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Phospholipase C, beta 1 Inositol 1,4,5- trisphosphate receptor type 1 protein kinase C beta Nuclear factor NF-kappa-B p105 subunit Histamine H1 receptor Gαq Gαq Histamine H1 receptor Histamine Inositol 1,4,5- trisphosphate Ca+ Chlorpheniramine Ca+ H2O Calcium Calcium GDP GTP Histamine 1,2-diacyl- sn-glycerol phosphatidylinositol 4,5- bisphosphate ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors Mast Cells Release Histamine Endoplasmic Reticulum Nucleus Calcium Ion Channel Cell Membrane Cytoplasm ↑ Antigen Presentation ↑ Mediator Release ↓ Mast Cell Stabilization The GPCR activates the G protein by exchanging GDP for GTP. This exchange triggers the dissociation of the Gα subunit from the Gβγ dimer and the receptor. Blocking the action of histamine at the H1 receptor helps to relieve allergic reactions.
Endoplasmic Reticulum GNG2 GNB1 PLCB1 ITPR1 PRKCB NFKB1 GNG2 HRH1 GNAQ GNAQ HRH1 GNB1 Histamine Inositol 1,4,5- trisphosphate Calcium Chlorpheniramine Calcium Water Guanosine diphosphate Guanosine triphosphate Histamine 1,2-diacyl- sn-glycerol phosphatidylinositol 4,5- bisphosphate Mast Cells Release Histamine
GNG2 GNB1 PLCB1 ITPR1 PRKCB NFKB1 GNG2 HRH1 GNAQ GNAQ HRH1 GNB1 Hsm Inotp Ca+ Chlopra Ca+ H2O Ca2+ Ca2+ GDP GTP Hsm 12DSG P45B ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors M C R H Endoplasmic Reticulum Nucleus Calcium Ion Channel Cell Membrane Cytoplasm ↑ Antigen Presentation ↑ Mediator Release ↓ Mast Cell Stabilization The GPCR activates the G protein by exchanging GDP for GTP. This exchange triggers the dissociation of the Gα subunit from the Gβγ dimer and the receptor. Blocking the action of histamine at the H1 receptor helps to relieve allergic reactions.
Endoplasmic Reticulum GNG2 GNB1 PLCB1 ITPR1 PRKCB NFKB1 GNG2 HRH1 GNAQ GNAQ HRH1 GNB1 Hsm Inotp Ca2+ Chlopra Ca2+ H2O GDP GTP Hsm 12DSG P45B M C R H