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DG(14:0/14:1(9Z)/0:0) 1.0 923 PubChem-compound Voltage-gated slow delayed rectifying potassium channel (IK5) Voltage-gated ultra rapid delayed rectifying potassium channel Disks large homolog 1 P62158 UniProt Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto) ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Acetylcholine-activated potassium channel (IKACh) SubPathwayActivation Inward rectifier potassium channel (IK1) Potassium voltage-gated channel subfamily A member 5 Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SubPathwayInhibition Transport119 false Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT O00180 UniProt Transport116 false Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 36894-69-6 CAS Transport120 false Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Transport123 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT P30556 UniProt Voltage-gated T-type calcium channel (ICaT) Calcium SubPathwayActivator Voltage-gated sodium channel (INa) Voltage-depenent L-type calcium channel P63252 UniProt Voltage-depenent L-type calcium channel SubPathwayActivation ATP-sensitive inward rectifier potassium channel (IKATP) Voltage-gated rapid delayed rectifying potassium channel (IKr) Ryanodine receptor 2 Voltage-dependent calcium channel subunit alpha-2/delta-2 1.0 P05023 UniProt P05026 UniProt 24765843 ChemSpider 1.0 P19429 UniProt CHEBI:16595 ChEBI HMDB10042 HMDB Sodium channel protein type 5 subunit alpha Q9NQ66 UniProt BTO:0000887 BRENDA TISSUE ONTOLOGY Q13936 UniProt 813 PubChem-compound Sodium/potassium ATPase Inositol 1,4,5-trisphosphate receptor type 1 CL:0000746 CELL TYPE ONTOLOGY Troponin, slow skeletal muscle SubPathwayActivation Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-1 24767919 ChemSpider P48050 UniProt C00238 KEGG Compound Q92736 UniProt 4.0 BiologicalState65 1.0 Cytosol 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayActivation Tropomyosin beta chain Beta-2-syntrophin 1.0 Alpha-1-syntrophin inositol_1,4,5-trisphosphate BioCyc HMDB00464 HMDB HMDB00586 HMDB Q13884 UniProt cAMP-dependent protein kinase type I-alpha regulatory subunit SubPathwayActivation Phosphatidylinositols BioCyc HMDB00588 HMDB Tropomyosin SubPathwayActivation 24203-36-9 CAS Sodium/potassium-transporting ATPase subunit alpha-4 C01330 KEGG Compound Troponin I, cardiac muscle Transport53 false Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 388562 ChemSpider Sodium/potassium-transporting ATPase subunit alpha-1 Transport62 false Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HMDB14736 HMDB Inward rectifier potassium channel 2 BiologicalState47 SMP00368 SMPDB P54710 UniProt BiologicalState46 BiologicalState45 1.0 1.0 Extracellular Space Labetalol SubPathwayInhibitor ATP-sensitive inward rectifier potassium channel 11 14127-61-8 CAS BiologicalState52 Q9NS61 UniProt P15382 UniProt SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCC 1.0 Q13733 UniProt Q9UK17 UniProt Calcium Type-1 angiotensin II receptor P63316 UniProt 1.0 1.0 Calmodulin SubPathwayActivator Sodium Troponin T, fast skeletal muscle CHEBI:29108 ChEBI CHEBI:29101 ChEBI CHEBI:29103 ChEBI CL:0000000 CELL TYPE ONTOLOGY 899 ChemSpider C01245 KEGG Compound P51787 UniProt 53477948 PubChem-compound Potassium Ryanodine receptor 2 PIP2(16:0/20:3(8Z,11Z,14Z)) P07951 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Potassium voltage-gated channel subfamily H member 2 Heart K%2b BioCyc P54709 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 4.0 17341-25-2 CAS Potassium voltage-gated channel subfamily KQT member 1 SubPathwayControl320 ActivatingSubPathwayControl SubPathway320Control SubPathwayControl321 SubPathway321Control ActivatingSubPathwayControl SubPathwayControl684 SubPathway684Control ActivatingSubPathwayControl SubPathwayControl322 ActivatingSubPathwayControl SubPathway322Control SubPathwayControl444 InhibitorySubPathwayControl SubPathway444Control SubPathwayControl323 SubPathway323Control ActivatingSubPathwayControl SubPathwayControl445 SubPathway445Control InhibitorySubPathwayControl SubPathwayControl324 ActivatingSubPathwayControl SubPathway324Control Potassium SubPathwayControl325 SubPathway325Control ActivatingSubPathwayControl SubPathwayControl326 ActivatingSubPathwayControl SubPathway326Control SubPathwayControl327 ActivatingSubPathwayControl SubPathway327Control Alpha-1A adrenergic receptor SubPathwayInhibition 791 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 SMILES CC(CCC1=CC=CC=C1)NCC(O)C1=CC(C(N)=O)=C(O)C=C1 Voltage-dependent T-type calcium channel subunit alpha-1G SubPathwayControl318 SubPathway318Control ActivatingSubPathwayControl SubPathwayControl319 SubPathway319Control InhibitorySubPathwayControl 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 BiologicalState18 O95180 UniProt Inositol 1,4,5-trisphosphate receptor type 1 C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 Voltage-dependent T-type calcium channel subunit alpha-1H Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase G-protein signalling cascade ActivatingSubPathway Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 InhibitorySubPathway Voltage-dependent L-type calcium channel subunit beta-1 HMDB07009 HMDB Beta-1 adrenergic receptor cAMP-dependent protein kinase type I-alpha regulatory subunit C00076 KEGG Compound P16615 UniProt Sodium 1.0 Ca Calcium 39.96259 1.0 Q9Y3Q4 UniProt 3734 ChemSpider Potassium voltage-gated channel subfamily E member 1 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 ActivatingSubPathway P02585 UniProt Kv channel-interacting protein 2 Q09428 UniProt CHEBI:6343 ChEBI Ryanodine receptor 2 Q12959 UniProt G-protein signalling cascade ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel ActivatingSubPathway Calcium activates Troponin ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2 ActivatingSubPathway Labetalol inhibition of Beta-1 adrenergic receptor InhibitorySubPathway Potassium voltage-gated channel subfamily E member 2 Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle ActivatingSubPathway Labetalol inhibition of Alpha-1A adrenergic receptor InhibitorySubPathway Muscle Contraction ActivatingSubPathway Calcium activates Ryanodine receptor 2 ActivatingSubPathway G-protein signalling cascade ActivatingSubPathway G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 4 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Q12809 UniProt Sodium channel protein type 5 subunit alpha P50993 UniProt Potassium channel subfamily K member 1 Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 K Potassium 38.963707 Voltage-dependent L-type calcium channel subunit alpha-1C Cardiomyocyte Troponin I, slow skeletal muscle ATP-sensitive inward rectifier potassium channel 8 Troponin I, fast skeletal muscle P17612 UniProt P26678 UniProt Inositol 1,4,5-trisphosphate SubPathwayActivator 2.0 Sodium/potassium-transporting ATPase subunit alpha-3 Myosin light chain kinase, smooth muscle 1.0 TransportCatalysis93 ACTIVATION TransportCatalysis92 ACTIVATION TransportCatalysis91 ACTIVATION TransportCatalysis90 ACTIVATION TransportCatalysis96 ACTIVATION C19H24N2O3 Labetalol 328.17868 TransportCatalysis9 ACTIVATION Alpha-1A adrenergic receptor SMILES [Na+] SMILES [K+] P48544 UniProt Troponin C, skeletal muscle Inward rectifier potassium channel 2 Ryanodine receptor 2 SubPathwayActivation P48549 UniProt Q5I7T1 UniProt P48788 UniProt GO:0016529 GENE ONTOLOGY CL:0000187 CELL TYPE ONTOLOGY O60706 UniProt P14415 UniProt ATP-binding cassette sub-family C member 8 GO:0005829 GENE ONTOLOGY Type-1 angiotensin II receptor SubPathwayActivator Tropomyosin alpha-1 chain 1.0 85166-31-0 CAS Labetalol SubPathwayInhibitor O43497 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide P35348 UniProt P45379 UniProt P45378 UniProt 266 ChemSpider Troponin T, slow skeletal muscle 4.0 Voltage-dependent L-type calcium channel subunit beta-1 Sodium/potassium-transporting ATPase subunit gamma P22460 UniProt Potassium voltage-gated channel subfamily H member 2 1.0 Calmodulin Beta-1-syntrophin Voltage-dependent L-type calcium channel subunit alpha-1C sarcoplasmic reticulum GO:0005886 GENE ONTOLOGY 1.0 53480233 PubChem-compound Voltage-dependent calcium channel subunit alpha-2/delta-2 ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 1.0 1.0 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/calcium exchanger 1 Potassium voltage-gated channel subfamily KQT member 1 P13637 UniProt Q9NY47 UniProt P09493 UniProt Myocyte 3869 PubChem-compound Calcium Muscle Voltage-dependent T-type calcium channel subunit alpha-1G Voltage-dependent T-type calcium channel subunit alpha-1H Cardiac phospholamban Muscarinic acetylcholine receptor M2 P08172 UniProt SMILES [Ca++] 1.0 Voltage-dependent L-type calcium channel subunit beta-1 Beta-1 adrenergic receptor SubPathwayInhibition cAMP-dependent protein kinase catalytic subunit alpha GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 1.0 3.0 Potassium voltage-gated channel subfamily E member 2 Q14643 UniProt Inositol 1,4,5-trisphosphate receptor type 1 3.1.4.11 false 3.1.4.11 PIP2(16:0/20:3(8Z,11Z,14Z)) → DG(14:0/14:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Endoplasmic Reticulum Sodium/potassium-transporting ATPase subunit beta-1 Kv channel-interacting protein 2 1.0 TransportCatalysis10 ACTIVATION Sodium/potassium-transporting ATPase subunit beta-2 B7ZKV8 UniProt Potassium voltage-gated channel subfamily E member 1 Q14524 UniProt Potassium channel subfamily K member 1 G protein-activated inward rectifier potassium channel 4 Q14654 UniProt 3.0 1.0 2.0 1.0 TransportCatalysis23 ACTIVATION Beta-2-syntrophin Potassium voltage-gated channel subfamily D member 3 Inward rectifier potassium channel 4 Alpha-1-syntrophin G protein-activated inward rectifier potassium channel 1 Q02641 UniProt Q15746 UniProt Troponin, cardiac muscle SubPathwayActivation Troponin T, cardiac muscle Cell Sodium/potassium-transporting ATPase subunit alpha-4 Sodium/potassium-transporting ATPase subunit alpha-2 Cardiac phospholamban Ryanodine receptor 2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Sodium/potassium-transporting ATPase subunit alpha-1 Troponin C, slow skeletal and cardiac muscles 439456 PubChem-compound ATP-sensitive inward rectifier potassium channel 8 GO:0005783 GENE ONTOLOGY Beta-1 adrenergic receptor SubPathwayActivator Q15842 UniProt C00626 KEGG Compound Transport35 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT ATP-sensitive inward rectifier potassium channel 11 Transport36 false Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit alpha-3 Q9Y6J6 UniProt cAMP-dependent protein kinase catalytic subunit alpha SubPathwayActivation SubPathwayActivator Myosin light chain kinase, smooth muscle SubPathwayActivation SubPathwayActivator Q13424 UniProt Q13425 UniProt 9606 TAXONOMY PW000389 PathWhiz 1.0 CA%2b2 BioCyc C31H58O5 DG(14:0/14:1(9Z)/0:0) 510.42844 Cell Membrane P10644 UniProt 271 PubChem-compound P32418 UniProt ATP-binding cassette sub-family C member 8 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC P13805 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide Labetalol Action Pathway Troponin C, skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, slow skeletal muscle ReactionCatalysis1269 ACTIVATION Troponin I, cardiac muscle Troponin I, fast skeletal muscle Troponin T, cardiac muscle BTO:0000562 BRENDA TISSUE ONTOLOGY Troponin T, slow skeletal muscle HMDB01498 HMDB 1.0 Calcium P08588 UniProt TransportCatalysis89 ACTIVATION TransportCatalysis88 ACTIVATION Inositol 1,4,5-trisphosphate receptor type 1 SubPathwayActivation TransportCatalysis87 ACTIVATION 1.0 Troponin T, fast skeletal muscle TransportCatalysis82 ACTIVATION Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Beta-1-syntrophin Tropomyosin beta chain TransportCatalysis86 ACTIVATION Muscarinic acetylcholine receptor M2 SubPathwayActivator TransportCatalysis85 ACTIVATION C07063 KEGG Compound Sodium/potassium-transporting ATPase subunit gamma TransportCatalysis84 ACTIVATION Tropomyosin alpha-1 chain TransportCatalysis83 ACTIVATION P19237 UniProt 5.0 Troponin, fast skeletal muscle SubPathwayActivation Cardiac phospholamban SubPathwayInhibitor Beta-1 adrenergic receptor Alpha-1A adrenergic receptor Muscarinic acetylcholine receptor M2 Cardiac phospholamban Beta-1 adrenergic receptor cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit Calmodulin Myosin light chain kinase, smooth muscle Type-1 angiotensin II receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Inositol 1,4,5- trisphosphate receptor type 1 Troponin C, skeletal muscle Troponin I, slow skeletal muscle Troponin T, slow skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, cardiac muscle Troponin T, cardiac muscle Troponin C, skeletal muscle Troponin I, fast skeletal muscle Troponin T, fast skeletal muscle Tropomyosin alpha-1 chain Tropomyosin beta chain Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Ryanodine receptor 2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Labetalol Labetalol Ca + Na + Na + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + Ca + Ca + Na + Na + Na + Na + K + K + Na + Na + Ca + Ca + Ca + Ca + Ca + PIP2(16:0/20:3(8Z,11Z,14Z)) Inositol 1,4,5- trisphosphate DG(14:0/14:1(9Z)/0:0) ATP H 2 O Ca + ADP P i Ca + Magnesium Calcium Calcium G-protein signalling cascade G-protein signalling cascade Muscle Contraction G-protein signalling cascade Cardiomyocyte Myocyte MYOCYTE SARCOPLASMIC RETICULUM In smooth muscle In striated muscle
DG(14:0/14:1(9Z)/0:0) 1.0 923 PubChem-compound Voltage-gated slow delayed rectifying potassium channel (IK5) Voltage-gated ultra rapid delayed rectifying potassium channel Disks large homolog 1 P62158 UniProt Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto) ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Acetylcholine-activated potassium channel (IKACh) SubPathwayActivation Inward rectifier potassium channel (IK1) Potassium voltage-gated channel subfamily A member 5 Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SubPathwayInhibition Transport119 false Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT O00180 UniProt Transport116 false Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 36894-69-6 CAS Transport120 false Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Transport123 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT P30556 UniProt Voltage-gated T-type calcium channel (ICaT) Calcium SubPathwayActivator Voltage-gated sodium channel (INa) Voltage-depenent L-type calcium channel P63252 UniProt Voltage-depenent L-type calcium channel SubPathwayActivation ATP-sensitive inward rectifier potassium channel (IKATP) Voltage-gated rapid delayed rectifying potassium channel (IKr) Ryanodine receptor 2 Voltage-dependent calcium channel subunit alpha-2/delta-2 1.0 P05023 UniProt P05026 UniProt 24765843 ChemSpider 1.0 P19429 UniProt CHEBI:16595 ChEBI HMDB10042 HMDB Sodium channel protein type 5 subunit alpha Q9NQ66 UniProt BTO:0000887 BRENDA TISSUE ONTOLOGY Q13936 UniProt 813 PubChem-compound Sodium/potassium ATPase Inositol 1,4,5-trisphosphate receptor type 1 CL:0000746 CELL TYPE ONTOLOGY Troponin, slow skeletal muscle SubPathwayActivation Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-1 24767919 ChemSpider P48050 UniProt C00238 KEGG Compound Q92736 UniProt 4.0 BiologicalState65 Homo sapiens, Heart 1.0 Cytosol 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayActivation Tropomyosin beta chain Beta-2-syntrophin 1.0 Alpha-1-syntrophin inositol_1,4,5-trisphosphate BioCyc HMDB00464 HMDB HMDB00586 HMDB Q13884 UniProt cAMP-dependent protein kinase type I-alpha regulatory subunit SubPathwayActivation Phosphatidylinositols BioCyc HMDB00588 HMDB Tropomyosin SubPathwayActivation 24203-36-9 CAS Sodium/potassium-transporting ATPase subunit alpha-4 C01330 KEGG Compound Troponin I, cardiac muscle Transport53 false Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 388562 ChemSpider Sodium/potassium-transporting ATPase subunit alpha-1 Transport62 false Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HMDB14736 HMDB Inward rectifier potassium channel 2 BiologicalState47 Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum http://identifiers.org/smpdb/SMP00368 SMPDB P54710 UniProt BiologicalState46 Homo sapiens, Cardiomyocyte , Cytosol BiologicalState45 Homo sapiens, Cardiomyocyte , Cell Membrane 1.0 1.0 Extracellular Space Labetalol SubPathwayInhibitor ATP-sensitive inward rectifier potassium channel 11 14127-61-8 CAS BiologicalState52 Homo sapiens, Muscle, Myocyte, Cell Membrane Q9NS61 UniProt P15382 UniProt SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCC 1.0 Q13733 UniProt Q9UK17 UniProt Calcium Type-1 angiotensin II receptor P63316 UniProt 1.0 1.0 Calmodulin SubPathwayActivator Sodium Troponin T, fast skeletal muscle CHEBI:29108 ChEBI CHEBI:29101 ChEBI CHEBI:29103 ChEBI CL:0000000 CELL TYPE ONTOLOGY 899 ChemSpider C01245 KEGG Compound P51787 UniProt 53477948 PubChem-compound Potassium Ryanodine receptor 2 PIP2(16:0/20:3(8Z,11Z,14Z)) P07951 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Potassium voltage-gated channel subfamily H member 2 Heart K%2b BioCyc P54709 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 4.0 17341-25-2 CAS Potassium voltage-gated channel subfamily KQT member 1 SubPathwayControl320 ActivatingSubPathwayControl SubPathway320Control SubPathwayControl321 SubPathway321Control ActivatingSubPathwayControl SubPathwayControl684 SubPathway684Control ActivatingSubPathwayControl SubPathwayControl322 ActivatingSubPathwayControl SubPathway322Control SubPathwayControl444 InhibitorySubPathwayControl SubPathway444Control SubPathwayControl323 SubPathway323Control ActivatingSubPathwayControl SubPathwayControl445 SubPathway445Control InhibitorySubPathwayControl SubPathwayControl324 ActivatingSubPathwayControl SubPathway324Control Potassium SubPathwayControl325 SubPathway325Control ActivatingSubPathwayControl SubPathwayControl326 ActivatingSubPathwayControl SubPathway326Control SubPathwayControl327 ActivatingSubPathwayControl SubPathway327Control Alpha-1A adrenergic receptor SubPathwayInhibition 791 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 SMILES CC(CCC1=CC=CC=C1)NCC(O)C1=CC(C(N)=O)=C(O)C=C1 Voltage-dependent T-type calcium channel subunit alpha-1G SubPathwayControl318 SubPathway318Control ActivatingSubPathwayControl SubPathwayControl319 SubPathway319Control InhibitorySubPathwayControl 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 BiologicalState18 Homo sapiens, Cell, Endoplasmic Reticulum O95180 UniProt Inositol 1,4,5-trisphosphate receptor type 1 C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 Voltage-dependent T-type calcium channel subunit alpha-1H Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase G-protein signalling cascade ActivatingSubPathway Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 InhibitorySubPathway Voltage-dependent L-type calcium channel subunit beta-1 HMDB07009 HMDB Beta-1 adrenergic receptor cAMP-dependent protein kinase type I-alpha regulatory subunit C00076 KEGG Compound P16615 UniProt Sodium 1.0 Ca Calcium 39.96259 1.0 Q9Y3Q4 UniProt 3734 ChemSpider Potassium voltage-gated channel subfamily E member 1 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 ActivatingSubPathway P02585 UniProt Kv channel-interacting protein 2 Q09428 UniProt CHEBI:6343 ChEBI Ryanodine receptor 2 Q12959 UniProt G-protein signalling cascade ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel ActivatingSubPathway Calcium activates Troponin ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2 ActivatingSubPathway Labetalol inhibition of Beta-1 adrenergic receptor InhibitorySubPathway Potassium voltage-gated channel subfamily E member 2 Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle ActivatingSubPathway Labetalol inhibition of Alpha-1A adrenergic receptor InhibitorySubPathway Muscle Contraction ActivatingSubPathway Calcium activates Ryanodine receptor 2 ActivatingSubPathway G-protein signalling cascade ActivatingSubPathway G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 4 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Q12809 UniProt Sodium channel protein type 5 subunit alpha P50993 UniProt Potassium channel subfamily K member 1 Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 K Potassium 38.963707 Voltage-dependent L-type calcium channel subunit alpha-1C Cardiomyocyte Troponin I, slow skeletal muscle ATP-sensitive inward rectifier potassium channel 8 Troponin I, fast skeletal muscle P17612 UniProt P26678 UniProt Inositol 1,4,5-trisphosphate SubPathwayActivator 2.0 Sodium/potassium-transporting ATPase subunit alpha-3 Myosin light chain kinase, smooth muscle 1.0 TransportCatalysis93 ACTIVATION TransportCatalysis92 ACTIVATION TransportCatalysis91 ACTIVATION TransportCatalysis90 ACTIVATION TransportCatalysis96 ACTIVATION C19H24N2O3 Labetalol 328.17868 TransportCatalysis9 ACTIVATION Alpha-1A adrenergic receptor SMILES [Na+] SMILES [K+] P48544 UniProt Troponin C, skeletal muscle Inward rectifier potassium channel 2 Ryanodine receptor 2 SubPathwayActivation P48549 UniProt Q5I7T1 UniProt P48788 UniProt GO:0016529 GENE ONTOLOGY CL:0000187 CELL TYPE ONTOLOGY O60706 UniProt P14415 UniProt ATP-binding cassette sub-family C member 8 GO:0005829 GENE ONTOLOGY Type-1 angiotensin II receptor SubPathwayActivator Tropomyosin alpha-1 chain 1.0 85166-31-0 CAS Labetalol SubPathwayInhibitor O43497 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide P35348 UniProt P45379 UniProt P45378 UniProt 266 ChemSpider Troponin T, slow skeletal muscle 4.0 Voltage-dependent L-type calcium channel subunit beta-1 Sodium/potassium-transporting ATPase subunit gamma P22460 UniProt Potassium voltage-gated channel subfamily H member 2 1.0 Calmodulin Beta-1-syntrophin Voltage-dependent L-type calcium channel subunit alpha-1C sarcoplasmic reticulum GO:0005886 GENE ONTOLOGY 1.0 53480233 PubChem-compound Voltage-dependent calcium channel subunit alpha-2/delta-2 ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 1.0 1.0 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/calcium exchanger 1 Potassium voltage-gated channel subfamily KQT member 1 P13637 UniProt Q9NY47 UniProt P09493 UniProt Myocyte 3869 PubChem-compound Calcium Muscle Voltage-dependent T-type calcium channel subunit alpha-1G Voltage-dependent T-type calcium channel subunit alpha-1H Cardiac phospholamban Muscarinic acetylcholine receptor M2 P08172 UniProt SMILES [Ca++] 1.0 Voltage-dependent L-type calcium channel subunit beta-1 Beta-1 adrenergic receptor SubPathwayInhibition cAMP-dependent protein kinase catalytic subunit alpha GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 1.0 3.0 Potassium voltage-gated channel subfamily E member 2 Q14643 UniProt Inositol 1,4,5-trisphosphate receptor type 1 3.1.4.11 false 3.1.4.11 PIP2(16:0/20:3(8Z,11Z,14Z)) → DG(14:0/14:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Endoplasmic Reticulum Sodium/potassium-transporting ATPase subunit beta-1 Kv channel-interacting protein 2 1.0 TransportCatalysis10 ACTIVATION Sodium/potassium-transporting ATPase subunit beta-2 B7ZKV8 UniProt Potassium voltage-gated channel subfamily E member 1 Q14524 UniProt Potassium channel subfamily K member 1 G protein-activated inward rectifier potassium channel 4 Q14654 UniProt 3.0 1.0 2.0 1.0 TransportCatalysis23 ACTIVATION Beta-2-syntrophin Potassium voltage-gated channel subfamily D member 3 Inward rectifier potassium channel 4 Alpha-1-syntrophin G protein-activated inward rectifier potassium channel 1 Q02641 UniProt Q15746 UniProt Troponin, cardiac muscle SubPathwayActivation Troponin T, cardiac muscle Cell Sodium/potassium-transporting ATPase subunit alpha-4 Sodium/potassium-transporting ATPase subunit alpha-2 Cardiac phospholamban Ryanodine receptor 2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Sodium/potassium-transporting ATPase subunit alpha-1 Troponin C, slow skeletal and cardiac muscles 439456 PubChem-compound ATP-sensitive inward rectifier potassium channel 8 GO:0005783 GENE ONTOLOGY Beta-1 adrenergic receptor SubPathwayActivator Q15842 UniProt C00626 KEGG Compound Transport35 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT ATP-sensitive inward rectifier potassium channel 11 Transport36 false Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit alpha-3 Q9Y6J6 UniProt cAMP-dependent protein kinase catalytic subunit alpha SubPathwayActivation SubPathwayActivator Myosin light chain kinase, smooth muscle SubPathwayActivation SubPathwayActivator Q13424 UniProt Q13425 UniProt 9606 TAXONOMY PW000389 PathWhiz 1.0 CA%2b2 BioCyc C31H58O5 DG(14:0/14:1(9Z)/0:0) 510.42844 Cell Membrane P10644 UniProt 271 PubChem-compound P32418 UniProt ATP-binding cassette sub-family C member 8 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC P13805 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide Labetalol Action Pathway Troponin C, skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, slow skeletal muscle ReactionCatalysis1269 ACTIVATION Troponin I, cardiac muscle Troponin I, fast skeletal muscle Troponin T, cardiac muscle BTO:0000562 BRENDA TISSUE ONTOLOGY Troponin T, slow skeletal muscle HMDB01498 HMDB 1.0 Calcium P08588 UniProt TransportCatalysis89 ACTIVATION TransportCatalysis88 ACTIVATION Inositol 1,4,5-trisphosphate receptor type 1 SubPathwayActivation TransportCatalysis87 ACTIVATION 1.0 Troponin T, fast skeletal muscle TransportCatalysis82 ACTIVATION Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Beta-1-syntrophin Tropomyosin beta chain TransportCatalysis86 ACTIVATION Muscarinic acetylcholine receptor M2 SubPathwayActivator TransportCatalysis85 ACTIVATION C07063 KEGG Compound Sodium/potassium-transporting ATPase subunit gamma TransportCatalysis84 ACTIVATION Tropomyosin alpha-1 chain TransportCatalysis83 ACTIVATION P19237 UniProt 5.0 Troponin, fast skeletal muscle SubPathwayActivation Cardiac phospholamban SubPathwayInhibitor ADRB1 ADRA1A CHRM2 PLN ADRB1 PRKACA PRKAR1A CALM1 MYLK AGTR1 PLCB1 ITPR1 TNNC2 TNNI1 TNNT1 TNNC1 TNNI3 TNNT2 TNNC2 TNNI2 TNNT3 TPM1 TPM2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 Unknown FXYD2 KCNJ2 KCNJ4 KCNJ3 KCNJ5 KCND3 KCNIP2 Unknown Unknown KCNQ1 KCNE1 KCNE2 KCNH2 ALG10B ABCC8 KCNJ8 KCNJ11 Unknown KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1C CACNA2D2 CACNB1 CACNA1H CACNA1G RYR2 ATP2A2 Labetalol Labetalol Calcium Sodium Sodium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Calcium Calcium Sodium Sodium Sodium Sodium Potassium Potassium Sodium Sodium Calcium Calcium Calcium Calcium Calcium PIP2(16:0/20:3(8Z,11Z,14Z)) Inositol 1,4,5- trisphosphate DG(14:0/14:1(9Z)/0:0) Adenosine triphosphate Water Calcium Adenosine diphosphate Phosphate Calcium G-protein signalling cascade G-protein signalling cascade Muscle Contraction G-protein signalling cascade Created with Snap