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Pathway Description
Dabigatran Etexilate Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-05
Last Updated: 2023-11-27
Dabigatran etexilate is an anticoagulant used to prevent venous thromboembolism, it is a prodrug that is administered orally and hydrolyzed via first-pass metabolism into the competitive thrombin inhibitor dabigatran. Dabigatran competitively binds and inhibits thrombin by doing so stops the formation of fibrin and therefore the meshwork for a thrombus. When administered orally, the capsule should not be tampered with in any way prior to administration. The highest concentration of the drug within the body peaks one hour after consumption. The maximum concentration can be prolonged to two hours if a high-fat meal is consumed prior, afterwards the drug is then primarily eliminated through urine and feces. This drug does interact with food, herbs and supplements with anticoagulant and antiplatelet activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. St. John's wort should also be avoided as it induces an enzyme that can reduce the concentration of active dabigatran. Dabigatran etexilate should be taken with a full glass of water and can be taken with or without the consumption of food.
References
Dabigatran Etexilate Pathway References
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Pubmed: 17869635
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Pubmed: 3030813
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Pubmed: 14574404
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Pubmed: 16710414
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