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Guanosine diphosphate Q14643 UniProt 1.0 Protein kinase C beta type C04637 KEGG Compound Inositol 1,4,5-trisphosphate receptor type 1 1.0 Protein kinase C beta type Endoplasmic Reticulum 937 ChemSpider Inositol 1,4,5-trisphosphate 51-45-6 CAS C01245 KEGG Compound C00035 KEGG Compound SMILES NCCC1=CNC=N1 direct_interaction 1,2-diacyl-sn-glycerol Inositol 1,4,5-trisphosphate receptor type 1 Histamine SubPathwayOutput SMILES O Calcium SubPathwayInteraction54299 SubPathway54299Reaction SubPathwayReaction P05771 UniProt C00044 KEGG Compound Water Mast Cells Release Histamine SubPathway Guanine nucleotide-binding protein G(q) subunit alpha 1.0 SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Histamine H1 receptor C8H12N2 Betahistine 136.10005 TransportCatalysis922 ACTIVATION 4.0 Cytoplasm 1.0 P59768 UniProt HMDB0015644 HMDB Histamine Homo sapiens Reaction101579 false Histamine H1 receptor (Homo sapiens) + Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens) → Guanosine triphosphate + Gαq (Homo sapiens) + Gβγ + Histamine + Histamine H1 receptor (Homo sapiens) LEFT_TO_RIGHT 2366 PubChem-compound Reaction100922 false Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT CHEBI:35677 ChEBI 7732-18-5 CAS CHEBI:16595 ChEBI Q9NQ66 UniProt 439456 PubChem-compound 1.0 1.0 85166-31-0 CAS GO:0005783 GENE ONTOLOGY Betahistine Interaction241 Guanosine triphosphate + Gαq (Homo sapiens) activates Phospholipase C, beta 1 774 PubChem-compound Interaction240 Histamine activates Histamine H1 receptor (Homo sapiens) + Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens) Interaction243 1,2-diacyl-sn-glycerol activates protein kinase C beta Interaction242 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 Interaction245 protein kinase C beta activates Nuclear factor NF-kappa-B p105 subunit Interaction244 Calcium activates protein kinase C beta P19838 UniProt Nuclear factor NF-kappa-B p105 subunit Inositol 1,4,5-trisphosphate receptor type 1 Guanine nucleotide-binding protein G(q) subunit alpha 8977 PubChem-compound Inositol 1,4,5-trisphosphate Histamine_Histamine H1 receptor (Homo sapiens) 6830 PubChem-compound ReactionCatalysis91035 ACTIVATION PW061694 PathWhiz 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 C10H15N5O11P2 Guanosine diphosphate 443.02432 HMDB0001498 HMDB 266 ChemSpider SMILES CNCCC1=CC=CC=N1 1.0 Inositol 1,4,5-trisphosphate receptor type 1 1.0 9606 TAXONOMY 962 PubChem-compound 4.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 Guanosine triphosphate P62873 UniProt 5638-76-6 CAS C00076 KEGG Compound 8630 ChemSpider CA%2b2 BioCyc GO:0005886 GENE ONTOLOGY Histamine H1 receptor (Homo sapiens)_Gαq (Homo sapiens)_Guanosine diphosphate_Gβγ (Homo sapiens) Histamine H1 receptor Ca Calcium 39.96259 Histamine 1.0 HMDB0002111 HMDB inositol_1,4,5-trisphosphate BioCyc 1,2-diacyl-sn-glycerol Cell Membrane CHEBI:15377 ChEBI P35367 UniProt 6569 ChemSpider C00001 KEGG Compound HISTAMINE BioCyc 271 PubChem-compound CHEBI:17552 ChEBI SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 1.0 1.0 GTP BioCyc C00641 KEGG Compound Interaction308 Betahistine inhibits Histamine + Histamine H1 receptor (Homo sapiens) 388562 ChemSpider HMDB0000464 HMDB SMP0060744 SMPDB GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Protein kinase C beta type 1,2-diacyl-sn-glycerol P50148 UniProt Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY HMDB0001273 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 Transport1035 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 2276 ChemSpider CHEBI:18295 ChEBI Gβγ HMDB0001201 HMDB HMDB0000870 HMDB 753 ChemSpider H2O Water 18.010565 14127-61-8 CAS SMILES [Ca++] C5H9N3 Histamine 111.07965 phosphatidylinositol 4,5-bisphosphate 86-01-1 CAS Guanosine triphosphate_Gαq (Homo sapiens) Nucleus Betahistine H1-Antihistamine Action Histamine H1 receptor CHEBI:15996 ChEBI 1.0 Calcium Inositol 1,4,5-trisphosphate receptor type 1 1.0 C00388 KEGG Compound C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 1.0 CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY 146-91-8 CAS Histamine_Histamine H1 receptor (Homo sapiens) 1.0 phosphatidylinositol 4,5-bisphosphate Phospholipase C, beta 1 Inositol 1,4,5- trisphosphate receptor type 1 protein kinase C beta Nuclear factor NF-kappa-B p105 subunit Histamine H1 receptor Gαq Gαq Histamine H1 receptor Histamine Inositol 1,4,5- trisphosphate Ca + Betahistine Ca + H 2 O Calcium Calcium GDP GTP Histamine 1,2-diacyl- sn-glycerol phosphatidylinositol 4,5- bisphosphate ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors Mast Cells Release Histamine Endoplasmic Reticulum Nucleus Calcium Ion Channel Cell Membrane Cytoplasm ↑ Antigen Presentation ↑ Mediator Release ↓ Mast Cell Stabilization
Guanosine diphosphate Q14643 UniProt 1.0 Protein kinase C beta type C04637 KEGG Compound Inositol 1,4,5-trisphosphate receptor type 1 1.0 Protein kinase C beta type Endoplasmic Reticulum 937 ChemSpider Inositol 1,4,5-trisphosphate 51-45-6 CAS C01245 KEGG Compound C00035 KEGG Compound SMILES NCCC1=CNC=N1 direct_interaction 1,2-diacyl-sn-glycerol Inositol 1,4,5-trisphosphate receptor type 1 Histamine SubPathwayOutput SMILES O Calcium SubPathwayInteraction54299 SubPathway54299Reaction SubPathwayReaction P05771 UniProt C00044 KEGG Compound Water Mast Cells Release Histamine SubPathway Guanine nucleotide-binding protein G(q) subunit alpha 1.0 SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Histamine H1 receptor C8H12N2 Betahistine 136.10005 TransportCatalysis922 ACTIVATION 4.0 Cytoplasm 1.0 P59768 UniProt HMDB0015644 HMDB Histamine Homo sapiens Reaction101579 false Histamine H1 receptor (Homo sapiens) + Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens) → Guanosine triphosphate + Gαq (Homo sapiens) + Gβγ + Histamine + Histamine H1 receptor (Homo sapiens) LEFT_TO_RIGHT 2366 PubChem-compound Reaction100922 false Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT CHEBI:35677 ChEBI 7732-18-5 CAS CHEBI:16595 ChEBI Q9NQ66 UniProt 439456 PubChem-compound 1.0 1.0 85166-31-0 CAS GO:0005783 GENE ONTOLOGY Betahistine Interaction241 Guanosine triphosphate + Gαq (Homo sapiens) activates Phospholipase C, beta 1 774 PubChem-compound Interaction240 Histamine activates Histamine H1 receptor (Homo sapiens) + Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens) Interaction243 1,2-diacyl-sn-glycerol activates protein kinase C beta Interaction242 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 Interaction245 protein kinase C beta activates Nuclear factor NF-kappa-B p105 subunit Interaction244 Calcium activates protein kinase C beta P19838 UniProt Nuclear factor NF-kappa-B p105 subunit Inositol 1,4,5-trisphosphate receptor type 1 Guanine nucleotide-binding protein G(q) subunit alpha 8977 PubChem-compound Inositol 1,4,5-trisphosphate Histamine_Histamine H1 receptor (Homo sapiens) 6830 PubChem-compound ReactionCatalysis91035 ACTIVATION PW061694 PathWhiz 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 C10H15N5O11P2 Guanosine diphosphate 443.02432 HMDB0001498 HMDB 266 ChemSpider SMILES CNCCC1=CC=CC=N1 1.0 Inositol 1,4,5-trisphosphate receptor type 1 1.0 9606 TAXONOMY 962 PubChem-compound 4.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 Guanosine triphosphate P62873 UniProt 5638-76-6 CAS C00076 KEGG Compound 8630 ChemSpider CA%2b2 BioCyc GO:0005886 GENE ONTOLOGY Histamine H1 receptor (Homo sapiens)_Gαq (Homo sapiens)_Guanosine diphosphate_Gβγ (Homo sapiens) Histamine H1 receptor Ca Calcium 39.96259 Histamine 1.0 HMDB0002111 HMDB inositol_1,4,5-trisphosphate BioCyc 1,2-diacyl-sn-glycerol Cell Membrane CHEBI:15377 ChEBI P35367 UniProt 6569 ChemSpider C00001 KEGG Compound HISTAMINE BioCyc 271 PubChem-compound CHEBI:17552 ChEBI SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 1.0 1.0 GTP BioCyc C00641 KEGG Compound Interaction308 Betahistine inhibits Histamine + Histamine H1 receptor (Homo sapiens) 388562 ChemSpider HMDB0000464 HMDB SMP0060744 SMPDB GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Protein kinase C beta type 1,2-diacyl-sn-glycerol P50148 UniProt Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY HMDB0001273 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 Transport1035 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 2276 ChemSpider CHEBI:18295 ChEBI Gβγ HMDB0001201 HMDB HMDB0000870 HMDB 753 ChemSpider H2O Water 18.010565 14127-61-8 CAS SMILES [Ca++] C5H9N3 Histamine 111.07965 phosphatidylinositol 4,5-bisphosphate 86-01-1 CAS Guanosine triphosphate_Gαq (Homo sapiens) Nucleus Betahistine H1-Antihistamine Action Histamine H1 receptor CHEBI:15996 ChEBI 1.0 Calcium Inositol 1,4,5-trisphosphate receptor type 1 1.0 C00388 KEGG Compound C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 1.0 CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY 146-91-8 CAS Histamine_Histamine H1 receptor (Homo sapiens) 1.0 phosphatidylinositol 4,5-bisphosphate Endoplasmic Reticulum GNG2 GNB1 PLCB1 ITPR1 PRKCB NFKB1 GNG2 HRH1 GNAQ GNAQ HRH1 GNB1 Histamine Inositol 1,4,5- trisphosphate Calcium Betahistine Calcium Water Guanosine diphosphate Guanosine triphosphate Histamine 1,2-diacyl- sn-glycerol phosphatidylinositol 4,5- bisphosphate Mast Cells Release Histamine