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Coagulation factor VII Tissue factor Coagulation factor XIa Coagulation factor IX Prothrombin Coagulation factor VIII Coagulation factor V Coagulation factor IX Coagulation factor X Coagulation factor X Prothrombin Thrombin Fibrinogen Coagulation factor XIIIa Fibrin (loose) P-glycoprotein Fibrin (mesh) Fibrin (mesh) Fibrin (mesh) Fibrin degradation products Fibrin degradation products Fibrin degradation products Plasminogen Coagulation factor X Coagulation factor XIII Thrombin Liver carboxylesterase 1 Coagulation factor VIII Coagulation factor V Coagulation factor VIIa Tissue factor Dabigatran Dabigatran Dabigatran etexilate Dabigatran etexilate Calcium Calcium Calcium Calcium Calcium Calcium Calcium Calcium Calcium Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic pathway. Extracellular Space The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel Hepatocyte Endoplasmic Reticulum Dabigatran etexilate is a prodrug, after being administered orally its metabolized to its active form Dabigatran Dabigatran inhibits thrombin, stopping the conversion of fibrinogen to fibrin and stopping the clotting cascade
Melanosome Endoplasmic Reticulum F7 Unknown Unknown F9 Unknown F8 F5 F9 F10 F10 Unknown Unknown Unknown F13A1 Unknown ABCB1 Unknown Unknown FGG Unknown Unknown FGG PLG F10 Unknown Unknown CES1 F8 F5 F7 Unknown Dabigatran Dabigatran Dabigatran etexilate Dabigatran etexilate
F7 F9 F8 F5 F9 F10 F10 F13A1 ABCB1 FGG FGG PLG F10 CES1 F8 F5 F7 Dabig Dabig Pradaxa Pradaxa Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Ca2+ Tenase Complex Prothrombinase Complex Extrinsic Pathway Vascular Injury At the site of injury collagen and tissue factor are exposed to coagulation factors in the blood activating the extrinsic pathway. Extracellular Space The fibrin mesh/clot forms at the site of vascular injury, blocking the leaking blood. Blood Vessel Hepatocyte Endoplasmic Reticulum Dabigatran etexilate is a prodrug, after being administered orally its metabolized to its active form Dabigatran Dabigatran inhibits thrombin, stopping the conversion of fibrinogen to fibrin and stopping the clotting cascade
Melanosome Endoplasmic Reticulum F7 F9 F8 F5 F9 F10 F10 F13A1 ABCB1 FGG FGG PLG F10 CES1 F8 F5 F7 Dabig Dabig Pradaxa Pradaxa