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P06213 UniProt 937 ChemSpider Tyrosine-protein kinase JAK2 P28482 UniProt direct_interaction Dual specificity mitogen-activated protein kinase kinase 1 SMILES O Insulin receptor Mitogen-activated protein kinase P04049 UniProt Ribosomal protein S6 kinase alpha-1 P35568 UniProt 1.0 Insulin receptor substrate 1 1.0 Ribosomal protein S6 kinase alpha-1 P29353 UniProt Interaction230 Tyrosine-protein kinase JAK2 activates STAT5A homodimer complex 1.0 Signal transducer and activator of transcription 5B P29350 UniProt 2280-44-6 CAS Insulin 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Protein kinase C alpha type P01112 UniProt 1.0 Interaction369 Insulin activates Insulin receptor 266 ChemSpider Mitogen-activated protein kinase 1 P17252 UniProt 1.0 Interaction374 Growth hormone 1 activates Growth hormone receptor Mitogen-activated protein kinase 1 P10912 UniProt Growth factor receptor-bound protein 2 1.0 O15524 UniProt C6H12O6 D-Glucose 180.06339 Ribosomal protein S6 kinase alpha-1 C00001 KEGG Compound Tyrosine-protein kinase JAK2 GLC BioCyc Signal transducer and activator of transcription 5A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Signal transducer and activator of transcription 5B Q07889 UniProt HMDB0000464 HMDB PW064811 PathWhiz PIP2 Growth Hormone Signaling Pathway Growth factor receptor-bound protein 2 GO:0005634 GENE ONTOLOGY P19174 UniProt Insulin Son of sevenless homolog 1 Son of sevenless homolog 1 Extracellular Space P01308 UniProt Q02750 UniProt Tyrosine-protein phosphatase non-receptor type 6 14127-61-8 CAS SMILES [Ca++] Water Growth hormone receptor Somatotropin GTPase HRas Calcium P27361 UniProt HMDB0000122 HMDB RAF proto-oncogene serine/threonine-protein kinase GO:0005615 GENE ONTOLOGY CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY P51692 UniProt Transport1179 false Ribosomal protein S6 kinase alpha-1 (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT Signal transducer and activator of transcription 5A PI3K C00031 KEGG Compound Growth hormone receptor 1.0 Calcium Transport1181 false STAT5B homodimer complex (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT PIP3 Transport1180 false STAT5A homodimer complex (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT D-Glucose Tyrosine-protein phosphatase non-receptor type 6 PIP2 Diacylglycerol PI3K Interaction500 Mitogen-activated protein kinase activates Ribosomal protein S6 kinase alpha-1 Interaction745 PIP2 activates PIP3 Interaction506 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 activates PIP2 Interaction508 PIP2 activates Diacylglycerol Interaction507 Water activates PIP2 Interaction509 Diacylglycerol activates Protein kinase C Cytoplasm Transport1172 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 5589 ChemSpider Homo sapiens Interaction511 Protein kinase C activates STAT5A homodimer complex Interaction510 Protein kinase C activates Calcium Interaction512 Protein kinase C activates STAT5B homodimer complex Insulin 7732-18-5 CAS Suppressor of cytokine signaling 1 Solute carrier family 2, facilitated glucose transporter member 4 Interaction516 Growth hormone receptor activates Tyrosine-protein kinase JAK2 O60674 UniProt SMP0063807 SMPDB Interaction518 protein tyrosine phosphatase, non-receptor type 6 inhibits Tyrosine-protein kinase JAK2 Interaction520 Suppressor of cytokine signaling 1 inhibits Tyrosine-protein kinase JAK2 Interaction522 Tyrosine-protein kinase JAK2 activates STAT5B homodimer complex Somatotropin Dual specificity mitogen-activated protein kinase kinase 1 Diacylglycerol Mitogen-activated protein kinase 3 Interaction528 Tyrosine-protein kinase JAK2 activates Insulin receptor substrate 1 Interaction529 Insulin receptor substrate 1 activates PI3K GO:0016020 GENE ONTOLOGY 9606 TAXONOMY 962 PubChem-compound P01241 UniProt Interaction531 D-Glucose activates Solute carrier family 2, facilitated glucose transporter member 4 Interaction530 PI3K activates Solute carrier family 2, facilitated glucose transporter member 4 Interaction533 Growth factor receptor-bound protein 2 activates Son of sevenless homolog 1 Interaction532 SHC-transforming protein 1 activates Growth factor receptor-bound protein 2 C00076 KEGG Compound SHC-transforming protein 1 P62993 UniProt Interaction534 Son of sevenless homolog 1 activates GTPase HRas with GTP Insulin receptor substrate 1 Interaction536 Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase PIP3 CA%2b2 BioCyc P14672 UniProt Ca Calcium 39.96259 Q15418 UniProt PIP2 HMDB0002111 HMDB Diacylglycerol Solute carrier family 2, facilitated glucose transporter member 4 CHEBI:15377 ChEBI Interaction420 RAF proto-oncogene serine/threonine-protein kinase activates Active Dual specificity mitogen-activated protein kinase kinase 1 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase Signal transducer and activator of transcription 5B CHEBI:4167 ChEBI Suppressor of cytokine signaling 1 Membrane 5793 PubChem-compound 2.0 PI3K Insulin receptor SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O H2O Water 18.010565 Protein kinase C alpha type Growth hormone receptor Nucleus Interaction201 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase Signal transducer and activator of transcription 5A SHC-transforming protein 1 GTPase HRas Protein kinase C alpha type Solute carrier family 2, facilitated glucose transporter member 4 Mitogen-activated protein kinase 3 1.0 P42229 UniProt Hepatocyte nuclear factor 1-alpha Serum response factor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Protein kinase C alpha type Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Somatotropin Growth hormone receptor Tyrosine- protein kinase JAK2 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B Insulin receptor substrate 1 Solute carrier family 2, facilitated glucose transporter member 4 Insulin Insulin receptor SHC- transforming protein 1 Growth factor receptor-bound protein 2 Son of sevenless homolog 1 GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 1 Mitogen- activated protein kinase 3 Ribosomal protein S6 kinase alpha-1 Suppressor of cytokine signaling 1 Tyrosine- protein phosphatase non-receptor type 6 Ribosomal protein S6 kinase alpha-1 Signal transducer and activator of transcription 5A Signal transducer and activator of transcription 5B H 2 O Ca + D-Glucose Ca + Ca + P i P i P i P i PIP2 PIP2 Diacylglycerol PI3K PIP3 Calcium release- activated calcium channel protein 1 Solute carrier family 2, facilitated glucose transporter member 4 G-Protein Gamma-Activated sequence Insulin Receptor Pathway Sis-inducible element serum-responsive element spi2.1 gene c-fos gene Extracellular Cytoplasm Nucleus
P06213 UniProt 937 ChemSpider Tyrosine-protein kinase JAK2 P28482 UniProt direct_interaction Dual specificity mitogen-activated protein kinase kinase 1 SMILES O Insulin receptor Mitogen-activated protein kinase P04049 UniProt Ribosomal protein S6 kinase alpha-1 P35568 UniProt 1.0 Insulin receptor substrate 1 1.0 Ribosomal protein S6 kinase alpha-1 P29353 UniProt Interaction230 Tyrosine-protein kinase JAK2 activates STAT5A homodimer complex 1.0 Signal transducer and activator of transcription 5B P29350 UniProt 2280-44-6 CAS Insulin 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Protein kinase C alpha type P01112 UniProt 1.0 Interaction369 Insulin activates Insulin receptor 266 ChemSpider Mitogen-activated protein kinase 1 P17252 UniProt 1.0 Interaction374 Growth hormone 1 activates Growth hormone receptor Mitogen-activated protein kinase 1 P10912 UniProt Growth factor receptor-bound protein 2 1.0 O15524 UniProt C6H12O6 D-Glucose 180.06339 Ribosomal protein S6 kinase alpha-1 C00001 KEGG Compound Tyrosine-protein kinase JAK2 GLC BioCyc Signal transducer and activator of transcription 5A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Signal transducer and activator of transcription 5B Q07889 UniProt HMDB0000464 HMDB PW064811 PathWhiz PIP2 Growth Hormone Signaling Pathway Growth factor receptor-bound protein 2 GO:0005634 GENE ONTOLOGY P19174 UniProt Insulin Son of sevenless homolog 1 Son of sevenless homolog 1 Extracellular Space P01308 UniProt Q02750 UniProt Tyrosine-protein phosphatase non-receptor type 6 14127-61-8 CAS SMILES [Ca++] Water Growth hormone receptor Somatotropin GTPase HRas Calcium P27361 UniProt HMDB0000122 HMDB RAF proto-oncogene serine/threonine-protein kinase GO:0005615 GENE ONTOLOGY CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY P51692 UniProt Transport1179 false Ribosomal protein S6 kinase alpha-1 (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT Signal transducer and activator of transcription 5A PI3K C00031 KEGG Compound Growth hormone receptor 1.0 Calcium Transport1181 false STAT5B homodimer complex (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT PIP3 Transport1180 false STAT5A homodimer complex (?) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT D-Glucose Tyrosine-protein phosphatase non-receptor type 6 PIP2 Diacylglycerol PI3K Interaction500 Mitogen-activated protein kinase activates Ribosomal protein S6 kinase alpha-1 Interaction745 PIP2 activates PIP3 Interaction506 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 activates PIP2 Interaction508 PIP2 activates Diacylglycerol Interaction507 Water activates PIP2 Interaction509 Diacylglycerol activates Protein kinase C Cytoplasm Transport1172 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 5589 ChemSpider Homo sapiens Interaction511 Protein kinase C activates STAT5A homodimer complex Interaction510 Protein kinase C activates Calcium Interaction512 Protein kinase C activates STAT5B homodimer complex Insulin 7732-18-5 CAS Suppressor of cytokine signaling 1 Solute carrier family 2, facilitated glucose transporter member 4 Interaction516 Growth hormone receptor activates Tyrosine-protein kinase JAK2 O60674 UniProt SMP0063807 SMPDB Interaction518 protein tyrosine phosphatase, non-receptor type 6 inhibits Tyrosine-protein kinase JAK2 Interaction520 Suppressor of cytokine signaling 1 inhibits Tyrosine-protein kinase JAK2 Interaction522 Tyrosine-protein kinase JAK2 activates STAT5B homodimer complex Somatotropin Dual specificity mitogen-activated protein kinase kinase 1 Diacylglycerol Mitogen-activated protein kinase 3 Interaction528 Tyrosine-protein kinase JAK2 activates Insulin receptor substrate 1 Interaction529 Insulin receptor substrate 1 activates PI3K GO:0016020 GENE ONTOLOGY 9606 TAXONOMY 962 PubChem-compound P01241 UniProt Interaction531 D-Glucose activates Solute carrier family 2, facilitated glucose transporter member 4 Interaction530 PI3K activates Solute carrier family 2, facilitated glucose transporter member 4 Interaction533 Growth factor receptor-bound protein 2 activates Son of sevenless homolog 1 Interaction532 SHC-transforming protein 1 activates Growth factor receptor-bound protein 2 C00076 KEGG Compound SHC-transforming protein 1 P62993 UniProt Interaction534 Son of sevenless homolog 1 activates GTPase HRas with GTP Insulin receptor substrate 1 Interaction536 Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase PIP3 CA%2b2 BioCyc P14672 UniProt Ca Calcium 39.96259 Q15418 UniProt PIP2 HMDB0002111 HMDB Diacylglycerol Solute carrier family 2, facilitated glucose transporter member 4 CHEBI:15377 ChEBI Interaction420 RAF proto-oncogene serine/threonine-protein kinase activates Active Dual specificity mitogen-activated protein kinase kinase 1 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase Signal transducer and activator of transcription 5B CHEBI:4167 ChEBI Suppressor of cytokine signaling 1 Membrane 5793 PubChem-compound 2.0 PI3K Insulin receptor SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O H2O Water 18.010565 Protein kinase C alpha type Growth hormone receptor Nucleus Interaction201 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase Signal transducer and activator of transcription 5A SHC-transforming protein 1 GTPase HRas Protein kinase C alpha type Solute carrier family 2, facilitated glucose transporter member 4 Mitogen-activated protein kinase 3 1.0 P42229 UniProt Nucleus HNF1A SRF PLCG1 PRKCA STAT5A STAT5B GH1 GHR JAK2 STAT5A STAT5B Unknown SLC2A4 Unknown INSR Unknown GRB2 SOS1 HRAS RAF1 MAP2K1 MAPK1 MAPK3 RPS6KA1 SOCS1 PTPN6 RPS6KA1 STAT5A STAT5B Water Calcium D-Glucose Calcium Calcium Phosphate Phosphate Phosphate Phosphate PIP2 PIP2 Diacylglycerol PI3K PIP3 ORAI1 SLC2A4