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Q14643 UniProt Protein kinase C beta type Nuclear factor NF-kappa-B p105 subunit Inositol 1,4,5-trisphosphate receptor type 1 C04637 KEGG Compound Reaction110904 false phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Protein kinase C alpha type Transcription factor p65 28935 ChemSpider P28482 UniProt C01245 KEGG Compound direct_interaction Voltage-dependent L-type calcium channel subunit alpha-1S 1.0 Inositol 1,4,5-trisphosphate receptor type 1 Dual specificity mitogen-activated protein kinase kinase 1 Calcium Mitogen-activated protein kinase NF-kappa-B inhibitor alpha CHEBI:48775 ChEBI Voltage-dependent L-type calcium channel subunit alpha-1D P05771 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C 31193 PubChem-compound P04049 UniProt Diacylglycerol SMILES [Cd++] C01413 KEGG Compound 4.0 Cytoplasm Interaction470 Protein kinase C complex activates Protein kinase C complex Interaction472 NFKBIA, NFKB1, RELA complex activates NF-kappa-B inhibitor alpha Protein kinase C alpha type Interaction471 Protein kinase C complex activates NFKBIA, NFKB1, RELA complex Interaction474 Protein kinase C complex activates Nuclear factor NF-kappa-B p105 subunit with GDP and P Interaction473 NFKBIA, NFKB1, RELA complex activates NFKB1,RELA complex Voltage-dependent L-type calcium channel subunit alpha-1C Interaction475 Nuclear factor NF-kappa-B p105 subunit with GDP and P activates GTPase HRas with GTP Homo sapiens 4.0 NF-kappa-B inhibitor alpha GTPase HRas Q9NQ66 UniProt CD%2b2 BioCyc SMP0063805 SMPDB Q13936 UniProt Voltage-dependent L-type calcium channel subunit alpha-1F Voltage-dependent L-type calcium channel subunit alpha-1D Cadmium Interaction481 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinases Interaction483 Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase Interaction482 RAF proto-oncogene serine/threonine-protein kinases activates Dual specificity mitogen-activated protein kinase kinase 1 Voltage-dependent L-type calcium channel subunit alpha-1F Diacylglycerol P01112 UniProt Interaction487 Voltage-dependent L-type calcium channel activates Cadmium Interaction486 Calcium activates Nuclear factor NF-kappa-B p105 subunit with GDP and P inositol 1,4,5-trisphosphate P19838 UniProt Interaction489 Inositol 1,4,5-trisphosphate receptor type 1 activates Calcium Dual specificity mitogen-activated protein kinase kinase 1 Interaction488 Cadmium activates Voltage-dependent L-type calcium channel Inositol 1,4,5-trisphosphate receptor type 1 Inositol 1,4,5-trisphosphate receptor type 1 Diacylglycerol Mitogen-activated protein kinase 3 Q04206 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Inositol 1,4,5-trisphosphate receptor type 1 PW064798 PathWhiz 266 ChemSpider Mitogen-activated protein kinase 1 P17252 UniProt Interaction490 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates phosphatidylinositol 4,5-bisphosphate Voltage-dependent L-type calcium channel subunit alpha-1S 9606 TAXONOMY Voltage-dependent L-type calcium channel subunit alpha-1F Interaction493 Diacylglycerol activates Inositol 1,4,5-trisphosphate receptor type 1 Protein kinase C complex Mitogen-activated protein kinase 1 C00076 KEGG Compound 1.0 CA%2b2 BioCyc GO:0005886 GENE ONTOLOGY 22537-48-0 CAS 1.0 Ca Calcium 39.96259 Cell Membrane NFKBIA, NFKB1, RELA complex Nuclear factor NF-kappa-B p105 subunit 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase Transcription factor p65 HMDB0000464 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 O60840 UniProt Protein kinase C beta type P25963 UniProt Nuclear factor NF-kappa-B p105 subunit Cadmium Induces DNA Synthesis and Proliferation in Macrophages NFKB1,RELA complex Q01668 UniProt Voltage-dependent L-type calcium channel subunit alpha-1S Voltage-dependent L-type calcium channel subunit alpha-1D phosphatidylinositol 4,5-bisphosphate Q02750 UniProt 14127-61-8 CAS SMILES [Ca++] Q13698 UniProt GTPase HRas Voltage-dependent L-type calcium channel Voltage-dependent L-type calcium channel subunit alpha-1C inositol 1,4,5-trisphosphate Cadmium GTPase HRas Cd Cadmium 113.90336 P27361 UniProt RAF proto-oncogene serine/threonine-protein kinase Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI HMDB0003638 HMDB phosphatidylinositol 4,5-bisphosphate Voltage-dependent L-type calcium channel Proto-oncogene c-Fos Transcription factor AP-1 Myc proto-oncogene protein CUB and zona pellucida-like domain- containing protein 1 Tumor necrosis factor Protein kinase C alpha type Protein kinase C beta type Protein kinase C alpha type Protein kinase C beta type Nuclear factor NF-kappa-B p105 subunit Transcription factor p65 NF-kappa-B inhibitor alpha NF-kappa-B inhibitor alpha Nuclear factor NF-kappa-B p105 subunit Transcription factor p65 Nuclear factor NF-kappa-B p105 subunit GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 1 Mitogen- activated protein kinase 3 Voltage- dependent L-type calcium channel subunit alpha-1D Voltage- dependent L-type calcium channel subunit alpha-1S Voltage- dependent L-type calcium channel subunit alpha-1F Voltage- dependent L-type calcium channel subunit alpha-1C Inositol 1,4,5- trisphosphate receptor type 1 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Ca + Cadmium Cadmium Guanosine diphosphate Phosphate ion Guanosine triphosphate Diacylglycerol phosphatidylinositol 4,5- bisphosphate inositol 1,4,5- trisphosphate IL4 Pathway; IL10 Pathway; Cell Proliferation; Reduced Phagocytic Activity Extracellular Cytoplasm Putative Cadmium Binding Protein? Nucleus
Q14643 UniProt Protein kinase C beta type Nuclear factor NF-kappa-B p105 subunit Inositol 1,4,5-trisphosphate receptor type 1 C04637 KEGG Compound Reaction110904 false phosphatidylinositol 4,5-bisphosphate → Diacylglycerol + inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Protein kinase C alpha type Transcription factor p65 28935 ChemSpider P28482 UniProt C01245 KEGG Compound direct_interaction Voltage-dependent L-type calcium channel subunit alpha-1S 1.0 Inositol 1,4,5-trisphosphate receptor type 1 Dual specificity mitogen-activated protein kinase kinase 1 Calcium Mitogen-activated protein kinase NF-kappa-B inhibitor alpha CHEBI:48775 ChEBI Voltage-dependent L-type calcium channel subunit alpha-1D P05771 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C 31193 PubChem-compound P04049 UniProt Diacylglycerol SMILES [Cd++] C01413 KEGG Compound 4.0 Cytoplasm Interaction470 Protein kinase C complex activates Protein kinase C complex Interaction472 NFKBIA, NFKB1, RELA complex activates NF-kappa-B inhibitor alpha Protein kinase C alpha type Interaction471 Protein kinase C complex activates NFKBIA, NFKB1, RELA complex Interaction474 Protein kinase C complex activates Nuclear factor NF-kappa-B p105 subunit with GDP and P Interaction473 NFKBIA, NFKB1, RELA complex activates NFKB1,RELA complex Voltage-dependent L-type calcium channel subunit alpha-1C Interaction475 Nuclear factor NF-kappa-B p105 subunit with GDP and P activates GTPase HRas with GTP Homo sapiens 4.0 NF-kappa-B inhibitor alpha GTPase HRas Q9NQ66 UniProt CD%2b2 BioCyc SMP0063805 SMPDB Q13936 UniProt Voltage-dependent L-type calcium channel subunit alpha-1F Voltage-dependent L-type calcium channel subunit alpha-1D Cadmium Interaction481 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinases Interaction483 Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase Interaction482 RAF proto-oncogene serine/threonine-protein kinases activates Dual specificity mitogen-activated protein kinase kinase 1 Voltage-dependent L-type calcium channel subunit alpha-1F Diacylglycerol P01112 UniProt Interaction487 Voltage-dependent L-type calcium channel activates Cadmium Interaction486 Calcium activates Nuclear factor NF-kappa-B p105 subunit with GDP and P inositol 1,4,5-trisphosphate P19838 UniProt Interaction489 Inositol 1,4,5-trisphosphate receptor type 1 activates Calcium Dual specificity mitogen-activated protein kinase kinase 1 Interaction488 Cadmium activates Voltage-dependent L-type calcium channel Inositol 1,4,5-trisphosphate receptor type 1 Inositol 1,4,5-trisphosphate receptor type 1 Diacylglycerol Mitogen-activated protein kinase 3 Q04206 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Inositol 1,4,5-trisphosphate receptor type 1 PW064798 PathWhiz 266 ChemSpider Mitogen-activated protein kinase 1 P17252 UniProt Interaction490 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates phosphatidylinositol 4,5-bisphosphate Voltage-dependent L-type calcium channel subunit alpha-1S 9606 TAXONOMY Voltage-dependent L-type calcium channel subunit alpha-1F Interaction493 Diacylglycerol activates Inositol 1,4,5-trisphosphate receptor type 1 Protein kinase C complex Mitogen-activated protein kinase 1 C00076 KEGG Compound 1.0 CA%2b2 BioCyc GO:0005886 GENE ONTOLOGY 22537-48-0 CAS 1.0 Ca Calcium 39.96259 Cell Membrane NFKBIA, NFKB1, RELA complex Nuclear factor NF-kappa-B p105 subunit 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase Transcription factor p65 HMDB0000464 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 O60840 UniProt Protein kinase C beta type P25963 UniProt Nuclear factor NF-kappa-B p105 subunit Cadmium Induces DNA Synthesis and Proliferation in Macrophages NFKB1,RELA complex Q01668 UniProt Voltage-dependent L-type calcium channel subunit alpha-1S Voltage-dependent L-type calcium channel subunit alpha-1D phosphatidylinositol 4,5-bisphosphate Q02750 UniProt 14127-61-8 CAS SMILES [Ca++] Q13698 UniProt GTPase HRas Voltage-dependent L-type calcium channel Voltage-dependent L-type calcium channel subunit alpha-1C inositol 1,4,5-trisphosphate Cadmium GTPase HRas Cd Cadmium 113.90336 P27361 UniProt RAF proto-oncogene serine/threonine-protein kinase Mitogen-activated protein kinase 3 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI HMDB0003638 HMDB phosphatidylinositol 4,5-bisphosphate Voltage-dependent L-type calcium channel FOS JUN MYC Unknown TNF PRKCA PRKCB PRKCA PRKCB NFKB1 RELA NFKBIA NFKBIA NFKB1 RELA NFKB1 HRAS RAF1 MAP2K1 MAPK1 MAPK3 CACNA1D CACNA1S CACNA1F CACNA1C ITPR1 PLCB1 Calcium Cadmium Cadmium Diacylglycerol phosphatidylinositol 4,5- bisphosphate inositol 1,4,5- trisphosphate