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Pathway Description
Thioguanine Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2020-08-08
Last Updated: 2023-10-25
Thioguanine is an antineoplastic compound used to treat acute leukemia. It is usually administered orally and delivered to the site of action through the blood. Thioguanine has similar properties to 6-mercaptopurine as they share similar metabolites with the exception of 6-meraptopurine inhibiting the purine de novo synthesis pathway. Thioguanine's metabolites thiodeoxyguanosine-5'-triphosphate and thioguanosine 5'-triphosphate can be incorporated into DNA and RNA respectively which causes proliferation and protein synthesis to be inhibited. Thioguanosine 5'-triphosphate also inhibits ras-related C3 botulinum toxin substrate 1 a small GTPase membrane protein responsible for regulating cellular functions like cell growth, antimicrobial cytotoxicity, apoptosis regulation of lymphocytes. With ras-related C3 botulinum toxin substrate 1 being inhibited, apoptosis of T and B lymphocytes is no longer regulated and they are killed off. This leads to immunosuppression.
References
Thioguanine Pathway References
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