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TransportCatalysis121 ACTIVATION TransportCatalysis120 ACTIVATION 51-41-2 CAS 923 PubChem-compound HMDB00259 HMDB C21H28N2OS 3-Methylthiofentanyl 356.19223 1.0 Dopamine Serotonin TransportCatalysis118 ACTIVATION 1.0 TransportCatalysis117 ACTIVATION TransportCatalysis116 ACTIVATION P01203 UniProt 1.0 Sodium-dependent noradrenaline transporter SubPathwayControl492 SubPathway492Control ActivatingSubPathwayControl SubPathwayControl493 ActivatingSubPathwayControl SubPathway493Control P31645 UniProt Alpha-1A adrenergic receptor Q01959 UniProt Pro-opiomelanocortin SMILES [Na+] Neuronal acetylcholine receptor subunit beta-2 SMILES [K+] Neuronal acetylcholine receptor subunit alpha-4 Glutamate [NMDA] receptor subunit 3A Neuroendocrine convertase 2 P21728 UniProt Q12879 UniProt TransportCatalysis127 ACTIVATION Q8TCU5 UniProt TransportCatalysis126 ACTIVATION TransportCatalysis125 ACTIVATION TransportCatalysis123 ACTIVATION TransportCatalysis122 ACTIVATION Voltage Gated Potassium Channel Sodium channel 1.0 1.0 L type Calcium channel 1.0 Nicotinic Acetylcholine Receptor 1.0 Dopamine SubPathwayActivator Sodium channel subunit beta-1 Sodium-dependent serotonin transporter 4.0 50-67-9 CAS Beta-endorphin 813 PubChem-compound P35348 UniProt Sodium channel protein type 10 subunit alpha 86052-04-2 CAS 1.0 Glutamate receptor ionotropic 266 ChemSpider 2.0 Norepinephrine C8H11NO3 Norepinephrine 169.0739 Transport154 false Potassium (→) Transport: Homo sapiens, Neuron, Cytoplasm to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT Transport153 false Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm LEFT_TO_RIGHT C00238 KEGG Compound CHEBI:18357 ChEBI Transport155 false Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm LEFT_TO_RIGHT 2.0 HMDB00216 HMDB 1.0 Q9NZV8 UniProt 681 PubChem-compound P17787 UniProt GO:0005886 GENE ONTOLOGY BiologicalState74 BiologicalState73 PW000656 PathWhiz 1.0 BiologicalState71 Transport158 false Norepinephrine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT Transport157 false Beta-endorphin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT Transport159 false Serotonin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT HMDB00464 HMDB Voltage-dependent calcium channel subunit alpha-2/delta-2 HMDB00586 HMDB HMDB00588 HMDB Transport161 false Norepinephrine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron LEFT_TO_RIGHT Transport160 false Serotonin (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Neuron LEFT_TO_RIGHT C03758 KEGG Compound Transport163 false Dopamine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron LEFT_TO_RIGHT 1.0 Transport162 false Dopamine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT 24203-36-9 CAS C01330 KEGG Compound Q05586 UniProt Q9NY47 UniProt CHEBI:18243 ChEBI CHEBI:53763 ChEBI SMILES NC[C@H](O)C1=CC(O)=C(O)C=C1 ReactionCatalysis1410 ACTIVATION Sodium-dependent noradrenaline transporter Neuroendocrine convertase 2 Neuronal acetylcholine receptor subunit alpha-4 Pro-opiomelanocortin CL:0000540 CELL TYPE ONTOLOGY D(1A) dopamine receptor Neuron Neuronal acetylcholine receptor subunit beta-2 Sodium-dependent dopamine transporter Voltage-dependent P/Q-type calcium channel subunit alpha-1A Extracellular Space Mu-type opioid receptor SubPathwayActivation 14127-61-8 CAS SMILES [Ca++] 1.0 C10H12N2O Serotonin 176.09496 Q9NS61 UniProt Norepinephrine SubPathwayActivator C8H11NO2 Dopamine 153.07898 Sodium-dependent serotonin transporter Calcium 1.0 Voltage-dependent L-type calcium channel subunit beta-1 Glutamate [NMDA] receptor subunit zeta-1 3-Methylthiofentanyl SubPathwayActivator Sodium GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 3-Methylthiofentanyl Action Pathway CHEBI:29101 ChEBI CHEBI:29103 ChEBI 3-Methylthiofentanyl activation of Mu-type opioid receptor ActivatingSubPathway Kv channel-interacting protein 2 Glutamate [NMDA] receptor subunit epsilon-1 1.0 Serotonin SubPathwayActivator 899 ChemSpider Sodium SMILES NCCC1=CC(O)=C(O)C=C1 SMILES NCCC1=CNC2=CC=C(O)C=C12 Calcium Q9Y5Y9 UniProt Potassium SMP00679 SMPDB Potassium voltage-gated channel subfamily D member 2 5-hydroxytryptamine receptor 1A SubPathwayActivation K%2b BioCyc 5202 PubChem-compound Q02641 UniProt Cytoplasm 1.0 1.0 17341-25-2 CAS 51-61-6 CAS P01189 UniProt HMDB00073 HMDB Beta-Endorphin activation of Mu-Type Receptor ActivatingSubPathway 1.0 Serotonin activate of 5-hydroxytryptamine receptor 1A ActivatingSubPathway Norepinephrine activation of Alpha-1A adrenergic receptor ActivatingSubPathway Alpha-1A adrenergic receptor SubPathwayActivation Dopamine activation of dopamine receptor ActivatingSubPathway 791 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 3.4.21.94 false 3.4.21.94 Pro-opiomelanocortin → Beta-endorphin LEFT_TO_RIGHT Beta-endorphin SubPathwayActivator NOREPINEPHRINE BioCyc 1.0 1.0 Sodium-dependent dopamine transporter Voltage-dependent P/Q-type calcium channel subunit alpha-1A DOPAMINE BioCyc Mu-type opioid receptor 661 ChemSpider 1.0 9606 TAXONOMY Glutamate [NMDA] receptor subunit zeta-1 Potassium 5-hydroxytryptamine receptor 1A Voltage-dependent L-type calcium channel subunit beta-1 388394 ChemSpider C00076 KEGG Compound P43681 UniProt CA%2b2 BioCyc Glutamate [NMDA] receptor subunit 3A 1.0 Ca Calcium 39.96259 P35372 UniProt O00555 UniProt Cell Membrane Sodium HMDB61718 HMDB Kv channel-interacting protein 2 271 PubChem-compound Glutamate [NMDA] receptor subunit epsilon-1 56092 ChemSpider Sodium channel subunit beta-1 CHEBI:28790 ChEBI 1.0 D(1A) dopamine receptor SubPathwayActivation Potassium voltage-gated channel subfamily D member 2 439260 PubChem-compound Beta-endorphin SMILES CCC(=O)N(C1CCN(CCC2=CC=CS2)CC1C)C1=CC=CC=C1 Q07699 UniProt P16519 UniProt P23975 UniProt Sodium channel protein type 10 subunit alpha 2.0 SubPathwayControl490 SubPathway490Control ActivatingSubPathwayControl SubPathwayControl491 SubPathway491Control ActivatingSubPathwayControl 4.0 C00547 KEGG Compound Na Sodium 22.989769 62296 PubChem-compound K Potassium 38.963707 5013 ChemSpider C00780 KEGG Compound Mu-type opioid receptor SubPathwayActivation SubPathwayControl915 SubPathway915Control ActivatingSubPathwayControl 1.0 P08908 UniProt Mu-type opioid receptor Alpha-1A adrenergic receptor 5- hydroxytryptamine receptor 1A D(1A) dopamine receptor Beta-endorphin Mu-type opioid receptor Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-4 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Sodium channel protein type 10 subunit alpha Sodium channel subunit beta-1 Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Beta-endorphin Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit 3A Sodium- dependent noradrenaline transporter Sodium- dependent serotonin transporter Sodium- dependent dopamine transporter Pro- opiomelanocortin Neuroendocrine convertase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma 3-Methylthiofentanyl Norepinephrine Serotonin Dopamine Ca + Ca + Na + Na + K + K + Ca + Ca + Na + K + Ca + Ca + Norepinephrine Serotonin Na + Na + Na + Na + Dopamine Na + Na + ATP H 2 O Na + K + ADP P i Na + K + Synaptic Vesicle
TransportCatalysis121 ACTIVATION TransportCatalysis120 ACTIVATION 51-41-2 CAS 923 PubChem-compound HMDB00259 HMDB C21H28N2OS 3-Methylthiofentanyl 356.19223 1.0 Dopamine Serotonin TransportCatalysis118 ACTIVATION 1.0 TransportCatalysis117 ACTIVATION TransportCatalysis116 ACTIVATION P01203 UniProt 1.0 Sodium-dependent noradrenaline transporter SubPathwayControl492 SubPathway492Control ActivatingSubPathwayControl SubPathwayControl493 ActivatingSubPathwayControl SubPathway493Control P31645 UniProt Alpha-1A adrenergic receptor Q01959 UniProt Pro-opiomelanocortin SMILES [Na+] Neuronal acetylcholine receptor subunit beta-2 SMILES [K+] Neuronal acetylcholine receptor subunit alpha-4 Glutamate [NMDA] receptor subunit 3A Neuroendocrine convertase 2 P21728 UniProt Q12879 UniProt TransportCatalysis127 ACTIVATION Q8TCU5 UniProt TransportCatalysis126 ACTIVATION TransportCatalysis125 ACTIVATION TransportCatalysis123 ACTIVATION TransportCatalysis122 ACTIVATION Voltage Gated Potassium Channel Sodium channel 1.0 1.0 L type Calcium channel 1.0 Nicotinic Acetylcholine Receptor 1.0 Dopamine SubPathwayActivator Sodium channel subunit beta-1 Sodium-dependent serotonin transporter 4.0 50-67-9 CAS Beta-endorphin 813 PubChem-compound P35348 UniProt Sodium channel protein type 10 subunit alpha 86052-04-2 CAS 1.0 Glutamate receptor ionotropic 266 ChemSpider 2.0 Norepinephrine C8H11NO3 Norepinephrine 169.0739 Transport154 false Potassium (→) Transport: Homo sapiens, Neuron, Cytoplasm to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT Transport153 false Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm LEFT_TO_RIGHT C00238 KEGG Compound CHEBI:18357 ChEBI Transport155 false Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm LEFT_TO_RIGHT 2.0 HMDB00216 HMDB 1.0 Q9NZV8 UniProt 681 PubChem-compound P17787 UniProt GO:0005886 GENE ONTOLOGY BiologicalState74 Homo sapiens, Neuron BiologicalState73 Homo sapiens, Neuron, Cell Membrane PW000656 PathWhiz 1.0 BiologicalState71 Homo sapiens, Neuron, Extracellular Space Transport158 false Norepinephrine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT Transport157 false Beta-endorphin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT Transport159 false Serotonin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT HMDB00464 HMDB Voltage-dependent calcium channel subunit alpha-2/delta-2 HMDB00586 HMDB HMDB00588 HMDB Transport161 false Norepinephrine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron LEFT_TO_RIGHT Transport160 false Serotonin (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Neuron LEFT_TO_RIGHT C03758 KEGG Compound Transport163 false Dopamine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron LEFT_TO_RIGHT 1.0 Transport162 false Dopamine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space LEFT_TO_RIGHT 24203-36-9 CAS C01330 KEGG Compound Q05586 UniProt Q9NY47 UniProt CHEBI:18243 ChEBI CHEBI:53763 ChEBI SMILES NC[C@H](O)C1=CC(O)=C(O)C=C1 ReactionCatalysis1410 ACTIVATION Sodium-dependent noradrenaline transporter Neuroendocrine convertase 2 Neuronal acetylcholine receptor subunit alpha-4 Pro-opiomelanocortin CL:0000540 CELL TYPE ONTOLOGY D(1A) dopamine receptor Neuron Neuronal acetylcholine receptor subunit beta-2 Sodium-dependent dopamine transporter Voltage-dependent P/Q-type calcium channel subunit alpha-1A Extracellular Space Mu-type opioid receptor SubPathwayActivation 14127-61-8 CAS SMILES [Ca++] 1.0 C10H12N2O Serotonin 176.09496 Q9NS61 UniProt Norepinephrine SubPathwayActivator C8H11NO2 Dopamine 153.07898 Sodium-dependent serotonin transporter Calcium 1.0 Voltage-dependent L-type calcium channel subunit beta-1 Glutamate [NMDA] receptor subunit zeta-1 3-Methylthiofentanyl SubPathwayActivator Sodium GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 3-Methylthiofentanyl Action Pathway CHEBI:29101 ChEBI CHEBI:29103 ChEBI 3-Methylthiofentanyl activation of Mu-type opioid receptor ActivatingSubPathway Kv channel-interacting protein 2 Glutamate [NMDA] receptor subunit epsilon-1 1.0 Serotonin SubPathwayActivator 899 ChemSpider Sodium SMILES NCCC1=CC(O)=C(O)C=C1 SMILES NCCC1=CNC2=CC=C(O)C=C12 Calcium Q9Y5Y9 UniProt Potassium http://identifiers.org/smpdb/SMP00679 SMPDB Potassium voltage-gated channel subfamily D member 2 5-hydroxytryptamine receptor 1A SubPathwayActivation K%2b BioCyc 5202 PubChem-compound Q02641 UniProt Cytoplasm 1.0 1.0 17341-25-2 CAS 51-61-6 CAS P01189 UniProt HMDB00073 HMDB Beta-Endorphin activation of Mu-Type Receptor ActivatingSubPathway 1.0 Serotonin activate of 5-hydroxytryptamine receptor 1A ActivatingSubPathway Norepinephrine activation of Alpha-1A adrenergic receptor ActivatingSubPathway Alpha-1A adrenergic receptor SubPathwayActivation Dopamine activation of dopamine receptor ActivatingSubPathway 791 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 3.4.21.94 false 3.4.21.94 Pro-opiomelanocortin → Beta-endorphin LEFT_TO_RIGHT Beta-endorphin SubPathwayActivator NOREPINEPHRINE BioCyc 1.0 1.0 Sodium-dependent dopamine transporter Voltage-dependent P/Q-type calcium channel subunit alpha-1A DOPAMINE BioCyc Mu-type opioid receptor 661 ChemSpider 1.0 9606 TAXONOMY Glutamate [NMDA] receptor subunit zeta-1 Potassium 5-hydroxytryptamine receptor 1A Voltage-dependent L-type calcium channel subunit beta-1 388394 ChemSpider C00076 KEGG Compound P43681 UniProt CA%2b2 BioCyc Glutamate [NMDA] receptor subunit 3A 1.0 Ca Calcium 39.96259 P35372 UniProt O00555 UniProt Cell Membrane Sodium HMDB61718 HMDB Kv channel-interacting protein 2 271 PubChem-compound Glutamate [NMDA] receptor subunit epsilon-1 56092 ChemSpider Sodium channel subunit beta-1 CHEBI:28790 ChEBI 1.0 D(1A) dopamine receptor SubPathwayActivation Potassium voltage-gated channel subfamily D member 2 439260 PubChem-compound Beta-endorphin SMILES CCC(=O)N(C1CCN(CCC2=CC=CS2)CC1C)C1=CC=CC=C1 Q07699 UniProt P16519 UniProt P23975 UniProt Sodium channel protein type 10 subunit alpha 2.0 SubPathwayControl490 SubPathway490Control ActivatingSubPathwayControl SubPathwayControl491 SubPathway491Control ActivatingSubPathwayControl 4.0 C00547 KEGG Compound Na Sodium 22.989769 62296 PubChem-compound K Potassium 38.963707 5013 ChemSpider C00780 KEGG Compound Mu-type opioid receptor SubPathwayActivation SubPathwayControl915 SubPathway915Control ActivatingSubPathwayControl 1.0 P08908 UniProt OPRM1 ADRA1A HTR1A DRD1 Unknown OPRM1 Unknown Unknown Unknown Unknown Unknown Unknown CACNA1A CACNB1 CACNA2D2 SCN10A SCN1B KCND2 KCNIP2 Unknown GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 Unknown Unknown ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 Unknown FXYD2 3- Methylthiofentanyl Norepinephrine Serotonin Dopamine Calcium Calcium Sodium Sodium Potassium Potassium Calcium Calcium Sodium Potassium Calcium Calcium Norepinephrine Serotonin Sodium Sodium Sodium Sodium Dopamine Sodium Sodium Adenosine triphosphate Water Sodium Potassium Adenosine diphosphate Phosphate Sodium Potassium Created with Snap