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Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Prostaglandin G/H synthase 1 Solute carrier family 22 member 7 Prostaglandin E synthase Prostacyclin synthase Thromboxane-A synthase Cytosolic phospholipase A2 Aspirin Aspirin Aspirin Prostaglandin H2 Prostaglandin E2 Prostaglandin I2 Thromboxane A2 Arachidonic acid O2 Prostaglandin G2 H2O Glutathione Heme Phospholipids Acceptor Reduced acceptor Prostaglandin G/H synthase 2 Heme Calcium Endoplasmic Reticulum Cytosol Extracellular Space Aspirin (acetylsalicylic acid) inhibits prostaglandin (PG) G/H synthase 1 and 2 (COX-1 and COX-2 respectively)on the endoplasmic reticulum membrane, preventing the conversion of arachidonic acid into PGH2. PG E2 is responsible for inflammation and pain by activating immune cells and stimulating pain fibres. Lower concentrations of PG E2 lowers inflammatory and relieving pain. Decreasing PGE2 in the central nervous system reduces fever Aspirin is administered orally and diffuses throughout the body Inhibition of COX-2 provides anti-inflammatory activity, as PG H2 cannot be synthesized and signal additional inflammatory PGs COX-1 is responsible for PG synthesis for gastrointestinal and renal function. COX-2 is responsible for PG synthesis for tissue injury and inflammation
Endoplasmic Reticulum PTGS1 PTGS2 PTGS1 SLC22A7 PTGES PTGIS TBXAS1 PLA2G4A Aspirin Aspirin Aspirin Prostaglandin H2 Prostaglandin E2 Prostaglandin I2 Thromboxane A2 Arachidonic acid Oxygen Prostaglandin G2 Water Phospholipids Acceptor Reduced acceptor PTGS2
PTGS1 PTGS2 PTGS1 SLC22A7 PTGES PTGIS TBXAS1 PLA2G4A Asprin Asprin Asprin PGH2 PGE2 PrstgI2 ThrmbA2 20:4 O2 PGG2 H2O GSH Heme Phosp Accepto RA PTGS2 Heme Ca2+ Endoplasmic Reticulum Cytosol Extracellular Space Aspirin (acetylsalicylic acid) inhibits prostaglandin (PG) G/H synthase 1 and 2 (COX-1 and COX-2 respectively)on the endoplasmic reticulum membrane, preventing the conversion of arachidonic acid into PGH2. PG E2 is responsible for inflammation and pain by activating immune cells and stimulating pain fibres. Lower concentrations of PG E2 lowers inflammatory and relieving pain. Decreasing PGE2 in the central nervous system reduces fever Aspirin is administered orally and diffuses throughout the body Inhibition of COX-2 provides anti-inflammatory activity, as PG H2 cannot be synthesized and signal additional inflammatory PGs COX-1 is responsible for PG synthesis for gastrointestinal and renal function. COX-2 is responsible for PG synthesis for tissue injury and inflammation
Endoplasmic Reticulum PTGS1 PTGS2 PTGS1 SLC22A7 PTGES PTGIS TBXAS1 PLA2G4A Asprin Asprin Asprin PGH2 PGE2 PrstgI2 ThrmbA2 20:4 O2 PGG2 H2O Phosp Accepto RA PTGS2