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9606 TAXONOMY 962 PubChem-compound Q14289 UniProt P2Y purinoceptor 2 (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) Protein kinase C beta type C41H72O9 Ionomycin 708.51764 937 ChemSpider C00076 KEGG Compound Ionomycin C01245 KEGG Compound PIP2(16:0/20:3(8Z,11Z,14Z)) Interaction1008 PIP2(16:0/20:3(8Z,11Z,14Z)) activates Protein kinase C alpha type (Homo sapiens) + protein kinase C beta (Homo sapiens) Interaction1007 P2Y purinoceptor 2 (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) activates PIP2(16:0/20:3(8Z,11Z,14Z)) direct_interaction CA%2b2 BioCyc P2Y purinoceptor 2 Inositol 1,4,5-trisphosphate SMILES O Calcium Ion Channel and Phorbal Esters Signaling Pathway GO:0005886 GENE ONTOLOGY 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Ca Calcium 39.96259 53480233 PubChem-compound inositol_1,4,5-trisphosphate BioCyc HMDB0002111 HMDB Cell Membrane CHEBI:15377 ChEBI P05771 UniProt Phosphatidylinositols BioCyc Protein-tyrosine kinase 2-beta C00001 KEGG Compound Protein-tyrosine kinase 2-beta 271 PubChem-compound 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider P41231 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O HMDB0000464 HMDB Protein kinase C beta type Water 1.0 Cytoplasm SMILES [H][C@@]1(CC[C@](C)(O1)[C@@H](C)O)[C@]1(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C\C[C@@H](C)C[C@@H](C)C(\O)=C\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O)O1 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC P19174 UniProt Protein kinase C alpha type (Homo sapiens)_protein kinase C beta (Homo sapiens) PW091052 PathWhiz 1.0 1.0 Homo sapiens 56092-81-0 CAS 7732-18-5 CAS CHEBI:16595 ChEBI Interaction637 Inositol 1,4,5-trisphosphate activates Calcium 439456 PubChem-compound H2O Water 18.010565 Protein kinase C alpha type 14127-61-8 CAS SMILES [Ca++] 85166-31-0 CAS HMDB0010042 HMDB Protein kinase C alpha type SMP0090032 SMPDB C00626 KEGG Compound 1.0 Interaction1011 Water activates PIP2(16:0/20:3(8Z,11Z,14Z)) Interaction1010 PIP2(16:0/20:3(8Z,11Z,14Z)) activates Inositol 1,4,5-trisphosphate Interaction1013 Calcium activates Protein-tyrosine kinase 2-beta Interaction1012 Ionomycin activates Calcium HMDB0001498 HMDB C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 266 ChemSpider GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI PIP2(16:0/20:3(8Z,11Z,14Z)) C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 24767919 ChemSpider P2Y purinoceptor 2 P17252 UniProt Protein- tyrosine kinase 2-beta P2Y purinoceptor 2 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Protein kinase C alpha type Protein kinase C beta type PIP2(16:0/20:3(8Z,11Z,14Z)) Inositol 1,4,5- trisphosphate H 2 O Ca + Ionomycin Ca + Ca + Calcium Calcium Phorbal Esters (acute) Phorbal Esters (overnight) Cytoplasm Extracellular
9606 TAXONOMY 962 PubChem-compound Q14289 UniProt P2Y purinoceptor 2 (Homo sapiens)_1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) Protein kinase C beta type C41H72O9 Ionomycin 708.51764 937 ChemSpider C00076 KEGG Compound Ionomycin C01245 KEGG Compound PIP2(16:0/20:3(8Z,11Z,14Z)) Interaction1008 PIP2(16:0/20:3(8Z,11Z,14Z)) activates Protein kinase C alpha type (Homo sapiens) + protein kinase C beta (Homo sapiens) Interaction1007 P2Y purinoceptor 2 (Homo sapiens) + 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens) activates PIP2(16:0/20:3(8Z,11Z,14Z)) direct_interaction CA%2b2 BioCyc P2Y purinoceptor 2 Inositol 1,4,5-trisphosphate SMILES O Calcium Ion Channel and Phorbal Esters Signaling Pathway GO:0005886 GENE ONTOLOGY 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Ca Calcium 39.96259 53480233 PubChem-compound inositol_1,4,5-trisphosphate BioCyc HMDB0002111 HMDB Cell Membrane CHEBI:15377 ChEBI P05771 UniProt Phosphatidylinositols BioCyc Protein-tyrosine kinase 2-beta C00001 KEGG Compound Protein-tyrosine kinase 2-beta 271 PubChem-compound 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider P41231 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O HMDB0000464 HMDB Protein kinase C beta type Water 1.0 Cytoplasm SMILES [H][C@@]1(CC[C@](C)(O1)[C@@H](C)O)[C@]1(C)CC[C@@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C\C[C@@H](C)C[C@@H](C)C(\O)=C\C(=O)[C@@H](C)C[C@@H](C)C[C@H](C)CCC(O)=O)O1 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC P19174 UniProt Protein kinase C alpha type (Homo sapiens)_protein kinase C beta (Homo sapiens) PW091052 PathWhiz 1.0 1.0 Homo sapiens 56092-81-0 CAS 7732-18-5 CAS CHEBI:16595 ChEBI Interaction637 Inositol 1,4,5-trisphosphate activates Calcium 439456 PubChem-compound H2O Water 18.010565 Protein kinase C alpha type 14127-61-8 CAS SMILES [Ca++] 85166-31-0 CAS HMDB0010042 HMDB Protein kinase C alpha type SMP0090032 SMPDB C00626 KEGG Compound 1.0 Interaction1011 Water activates PIP2(16:0/20:3(8Z,11Z,14Z)) Interaction1010 PIP2(16:0/20:3(8Z,11Z,14Z)) activates Inositol 1,4,5-trisphosphate Interaction1013 Calcium activates Protein-tyrosine kinase 2-beta Interaction1012 Ionomycin activates Calcium HMDB0001498 HMDB C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 266 ChemSpider GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI PIP2(16:0/20:3(8Z,11Z,14Z)) C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 24767919 ChemSpider P2Y purinoceptor 2 P17252 UniProt PTK2B P2RY2 PLCG1 PRKCA PRKCB PIP2(16:0/20:3(8Z,11Z,14Z)) Inositol 1,4,5- trisphosphate Water Calcium Ionomycin Calcium Calcium