Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Small Molecule Pathway Database.
Loading Pathway...
C6H14O12P2 D-Fructose 2,6-bisphosphate 339.99606 HMDB01346 HMDB 6022 PubChem-compound 388350 ChemSpider 937 ChemSpider 18186-48-6 CAS HMDB00250 HMDB C3H6O3 Glyceraldehyde 90.03169 C00794 KEGG Compound HMDB01341 HMDB Sorbitol 439153 PubChem-compound 1.0 1.0 P50053 UniProt HMDB01112 HMDB HMDB06800 HMDB C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 C00325 KEGG Compound C02985 KEGG Compound ATP BioCyc 2.0 1.0 53188-23-1 CAS HMDB01473 HMDB 559142 ChemSpider Triosephosphate isomerase 388338 ChemSpider D-Fructose 2,6-bisphosphate 5742 ChemSpider P34949 UniProt MANNOSE-1P BioCyc CHEBI:16474 ChEBI SMP00040 SMPDB ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc SMP00045 SMPDB Guanosine triphosphate SMP00043 SMPDB HMDB00124 HMDB 1.0 HMDB00247 HMDB PW000159 PathWhiz 709 ChemSpider 27251-84-9 CAS 488-69-7 CAS PPI BioCyc 2438-80-4 CAS 1.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 388554 ChemSpider Q13630 UniProt C10H16N5O14P3 Guanosine triphosphate 522.99066 HMDB00217 HMDB C00111 KEGG Compound 1.0 Q00796 UniProt 50-70-4 CAS C00354 KEGG Compound P60174 UniProt P15121 UniProt 439198 PubChem-compound 94762 ChemSpider 7664-38-2 CAS Fructose 6-phosphate SubPathwayInput HMDB00221 HMDB C6H12O6 D-Fructose 180.06339 C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI 2.0 Fructose-bisphosphate aldolase B Phosphomannomutase 1 C00001 KEGG Compound CHEBI:18361 ChEBI C00005 KEGG Compound C00004 KEGG Compound C6H13O9P Beta-D-Fructose 2-phosphate 260.02972 CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADP C00002 KEGG Compound 193537 PubChem-compound MANNOSE-6P BioCyc C6H12O6 Alpha-D-Glucose 180.06339 HMDB01429 HMDB Q9NRX4 UniProt 1.0 C6H13O9P Fructose 1-phosphate 260.02972 388775 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 CHEBI:17009 ChEBI Adenosine triphosphate C01222 KEGG Compound P16118 UniProt O14772 UniProt Q92871 UniProt FRUCTOSE-6P BioCyc Fucose-1-phosphate guanylyltransferase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C(=O)N1 C6H13O9P Mannose 6-phosphate 260.02972 C00013 KEGG Compound L-fucose kinase 105021 PubChem-compound Sorbitol dehydrogenase 4.2.1.47 false 4.2.1.47 Guanosine diphosphate mannose → GDP-4-Dehydro-6-deoxy-D-mannose + Water LEFT_TO_RIGHT GDP-L-fucose synthase L-fucose kinase NAD(P) BioCyc 2.0 CHEBI:17138 ChEBI C6H13O8P Fucose 1-phosphate 244.0348 1.0 56-65-5 CAS 53-84-9 CAS C00267 KEGG Compound 62713 ChemSpider 644175 PubChem-compound Mannose-1-phosphate guanyltransferase beta CHEBI:26078 ChEBI GDP-mannose 4,6 dehydratase 1.0 C16H25N5O15P2 GDP-L-fucose 589.0822 10400369 PubChem-compound 3672-15-9 CAS CL:0000000 CELL TYPE ONTOLOGY C00275 KEGG Compound C6H13O9P D-Mannose 1-phosphate 260.02972 C02336 KEGG Compound C00159 KEGG Compound 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Alpha-D-Glucose SubPathwayInput Adenosine diphosphate Beta-D-Fructose 2-phosphate Guanosine diphosphate mannose SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 2.7.1.11 false 2.7.1.11 Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT 2.7.7.13 false 2.7.7.13 D-Mannose 1-phosphate + Guanosine triphosphate → Guanosine diphosphate mannose + Pyrophosphate LEFT_TO_RIGHT C01019 KEGG Compound 751 PubChem-compound 1.1.1.271 false 1.1.1.271 GDP-L-fucose + NADP ↔ GDP-4-Dehydro-6-deoxy-D-mannose + NADPH REVERSIBLE 5.3.1.8 false 5.3.1.8 Mannose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE 5.4.2.8 false 5.4.2.8 D-Mannose 1-phosphate ↔ Mannose 6-phosphate REVERSIBLE 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Mannose → Adenosine diphosphate + Mannose 6-phosphate LEFT_TO_RIGHT C00044 KEGG Compound 648 ChemSpider 2.7.1.52 false 2.7.1.52 Adenosine triphosphate + L-Fucose → Adenosine diphosphate + Fucose 1-phosphate LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE HMDB00660 HMDB 2.7.7.30 false 2.7.7.30 Fucose 1-phosphate + Guanosine triphosphate ↔ GDP-L-fucose + Pyrophosphate REVERSIBLE SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES C[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@@H](O)C1=O 6-phosphofructokinase, liver type 1.0 HMDB00538 HMDB 5.3.1.1 false 5.3.1.1 Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate REVERSIBLE 668 PubChem-compound GDP-L-fucose synthase 4.1.2.13 false 4.1.2.13 Fructose 1-phosphate ↔ Dihydroxyacetone phosphate + Glyceraldehyde REVERSIBLE 19046-69-6 CAS Hexokinase-1 7732-18-5 CAS 1.0 591-59-3 CAS Mannose 6-phosphate FRU1P BioCyc 492-62-6 CAS Adenosine diphosphate 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CPD-488 BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 445557 PubChem-compound Pyrophosphate SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SMILES OCC(=O)COP(O)(O)=O D-Fructose 962 PubChem-compound 5800 ChemSpider Fructose-1,6-bisphosphatase 1 GDP-L-fucose synthase 979 ChemSpider Fructose-1,6-bisphosphatase 1 Mannose-6-phosphate isomerase 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 731 ChemSpider H3O4P Phosphoric acid 97.9769 C00085 KEGG Compound 559210 ChemSpider C6H12O5 L-Fucose 164.06847 BiologicalState8 729 PubChem-compound C6H12O6 D-Mannose 180.06339 GUANOSINE_DIPHOSPHATE_FUCOSE BioCyc BiologicalState3 Fructose-bisphosphate aldolase A Fructose-bisphosphate aldolase A 14265-44-2 CAS SubPathwayInteraction866 SubPathway866Reaction SubPathwayReaction SubPathwayInteraction867 SubPathway867Reaction SubPathwayReaction SubPathwayInteraction864 SubPathway864Reaction SubPathwayReaction SubPathwayInteraction865 SubPathway865Reaction SubPathwayReaction 58-64-0 CAS Fructose-1,6-bisphosphatase 1 SubPathwayInteraction868 SubPathway868Reaction SubPathwayReaction GTP BioCyc GDP-mannose 4,6 dehydratase 71358 ChemSpider C00096 KEGG Compound CHEBI:704854 ChEBI 4.0 644102 PubChem-compound 1.0 C02154 KEGG Compound 17893 ChemSpider 22833512 PubChem-compound 18396 PubChem-compound H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 167949 ChemSpider NADH BioCyc 393165 ChemSpider Fructose intolerance, hereditary NAD BioCyc L-Fucose 1.0 P17858 UniProt 1.0 NAD Fructose 6-phosphate 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate LEFT_TO_RIGHT 17215925 ChemSpider CPD-535 BioCyc 6-phosphofructokinase, liver type 388911 ChemSpider 2.0 MANNOSE BioCyc Mannose 6-phosphate C03267 KEGG Compound CHEBI:5445 ChEBI Triosephosphate isomerase SMILES O C01094 KEGG Compound 439709 PubChem-compound 4.0 1004 PubChem-compound CHEBI:2181 ChEBI 643-13-0 CAS Water C3H7O6P Dihydroxyacetone phosphate 169.99803 C6H14O6 Sorbitol 182.07904 CHEBI:15846 ChEBI D-Fructose ADP BioCyc Phosphomannomutase 1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 SMP00725 SMPDB L-FUCOSE BioCyc 53-59-8 CAS CHEBI:15820 ChEBI HMDB06330 HMDB SMILES OC[C@H]1OC(OP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]1O Mannose-6-phosphate isomerase Fructose 1,6-bisphosphate 56-82-6 CAS D-Mannose 1-phosphate HMDB00902 HMDB CHEBI:16905 ChEBI CHEBI:16908 ChEBI D-Glyceraldehyde 3-phosphate Sorbitol dehydrogenase O4P Phosphate 94.95342 6830 PubChem-compound 15978-08-2 CAS Adenosine triphosphate Q9Y5P6 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:15946 ChEBI 16562-58-6 CAS PW000702 PathWhiz C21H29N7O17P3 NADP 744.08325 Mitochondrion NADPH BioCyc C16H23N5O15P2 GDP-4-Dehydro-6-deoxy-D-mannose 587.0666 16190 ChemSpider CHEBI:35374 ChEBI Triosephosphate isomerase 58-68-4 CAS SMILES [O-]P([O-])([O-])=O CHEBI:28602 ChEBI 1.0 439871 PubChem-compound Sorbitol dehydrogenase Ketohexokinase C6H13O9P Fructose 6-phosphate 260.02972 GDP-MANNOSE BioCyc 79082-92-1 CAS Fructose-bisphosphate aldolase A 4.0 Fructose-bisphosphate aldolase B 1.0 6-phosphofructokinase, liver type 17106 PubChem-compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Fucose-1-phosphate guanylyltransferase Ketohexokinase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc 57-04-5 CAS CHEBI:4208 ChEBI 69507 PubChem-compound 53-57-6 CAS CHEBI:17924 ChEBI CHEBI:16955 ChEBI Ketohexokinase 1.0 Phosphomannomutase 1 CHEBI:12350 ChEBI SMILES OP(O)(O)=O 1.0 O7P2 Pyrophosphate 173.91193 Fucose 1-phosphate 1.0 C21H29N7O14P2 NADH 665.12476 17372 ChemSpider SMILES C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O 1.0 5957 PubChem-compound SMILES OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O Hexokinase-1 530-26-7 CAS Glycolysis SubPathway Amino Sugar Metabolism SubPathway Amino Sugar Metabolism SubPathway CHEBI:15996 ChEBI CHEBI:49728 ChEBI HMDB01095 HMDB ReactionCatalysis1315 ACTIVATION GO:0005739 GENE ONTOLOGY GDP-4-Dehydro-6-deoxy-D-mannose C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY 4.0 CHEBI:17925 ChEBI 15839-70-0 CAS Fructose 1-phosphate Galactose Metabolism SubPathway Glycolysis SubPathway Mannose-1-phosphate guanyltransferase beta NADH SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES OC[C@H]1O[C@](O)(COP(O)(O)=O)[C@@H](O)[C@@H]1O 5682 ChemSpider P19367 UniProt CHEBI:28645 ChEBI 1.0 D-Mannose 14000-31-8 CAS 5675 ChemSpider HMDB01076 HMDB HMDB01078 HMDB SMILES C[C@@H]1OC(OP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES C[C@@H]1OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@H](O)[C@@H]1O Cytoplasm GDP-L-fucose NADPH Cell ReactionCatalysis333 ACTIVATION HMDB01047 HMDB ReactionCatalysis334 ACTIVATION ReactionCatalysis331 ACTIVATION HMDB03345 HMDB SMILES OCC(O)C=O ReactionCatalysis332 ACTIVATION CHEBI:15422 ChEBI P09467 UniProt 388299 ChemSpider 1.0 HMDB01163 HMDB SMILES OC[C@@]1(OP(O)(O)=O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 1.0 439211 PubChem-compound 1.0 Dihydroxyacetone phosphate SubPathwayInput HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc Aldose reductase SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 5576 ChemSpider HMDB01051 HMDB Phosphoric acid HMDB02142 HMDB CHEBI:16761 ChEBI 439446 PubChem-compound Reaction260 false D-Fructose 2,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT O60547 UniProt Glyceraldehyde GLYCERALD BioCyc 8575807 ChemSpider 1.0 9606 TAXONOMY C00636 KEGG Compound C16H25N5O16P2 Guanosine diphosphate mannose 605.07715 P04075 UniProt 1.0 2.7.1.3 false 2.7.1.3 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 1-phosphate LEFT_TO_RIGHT PW000146 PathWhiz 1.0 HMDB00174 HMDB 5893 PubChem-compound HMDB01265 HMDB HMDB02111 HMDB Q8N0W3 UniProt 1.0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 1.1.1.14 false 1.1.1.14 NAD + Sorbitol ↔ D-Fructose + NADH REVERSIBLE 3.1.3.- false 3.1.3.- Beta-D-Fructose 2-phosphate + Water → D-Fructose + Phosphoric acid LEFT_TO_RIGHT 1.1.1.21 false 1.1.1.21 NADP + Sorbitol ↔ Alpha-D-Glucose + NADPH REVERSIBLE ReactionCatalysis348 ACTIVATION ReactionCatalysis346 ACTIVATION ReactionCatalysis347 ACTIVATION CHEBI:15377 ChEBI ReactionCatalysis344 ACTIVATION ReactionCatalysis345 ACTIVATION ReactionCatalysis342 ACTIVATION 1.0 ReactionCatalysis343 ACTIVATION ReactionCatalysis340 ACTIVATION ReactionCatalysis341 ACTIVATION 6569 ChemSpider CHEBI:16108 ChEBI 18950 PubChem-compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound HMDB01273 HMDB 2.0 1.0 Phosphate 3123-67-9 CAS CHEBI:28319 ChEBI 79025 PubChem-compound ReactionCatalysis339 ACTIVATION PW000008 PathWhiz ReactionCatalysis337 ACTIVATION ReactionCatalysis338 ACTIVATION ReactionCatalysis335 ACTIVATION 14 kDa phosphohistidine phosphatase ReactionCatalysis336 ACTIVATION HMDB01487 HMDB Aldose reductase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 SMILES OC(COP(O)(O)=O)C=O P05062 UniProt 1.0 86-01-1 CAS GAP BioCyc 1061 PubChem-compound ReactionCatalysis122 ACTIVATION 5780 PubChem-compound HMDB00169 HMDB SMILES OC[C@H]1O[C@@](CO)(OP(O)(O)=O)[C@@H](O)[C@@H]1O C00661 KEGG Compound 14 kDa phosphohistidine phosphatase C00665 KEGG Compound SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O 1.0 Aldose reductase Sorbitol dehydrogenase 14 kDa phosphohistidine phosphatase Hexokinase-1 Mannose-6- phosphate isomerase Hexokinase-1 Phosphomannomutase 1 6- phosphofructokinase, liver type Fructose-1,6- bisphosphatase 1 Mannose-1- phosphate guanyltransferase beta Fructose- bisphosphate aldolase A Fructose- bisphosphate aldolase B GDP-mannose 4,6 dehydratase GDP-L-fucose synthase Fucose-1- phosphate guanylyltransferase L-fucose kinase Ketohexokinase Triosephosphate isomerase Fructose- bisphosphate aldolase A 6- phosphofructo- 2- kinase/fructose- 2,6- bisphosphatase 1 Alpha-D-Glucose Fructose 6-phosphate Dihydroxyacetone phosphate NADP Sorbitol NADPH NAD Accumulation D-Fructose NADH Beta-D-Fructose 2-phosphate H 2 O P i ATP ADP Mannose 6-phosphate D-Mannose ATP ADP D-Mannose 1-phosphate ATP Fructose 1,6-bisphosphate ADP H 2 O P i GTP Guanosine diphosphate mannose PP i D- Glyceraldehyde 3-phosphate GDP-4-Dehydro-6-deoxy-D- mannose H 2 O GDP-L-fucose NADP NADPH Fucose 1-phosphate GTP PP i L-Fucose ATP ADP ATP Fructose 1-phosphate ADP Glyceraldehyde D-Fructose 2,6- bisphosphate H 2 O P i Zinc (II) ion Zinc (II) ion Magnesium Magnesium Magnesium NADP Galactose Metabolism Glycolysis Glycolysis Amino Sugar Metabolism Mitochondrial Membrane Mitochondria Intracellular Space Liver
C6H14O12P2 D-Fructose 2,6-bisphosphate 339.99606 HMDB01346 HMDB 6022 PubChem-compound 388350 ChemSpider 937 ChemSpider 18186-48-6 CAS HMDB00250 HMDB C3H6O3 Glyceraldehyde 90.03169 C00794 KEGG Compound HMDB01341 HMDB Sorbitol 439153 PubChem-compound 1.0 1.0 P50053 UniProt HMDB01112 HMDB HMDB06800 HMDB C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 C00325 KEGG Compound C02985 KEGG Compound ATP BioCyc 2.0 1.0 53188-23-1 CAS HMDB01473 HMDB 559142 ChemSpider Triosephosphate isomerase 388338 ChemSpider D-Fructose 2,6-bisphosphate 5742 ChemSpider P34949 UniProt MANNOSE-1P BioCyc CHEBI:16474 ChEBI http://identifiers.org/smpdb/SMP00040 SMPDB ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc http://identifiers.org/smpdb/SMP00045 SMPDB Guanosine triphosphate http://identifiers.org/smpdb/SMP00043 SMPDB HMDB00124 HMDB 1.0 HMDB00247 HMDB PW000159 PathWhiz 709 ChemSpider 27251-84-9 CAS 488-69-7 CAS PPI BioCyc 2438-80-4 CAS 1.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 388554 ChemSpider Q13630 UniProt C10H16N5O14P3 Guanosine triphosphate 522.99066 HMDB00217 HMDB C00111 KEGG Compound 1.0 Q00796 UniProt 50-70-4 CAS C00354 KEGG Compound P60174 UniProt P15121 UniProt 439198 PubChem-compound 94762 ChemSpider 7664-38-2 CAS Galactose Metabolism SubPathway Fructose 6-phosphate SubPathwayInput HMDB00221 HMDB C6H12O6 D-Fructose 180.06339 C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI 2.0 Fructose-bisphosphate aldolase B Phosphomannomutase 1 C00001 KEGG Compound CHEBI:18361 ChEBI C00005 KEGG Compound C00004 KEGG Compound C6H13O9P Beta-D-Fructose 2-phosphate 260.02972 CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADP C00002 KEGG Compound 193537 PubChem-compound MANNOSE-6P BioCyc C6H12O6 Alpha-D-Glucose 180.06339 HMDB01429 HMDB Q9NRX4 UniProt 1.0 C6H13O9P Fructose 1-phosphate 260.02972 388775 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 CHEBI:17009 ChEBI Adenosine triphosphate C01222 KEGG Compound P16118 UniProt O14772 UniProt Q92871 UniProt FRUCTOSE-6P BioCyc Fucose-1-phosphate guanylyltransferase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C(=O)N1 C6H13O9P Mannose 6-phosphate 260.02972 C00013 KEGG Compound L-fucose kinase 105021 PubChem-compound Sorbitol dehydrogenase 4.2.1.47 false 4.2.1.47 Guanosine diphosphate mannose → GDP-4-Dehydro-6-deoxy-D-mannose + Water LEFT_TO_RIGHT GDP-L-fucose synthase L-fucose kinase NAD(P) BioCyc 2.0 CHEBI:17138 ChEBI C6H13O8P Fucose 1-phosphate 244.0348 1.0 56-65-5 CAS 53-84-9 CAS C00267 KEGG Compound 62713 ChemSpider 644175 PubChem-compound Mannose-1-phosphate guanyltransferase beta CHEBI:26078 ChEBI GDP-mannose 4,6 dehydratase 1.0 C16H25N5O15P2 GDP-L-fucose 589.0822 10400369 PubChem-compound 3672-15-9 CAS CL:0000000 CELL TYPE ONTOLOGY C00275 KEGG Compound C6H13O9P D-Mannose 1-phosphate 260.02972 C02336 KEGG Compound C00159 KEGG Compound 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Alpha-D-Glucose SubPathwayInput Adenosine diphosphate Beta-D-Fructose 2-phosphate Guanosine diphosphate mannose SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 2.7.1.11 false 2.7.1.11 Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT 2.7.7.13 false 2.7.7.13 D-Mannose 1-phosphate + Guanosine triphosphate → Guanosine diphosphate mannose + Pyrophosphate LEFT_TO_RIGHT C01019 KEGG Compound 751 PubChem-compound 1.1.1.271 false 1.1.1.271 GDP-L-fucose + NADP ↔ GDP-4-Dehydro-6-deoxy-D-mannose + NADPH REVERSIBLE 5.3.1.8 false 5.3.1.8 Mannose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE 5.4.2.8 false 5.4.2.8 D-Mannose 1-phosphate ↔ Mannose 6-phosphate REVERSIBLE 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Mannose → Adenosine diphosphate + Mannose 6-phosphate LEFT_TO_RIGHT C00044 KEGG Compound 648 ChemSpider 2.7.1.52 false 2.7.1.52 Adenosine triphosphate + L-Fucose → Adenosine diphosphate + Fucose 1-phosphate LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE HMDB00660 HMDB 2.7.7.30 false 2.7.7.30 Fucose 1-phosphate + Guanosine triphosphate ↔ GDP-L-fucose + Pyrophosphate REVERSIBLE SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES C[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@@H](O)C1=O 6-phosphofructokinase, liver type 1.0 HMDB00538 HMDB 5.3.1.1 false 5.3.1.1 Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate REVERSIBLE 668 PubChem-compound GDP-L-fucose synthase 4.1.2.13 false 4.1.2.13 Fructose 1-phosphate ↔ Dihydroxyacetone phosphate + Glyceraldehyde REVERSIBLE 19046-69-6 CAS Hexokinase-1 7732-18-5 CAS 1.0 591-59-3 CAS Mannose 6-phosphate FRU1P BioCyc 492-62-6 CAS Adenosine diphosphate 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CPD-488 BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 445557 PubChem-compound Pyrophosphate SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SMILES OCC(=O)COP(O)(O)=O D-Fructose Glycolysis SubPathway 962 PubChem-compound 5800 ChemSpider Fructose-1,6-bisphosphatase 1 GDP-L-fucose synthase 979 ChemSpider Fructose-1,6-bisphosphatase 1 Mannose-6-phosphate isomerase 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 731 ChemSpider H3O4P Phosphoric acid 97.9769 C00085 KEGG Compound 559210 ChemSpider C6H12O5 L-Fucose 164.06847 BiologicalState8 Homo sapiens, Cell, Cytoplasm 729 PubChem-compound C6H12O6 D-Mannose 180.06339 GUANOSINE_DIPHOSPHATE_FUCOSE BioCyc BiologicalState3 Homo sapiens, Cell, Mitochondrion Fructose-bisphosphate aldolase A Fructose-bisphosphate aldolase A 14265-44-2 CAS SubPathwayInteraction866 SubPathway866Reaction SubPathwayReaction SubPathwayInteraction867 SubPathway867Reaction SubPathwayReaction SubPathwayInteraction864 SubPathway864Reaction SubPathwayReaction SubPathwayInteraction865 SubPathway865Reaction SubPathwayReaction 58-64-0 CAS Fructose-1,6-bisphosphatase 1 SubPathwayInteraction868 SubPathway868Reaction SubPathwayReaction GTP BioCyc GDP-mannose 4,6 dehydratase 71358 ChemSpider C00096 KEGG Compound CHEBI:704854 ChEBI 4.0 644102 PubChem-compound 1.0 C02154 KEGG Compound 17893 ChemSpider 22833512 PubChem-compound 18396 PubChem-compound H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 167949 ChemSpider NADH BioCyc 393165 ChemSpider Fructose intolerance, hereditary NAD BioCyc L-Fucose 1.0 P17858 UniProt 1.0 NAD Fructose 6-phosphate 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate LEFT_TO_RIGHT 17215925 ChemSpider CPD-535 BioCyc 6-phosphofructokinase, liver type 388911 ChemSpider 2.0 MANNOSE BioCyc Mannose 6-phosphate C03267 KEGG Compound CHEBI:5445 ChEBI Triosephosphate isomerase SMILES O C01094 KEGG Compound 439709 PubChem-compound 4.0 1004 PubChem-compound CHEBI:2181 ChEBI 643-13-0 CAS Water C3H7O6P Dihydroxyacetone phosphate 169.99803 C6H14O6 Sorbitol 182.07904 CHEBI:15846 ChEBI D-Fructose ADP BioCyc Phosphomannomutase 1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 http://identifiers.org/smpdb/SMP00725 SMPDB L-FUCOSE BioCyc 53-59-8 CAS CHEBI:15820 ChEBI HMDB06330 HMDB SMILES OC[C@H]1OC(OP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]1O Mannose-6-phosphate isomerase Fructose 1,6-bisphosphate 56-82-6 CAS D-Mannose 1-phosphate HMDB00902 HMDB CHEBI:16905 ChEBI CHEBI:16908 ChEBI D-Glyceraldehyde 3-phosphate Sorbitol dehydrogenase O4P Phosphate 94.95342 6830 PubChem-compound 15978-08-2 CAS Adenosine triphosphate Q9Y5P6 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:15946 ChEBI 16562-58-6 CAS PW000702 PathWhiz C21H29N7O17P3 NADP 744.08325 Mitochondrion NADPH BioCyc C16H23N5O15P2 GDP-4-Dehydro-6-deoxy-D-mannose 587.0666 16190 ChemSpider CHEBI:35374 ChEBI Triosephosphate isomerase 58-68-4 CAS SMILES [O-]P([O-])([O-])=O CHEBI:28602 ChEBI 1.0 439871 PubChem-compound Sorbitol dehydrogenase Ketohexokinase C6H13O9P Fructose 6-phosphate 260.02972 GDP-MANNOSE BioCyc 79082-92-1 CAS Fructose-bisphosphate aldolase A 4.0 Fructose-bisphosphate aldolase B 1.0 6-phosphofructokinase, liver type 17106 PubChem-compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Fucose-1-phosphate guanylyltransferase Ketohexokinase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc 57-04-5 CAS CHEBI:4208 ChEBI 69507 PubChem-compound 53-57-6 CAS CHEBI:17924 ChEBI CHEBI:16955 ChEBI Ketohexokinase 1.0 Phosphomannomutase 1 CHEBI:12350 ChEBI SMILES OP(O)(O)=O 1.0 O7P2 Pyrophosphate 173.91193 Fucose 1-phosphate 1.0 C21H29N7O14P2 NADH 665.12476 17372 ChemSpider SMILES C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O 1.0 5957 PubChem-compound SMILES OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O Hexokinase-1 530-26-7 CAS CHEBI:15996 ChEBI CHEBI:49728 ChEBI HMDB01095 HMDB ReactionCatalysis1315 ACTIVATION GO:0005739 GENE ONTOLOGY GDP-4-Dehydro-6-deoxy-D-mannose C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY 4.0 CHEBI:17925 ChEBI 15839-70-0 CAS Fructose 1-phosphate Mannose-1-phosphate guanyltransferase beta NADH SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES OC[C@H]1O[C@](O)(COP(O)(O)=O)[C@@H](O)[C@@H]1O 5682 ChemSpider P19367 UniProt CHEBI:28645 ChEBI 1.0 D-Mannose 14000-31-8 CAS 5675 ChemSpider HMDB01076 HMDB HMDB01078 HMDB SMILES C[C@@H]1OC(OP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES C[C@@H]1OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@H](O)[C@@H]1O Cytoplasm GDP-L-fucose NADPH Cell ReactionCatalysis333 ACTIVATION HMDB01047 HMDB ReactionCatalysis334 ACTIVATION ReactionCatalysis331 ACTIVATION HMDB03345 HMDB SMILES OCC(O)C=O ReactionCatalysis332 ACTIVATION CHEBI:15422 ChEBI P09467 UniProt 388299 ChemSpider 1.0 HMDB01163 HMDB SMILES OC[C@@]1(OP(O)(O)=O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 1.0 439211 PubChem-compound 1.0 Dihydroxyacetone phosphate SubPathwayInput HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc Aldose reductase SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 5576 ChemSpider HMDB01051 HMDB Phosphoric acid HMDB02142 HMDB CHEBI:16761 ChEBI 439446 PubChem-compound Reaction260 false D-Fructose 2,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT O60547 UniProt Glyceraldehyde GLYCERALD BioCyc 8575807 ChemSpider 1.0 9606 TAXONOMY C00636 KEGG Compound C16H25N5O16P2 Guanosine diphosphate mannose 605.07715 P04075 UniProt 1.0 2.7.1.3 false 2.7.1.3 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 1-phosphate LEFT_TO_RIGHT PW000146 PathWhiz 1.0 HMDB00174 HMDB 5893 PubChem-compound HMDB01265 HMDB HMDB02111 HMDB Q8N0W3 UniProt 1.0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 1.1.1.14 false 1.1.1.14 NAD + Sorbitol ↔ D-Fructose + NADH REVERSIBLE 3.1.3.- false 3.1.3.- Beta-D-Fructose 2-phosphate + Water → D-Fructose + Phosphoric acid LEFT_TO_RIGHT 1.1.1.21 false 1.1.1.21 NADP + Sorbitol ↔ Alpha-D-Glucose + NADPH REVERSIBLE ReactionCatalysis348 ACTIVATION ReactionCatalysis346 ACTIVATION ReactionCatalysis347 ACTIVATION CHEBI:15377 ChEBI ReactionCatalysis344 ACTIVATION ReactionCatalysis345 ACTIVATION ReactionCatalysis342 ACTIVATION 1.0 ReactionCatalysis343 ACTIVATION ReactionCatalysis340 ACTIVATION ReactionCatalysis341 ACTIVATION 6569 ChemSpider CHEBI:16108 ChEBI 18950 PubChem-compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound HMDB01273 HMDB 2.0 1.0 Phosphate 3123-67-9 CAS CHEBI:28319 ChEBI 79025 PubChem-compound