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Pathway Description
Fructose Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-12-21
Last Updated: 2019-09-12
The biosynthesis of fructose has multiple point of origin:
-Sucrose is metabolized by an invertase resulting in the release of B-D-fructofuranose and D-glucopyranose. D-glucopyranose is then phosphorylated through a ATP driven glucokinase resulting in the release of a hydrogen ion, ADP and D-glucopyranose 6-phosphate. The latter compound is then isomerized through a D-glucopyranose 6-phosphate isomerase resulting in the release of a B-D-fructofuranose 6-phosphate
-Sucrose is metabolized by an invertase resulting in the release of B-D-fructofuranose and D-glucopyranose. B-D-fructofuranoseis phosphorylated through an ATP driven fructokinase resulting in the release of B-D-fructofuranose 6-phosphate.
-D-sorbitol reacts with sorbitol dehydrogenase resulting in the release of keto-D-fructose.The latter compound reacts spontaneously in B-D-fructofuranose. The latter compound is then phosphorylated through a fructokinase resulting in the release of B-D-fructofuranose 6-phosphate
-Sucrose 6-phosphate reacts with an invertase resulting in the release of B-D-fructofuranose and B-D-glucose 6-phosphate. The latter compound is then phosphorylated through a fructokinase resulting in the release of B-D-fructofuranose 6-phosphate
The degradation of B-D-fructofuranose 6-phosphate starts with the phosphorylation of B-D-fructofuranose 6-phosphate through a 6-phosphofructo-2-kinase resulting in the release of B-D-fructose 2,6-bisphosphate that can be latter incorporated into glycolysis
References
Fructose Metabolism References
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Pubmed: 1657152
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Boles E, Gohlmann HW, Zimmermann FK: Cloning of a second gene encoding 5-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate. Mol Microbiol. 1996 Apr;20(1):65-76. doi: 10.1111/j.1365-2958.1996.tb02489.x.
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Paravicini G, Kretschmer M: The yeast FBP26 gene codes for a fructose-2,6-bisphosphatase. Biochemistry. 1992 Aug 11;31(31):7126-33. doi: 10.1021/bi00146a014.
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Pubmed: 6300785
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Pubmed: 1888528
Jacq C, Alt-Morbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Blocker H, Blugeon C, Boskovic J, Brandt P, Bruckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature. 1997 May 29;387(6632 Suppl):75-8.
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Pubmed: 9832517
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