Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Small Molecule Pathway Database.
Loading Pathway...
17215925 ChemSpider 6022 PubChem-compound C4H4O5 Oxalacetic acid 132.00587 C23H38N7O17P3S Acetyl-CoA 809.1258 Malate dehydrogenase, cytoplasmic Mitochondrial pyruvate carrier 1 HMDB01341 HMDB 1.0 CHEBI:30797 ChEBI 439153 PubChem-compound CIT BioCyc 1.0 Acetyl-CoA SubPathwayInput Transfer of Acetyl Groups into Mitochondria 58838673 PubChem-compound TransportCatalysis132 ACTIVATION P11498 UniProt OXALACETIC_ACID BioCyc 1.0 ATP BioCyc TransportCatalysis6 ACTIVATION D-Glucose 4.0 328-42-7 CAS 6816 PubChem-compound SMILES O[C@@H](CC(O)=O)C(O)=O SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 Reaction1367 false D-Glucose → Pyruvic acid LEFT_TO_RIGHT 1.2.4.1 false 1.2.4.1 Pyruvic acid → Acetyl-CoA LEFT_TO_RIGHT HMDB00595 HMDB PW000167 PathWhiz 53-59-8 CAS HMDB01206 HMDB HCO3 BioCyc 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI GO:0005829 GENE ONTOLOGY 2280-44-6 CAS ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc 1.0 HMDB59597 HMDB 274 ChemSpider HMDB00902 HMDB Citric acid 97-67-6 CAS CHEBI:16908 ChEBI HMDB00243 HMDB HMDB00122 HMDB PW000154 PathWhiz Pyruvate dehydrogenase E1 component subunit beta, mitochondrial O4P Phosphate 94.95342 945 ChemSpider 77-92-9 CAS 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 1.0 Adenosine triphosphate CHEBI:30769 ChEBI 1.0 C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 Mitochondrion P40925 UniProt 1.0 NADPH BioCyc HMDB01423 HMDB 1.0 1.0 1.0 HMDB00217 HMDB ReactionCatalysis1082 ACTIVATION Carbon dioxide Mitochondrial citrate transport protein Cytosol Q02978 UniProt L-Malic acid 58-68-4 CAS 4.0 Transport72 false Citric acid (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT SMILES [O-]P([O-])([O-])=O Reaction390 false L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE 124-38-9 CAS 1.0 SMP00466 SMPDB C6H12O6 D-Glucose 180.06339 HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound HMDB00223 HMDB C00006 KEGG Compound 1.0 ReactionCatalysis4 ACTIVATION CHEBI:18009 ChEBI GLC BioCyc 1.0 C00005 KEGG Compound C00004 KEGG Compound Pyruvic acid CHEBI:18367 ChEBI NADPH 1.0 C00003 KEGG Compound 1032 ChemSpider 1031 ChemSpider C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Mitochondrial 2-oxoglutarate/malate carrier protein SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GO:0005759 GENE ONTOLOGY Hydrogen HMDB01429 HMDB 1.0 Phosphate H2 Hydrogen 2.01565 53-57-6 CAS Pyruvate carboxylase, mitochondrial Pyruvic acid Coenzyme A Malate dehydrogenase, cytoplasmic C21H28N7O14P2 NAD 664.11694 Transport173 false L-Malic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT NADP-dependent malic enzyme C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound 1.0 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial ReactionCatalysis79 ACTIVATION NAD(P) BioCyc C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound Pyruvate dehydrogenase E1 component subunit beta, mitochondrial H Hydrogen Ion 1.007825 1.0 C00149 KEGG Compound ATP-citrate synthase 1.0 C00022 KEGG Compound 56-65-5 CAS Pyruvate carboxylase, mitochondrial 53-84-9 CAS P48163 UniProt C00024 KEGG Compound Q6LAP8 UniProt Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 GO:0005737 GENE ONTOLOGY NADP C6H8O7 Citric acid 192.02701 769 PubChem-compound CL:0000000 CELL TYPE ONTOLOGY NADH SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O HMDB00094 HMDB CPD-8587 BioCyc 19782904 PubChem-compound C00031 KEGG Compound C00158 KEGG Compound CHEBI:18276 ChEBI C00036 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI C00282 KEGG Compound Oxalacetic acid Adenosine diphosphate Malate dehydrogenase, cytoplasmic Mitochondrial Matrix CO-A BioCyc 222656 PubChem-compound 5675 ChemSpider 72-89-9 CAS Pyruvate carboxylase, mitochondrial C00288 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 762 ChemSpider C21H36N7O16P3S Coenzyme A 767.11523 SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O Mitochondrial 2-oxoglutarate/malate carrier protein Adenosine diphosphate HMDB00538 HMDB Cytoplasm 1.0 ReactionCatalysis1054 ACTIVATION 2.0 ReactionCatalysis1056 ACTIVATION L-Malic acid 4.0 Cell Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial CHEBI:15422 ChEBI 5589 ChemSpider 6557 ChemSpider Hydrogen carbonate SMILES OC(=O)CC(=O)C(O)=O SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N Oxalacetic acid 388299 ChemSpider 1.0 TransportCatalysis36 ACTIVATION Hydrogen Ion 127-17-3 CAS Pyruvic acid ReactionCatalysis1067 ACTIVATION SubPathwayInteraction210 SubPathway210Reaction SubPathwayReaction P53396 UniProt NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 SMP00456 SMPDB CHEBI:16526 ChEBI Pyruvate dehydrogenase E1 305 ChemSpider CHEBI:16761 ChEBI 1.0 SMILES CC(=O)C(O)=O Mitochondrial pyruvate carrier 1 6.4.1.1 false 6.4.1.1 Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT ATP-citrate synthase HMDB01967 HMDB 9606 TAXONOMY 1333-74-0 CAS NADP-dependent malic enzyme P08559 UniProt CHEBI:17544 ChEBI 5800 ChemSpider 392413 ChemSpider CO2 Carbon dioxide 43.98983 5893 PubChem-compound C00080 KEGG Compound 1.1.1.40 false 1.1.1.40 L-Malic acid + NADP → Carbon dioxide + Hydrogen + NADPH + Pyruvic acid LEFT_TO_RIGHT BiologicalState8 Q9Y5U8 UniProt CHEBI:32816 ChEBI BiologicalState3 BiologicalState4 BiologicalState2 2.0 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS PYRUVATE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound L-Malic acid 280 PubChem-compound CHEBI:4167 ChEBI CHEBI:30744 ChEBI P11177 UniProt Oxalacetic acid HMDB01487 HMDB HMDB00156 HMDB 5793 PubChem-compound 444493 PubChem-compound 1.0 1.0 HMDB01362 HMDB 1.0 SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O 22833512 PubChem-compound 2.3.3.8 false 2.3.3.8 Adenosine triphosphate + Citric acid + Coenzyme A → Acetyl-CoA + Adenosine diphosphate + Oxalacetic acid LEFT_TO_RIGHT 1.0 ACETYL-COA BioCyc Citric acid 193317 ChemSpider Fatty Acid Biosynthesis SubPathway NADH BioCyc NAD BioCyc 1060 PubChem-compound 1061 PubChem-compound 1.0 1.0 Mitochondrial citrate transport protein 1.0 749 ChemSpider 71-52-3 CAS CHEBI:15351 ChEBI 970 PubChem-compound Reaction1341 false Hydrogen + NADPH + Oxalacetic acid → L-Malic acid + NAD LEFT_TO_RIGHT ATP-citrate synthase Acetyl-CoA NADP-dependent malic enzyme C4H6O5 L-Malic acid 134.02153 85-61-0 CAS NAD CHO3 Hydrogen carbonate 60.99257 SMILES [H][H] Mitochondrial citrate transport protein Mitochondrial 2- oxoglutarate/malate carrier protein Mitochondrial pyruvate carrier 1 NADP-dependent malic enzyme Malate dehydrogenase, cytoplasmic ATP-citrate synthase Citrate synthase, mitochondrial Pyruvate dehydrogenase E1 Malate dehydrogenase, cytoplasmic Pyruvate carboxylase, mitochondrial Acetyl-CoA Citric acid Citric acid L-Malic acid Pyruvic acid Pyruvic acid NADP NADPH H + CO 2 Oxalacetic acid H + NADPH NAD CoA ATP ADP Oxalacetic acid Acetyl-CoA H 2 O CoA Pyruvic acid L-Malic acid NAD NADH H + D-Glucose ATP CO 2 ADP P i Manganese Thiamine pyrophosphate Biotin Manganese Fatty Acid Biosynthesis Mitochondrion Cytosol Outer Mitochondrial Membrane Inner Mitochondrial Membrane Mitochondrial Matrix Intracellular Space
17215925 ChemSpider 6022 PubChem-compound C4H4O5 Oxalacetic acid 132.00587 C23H38N7O17P3S Acetyl-CoA 809.1258 Malate dehydrogenase, cytoplasmic Mitochondrial pyruvate carrier 1 HMDB01341 HMDB 1.0 CHEBI:30797 ChEBI 439153 PubChem-compound CIT BioCyc 1.0 Acetyl-CoA SubPathwayInput Transfer of Acetyl Groups into Mitochondria 58838673 PubChem-compound TransportCatalysis132 ACTIVATION P11498 UniProt OXALACETIC_ACID BioCyc 1.0 ATP BioCyc TransportCatalysis6 ACTIVATION D-Glucose 4.0 328-42-7 CAS 6816 PubChem-compound SMILES O[C@@H](CC(O)=O)C(O)=O SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 Reaction1367 false D-Glucose → Pyruvic acid LEFT_TO_RIGHT 1.2.4.1 false 1.2.4.1 Pyruvic acid → Acetyl-CoA LEFT_TO_RIGHT HMDB00595 HMDB PW000167 PathWhiz 53-59-8 CAS HMDB01206 HMDB HCO3 BioCyc 5742 ChemSpider 1038 PubChem-compound CHEBI:16474 ChEBI GO:0005829 GENE ONTOLOGY 2280-44-6 CAS ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc 1.0 HMDB59597 HMDB 274 ChemSpider HMDB00902 HMDB Citric acid 97-67-6 CAS CHEBI:16908 ChEBI HMDB00243 HMDB HMDB00122 HMDB PW000154 PathWhiz Pyruvate dehydrogenase E1 component subunit beta, mitochondrial O4P Phosphate 94.95342 945 ChemSpider 77-92-9 CAS 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 1.0 Adenosine triphosphate CHEBI:30769 ChEBI 1.0 C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 Mitochondrion P40925 UniProt 1.0 NADPH BioCyc HMDB01423 HMDB 1.0 1.0 1.0 HMDB00217 HMDB ReactionCatalysis1082 ACTIVATION Carbon dioxide Mitochondrial citrate transport protein Cytosol Q02978 UniProt L-Malic acid 58-68-4 CAS 4.0 Transport72 false Citric acid (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT SMILES [O-]P([O-])([O-])=O Reaction390 false L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE 124-38-9 CAS 1.0 http://identifiers.org/smpdb/SMP00466 SMPDB C6H12O6 D-Glucose 180.06339 HMDB00221 HMDB C00009 KEGG Compound C00008 KEGG Compound HMDB00223 HMDB C00006 KEGG Compound 1.0 ReactionCatalysis4 ACTIVATION CHEBI:18009 ChEBI GLC BioCyc 1.0 C00005 KEGG Compound C00004 KEGG Compound Pyruvic acid CHEBI:18367 ChEBI NADPH 1.0 C00003 KEGG Compound 1032 ChemSpider 1031 ChemSpider C00002 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Mitochondrial 2-oxoglutarate/malate carrier protein SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GO:0005759 GENE ONTOLOGY Hydrogen HMDB01429 HMDB 1.0 Phosphate H2 Hydrogen 2.01565 53-57-6 CAS Pyruvate carboxylase, mitochondrial Pyruvic acid Coenzyme A Malate dehydrogenase, cytoplasmic C21H28N7O14P2 NAD 664.11694 Transport173 false L-Malic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT NADP-dependent malic enzyme C00011 KEGG Compound SMILES O=C=O C00010 KEGG Compound 1.0 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial ReactionCatalysis79 ACTIVATION NAD(P) BioCyc C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound Pyruvate dehydrogenase E1 component subunit beta, mitochondrial H Hydrogen Ion 1.007825 1.0 C00149 KEGG Compound ATP-citrate synthase 1.0 C00022 KEGG Compound 56-65-5 CAS Pyruvate carboxylase, mitochondrial 53-84-9 CAS P48163 UniProt C00024 KEGG Compound Q6LAP8 UniProt Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 GO:0005737 GENE ONTOLOGY NADP C6H8O7 Citric acid 192.02701 769 PubChem-compound CL:0000000 CELL TYPE ONTOLOGY NADH SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O HMDB00094 HMDB CPD-8587 BioCyc 19782904 PubChem-compound C00031 KEGG Compound C00158 KEGG Compound CHEBI:18276 ChEBI C00036 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O CHEBI:1146900 ChEBI C00282 KEGG Compound Oxalacetic acid Adenosine diphosphate Malate dehydrogenase, cytoplasmic Mitochondrial Matrix CO-A BioCyc 222656 PubChem-compound 5675 ChemSpider 72-89-9 CAS Pyruvate carboxylase, mitochondrial C00288 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 762 ChemSpider C21H36N7O16P3S Coenzyme A 767.11523 SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O Mitochondrial 2-oxoglutarate/malate carrier protein Adenosine diphosphate HMDB00538 HMDB Cytoplasm 1.0 ReactionCatalysis1054 ACTIVATION 2.0 ReactionCatalysis1056 ACTIVATION L-Malic acid 4.0 Cell Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial CHEBI:15422 ChEBI 5589 ChemSpider 6557 ChemSpider Hydrogen carbonate SMILES OC(=O)CC(=O)C(O)=O SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N Oxalacetic acid 388299 ChemSpider 1.0 TransportCatalysis36 ACTIVATION Hydrogen Ion 127-17-3 CAS Pyruvic acid ReactionCatalysis1067 ACTIVATION SubPathwayInteraction210 SubPathway210Reaction SubPathwayReaction P53396 UniProt NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 http://identifiers.org/smpdb/SMP00456 SMPDB CHEBI:16526 ChEBI Pyruvate dehydrogenase E1 305 ChemSpider CHEBI:16761 ChEBI 1.0 SMILES CC(=O)C(O)=O Mitochondrial pyruvate carrier 1 6.4.1.1 false 6.4.1.1 Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT ATP-citrate synthase HMDB01967 HMDB 9606 TAXONOMY 1333-74-0 CAS NADP-dependent malic enzyme P08559 UniProt CHEBI:17544 ChEBI 5800 ChemSpider 392413 ChemSpider CO2 Carbon dioxide 43.98983 5893 PubChem-compound C00080 KEGG Compound 1.1.1.40 false 1.1.1.40 L-Malic acid + NADP → Carbon dioxide + Hydrogen + NADPH + Pyruvic acid LEFT_TO_RIGHT BiologicalState8 Homo sapiens, Cell, Cytoplasm Q9Y5U8 UniProt CHEBI:32816 ChEBI BiologicalState3 Homo sapiens, Cell, Mitochondrion BiologicalState4 Homo sapiens, Cell, Mitochondrial Matrix BiologicalState2 Homo sapiens, Cell, Cytosol 2.0 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS PYRUVATE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound L-Malic acid 280 PubChem-compound CHEBI:4167 ChEBI CHEBI:30744 ChEBI P11177 UniProt Oxalacetic acid HMDB01487 HMDB HMDB00156 HMDB 5793 PubChem-compound 444493 PubChem-compound 1.0 1.0 HMDB01362 HMDB 1.0 SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O 22833512 PubChem-compound 2.3.3.8 false 2.3.3.8 Adenosine triphosphate + Citric acid + Coenzyme A → Acetyl-CoA + Adenosine diphosphate + Oxalacetic acid LEFT_TO_RIGHT 1.0 ACETYL-COA BioCyc Citric acid 193317 ChemSpider Fatty Acid Biosynthesis SubPathway NADH BioCyc NAD BioCyc 1060 PubChem-compound 1061 PubChem-compound 1.0 1.0 Mitochondrial citrate transport protein 1.0 749 ChemSpider 71-52-3 CAS CHEBI:15351 ChEBI 970 PubChem-compound Reaction1341 false Hydrogen + NADPH + Oxalacetic acid → L-Malic acid + NAD LEFT_TO_RIGHT ATP-citrate synthase Acetyl-CoA NADP-dependent malic enzyme C4H6O5 L-Malic acid 134.02153 85-61-0 CAS NAD CHO3 Hydrogen carbonate 60.99257 SMILES [H][H] Mitochondria Unknown SLC25A11 MPC1 ME1 MDH1 ACLY CS PDHA1 PDHB MDH1 PC Acetyl-CoA Citric acid Citric acid L-Malic acid Pyruvic acid Pyruvic acid NADP NADPH Hydrogen Carbon dioxide Oxalacetic acid Hydrogen NADPH NAD Coenzyme A Adenosine triphosphate Adenosine diphosphate Oxalacetic acid Acetyl-CoA Water Coenzyme A Pyruvic acid L-Malic acid NAD NADH Hydrogen Ion D-Glucose Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Phosphate Fatty Acid Biosynthesis