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Pathway Description
Intestinal Serotonin pathway
Homo sapiens
Signaling Pathway
Created: 2022-03-28
Last Updated: 2023-10-25
More than 90% of serotonin or 5-hydroxytryptamine is produced and found in the gut. Serotonin activates alpha adrenergic receptors which activates the Gq protein cascade. This activates Phospolipase C which catalyzes Phosphatidylinositol 4,5-bisphosphate into Inositol 1,4,5-trisphosphate and Diacylglycerol. Diacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell. Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor on the sarcoplasmic reticulum which also allows calcium to enter the cell from the sarcoplasmic reticulum. This high concentration of calcium in the cytosol attaches to calmodulin which activates Myosin light chain kinase. This enzyme catalyzes Myosin light chain 3 into myosin LC-P which causes myosin to bind to actin and contract the muscle cell. The contraction of this smooth muscle causes the blood vessel to constrict. This causes the intestine to contract more often which causes food to move through more quickly. The faster the food moves through the intestine, the less nutrients are absorbed from the food into blood vessels.
References
Intestinal Serotonin pathway References
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