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P2Y purinoceptor 12 Gαi Adenylate Cyclase Plasma membrane Ca-ADPase ADP cAMP Ticagrelor Ca+ Ca+ Ticagrelor Ticagrelor Magnesium cAMP Ticagrelor has high affinity for the P2Y12 receptor to which it binds reversibly, preventing binding of ADP. Gi protein no longer inhibits adenylate cyclase, leading to a buildup of cAMP activating calcium efflux pump and prevents platelet activation Normally, ADP binds to P2Y12, activating the coupled Gi protein, inhibiting adenylate cyclase and leading to a shortage of cAMP. Calcium efflux is inactivated by lack of cAMP, inducing platelet activation and aggregation. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Ticagrelor is administered orally and travels through the bloodstream Blood Vessel
Melanosome Chloroplast Chloroplast P2RY12 GNAI1 ADCY10 Unknown Adenosine diphosphate cAMP Ticagrelor Calcium Calcium Ticagrelor Ticagrelor
P2RY12 GNAI1 ADCY10 ADP cAMP Azd6140 Ca+ Ca+ Azd6140 Azd6140 Mg2+ cAMP Ticagrelor has high affinity for the P2Y12 receptor to which it binds reversibly, preventing binding of ADP. Gi protein no longer inhibits adenylate cyclase, leading to a buildup of cAMP activating calcium efflux pump and prevents platelet activation Normally, ADP binds to P2Y12, activating the coupled Gi protein, inhibiting adenylate cyclase and leading to a shortage of cAMP. Calcium efflux is inactivated by lack of cAMP, inducing platelet activation and aggregation. Platelet Extracellular Space Affected Organs Symptom Relief Blood Clot Blood Vessel or Cell Damage Ticagrelor is administered orally and travels through the bloodstream Blood Vessel
Melanosome Chloroplast Chloroplast P2RY12 GNAI1 ADCY10 ADP cAMP Azd6140 Ca2+ Ca2+ Azd6140 Azd6140