Browsing Pathways
Showing 481 -
490 of 605359 pathways
SMPDB ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
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SMP0144425View Pathway |
Tegafur-uracil Drug Metabolism Action Pathway |
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SMP0144382View Pathway |
Tegafur Drug Metabolism Action Pathway |
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SMP0144266View Pathway |
Tedizolid phosphate Drug Metabolism Action Pathway |
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SMP0126767View Pathway |
Tedizolid Phosphate Action PathwayTedizolid phosphate is an antibiotic, also known as Sivextro, used in the treatment of gram-positive bacterial infections. Tedizolid phosphate is a prodrug and is metabolized in the liver to its active form of Tedizolid. Tedizolid is part of the oxazolidinones class of antibacterials that are capable of inhibiting bacteria that are resistant to other antibiotics. The mechanism of action binds to the A site of the ribosome that interacts with the 23S rRNA subunit, which makes subsequent peptides nonfunctional protein.
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SMP0145185View Pathway |
Tedizolid Drug Metabolism Action Pathway |
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SMP0144820View Pathway |
Tecovirimat Drug Metabolism Action Pathway |
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SMP0126034View Pathway |
Tecovirimat Action PathwayTecovirimat (Tpoxx) is an antiviral used in the treatment of smallpox, monkeypox and cowpox. In fact, this drug is effective against all orthopoxviruses, including vaccinia, cowpox, ectromelia, rabbitpox, monkeypox and variola virus (smallpox). Tecovirimat was approved by the FDA in July 2018. Tecovirimal is an inhibitor of the P37 protein (VP37 envelope-wrapping protein)) of the orthopoxvirus. This protein is essential to form the wrapping complex of mature virions with late endosomal membranes by interacting with proteins such as Rab9 GTPase and TIP47.. The P37 protein is encoded by a highly conserved gene in all members of the orthopoxvirus genus. When Tecovirimat binds P37, this protein can not interact with the Rab9 GTPase and TIP47, which are components of late endosome-derived transport vesicles. In consequence, there is no formation of the wrapping complex for enveloped virions. This drug is available as an oral tablet and an intravenous formulation.
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SMP0144389View Pathway |
Technetium Tc-99m tilmanocept Drug Metabolism Action Pathway |
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SMP0144357View Pathway |
Technetium Tc-99m tetrofosmin Drug Metabolism Action Pathway |
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SMP0144467View Pathway |
Technetium Tc-99m sulfur colloid Drug Metabolism Action Pathway |
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Showing 481 -
490 of 4295 pathways