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1.0 ATP-dependent 6-phosphofructokinase subunit alpha 1.0 17215925 ChemSpider 446013 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 31348 PubChem-compound Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial direct_interaction Tricarboxylate transport protein, mitochondrial 1.0 Citrate synthase, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Inhibitor of nuclear factor kappa-B kinase subunit beta C4H4O5 2-Hydroxybutanedioate 132.00697 H Hydrogen ion 1.007825 C205H366N3O117P5 Lipopolysaccharide 4897.147 C4H2O5 2-Oxobutanedioate 129.99022 C6H5O7 Citrate 189.00352 C23H38N7O17P3S Acetyl Coenzyme A 809.1258 1.0 ATP-citrate synthase Reaction1248 false Acetyl-CoA → Malonyl-CoA LEFT_TO_RIGHT HMDB0001197 HMDB C3H4O3 Pyruvic acid 88.016045 53-59-8 CAS CHEBI:16238 ChEBI TNF receptor-associated factor 6 Citrate Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial CHEBI:16474 ChEBI Monocyte differentiation antigen CD14 1.0 Q99836 UniProt 393487 ChemSpider ReactionCatalysis962 ACTIVATION C27H35N9O15P2 FADH 787.1728 Inhibitor of nuclear factor kappa-B kinase subunit beta Q04206 UniProt Reaction139099 false NADPH → NADP LEFT_TO_RIGHT Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial 1.0 C21H30N7O17P3 NADPH 745.0911 Fatty Acid Mitochondrion C21H29N7O17P3 NADP 744.08325 Acetyl-CoA P40925 UniProt NADP-dependent malic enzyme NADPH BioCyc 1.0 LPS Receptor Complex Citrate synthase, mitochondrial NADP-dependent malic enzyme SMILES [O-]C(=O)CC(=O)C([O-])=O Q9Y4K3 UniProt 1.0 HMDB0000217 HMDB SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N SMILES OC(CC([O-])=O)(CC([O-])=O)C([O-])=O SMILES OC(CC([O-])=O)C([O-])=O SMILES CCCCCCCCCCCCCCCC1[C@@H](CP(O)(O)=O)OC(CO[C@@H]2OC(CO[C@@]3(CC(O[C@@]4(CC(O[C@@]5(CC(O)[C@@H](O)C(O5)C(O)CO)C(O)=O)[C@@H](O)C(O4)C(O)CO)C(O)=O)[C@@H](O[C@@H]4OC(C(O)CO)[C@@H](OP(O)(=O)OP(O)(=O)OCCN)C(O[C@H]5OC(C(O)CO[C@H]6OC[C@](O)(C(O)CO)C(O)[C@H]6O)[C@@H](OP(O)(O)=O)C(O[C@H]6OC(CO[C@H]7OC(CO)[C@H](O)C(O)C7O)[C@@H](O)C(O[C@H]7OC(CO)[C@H](O)C(O)C7O[C@H]7OC(CO)[C@@H](O[C@H]8OC(CO)[C@H](O)C(OC9O[C@@H](C)C(O[C@H]%10OC(CO)[C@@H](O)C(O[C@H]%11OC(C)[C@H](O)CC%11O)C%10O[C@H]%10OC(CO)[C@H](O)C(O)C%10O)C(O)[C@H]9O)C8O)C(O)C7O[C@H]7OC(CO)[C@@H](O)C(O)[C@@H]7NC(C)=O)C6O)[C@H]5O)[C@H]4O)C(O3)C(O)CO)C(O)=O)[C@@H](OP(O)(O)=O)C(OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H]2NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H](O)[C@@H]1OC(=O)CC(O)CCCCCCCCCCC CHEBI:15531 ChEBI C00006 KEGG Compound Succinate dehydrogenase Q13085 UniProt CHEBI:18009 ChEBI 559059 ChemSpider SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1 Tricarboxylate transport protein, mitochondrial Nuclear factor NF-kappa-B p105 subunit Succinate dehydrogenase cytochrome b560 subunit, mitochondrial C00005 KEGG Compound Transcription factor p65 1910-41-4 CAS CHEBI:35366 ChEBI 1031 ChemSpider NADP SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB NF-kappa-B essential modulator SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O P25963 UniProt Mitochondrial Inner Membrane Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY 2-Hydroxybutanedioate Toll/interleukin-1 receptor domain-containing adapter protein Transport9371 false Citrate (→) Transport: Homo sapiens, Cell, Mitochondrial Inner Membrane to Homo sapiens, Cell, Mitochondrial Outer Membrane LEFT_TO_RIGHT P31040 UniProt Toll/interleukin-1 receptor domain-containing adapter protein 53-57-6 CAS P58753 UniProt C27H33N9O15P2 FAD 785.1571 Malate dehydrogenase, cytoplasmic NADP-dependent malic enzyme C00016 KEGG Compound FAD Extracellular Space 1.0 Acetyl Coenzyme A 164550 PubChem-compound NAD(P) BioCyc HMDB0001206 HMDB GO:0005743 GENE ONTOLOGY ATP-citrate synthase GO:0005741 GENE ONTOLOGY ATP-dependent 6-phosphofructokinase subunit alpha FADH 1.0 1.0 Myeloid differentiation primary response protein MyD88 Pyruvic acid 1.0 ATP-citrate synthase TNF receptor-associated factor 6 SMP0100046 SMPDB Malonyl-CoA C00022 KEGG Compound C01352 KEGG Compound Myeloid differentiation primary response protein MyD88 (Homo sapiens)_Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens)_TNF receptor-associated factor 6 (Homo sapiens) P48163 UniProt C00024 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O HMDB0000243 HMDB GO:0005739 GENE ONTOLOGY O14521 UniProt GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 2-Oxobutanedioate Mitochondrial Outer Membrane LPS Receptor Complex Hydrogen ion 2.0 SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2 Transcription factor p65 1.0 ReactionCatalysis154506 ACTIVATION 1.0 Malate dehydrogenase, cytoplasmic Citrate NF-kappa-B inhibitor alpha Citrate Lipopolysaccharide CHEBI:17877 ChEBI Interaction1031 Citrate inhibits Succinate dehydrogenase NFKB1,NFKBIA,RELA Complex with Phosphate Interaction1030 Citrate inhibits 6-phosphofructokinase, muscle type 5675 ChemSpider 1.0 Interaction1037 CHUK-IKBKB-IKBKG complex activates NFKB1,NFKBIA,RELA Complex with Phosphate 72-89-9 CAS Interaction1036 LPS Receptor Complex activates CHUK-IKBKB-IKBKG complex Interaction1035 Myeloid differentiation primary response protein MyD88 (Homo sapiens) + Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens) + TNF receptor-associated factor 6 (Homo sapiens) activates LPS Receptor Complex Q9Y6K9 UniProt Interaction1034 Lipopolysaccharide activates LPS Receptor Complex Reaction164134 false FAD → FADH LEFT_TO_RIGHT Reaction164135 false Citrate → Acetyl-CoA LEFT_TO_RIGHT ReactionCatalysis154504 ACTIVATION Reaction164132 false 2-Oxobutanedioate + Acetyl Coenzyme A → Citrate LEFT_TO_RIGHT Interaction1038 NFKB1,NFKBIA,RELA Complex with Phosphate activates Nuclear factor NF-kappa-B p105 subunit ReactionCatalysis154502 ACTIVATION 1.0 ReactionCatalysis154501 ACTIVATION Reaction164138 false 2-Oxobutanedioate → 2-Hydroxybutanedioate LEFT_TO_RIGHT ReactionCatalysis154500 ACTIVATION Reaction164136 false Malonyl-CoA → Fatty Acid LEFT_TO_RIGHT Reaction164137 false Citrate → 2-Oxobutanedioate LEFT_TO_RIGHT Cytoplasm 1.0 NADPH 10213 ChemSpider Acetyl-CoA carboxylase 1 O00206 UniProt Citrate synthase, mitochondrial Lymphocyte antigen 96 Myeloid differentiation primary response protein MyD88 Monocyte differentiation antigen CD14 1.0 643975 PubChem-compound Homo sapiens 160434 PubChem-compound PW101069 PathWhiz SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 524-14-1 CAS 2-Oxobutanedioate NF-kappa-B inhibitor alpha CHUK-IKBKB-IKBKG complex 1.0 127-17-3 CAS HMDB0001248 HMDB P21912 UniProt Q9Y6Y9 UniProt Reaction164141 false Pyruvic acid → Hydrogen ion + NADPH LEFT_TO_RIGHT Reaction164142 false NADP → Pyruvic acid LEFT_TO_RIGHT Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Reaction164140 false 2-Hydroxybutanedioate → Pyruvic acid LEFT_TO_RIGHT P53396 UniProt 1.0 P19838 UniProt Nuclear factor NF-kappa-B p105 subunit LPS and Citrate Signaling and Inflammation Toll-like receptor 4 Toll-like receptor 4 SMILES CC(=O)C(O)=O Inhibitor of nuclear factor kappa-B kinase subunit alpha 9606 TAXONOMY P53007 UniProt 1.0 Monocyte differentiation antigen CD14 392413 ChemSpider Fatty Acid 1.0 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial C00083 KEGG Compound Transcription factor p65 CHEBI:32816 ChEBI Lymphocyte antigen 96 1.0 4.0 146-14-5 CAS C24H38N7O19P3S Malonyl-CoA 853.1156 PYRUVATE BioCyc NF-kappa-B inhibitor alpha O15111 UniProt 1.0 5886 PubChem-compound Acetyl-CoA carboxylase 1 P16861 UniProt 1.0 444493 PubChem-compound P08571 UniProt NFKB1,NFKBIA,RELA Complex with Phosphate 10663 PubChem-compound 22833512 PubChem-compound ACETYL-COA BioCyc FAD BioCyc Inhibitor of nuclear factor kappa-B kinase subunit alpha FADH2 BioCyc TransportCatalysis1142 ACTIVATION NF-kappa-B essential modulator Nucleus 1060 PubChem-compound SMILES [H+] 1.0 1.0 CHEBI:15351 ChEBI 4.0 Lymphocyte antigen 96 Q99643 UniProt O75390 UniProt 11970143 PubChem-compound Toll-like receptor 4 O14920 UniProt MALONYL-COA BioCyc HMDB0001175 HMDB Citrate ATP-dependent 6- phosphofructokinase subunit alpha Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Monocyte differentiation antigen CD14 Toll-like receptor 4 Lymphocyte antigen 96 Inhibitor of nuclear factor kappa-B kinase subunit alpha Inhibitor of nuclear factor kappa-B kinase subunit beta NF-kappa-B essential modulator Nuclear factor NF-kappa-B p105 subunit NF-kappa-B inhibitor alpha Transcription factor p65 Nuclear factor NF-kappa-B p105 subunit Tricarboxylate transport protein, mitochondrial Citrate synthase, mitochondrial ATP-citrate synthase Acetyl-CoA carboxylase 1 Malate dehydrogenase, cytoplasmic NADP-dependent malic enzyme Myeloid differentiation primary response protein MyD88 Toll/interleukin- 1 receptor domain- containing adapter protein TNF receptor- associated factor 6 Citrate Citrate Lipopolysaccharide Acetyl Coenzyme A 2- Oxobutanedioate FAD FADH 2 Acetyl-CoA Malonyl-CoA 2- Oxobutanedioate 2- Hydroxybutanedioate Pyruvic acid NADPH Hydrogen ion NADP FAD 2Fe-2S Phosphate Biotin Manganese Manganese Fatty Acid Phosphorylation Induce CIC gene expression Ubiquitination causes proteasome degradation Extracellular Space Cytoplasm Mitochondria Nucleus
1.0 ATP-dependent 6-phosphofructokinase subunit alpha 1.0 17215925 ChemSpider 446013 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 31348 PubChem-compound Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial direct_interaction Tricarboxylate transport protein, mitochondrial 1.0 Citrate synthase, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Inhibitor of nuclear factor kappa-B kinase subunit beta C4H4O5 2-Hydroxybutanedioate 132.00697 H Hydrogen ion 1.007825 C205H366N3O117P5 Lipopolysaccharide 4897.147 C4H2O5 2-Oxobutanedioate 129.99022 C6H5O7 Citrate 189.00352 C23H38N7O17P3S Acetyl Coenzyme A 809.1258 1.0 ATP-citrate synthase Reaction1248 false Acetyl-CoA → Malonyl-CoA LEFT_TO_RIGHT HMDB0001197 HMDB C3H4O3 Pyruvic acid 88.016045 53-59-8 CAS CHEBI:16238 ChEBI TNF receptor-associated factor 6 Citrate Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial CHEBI:16474 ChEBI Monocyte differentiation antigen CD14 1.0 Q99836 UniProt 393487 ChemSpider ReactionCatalysis962 ACTIVATION C27H35N9O15P2 FADH 787.1728 Inhibitor of nuclear factor kappa-B kinase subunit beta Q04206 UniProt Reaction139099 false NADPH → NADP LEFT_TO_RIGHT Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial 1.0 C21H30N7O17P3 NADPH 745.0911 Fatty Acid Mitochondrion C21H29N7O17P3 NADP 744.08325 Acetyl-CoA P40925 UniProt NADP-dependent malic enzyme NADPH BioCyc 1.0 LPS Receptor Complex Citrate synthase, mitochondrial NADP-dependent malic enzyme SMILES [O-]C(=O)CC(=O)C([O-])=O Q9Y4K3 UniProt 1.0 HMDB0000217 HMDB SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N SMILES OC(CC([O-])=O)(CC([O-])=O)C([O-])=O SMILES OC(CC([O-])=O)C([O-])=O SMILES CCCCCCCCCCCCCCCC1[C@@H](CP(O)(O)=O)OC(CO[C@@H]2OC(CO[C@@]3(CC(O[C@@]4(CC(O[C@@]5(CC(O)[C@@H](O)C(O5)C(O)CO)C(O)=O)[C@@H](O)C(O4)C(O)CO)C(O)=O)[C@@H](O[C@@H]4OC(C(O)CO)[C@@H](OP(O)(=O)OP(O)(=O)OCCN)C(O[C@H]5OC(C(O)CO[C@H]6OC[C@](O)(C(O)CO)C(O)[C@H]6O)[C@@H](OP(O)(O)=O)C(O[C@H]6OC(CO[C@H]7OC(CO)[C@H](O)C(O)C7O)[C@@H](O)C(O[C@H]7OC(CO)[C@H](O)C(O)C7O[C@H]7OC(CO)[C@@H](O[C@H]8OC(CO)[C@H](O)C(OC9O[C@@H](C)C(O[C@H]%10OC(CO)[C@@H](O)C(O[C@H]%11OC(C)[C@H](O)CC%11O)C%10O[C@H]%10OC(CO)[C@H](O)C(O)C%10O)C(O)[C@H]9O)C8O)C(O)C7O[C@H]7OC(CO)[C@@H](O)C(O)[C@@H]7NC(C)=O)C6O)[C@H]5O)[C@H]4O)C(O3)C(O)CO)C(O)=O)[C@@H](OP(O)(O)=O)C(OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H]2NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H](O)[C@@H]1OC(=O)CC(O)CCCCCCCCCCC CHEBI:15531 ChEBI C00006 KEGG Compound Succinate dehydrogenase Q13085 UniProt CHEBI:18009 ChEBI 559059 ChemSpider SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1 Tricarboxylate transport protein, mitochondrial Nuclear factor NF-kappa-B p105 subunit Succinate dehydrogenase cytochrome b560 subunit, mitochondrial C00005 KEGG Compound Transcription factor p65 1910-41-4 CAS CHEBI:35366 ChEBI 1031 ChemSpider NADP SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB NF-kappa-B essential modulator SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O P25963 UniProt Mitochondrial Inner Membrane Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY 2-Hydroxybutanedioate Toll/interleukin-1 receptor domain-containing adapter protein Transport9371 false Citrate (→) Transport: Homo sapiens, Cell, Mitochondrial Inner Membrane to Homo sapiens, Cell, Mitochondrial Outer Membrane LEFT_TO_RIGHT P31040 UniProt Toll/interleukin-1 receptor domain-containing adapter protein 53-57-6 CAS P58753 UniProt C27H33N9O15P2 FAD 785.1571 Malate dehydrogenase, cytoplasmic NADP-dependent malic enzyme C00016 KEGG Compound FAD Extracellular Space 1.0 Acetyl Coenzyme A 164550 PubChem-compound NAD(P) BioCyc HMDB0001206 HMDB GO:0005743 GENE ONTOLOGY ATP-citrate synthase GO:0005741 GENE ONTOLOGY ATP-dependent 6-phosphofructokinase subunit alpha FADH 1.0 1.0 Myeloid differentiation primary response protein MyD88 Pyruvic acid 1.0 ATP-citrate synthase TNF receptor-associated factor 6 SMP0100046 SMPDB Malonyl-CoA C00022 KEGG Compound C01352 KEGG Compound Myeloid differentiation primary response protein MyD88 (Homo sapiens)_Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens)_TNF receptor-associated factor 6 (Homo sapiens) P48163 UniProt C00024 KEGG Compound SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O HMDB0000243 HMDB GO:0005739 GENE ONTOLOGY O14521 UniProt GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 2-Oxobutanedioate Mitochondrial Outer Membrane LPS Receptor Complex Hydrogen ion 2.0 SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2 Transcription factor p65 1.0 ReactionCatalysis154506 ACTIVATION 1.0 Malate dehydrogenase, cytoplasmic Citrate NF-kappa-B inhibitor alpha Citrate Lipopolysaccharide CHEBI:17877 ChEBI Interaction1031 Citrate inhibits Succinate dehydrogenase NFKB1,NFKBIA,RELA Complex with Phosphate Interaction1030 Citrate inhibits 6-phosphofructokinase, muscle type 5675 ChemSpider 1.0 Interaction1037 CHUK-IKBKB-IKBKG complex activates NFKB1,NFKBIA,RELA Complex with Phosphate 72-89-9 CAS Interaction1036 LPS Receptor Complex activates CHUK-IKBKB-IKBKG complex Interaction1035 Myeloid differentiation primary response protein MyD88 (Homo sapiens) + Toll/interleukin-1 receptor domain-containing adapter protein (Homo sapiens) + TNF receptor-associated factor 6 (Homo sapiens) activates LPS Receptor Complex Q9Y6K9 UniProt Interaction1034 Lipopolysaccharide activates LPS Receptor Complex Reaction164134 false FAD → FADH LEFT_TO_RIGHT Reaction164135 false Citrate → Acetyl-CoA LEFT_TO_RIGHT ReactionCatalysis154504 ACTIVATION Reaction164132 false 2-Oxobutanedioate + Acetyl Coenzyme A → Citrate LEFT_TO_RIGHT Interaction1038 NFKB1,NFKBIA,RELA Complex with Phosphate activates Nuclear factor NF-kappa-B p105 subunit ReactionCatalysis154502 ACTIVATION 1.0 ReactionCatalysis154501 ACTIVATION Reaction164138 false 2-Oxobutanedioate → 2-Hydroxybutanedioate LEFT_TO_RIGHT ReactionCatalysis154500 ACTIVATION Reaction164136 false Malonyl-CoA → Fatty Acid LEFT_TO_RIGHT Reaction164137 false Citrate → 2-Oxobutanedioate LEFT_TO_RIGHT Cytoplasm 1.0 NADPH 10213 ChemSpider Acetyl-CoA carboxylase 1 O00206 UniProt Citrate synthase, mitochondrial Lymphocyte antigen 96 Myeloid differentiation primary response protein MyD88 Monocyte differentiation antigen CD14 1.0 643975 PubChem-compound Homo sapiens 160434 PubChem-compound PW101069 PathWhiz SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 524-14-1 CAS 2-Oxobutanedioate NF-kappa-B inhibitor alpha CHUK-IKBKB-IKBKG complex 1.0 127-17-3 CAS HMDB0001248 HMDB P21912 UniProt Q9Y6Y9 UniProt Reaction164141 false Pyruvic acid → Hydrogen ion + NADPH LEFT_TO_RIGHT Reaction164142 false NADP → Pyruvic acid LEFT_TO_RIGHT Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Reaction164140 false 2-Hydroxybutanedioate → Pyruvic acid LEFT_TO_RIGHT P53396 UniProt 1.0 P19838 UniProt Nuclear factor NF-kappa-B p105 subunit LPS and Citrate Signaling and Inflammation Toll-like receptor 4 Toll-like receptor 4 SMILES CC(=O)C(O)=O Inhibitor of nuclear factor kappa-B kinase subunit alpha 9606 TAXONOMY P53007 UniProt 1.0 Monocyte differentiation antigen CD14 392413 ChemSpider Fatty Acid 1.0 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial C00083 KEGG Compound Transcription factor p65 CHEBI:32816 ChEBI Lymphocyte antigen 96 1.0 4.0 146-14-5 CAS C24H38N7O19P3S Malonyl-CoA 853.1156 PYRUVATE BioCyc NF-kappa-B inhibitor alpha O15111 UniProt 1.0 5886 PubChem-compound Acetyl-CoA carboxylase 1 P16861 UniProt 1.0 444493 PubChem-compound P08571 UniProt NFKB1,NFKBIA,RELA Complex with Phosphate 10663 PubChem-compound 22833512 PubChem-compound ACETYL-COA BioCyc FAD BioCyc Inhibitor of nuclear factor kappa-B kinase subunit alpha FADH2 BioCyc TransportCatalysis1142 ACTIVATION NF-kappa-B essential modulator Nucleus 1060 PubChem-compound SMILES [H+] 1.0 1.0 CHEBI:15351 ChEBI 4.0 Lymphocyte antigen 96 Q99643 UniProt O75390 UniProt 11970143 PubChem-compound Toll-like receptor 4 O14920 UniProt MALONYL-COA BioCyc HMDB0001175 HMDB Citrate