SMPDB

Pathway Description

Didanosine Action Pathway

Homo sapiens

Drug Action Pathway

Created: 2014-06-23

Last Updated: 2019-08-16

Didanosine (ddl) can be metabolized into dideoxyadenosine triphosphate (ddATP) by series of reaction. Dideoxyadenosine triphosphate can bind and inhibit HIV reverse transcriptase enzyme competitively against natural dATP. Dideoxyadenosine triphosphate will terminate the viral DNA chain to make it missing 3'-OH group so that formation of 5' to 3' phosphodiester could be prevented, which 5' to 3' phosphodiester is required for DNA chain elongation and result in terminated DNA growth.

References

Didanosine Pathway References

Munir N.Nassar Tracy Chen Michael J.ReffShreeram N.Agharkar. (1993) Didanosine. Analytical Profiles of Drug Substances and Excipients, Volume 22, 1993, Pages 185-227

Viral Transcription Inhibition References

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Highlight Compounds

	Adenosine monophosphate
	Adenosine triphosphate
	Didanosine
	Dideoxyadenosine Triphosphate
	Pyrophosphate

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