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1.0 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 Phosphatidate cytidylyltransferase 2 937 ChemSpider 439162 PubChem-compound Q9NUQ2 UniProt 439153 PubChem-compound Coenzyme A SMILES O HMDB0000095 HMDB 6131 PubChem-compound Pyrophosphate Reaction61492 false Glycerol 3-phosphate + a CDP-diacylglycerol  → Cytidine monophosphate + an L-1-phosphatidylglycerol-phosphate  LEFT_TO_RIGHT 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 559142 ChemSpider Reaction55814 false Dihydroxyacetone phosphate + Hydrogen Ion + NADH → Glycerol 3-phosphate + NAD LEFT_TO_RIGHT CHEBI:15846 ChEBI 2.0 NADH 1038 PubChem-compound SubPathwayInteraction68315 SubPathway68315Reaction SubPathwayReaction Cardiolipin synthase GO:0005829 GENE ONTOLOGY Reaction65383 false 1-acyl-sn-glycerol 3-phosphate  + long-chain fatty acyl-CoA → 1,2-diacyl-sn-glycerol 3-phosphate + Coenzyme A LEFT_TO_RIGHT 1.0 CHEBI:16908 ChEBI Cytidine triphosphate 1.0 Phosphate O4P Phosphate 94.95342 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 Reaction61472 false Water + an L-1-phosphatidylglycerol-phosphate  → Phosphate + an L-1-phosphatidyl-glycerol  LEFT_TO_RIGHT Reaction61471 false a CDP-diacylglycerol  + an L-1-phosphatidyl-glycerol  → Cytidine monophosphate + a cardiolipin LEFT_TO_RIGHT PPI BioCyc ReactionCatalysis51617 ACTIVATION Glycolysis SubPathway 1.0 63-37-6 CAS 1,2-diacyl-sn-glycerol 3-phosphate PW075700 PathWhiz C00111 KEGG Compound Cytosol 1.0 58-68-4 CAS 1-acyl-sn-glycerol 3-phosphate  HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O an L-1-phosphatidylglycerol-phosphate  ReactionCatalysis55508 ACTIVATION C00009 KEGG Compound Cytidine monophosphate Hydrogen Ion C00001 KEGG Compound HMDB0001429 HMDB CTP BioCyc 1.0 CHEBI:18361 ChEBI C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider Q9HCL2 UniProt C3H9O6P Glycerol 3-phosphate 172.01367 Glycerol-3-phosphate acyltransferase 1, mitochondrial Mitochondrial Inner Membrane 57-04-5 CAS 1.0 C21H28N7O14P2 NAD 664.11694 1.0 CHEBI:17361 ChEBI C00010 KEGG Compound HMDB0000902 HMDB C00013 KEGG Compound 1.0 O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 GO:0005743 GENE ONTOLOGY CHEBI:15978 ChEBI C9H16N3O14P3 Cytidine triphosphate 482.9845 GO:0005741 GENE ONTOLOGY 1.0 H Hydrogen Ion 1.007825 388308 ChemSpider Water 53-84-9 CAS Cardiolipin synthase ReactionCatalysis45939 ACTIVATION CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial Q9UJA2 UniProt HMDB0000126 HMDB 1.0 C9H14N3O8P Cytidine monophosphate 323.05185 Mitochondrial Outer Membrane 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 1-acyl-sn-glycerol 3-phosphate  Glycerol 3-phosphate 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 1,2-diacyl-sn-glycerol 3-phosphate Q32NB8 UniProt 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Dihydroxyacetone phosphate SubPathwayOutput Glycerol-3-phosphate acyltransferase 1, mitochondrial Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:1146900 ChEBI P21695 UniProt SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0000250 HMDB 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS CO-A BioCyc Phosphatidate cytidylyltransferase 2 1.0 648 ChemSpider 2.7.7.41 false 2.7.7.41 1,2-diacyl-sn-glycerol 3-phosphate + Cytidine triphosphate → Pyrophosphate + a CDP-diacylglycerol  LEFT_TO_RIGHT long-chain fatty acyl-CoA ReactionCatalysis51597 ACTIVATION SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O C21H36N7O16P3S Coenzyme A 767.11523 ReactionCatalysis51596 ACTIVATION Q8WUK0 UniProt HMDB0001473 HMDB 5901 ChemSpider 1.0 an L-1-phosphatidylglycerol-phosphate  6557 ChemSpider 668 PubChem-compound Homo sapiens C00055 KEGG Compound 388299 ChemSpider 7732-18-5 CAS Cardiolipin Biosynthesis (Barth Syndrome) HMDB0001487 HMDB CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial 1.0 C00063 KEGG Compound an L-1-phosphatidyl-glycerol  NAD DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 Glycerol 3-phosphate 65-47-4 CAS SMILES OCC(=O)COP(O)(O)=O Transport1194 true 1,2-diacyl-sn-glycerol 3-phosphate (?) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Inner Membrane REVERSIBLE a cardiolipin a CDP-diacylglycerol  9606 TAXONOMY 962 PubChem-compound O95674 UniProt a CDP-diacylglycerol  5893 PubChem-compound CMP BioCyc C00080 KEGG Compound ReactionCatalysis51662 ACTIVATION a cardiolipin Glycerol 3-phosphate long-chain fatty acyl-CoA HMDB0002111 HMDB CHEBI:17677 ChEBI CHEBI:15377 ChEBI Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:15378 ChEBI SMILES [H+] 6176 PubChem-compound 14265-44-2 CAS 1.0 CHEBI:16108 ChEBI 17989-41-2 CAS GLYCEROL-3P BioCyc C00093 KEGG Compound an L-1-phosphatidyl-glycerol  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 644102 PubChem-compound 5941 ChemSpider ReactionCatalysis45523 ACTIVATION 1.0 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon H2O Water 18.010565 NADH BioCyc NAD BioCyc 1,2-diacyl-sn-glycerol 3-phosphate 1061 PubChem-compound HMDB0059597 HMDB 2.3.1.15 false 2.3.1.15 Glycerol 3-phosphate + long-chain fatty acyl-CoA → 1-acyl-sn-glycerol 3-phosphate  + Coenzyme A LEFT_TO_RIGHT SMP0074684 SMPDB 1.0 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic HMDB0000082 HMDB 85-61-0 CAS SMILES OC[C@@H](O)COP(O)(O)=O Glycerol-3- phosphate dehydrogenase [NAD(+)], cytoplasmic glycerol-3- phosphate acyltransferase 1-acyl-sn- glycerol-3- phosphate acyltransferase epsilon Phosphatidate cytidylyltransferase 2 CDP- diacylglycerol- -glycerol-3- phosphate 3- phosphatidyltransferase, mitochondrial Phosphatidylglycerophosphatase and protein- tyrosine phosphatase 1 Cardiolipin synthase Dihydroxyacetone phosphate NADH H + NAD Glycerol 3-phosphate CoA CoA Cytidine triphosphate PP i Glycerol 3-phosphate Cytidine monophosphate H 2 O P i Cytidine monophosphate 1,2-diacyl- sn-glycerol 3-phosphate 1,2-diacyl- sn-glycerol 3-phosphate long-chain fatty acyl-CoA 1-acyl-sn- glycerol 3-phosphate long-chain fatty acyl-CoA a CDP- diacylglycerol an L-1- phosphatidylglycerol- phosphate an L-1- phosphatidyl- glycerol a CDP- diacylglycerol a cardiolipin Glycolysis Cytosol Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Mitochondrial Inner Membrane
1.0 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 Phosphatidate cytidylyltransferase 2 937 ChemSpider 439162 PubChem-compound Q9NUQ2 UniProt 439153 PubChem-compound Coenzyme A SMILES O HMDB0000095 HMDB 6131 PubChem-compound Pyrophosphate Reaction61492 false Glycerol 3-phosphate + a CDP-diacylglycerol  → Cytidine monophosphate + an L-1-phosphatidylglycerol-phosphate  LEFT_TO_RIGHT 6816 PubChem-compound C3H7O6P Dihydroxyacetone phosphate 169.99803 559142 ChemSpider Reaction55814 false Dihydroxyacetone phosphate + Hydrogen Ion + NADH → Glycerol 3-phosphate + NAD LEFT_TO_RIGHT CHEBI:15846 ChEBI 2.0 NADH 1038 PubChem-compound SubPathwayInteraction68315 SubPathway68315Reaction SubPathwayReaction Cardiolipin synthase GO:0005829 GENE ONTOLOGY Reaction65383 false 1-acyl-sn-glycerol 3-phosphate  + long-chain fatty acyl-CoA → 1,2-diacyl-sn-glycerol 3-phosphate + Coenzyme A LEFT_TO_RIGHT 1.0 CHEBI:16908 ChEBI Cytidine triphosphate 1.0 Phosphate O4P Phosphate 94.95342 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 Reaction61472 false Water + an L-1-phosphatidylglycerol-phosphate  → Phosphate + an L-1-phosphatidyl-glycerol  LEFT_TO_RIGHT Reaction61471 false a CDP-diacylglycerol  + an L-1-phosphatidyl-glycerol  → Cytidine monophosphate + a cardiolipin LEFT_TO_RIGHT PPI BioCyc ReactionCatalysis51617 ACTIVATION Glycolysis SubPathway 1.0 63-37-6 CAS 1,2-diacyl-sn-glycerol 3-phosphate PW075700 PathWhiz C00111 KEGG Compound Cytosol 1.0 58-68-4 CAS 1-acyl-sn-glycerol 3-phosphate  HMDB0001423 HMDB SMILES [O-]P([O-])([O-])=O an L-1-phosphatidylglycerol-phosphate  ReactionCatalysis55508 ACTIVATION C00009 KEGG Compound Cytidine monophosphate Hydrogen Ion C00001 KEGG Compound HMDB0001429 HMDB CTP BioCyc 1.0 CHEBI:18361 ChEBI C00004 KEGG Compound CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider Q9HCL2 UniProt C3H9O6P Glycerol 3-phosphate 172.01367 Glycerol-3-phosphate acyltransferase 1, mitochondrial Mitochondrial Inner Membrane 57-04-5 CAS 1.0 C21H28N7O14P2 NAD 664.11694 1.0 CHEBI:17361 ChEBI C00010 KEGG Compound HMDB0000902 HMDB C00013 KEGG Compound 1.0 O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 GO:0005743 GENE ONTOLOGY CHEBI:15978 ChEBI C9H16N3O14P3 Cytidine triphosphate 482.9845 GO:0005741 GENE ONTOLOGY 1.0 H Hydrogen Ion 1.007825 388308 ChemSpider Water 53-84-9 CAS Cardiolipin synthase ReactionCatalysis45939 ACTIVATION CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial Q9UJA2 UniProt HMDB0000126 HMDB 1.0 C9H14N3O8P Cytidine monophosphate 323.05185 Mitochondrial Outer Membrane 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon 1-acyl-sn-glycerol 3-phosphate  Glycerol 3-phosphate 1.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 1,2-diacyl-sn-glycerol 3-phosphate Q32NB8 UniProt 5682 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Dihydroxyacetone phosphate SubPathwayOutput Glycerol-3-phosphate acyltransferase 1, mitochondrial Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:1146900 ChEBI P21695 UniProt SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0000250 HMDB 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS CO-A BioCyc Phosphatidate cytidylyltransferase 2 1.0 648 ChemSpider 2.7.7.41 false 2.7.7.41 1,2-diacyl-sn-glycerol 3-phosphate + Cytidine triphosphate → Pyrophosphate + a CDP-diacylglycerol  LEFT_TO_RIGHT long-chain fatty acyl-CoA ReactionCatalysis51597 ACTIVATION SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O C21H36N7O16P3S Coenzyme A 767.11523 ReactionCatalysis51596 ACTIVATION Q8WUK0 UniProt HMDB0001473 HMDB 5901 ChemSpider 1.0 an L-1-phosphatidylglycerol-phosphate  6557 ChemSpider 668 PubChem-compound Homo sapiens C00055 KEGG Compound 388299 ChemSpider 7732-18-5 CAS Cardiolipin Biosynthesis (Barth Syndrome) HMDB0001487 HMDB CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial 1.0 C00063 KEGG Compound an L-1-phosphatidyl-glycerol  NAD DIHYDROXY-ACETONE-PHOSPHATE BioCyc 1.0 Glycerol 3-phosphate 65-47-4 CAS SMILES OCC(=O)COP(O)(O)=O Transport1194 true 1,2-diacyl-sn-glycerol 3-phosphate (?) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Inner Membrane REVERSIBLE a cardiolipin a CDP-diacylglycerol  9606 TAXONOMY 962 PubChem-compound O95674 UniProt a CDP-diacylglycerol  5893 PubChem-compound CMP BioCyc C00080 KEGG Compound ReactionCatalysis51662 ACTIVATION a cardiolipin Glycerol 3-phosphate long-chain fatty acyl-CoA HMDB0002111 HMDB CHEBI:17677 ChEBI CHEBI:15377 ChEBI Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic CHEBI:15378 ChEBI SMILES [H+] 6176 PubChem-compound 14265-44-2 CAS 1.0 CHEBI:16108 ChEBI 17989-41-2 CAS GLYCEROL-3P BioCyc C00093 KEGG Compound an L-1-phosphatidyl-glycerol  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 644102 PubChem-compound 5941 ChemSpider ReactionCatalysis45523 ACTIVATION 1.0 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon H2O Water 18.010565 NADH BioCyc NAD BioCyc 1,2-diacyl-sn-glycerol 3-phosphate 1061 PubChem-compound HMDB0059597 HMDB 2.3.1.15 false 2.3.1.15 Glycerol 3-phosphate + long-chain fatty acyl-CoA → 1-acyl-sn-glycerol 3-phosphate  + Coenzyme A LEFT_TO_RIGHT SMP0074684 SMPDB 1.0 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic HMDB0000082 HMDB 85-61-0 CAS SMILES OC[C@@H](O)COP(O)(O)=O Mitochondria GPD1 GPAM AGPAT5 CDS2 PGS1 PTPMT1 CRLS1 Dihydroxyacetone phosphate NADH Hydrogen Ion NAD Glycerol 3-phosphate Coenzyme A Coenzyme A Cytidine triphosphate Pyrophosphate Glycerol 3-phosphate Cytidine monophosphate Water Phosphate Cytidine monophosphate 1,2-diacyl- sn-glycerol 3-phosphate 1,2-diacyl- sn-glycerol 3-phosphate long-chain fatty acyl-CoA 1-acyl-sn- glycerol 3-phosphate long-chain fatty acyl-CoA a CDP- diacylglycerol an L-1- phosphatidylglycerol- phosphate an L-1- phosphatidyl- glycerol a CDP- diacylglycerol a cardiolipin Glycolysis