SMPDB

Showing 691 - 700 of 605359 pathways

SMPDB ID	Pathway Name and Description	Pathway Class	Chemical Compounds	Proteins
SMP0126351 View Pathway	Tiludronic Acid Action Pathway Tiludronic acid is a first-generation bisphosphonate used to treat Paget's disease, similar to etidronic acid and clodronic acid. Tiludronic acid binds to hydroxylapatite in the bone, during bone resorption it is released and taken up by osteoclasts through endocytosis. Once inside the osteoclast, it is released into the cytosol and goes to interrupt osteoclast activity and function. Tiludronic acid has a structure similar to pyrophosphate and due to this can be incorporated into ATP analogues that cannot be hydrolyzed. Due to this the osteoclast cannot utilize ATP and begins to go through apoptosis. If a patient has an overdose they may present with hypocalcemia, which can be treated with supportive care. Tiludronic acid should be taken 2 hours before or after consuming a meal and/or calcium supplements. Avoiding taking it with antacids as it will greatly reduce the bioavailability. BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	3-Hydroxy-3-methylglutaryl-CoA Acetoacetyl-CoA Acetyl-CoA Adenosine diphosphate Adenosine triphosphate Carbon dioxide Cholesterol Coenzyme A Dimethylallylpyrophosphate Farnesyl pyrophosphate Geranyl-PP Geranylgeranyl-PP Hydrogen Ion Isopentenyl pyrophosphate Isopentenyl-PP Magnesium Mevalonate Mevalonate-5P Mevalonate-5PP NADP NADPH Phosphate Pyrophosphate Squalene Tiludronate Water ( show all show less )	3-hydroxymethyl-3-methylglutar... Acetyl-CoA acetyltransferase, ... ADP/ATP translocase 1 ATP synthase lipid-binding pro... ATP synthase subunit a ATP synthase subunit alpha, mi... ATP synthase subunit b, mitoch... ATP synthase subunit beta, mit... ATP synthase subunit delta, mi... ATP synthase subunit epsilon, ... ATP synthase subunit gamma, mi... Diphosphomevalonate decarboxyl... Farnesyl pyrophosphate synthas... Geranylgeranyl pyrophosphate s... Hydroxymethylglutaryl-CoA synt... Mevalonate kinase Phosphomevalonate kinase Squalene synthase ( show all show less )
SMP0145347 View Pathway	Tiludronate Drug Metabolism Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic	Tiludronate
SMP0130159 View Pathway	Tilsotolimod Drug Metabolism BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic		Cystatin-B Tilsotolimod
SMP0145244 View Pathway	Tilmanocept Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Tilmanocept
SMP0128547 View Pathway	Tilletia caries Drug Metabolism BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic		Cystatin-B Tilletia caries
SMP0128786 View Pathway	Tilia cordata pollen Drug Metabolism BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic		Cystatin-B Tilia cordata pollen
SMP0128572 View Pathway	Tilia americana pollen Drug Metabolism BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic		Cystatin-B Tilia americana pollen
SMP0129216 View Pathway	Tildrakizumab Drug Metabolism BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic		Cystatin-B Tildrakizumab
SMP0144944 View Pathway	Tilbroquinol Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Tilbroquinol
SMP0130831 View Pathway	Tilbroquinol Drug Metabolism Tilbroquinol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tilbroquinol passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic	Tilbroquinol	Solute carrier organic anion t...