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HMDB01586 HMDB 6022 PubChem-compound http://identifiers.org/smpdb/SMP00027 SMPDB Mitochondrial pyruvate carrier 1 937 ChemSpider 96860 ChemSpider HMDB01341 HMDB 1.0 Glucose-6-phosphatase 439278 PubChem-compound 439153 PubChem-compound Phosphoglycerate mutase 2 Phosphoglycerate mutase 1 Bisphosphoglycerate mutase ReactionCatalysis942 ACTIVATION 50 ChemSpider ReactionCatalysis940 ACTIVATION 58238 ChemSpider HMDB01112 HMDB PW000055 PathWhiz C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 PW000054 PathWhiz http://identifiers.org/smpdb/SMP00039 SMPDB OXALACETIC_ACID BioCyc ATP BioCyc HMDB00263 HMDB HMDB01473 HMDB Reaction1242 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1243 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1240 false Glyceric acid 1,3-biphosphate ↔ 2,3-Diphosphoglyceric acid REVERSIBLE ReactionCatalysis939 ACTIVATION ReactionCatalysis937 ACTIVATION Oxoglutaric acid Reaction1246 false 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid REVERSIBLE http://identifiers.org/smpdb/SMP00031 SMPDB HMDB01201 HMDB HMDB00595 HMDB Malic acid 5743 ChemSpider 1.0 HCO3 BioCyc 5742 ChemSpider NADH PW000042 PathWhiz 2280-44-6 CAS ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc HMDB59597 HMDB 1.0 ReactionCatalysis965 ACTIVATION SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Malate dehydrogenase, mitochondrial http://identifiers.org/smpdb/SMP00043 SMPDB HMDB00122 HMDB ReactionCatalysis960 ACTIVATION HMDB00243 HMDB HMDB00124 HMDB C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 PW000032 PathWhiz PW000159 PathWhiz 709 ChemSpider PW000036 PathWhiz C00221 KEGG Compound 2,3-Diphosphoglyceric acid 704 ChemSpider 1.0 945 ChemSpider PW000031 PathWhiz C00103 KEGG Compound 1010 ChemSpider PW000150 PathWhiz C10H15N5O11P2 Guanosine diphosphate 443.02432 O43826 UniProt 439165 PubChem-compound 488-69-7 CAS ReactionCatalysis958 ACTIVATION ReactionCatalysis713 ACTIVATION ReactionCatalysis955 ACTIVATION http://identifiers.org/smpdb/SMP00058 SMPDB ReactionCatalysis954 ACTIVATION 2.0 ReactionCatalysis952 ACTIVATION 1.0 http://identifiers.org/smpdb/SMP00055 SMPDB C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 138-08-9 CAS 1.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 59-56-3 CAS C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 Transport68 false Glucose 6-phosphate (←) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT C00111 KEGG Compound Transport67 false Phosphate (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Cytosol Alpha-enolase Q02978 UniProt C00236 KEGG Compound 388311 ChemSpider 1.0 C00597 KEGG Compound C00354 KEGG Compound P60174 UniProt Transport70 false Phosphoenolpyruvic acid (?) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Aldose 1-epimerase Glyceraldehyde-3-phosphate dehydrogenase Starch and Sucrose Metabolism SubPathway 7664-38-2 CAS 1.0 HMDB00208 HMDB Fructose 1,6-bisphosphate 1.0 Galactose Metabolism SubPathway false Fructose 6-phosphate ↔ Glucose 6-phosphate REVERSIBLE false Alpha-D-Glucose ↔ Beta-D-Glucose REVERSIBLE C00009 KEGG Compound C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O HMDB00223 HMDB 1.0 C3H8O10P2 2,3-Diphosphoglyceric acid 265.95926 Hydrogen Ion C00001 KEGG Compound P15259 UniProt Fructose 6-phosphate SubPathwayInput SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 CHEBI:18367 ChEBI C00004 KEGG Compound Pyruvic acid SubPathwayOutput 1032 ChemSpider C00003 KEGG Compound 1.0 C00002 KEGG Compound 1031 ChemSpider Mitochondrial 2-oxoglutarate/malate carrier protein GLC-1-P BioCyc C6H12O6 Alpha-D-Glucose 180.06339 HMDB01429 HMDB Phosphate HMDB01401 HMDB 388411 ChemSpider 388538 ChemSpider Pyruvic acid SubPathwayOutput C21H28N7O14P2 NAD 664.11694 http://identifiers.org/smpdb/SMP00006 SMPDB 107689 PubChem-compound 2.0 http://identifiers.org/smpdb/SMP00008 SMPDB C00011 KEGG Compound 161681 ChemSpider FRUCTOSE-6P BioCyc Glucose-6-phosphatase CHEBI:17138 ChEBI H Hydrogen Ion 1.007825 1.0 http://identifiers.org/smpdb/SMP00016 SMPDB P52789 UniProt C00022 KEGG Compound 56-65-5 CAS P18669 UniProt Pyruvate carboxylase, mitochondrial 53-84-9 CAS C00026 KEGG Compound C00267 KEGG Compound 62713 ChemSpider CHEBI:26078 ChEBI 1.0 ReactionCatalysis513 ACTIVATION http://identifiers.org/smpdb/SMP00010 SMPDB P06733 UniProt 769 PubChem-compound 525 PubChem-compound CL:0000000 CELL TYPE ONTOLOGY C00031 KEGG Compound 186004 PubChem-compound C00036 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00035 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 328-50-7 CAS L-Lactic acid SubPathwayOutput Oxalacetic acid D-Glucose SubPathwayOutput SubPathwayInput Adenosine diphosphate 492-61-5 CAS 4.0 false Glucose 1-phosphate + Water → D-Glucose + Phosphate LEFT_TO_RIGHT false Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT P06744 UniProt C00044 KEGG Compound 648 ChemSpider false Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE false Glucose 6-phosphate + Water ↔ D-Glucose + Phosphate REVERSIBLE C00288 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PHOSPHO-ENOL-PYRUVATE BioCyc HMDB00538 HMDB 4.0 SMILES OC(=O)C(=C)OP(O)(O)=O 64689 PubChem-compound Reaction812 false D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH REVERSIBLE 1.0 C3H7O7P 3-Phosphoglyceric acid 185.99294 false Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate REVERSIBLE 668 PubChem-compound Hexokinase-2 SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS CHEBI:16077 ChEBI CHEBI:4170 ChEBI 591-59-3 CAS NAD SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O Pyruvic acid http://identifiers.org/smpdb/SMP00562 SMPDB 1.0 492-62-6 CAS 1.0 SubPathwayInteraction202 SubPathwayReaction SubPathway202Reaction NAD SubPathwayInteraction203 SubPathway203Reaction SubPathwayReaction SubPathwayInteraction200 SubPathway200Reaction SubPathwayReaction false Glucose 1-phosphate ↔ Glucose 6-phosphate REVERSIBLE Malic acid SubPathwayInteraction201 SubPathwayReaction SubPathway201Reaction C10H16N5O13P3 Adenosine triphosphate 506.99576 SubPathwayInteraction206 SubPathway206Reaction SubPathwayReaction Phosphoric acid DPG BioCyc SubPathwayInteraction207 SubPathwayReaction SubPathway207Reaction DIHYDROXY-ACETONE-PHOSPHATE BioCyc MAL BioCyc SubPathwayInteraction204 SubPathwayReaction SubPathway204Reaction SubPathwayInteraction205 SubPathwayReaction SubPathway205Reaction C00186 KEGG Compound SubPathwayInteraction208 SubPathway208Reaction SubPathwayReaction SubPathwayInteraction209 SubPathway209Reaction SubPathwayReaction C01159 KEGG Compound 445557 PubChem-compound SMILES CC(=O)C(O)=O 663 ChemSpider Alpha-D-Glucose C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI Mitochondrial pyruvate carrier 1 false Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT SMILES OCC(=O)COP(O)(O)=O Tyrosine Metabolism SubPathway HMDB00516 HMDB HMDB01967 HMDB Glycerolipid Metabolism SubPathway 3-Phosphoglyceric acid SubPathwayInput Propanoate Metabolism SubPathway P07738 UniProt 962 PubChem-compound 724 PubChem-compound P11168 UniProt 5800 ChemSpider Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Malate dehydrogenase, mitochondrial Fructose-bisphosphate aldolase A Fructose-1,6-bisphosphatase 1 979 ChemSpider CO2 Carbon dioxide 43.98983 C00080 KEGG Compound C00085 KEGG Compound H3O4P Phosphoric acid 97.9769 C01172 KEGG Compound 2.0 729 PubChem-compound Phosphoglycerate mutase 1 Q9Y5U8 UniProt BiologicalState3 Homo sapiens, Cell, Mitochondrion C4H6O5 Malic acid 134.02153 BiologicalState2 Homo sapiens, Cell, Cytosol 14265-44-2 CAS CHEBI:44897 ChEBI Glucose-6-phosphate isomerase PYRUVATE BioCyc HMDB00744 HMDB 58-64-0 CAS C6H13O9P Glucose 1-phosphate 260.02972 GTP BioCyc C00092 KEGG Compound 71358 ChemSpider G3P BioCyc Glucose-6-phosphate isomerase CHEBI:4167 ChEBI Oxalacetic acid C3H6O3 L-Lactic acid 90.03169 P04406 UniProt 1.0 56-73-5 CAS 2-PG BioCyc 1.0 23-DIPHOSPHOGLYCERATE BioCyc SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O Phosphoglucomutase-1 1.0 Pantothenate kinase 1 Malate dehydrogenase, mitochondrial 510 ChemSpider H2O Water 18.010565 138-81-8 CAS SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 1.0 393165 ChemSpider Triosephosphate isomerase NADH BioCyc 1.0 Glucose 6-phosphate Beta-D-Glucose NAD BioCyc 1.0 Glucose-6-phosphate translocase Malic acid 1.0 Glyceraldehyde-3-phosphate dehydrogenase 749 ChemSpider 71-52-3 CAS 1.0 970 PubChem-compound 4.0 980 ChemSpider 1.0 146-91-8 CAS CHO3 Hydrogen carbonate 60.99257 CHEBI:15903 ChEBI Aldose 1-epimerase 820-11-1 CAS 2-Phospho-D-glyceric acid 1.0 Pantothenate and CoA Biosynthesis SubPathway Nucleotide Sugars Metabolism SubPathway C4H4O5 Oxalacetic acid 132.00587 Thiamine Metabolism SubPathway 4.0 CHEBI:6650 ChEBI Glyceraldehyde-3-phosphate dehydrogenase 1.0 1.0 SMILES O P35575 UniProt Q96C23 UniProt C6H12O6 Beta-D-Glucose 180.06339 1.0 HMDB00807 HMDB Triosephosphate isomerase P11498 UniProt Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Fructose and Mannose Degradation SubPathway 1004 PubChem-compound 1005 PubChem-compound TransportCatalysis6 ACTIVATION TransportCatalysis8 ACTIVATION 643-13-0 CAS 1981-49-3 CAS 328-42-7 CAS C3H7O6P Dihydroxyacetone phosphate 169.99803 51 PubChem-compound SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 1038 PubChem-compound Pantothenate kinase 1 GO:0005829 GENE ONTOLOGY 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 Hydrogen Ion CHEBI:16905 ChEBI HMDB00902 HMDB Fructose-1,6-bisphosphatase 1 Guanosine triphosphate CHEBI:16908 ChEBI Guanosine diphosphate O4P Phosphate 94.95342 6830 PubChem-compound 1.0 Adenosine triphosphate CHEBI:15946 ChEBI L-LACTATE BioCyc Mitochondrion P40926 UniProt Hexokinase-2 Solute carrier family 2, facilitated glucose transporter member 2 Glucose 1-phosphate SubPathwayOutput Carbon dioxide 683 PubChem-compound Phosphoenolpyruvic acid SubPathwayInput Triosephosphate isomerase 58-68-4 CAS SMILES [O-]P([O-])([O-])=O Pantothenate kinase 1 SMILES OC(=O)CCC(=O)C(O)=O PW000538 PathWhiz 1.0 C6H13O9P Fructose 6-phosphate 260.02972 124-38-9 CAS CHEBI:30915 ChEBI C6H12O6 D-Glucose 180.06339 2.0 Fructose-bisphosphate aldolase A CHEBI:17835 ChEBI Phosphoenolpyruvic acid ReactionCatalysis4 ACTIVATION GLC BioCyc 1.0 1.0 Malate dehydrogenase, mitochondrial GO:0005758 GENE ONTOLOGY GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc GO:0005759 GENE ONTOLOGY 1.0 57-04-5 CAS 69507 PubChem-compound Pyruvate carboxylase, mitochondrial P35558 UniProt 1.0 SMILES O=C=O 1.0 Malate dehydrogenase, mitochondrial SubPathwayInteraction814 SubPathway814Reaction SubPathwayReaction SMILES OP(O)(O)=O SMILES OC(CC(O)=O)C(O)=O 5958 PubChem-compound C21H29N7O14P2 NADH 665.12476 D-Glucose 5957 PubChem-compound Malic acid P00338 UniProt CHEBI:15996 ChEBI SMILES OC[C@H]1OC(OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O L-lactate dehydrogenase A chain Alpha-enolase 1.0 C3H5O6P Phosphoenolpyruvic acid 167.98238 1.0 Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 HMDB03391 HMDB SMILES C[C@H](O)C(O)=O P36871 UniProt D-Glyceraldehyde 3-phosphate SubPathwayOutput SubPathwayInput CHEBI:17925 ChEBI Fructose-1,6-diphosphatase deficiency C00711 KEGG Compound Endoplasmic Reticulum 1.0 L-lactate dehydrogenase A chain CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O TransportCatalysis15 ACTIVATION 5682 ChemSpider Dihydroxyacetone phosphate Mitochondrial Matrix C6H13O9P Glucose 6-phosphate 260.02972 2.0 ReactionCatalysis661 ACTIVATION Phosphoglucomutase-1 HMDB03498 HMDB Phosphoglycerate mutase 2 Pyruvate carboxylase, mitochondrial Mitochondrial 2-oxoglutarate/malate carrier protein Adenosine diphosphate SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O Q8TE04 UniProt 6915-15-7 CAS ReactionCatalysis658 ACTIVATION ReactionCatalysis1053 ACTIVATION false 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water REVERSIBLE Cell 439427 PubChem-compound HMDB03345 HMDB 1.0 CHEBI:15422 ChEBI CHEBI:17720 ChEBI 5589 ChemSpider P09467 UniProt Glucose-6-phosphate translocase TransportCatalysis34 ACTIVATION Hydrogen carbonate Beta-D-Glucose 6-phosphate Transport42 false D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 388299 ChemSpider 1.0 1.0 79-33-4 CAS 127-17-3 CAS Fructose-1,6-bisphosphatase 1 HMDB00190 HMDB CHEBI:17719 ChEBI GO:0005783 GENE ONTOLOGY Water false L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid REVERSIBLE HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc 1.0 CHEBI:16526 ChEBI SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O HMDB01294 HMDB 8977 PubChem-compound HMDB02142 HMDB CHEBI:16761 ChEBI Transport32 false Oxoglutaric acid (←), Malic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space LEFT_TO_RIGHT GLC-6-P BioCyc false Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE 1.0 NADH 1.0 9606 TAXONOMY PW000144 PathWhiz P04075 UniProt Glucose 6-phosphate CHEBI:17544 ChEBI PW000142 PathWhiz PW000149 PathWhiz 2-KETOGLUTARATE BioCyc PW000025 PathWhiz SMILES OC(COP(O)(O)=O)C(O)=O Oxoglutaric acid C00631 KEGG Compound 8630 ChemSpider 5893 PubChem-compound HMDB02111 HMDB http://identifiers.org/smpdb/SMP00060 SMPDB SubPathwayInteraction190 SubPathway190Reaction SubPathwayReaction false 3-Phosphoglyceric acid + Adenosine triphosphate → Adenosine diphosphate + Glyceric acid 1,3-biphosphate LEFT_TO_RIGHT SubPathwayInteraction194 SubPathway194Reaction SubPathwayReaction http://identifiers.org/smpdb/SMP00067 SMPDB SubPathwayInteraction195 SubPathway195Reaction SubPathwayReaction Fructose-bisphosphate aldolase A false Adenosine triphosphate + Beta-D-Glucose → Adenosine diphosphate + Beta-D-Glucose 6-phosphate LEFT_TO_RIGHT Mitochondrial Intermembrane Space SubPathwayInteraction193 SubPathwayReaction SubPathway193Reaction CHEBI:32816 ChEBI SubPathwayInteraction198 SubPathway198Reaction SubPathwayReaction ReactionCatalysis349 ACTIVATION http://identifiers.org/smpdb/SMP00064 SMPDB SubPathwayInteraction199 SubPathwayReaction SubPathway199Reaction SubPathwayInteraction196 SubPathwayReaction SubPathway196Reaction ReactionCatalysis347 ACTIVATION SubPathwayInteraction197 SubPathway197Reaction SubPathwayReaction CHEBI:15377 ChEBI ReactionCatalysis344 ACTIVATION ReactionCatalysis343 ACTIVATION CHEBI:15378 ChEBI SMILES [H+] Glucose-6-phosphate isomerase CHEBI:16108 ChEBI 6569 ChemSpider HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glyceric acid 1,3-biphosphate CHEBI:17552 ChEBI HMDB01273 HMDB Phosphate SMILES OC[C@@H](OP(O)(O)=O)C(O)=O CHEBI:422 ChEBI 280 PubChem-compound CHEBI:30744 ChEBI 79025 PubChem-compound Phosphate http://identifiers.org/smpdb/SMP00076 SMPDB false Guanosine triphosphate + Oxalacetic acid ↔ Carbon dioxide + Guanosine diphosphate + Phosphoenolpyruvic acid REVERSIBLE HMDB01487 HMDB PW000002 PathWhiz 5793 PubChem-compound PW000001 PathWhiz ReactionCatalysis375 ACTIVATION ReactionCatalysis373 ACTIVATION Pyruvate Metabolism SubPathway SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 1.0 Pentose Phosphate Pathway SubPathway 1.0 SMILES OC(COP(O)(O)=O)C=O false Adenosine triphosphate + Alpha-D-Glucose → Adenosine diphosphate + Glucose 6-phosphate LEFT_TO_RIGHT Aspartate Metabolism SubPathway Alanine Metabolism SubPathway 86-01-1 CAS false Beta-D-Glucose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE GAP BioCyc 1060 PubChem-compound 1061 PubChem-compound 2.0 Bisphosphoglycerate mutase Phenylalanine and Tyrosine Metabolism SubPathway C00661 KEGG Compound SMILES OC(=O)[C@@H](COP(O)(O)=O)OP(O)(O)=O 1.0 Solute carrier family 2, facilitated glucose transporter member 2 Bisphosphoglycerate mutase SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O 1.0