activated protein kinase kinase 1 1.0 Interleukin-4 Interleukin-13 GRB2-associated-binding protein 2 Lymphocyte cytosolic protein 2 High affinity immunoglobulin epsilon receptor subunit gamma Tyrosine-protein kinase Lyn Cytosolic phospholipase A2 C26H41NO34S4 Heparin 1039.0393 Dual specificity mitogen-activated protein kinase kinase 1 P47712 UniProt 1.0 1.0 9606 TAXONOMY Dual specificity mitogen-activated protein kinase kinase 6 2.0 1.0 Tyrosine-protein kinase Fyn Interleukin-3 Dual specificity mitogen-activated protein kinase kinase 3 C00076 KEGG Compound High affinity immunoglobulin epsilon receptor subunit beta P62993 UniProt P45985 UniProt P45983 UniProt CA%2b2 BioCyc Dual specificity mitogen-activated protein kinase kinase 6 Q01362 UniProt Ca Calcium 39.96259 BiologicalState2 1.0 Cell Membrane Mitogen-activated protein kinase 14 Tumor necrosis factor P01375 UniProt HISTAMINE BioCyc 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase HMDB01394 HMDB Mono- and diglycerides SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](O)O[C@H](O[C@H]3[C@H](O)[C@@H](OS(O)(=O)=O)C(O)O[C@H]3C(O)=O)[C@H](OS(O)(=O)=O)[C@H]2CS(O)(=O)=O)O[C@@H]1C(O)=O 395250 ChemSpider P27986 UniProt O43561 UniProt SMP00075 SMPDB 1.0 Guanine nucleotide exchange factor VAV3 72025-60-6 CAS 5254058 ChemSpider Interleukin-3 SubPathwayOutput C25H40N2O6S Leukotriene D4 496.2607 CHEBI:18295 ChEBI Mitogen-activated protein kinase 14 SubPathwayInput 41598-07-6 CAS 753 ChemSpider CHEBI:28304 ChEBI P42336 UniProt 6850771 PubChem-compound [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial 5280749 PubChem-compound GRB2-associated-binding protein 2 C5H9N3 Histamine 111.07965 1.0 HMDB01498 HMDB 1.0 506-32-1 CAS 4444323 ChemSpider Mitogen-activated protein kinase 8 Linker for activation of T-cells family member 1 Dual specificity mitogen-activated protein kinase kinase 3 C02166 KEGG Compound High affinity immunoglobulin epsilon receptor SubPathwayActivation SubPathwayActivator ARACHIDONIC_ACID BioCyc 67254-73-3 CAS Dual specificity mitogen-activated protein kinase kinase SubPathwayInput Inositol 1,4,5-trisphosphate 1.0 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 SubPathwayInput 73836-78-9 CAS High affinity immunoglobulin epsilon receptor subunit gamma High affinity immunoglobulin epsilon receptor subunit gamma Immunoglobulin E High affinity immunoglobulin epsilon receptor subunit alpha High affinity immunoglobulin epsilon receptor subunit beta High affinity immunoglobulin epsilon receptor subunit gamma Immunoglobulin E High affinity immunoglobulin epsilon receptor subunit alpha High affinity immunoglobulin epsilon receptor subunit beta High affinity immunoglobulin epsilon receptor subunit gamma Phosphatidylinositol 3,4,5- trisphosphate 5-phosphatase 1 Protein kinase C alpha type RAC-alpha serine/threonine- protein kinase Mitogen- activated protein kinase 8 Mitogen- activated protein kinase 14 Mitogen- activated protein kinase 1 Interleukin-4 Interleukin-13 Interleukin-3 Interleukin-5 Granulocyte- macrophage colony- stimulating factor Tumor necrosis factor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Dual specificity mitogen- activated protein kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 2 Tyrosine- protein kinase Lyn Tyrosine- protein kinase BTK Tyrosine- protein kinase Fyn Tyrosine- protein kinase SYK GRB2- associated- binding protein 2 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Lymphocyte cytosolic protein 2 Guanine nucleotide exchange factor VAV3 Linker for activation of T-cells family member 1 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Ras-related C3 botulinum toxin substrate 1 Dual specificity mitogen- activated protein kinase kinase 4 Dual specificity mitogen- activated protein kinase kinase 7 Dual specificity mitogen- activated protein kinase kinase 3 Dual specificity mitogen- activated protein kinase kinase 6 Growth factor receptor-bound protein 2 Son of sevenless homolog 1 GTPase NRas GTPase KRas GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Cytosolic phospholipase A2 Phosphatidylinositol- 3,4,5- trisphosphate Histamine Heparin Arachidonic acid Prostaglandin D2 Leukotriene E4 Leukotriene D4 Leukotriene C4 Phosphatidylinositol- 3,4,5- trisphosphate Inositol 1,4,5- trisphosphate Mono- and diglycerides Ca + Calcium Magnesium Magnesium Magnesium Calcium Zinc Manganese Magnesium Zinc Degranulation Cytokine gene transcription Generation of eicosanoids Phosphatidylinositol signaling system MAPK signaling pathway Arachidonic Acid Metabolism Mast Cell Antigen Antigen Indirect activation Indirect activation Indirect activation Indirect activation Indirect activation Release from granules Indirect activation Indirect activation Secretion Indirect activation Extracellular Space
1.0 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial 4.0 1.0 C20H32O2 Arachidonic acid 304.24023 CHEBI:15843 ChEBI Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Dual specificity mitogen-activated protein kinase kinase 7 Q06187 UniProt 1.0 1.0 Q9UQC2 UniProt 2.0 P28482 UniProt P63000 UniProt SMILES NCCC1=CNC=N1 Interleukin-13 SubPathwayOutput C23H37NO5S Leukotriene E4 439.23926 HMDB03080 HMDB Cytosolic phospholipase A2 P43405 UniProt 1.0 9005-49-6 CAS 1.0 GTPase KRas P04049 UniProt GTPase NRas LEUKOTRIENE-C4 BioCyc Tyrosine-protein kinase BTK Calcium SubPathwayInput 1.0 HMDB02200 HMDB 1.0 20-HYDROXY-LEUKOTRIENE-E4 BioCyc Leukotriene D4 SubPathwayOutput 1.0 CHEBI:1044940 ChEBI 1.0 RAC-alpha serine/threonine-protein kinase SubPathwayInput SubPathwayInteraction730 SubPathwayReaction SubPathway730Reaction 4444133 ChemSpider PW000044 PathWhiz 1.0 C00219 KEGG Compound SubPathwayControl720 InhibitorySubPathwayControl SubPathway720Control High affinity immunoglobulin epsilon receptor subunit gamma C00696 KEGG Compound CHEBI:16595 ChEBI GO:0005829 GENE ONTOLOGY Ras-related C3 botulinum toxin substrate 1 Immunoglobulin E SubPathwayActivation SubPathwayActivator 1.0 GTPase KRas 85166-31-0 CAS HMDB32436 HMDB 17216115 ChemSpider SMILES [H][C@](O)(CCCCC)\C=C\[C@@]1([H])C(=O)C[C@]([H])(O)[C@]1([H])C\C=C/CCCC(O)=O Protein kinase C alpha type Dual specificity mitogen-activated protein kinase kinase 4 C30H47N3O9S Leukotriene C4 625.3033 1.0 Q9UKW4 UniProt P35225 UniProt SubPathwayInteraction723 SubPathwayReaction SubPathway723Reaction P01112 UniProt P01111 UniProt SubPathwayInteraction722 SubPathwayReaction SubPathway722Reaction 5280493 PubChem-compound SubPathwayInteraction727 SubPathwayReaction SubPathway727Reaction GTPase HRas SubPathwayInteraction728 SubPathway728Reaction SubPathwayReaction [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial P06241 UniProt HEPARIN BioCyc SubPathwayInteraction729 SubPathway729Reaction SubPathwayReaction SubPathwayControl719 SubPathway719Control ActivatingSubPathwayControl SMILES CCCCCC=CCC=CC=CC=CC(SCC(N)C(=O)NCC(O)=O)C(O)CCCC(O)=O 266 ChemSpider C100H188O22 Mono- and diglycerides 1741.3593 4940074 ChemSpider P01116 UniProt P17252 UniProt Q16539 UniProt P36507 UniProt GTPase NRas Ras-related C3 botulinum toxin substrate 1 SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(C)=O.CCCCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(C)=O.CCCCCCCCCCCCCCCCCC(=O)OCC(COC(C)=O)OC(C)=O.CCCCCCCCCCCCCCCCCCCC(=O)OCC(COC(C)=O)OC(C)=O Tyrosine-protein kinase Fyn CHEBI:16978 ChEBI Phosphatidylinositol 3-kinase 1.0 Mitogen-activated protein kinase 1 Immunoglobulin Activation ActivatingSubPathway High affinity immunoglobulin epsilon receptor subunit beta Tyrosine-protein kinase SYK Cytosol 1.0 Growth factor receptor-bound protein 2 1.0 Reaction2144 true 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 → Inositol 1,4,5-trisphosphate + Mono- and diglycerides LEFT_TO_RIGHT 1.0 Tumor necrosis factor Reaction2145 true Mono- and diglycerides → Protein kinase C alpha type LEFT_TO_RIGHT Reaction2142 true Guanine nucleotide exchange factor VAV3 → Ras-related C3 botulinum toxin substrate 1 LEFT_TO_RIGHT Reaction2143 true Phosphatidylinositol 3-kinase → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Ras-related C3 botulinum toxin substrate 1 + [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial LEFT_TO_RIGHT Reaction2140 true GRB2-associated-binding protein 2 → Phosphatidylinositol 3-kinase LEFT_TO_RIGHT Reaction2141 true Lymphocyte cytosolic protein 2 → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Guanine nucleotide exchange factor VAV3 LEFT_TO_RIGHT Lymphocyte cytosolic protein 2 GO:0005886 GENE ONTOLOGY inositol_1,4,5-trisphosphate BioCyc Reaction2148 true Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 7 → Mitogen-activated protein kinase 8 LEFT_TO_RIGHT Reaction2149 true Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 6 → Mitogen-activated protein kinase 14 LEFT_TO_RIGHT Ig epsilon chain C region Reaction2146 true [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial → RAC-alpha serine/threonine-protein kinase LEFT_TO_RIGHT Reaction2147 true Ras-related C3 botulinum toxin substrate 1 → Dual specificity mitogen-activated protein kinase kinase 3 + Dual specificity mitogen-activated protein kinase kinase 4 + Dual specificity mitogen-activated protein kinase kinase 6 + Dual specificity mitogen-activated protein kinase kinase 7 LEFT_TO_RIGHT 1.0 1.0 Generation of eicosanoids SubPathway HMDB00464 HMDB 1.0 P52564 UniProt Degranulation SubPathway http://identifiers.org/smpdb/SMP00358 SMPDB Phosphatidylinositol signaling system SubPathway MAPK signaling pathway SubPathway Dual specificity mitogen-activated protein kinase kinase 2 Guanine nucleotide exchange factor VAV3 Granulocyte-macrophage colony-stimulating factor SubPathwayOutput Leukotriene E4 SubPathwayOutput CHEBI:15650 ChEBI 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider Q07889 UniProt SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O 75715-89-8 CAS 6435286 PubChem-compound Reaction2139 true Tyrosine-protein kinase Fyn → GRB2-associated-binding protein 2 LEFT_TO_RIGHT CHEBI:16618 ChEBI Leukotriene C4 SubPathwayOutput Reaction2138 true Phosphatidylinositol-3,4,5-trisphosphate + Tyrosine-protein kinase BTK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + Phosphatidylinositol-3,4,5-trisphosphate LEFT_TO_RIGHT Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 inhibition of Phosphatidylinositol-3,4,5-trisphosphate InhibitorySubPathway Reaction2135 true High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase Lyn → Tyrosine-protein kinase BTK + Tyrosine-protein kinase Fyn LEFT_TO_RIGHT BiologicalState80 Homo sapiens, Cell, Extracellular Space Reaction2136 true High affinity immunoglobulin epsilon receptor + Tyrosine-protein kinase SYK → 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 + GRB2-associated-binding protein 2 + Guanine nucleotide exchange factor VAV3 + Linker for activation of T-cells family member 1 + Lymphocyte cytosolic protein 2 + Phosphatidylinositol 3-kinase LEFT_TO_RIGHT P19174 UniProt Cytokine gene transcription SubPathway 22833565 PubChem-compound High affinity immunoglobulin epsilon receptor subunit alpha Arachidonic acid SubPathwayInput 1.0 HMDB01403 HMDB Son of sevenless homolog 1 1.0 Linker for activation of T-cells family member 1 Dual specificity mitogen-activated protein kinase kinase 2 C00374 KEGG Compound Dual specificity mitogen-activated protein kinase kinase 7 448457 PubChem-compound C12H24O22P4 Phosphatidylinositol-3,4,5-trisphosphate 643.97095 1.0 PHOSPHATIDYL-INOSITOL-345-TRISPHOSPHAT BioCyc 444899 PubChem-compound P12319 UniProt Extracellular Space 2.0 Q02750 UniProt Interleukin-5 14127-61-8 CAS SMILES [Ca++] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 SubPathwayInhibitor Arachidonic Acid Metabolism SubPathway Q15118 UniProt HMDB04249 HMDB P05112 UniProt GTPase HRas P04141 UniProt 3.0 P05113 UniProt 1.0 Protein kinase C alpha type SubPathwayInput C05952 KEGG Compound C00388 KEGG Compound P31749 UniProt C05951 KEGG Compound Reaction2155 true Dual specificity mitogen-activated protein kinase kinase → Mitogen-activated protein kinase 1 LEFT_TO_RIGHT Reaction2156 true Mitogen-activated protein kinase 1 → Cytosolic phospholipase A2 LEFT_TO_RIGHT Reaction2153 true GTPase HRas + GTPase KRas + GTPase NRas → RAF proto-oncogene serine/threonine-protein kinase LEFT_TO_RIGHT Reaction2154 true RAF proto-oncogene serine/threonine-protein kinase → Dual specificity mitogen-activated protein kinase kinase LEFT_TO_RIGHT Tyrosine-protein kinase SYK C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 Reaction2151 true Growth factor receptor-bound protein 2 → Son of sevenless homolog 1 LEFT_TO_RIGHT GO:0005615 GENE ONTOLOGY Reaction2152 true Son of sevenless homolog 1 → GTPase HRas + GTPase KRas + GTPase NRas LEFT_TO_RIGHT CHEBI:29108 ChEBI Reaction2150 true Linker for activation of T-cells family member 1 → Growth factor receptor-bound protein 2 LEFT_TO_RIGHT 1.0 Heparin SubPathwayOutput 1.0 Reaction2157 true Cytosolic phospholipase A2 → Arachidonic acid LEFT_TO_RIGHT Interleukin-5 Tyrosine-protein kinase BTK Tyrosine-protein kinase Lyn CL:0000000 CELL TYPE ONTOLOGY Mitogen-activated protein kinase 1 SubPathwayInput 51-45-6 CAS SMILES CC(=O)OC(COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(C)=O C01245 KEGG Compound Dual specificity mitogen-activated protein kinase kinase 4 1.0 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol-3,4,5-trisphosphate SubPathwayInhibition Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 2.0 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1.0 2.0 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O BioCyc P07948 UniProt 392692 ChemSpider 1.0 C20H32O5 Prostaglandin D2 352.22498 PW000453 PathWhiz High affinity immunoglobulin epsilon receptor subunit gamma Tumor necrosis factor SubPathwayOutput 1.0 HMDB01198 HMDB SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O C05981 KEGG Compound RAC-alpha serine/threonine-protein kinase Mitogen-activated protein kinase 8 SubPathwayInput Growth factor receptor-bound protein 2 Histamine SubPathwayOutput P30273 UniProt Son of sevenless homolog 1 P01854 UniProt Cell Prostaglandin D2 SubPathwayOutput HMDB00870 HMDB Q92835 UniProt RAF proto-oncogene serine/threonine-protein kinase High affinity immunoglobulin epsilon receptor subunit alpha 1.0 SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O Phosphatidylinositol 3-kinase regulatory subunit alpha Q13094 UniProt HMDB01043 HMDB Dual specificity mitogen-activated protein kinase kinase 6 P46734 UniProt 1.0 SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SCC(N)C(O)=O)[C@@H](O)CCCC(O)=O High affinity immunoglobulin epsilon receptor subunit beta High affinity immunoglobulin epsilon receptor subunit alpha 439456 PubChem-compound 1.0 Interleukin-4 SubPathwayOutput High affinity immunoglobulin epsilon receptor O14733 UniProt Interleukin-5 SubPathwayOutput P08700 UniProt CHEBI:15555 ChEBI BiologicalState14 Homo sapiens, Cell Membrane 774 PubChem-compound Fc Epsilon Receptor I Signaling in Mast Cells Ig epsilon chain C region Granulocyte-macrophage colony-stimulating factor Dual specificity mitogen-activated protein kinase kinase 1 1.0 Interleukin-4 Interleukin-13 GRB2-associated-binding protein 2 Lymphocyte cytosolic protein 2 High affinity immunoglobulin epsilon receptor subunit gamma Tyrosine-protein kinase Lyn Cytosolic phospholipase A2 C26H41NO34S4 Heparin 1039.0393 Dual specificity mitogen-activated protein kinase kinase 1 P47712 UniProt 1.0 1.0 9606 TAXONOMY Dual specificity mitogen-activated protein kinase kinase 6 2.0 1.0 Tyrosine-protein kinase Fyn Interleukin-3 Dual specificity mitogen-activated protein kinase kinase 3 C00076 KEGG Compound High affinity immunoglobulin epsilon receptor subunit beta P62993 UniProt P45985 UniProt P45983 UniProt CA%2b2 BioCyc Dual specificity mitogen-activated protein kinase kinase 6 Q01362 UniProt Ca Calcium 39.96259 BiologicalState2 Homo sapiens, Cell, Cytosol 1.0 Cell Membrane Mitogen-activated protein kinase 14 Tumor necrosis factor P01375 UniProt HISTAMINE BioCyc 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase HMDB01394 HMDB Mono- and diglycerides SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@H](O)O[C@H](O[C@H]3[C@H](O)[C@@H](OS(O)(=O)=O)C(O)O[C@H]3C(O)=O)[C@H](OS(O)(=O)=O)[C@H]2CS(O)(=O)=O)O[C@@H]1C(O)=O 395250 ChemSpider P27986 UniProt O43561 UniProt http://identifiers.org/smpdb/SMP00075 SMPDB 1.0 Guanine nucleotide exchange factor VAV3 72025-60-6 CAS 5254058 ChemSpider Interleukin-3 SubPathwayOutput C25H40N2O6S Leukotriene D4 496.2607 CHEBI:18295 ChEBI Mitogen-activated protein kinase 14 SubPathwayInput 41598-07-6 CAS 753 ChemSpider CHEBI:28304 ChEBI P42336 UniProt 6850771 PubChem-compound [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial 5280749 PubChem-compound GRB2-associated-binding protein 2 C5H9N3 Histamine 111.07965 1.0 HMDB01498 HMDB 1.0 506-32-1 CAS 4444323 ChemSpider Mitogen-activated protein kinase 8 Linker for activation of T-cells family member 1 Dual specificity mitogen-activated protein kinase kinase 3 C02166 KEGG Compound High affinity immunoglobulin epsilon receptor SubPathwayActivation SubPathwayActivator ARACHIDONIC_ACID BioCyc 67254-73-3 CAS Dual specificity mitogen-activated protein kinase kinase SubPathwayInput Inositol 1,4,5-trisphosphate 1.0 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 SubPathwayInput 73836-78-9 CAS Unknown Unknown Unknown FCER1A Unknown Unknown Unknown FCER1A Unknown Unknown INPP5D PRKCA AKT1 MAPK8 MAPK14 MAPK1 Unknown Unknown IL3 IL5 Unknown TNF PLCG1 Unknown MAP2K2 Unknown BTK FYN SYK Unknown PIK3CA PIK3R1 Unknown VAV3 LAT PDK1 RAC1 MAP2K4 MAP2K7 MAP2K3 MAP2K6 GRB2 SOS1 NRAS KRAS HRAS RAF1 PLA2G4A Phosphatidylinositol- 3,4,5- trisphosphate Histamine Heparin Arachidonic acid Prostaglandin D2 Leukotriene E4 Leukotriene D4 Leukotriene C4 Phosphatidylinositol- 3,4,5- trisphosphate Inositol 1,4,5- trisphosphate Mono- and diglycerides Calcium Degranulation Cytokine gene transcription Generation of eicosanoids Phosphatidylinositol signaling system MAPK signaling pathway Arachidonic Acid Metabolism