Browsing Pathways
Showing 721 -
730 of 605359 pathways
SMPDB ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
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SMP0174732View Pathway |
Tiaprofenic acid Predicted Metabolism PathwayMetabolites of Tiaprofenic acid are predicted with biotransformer.
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SMP0143799View Pathway |
Tiaprofenic acid Drug Metabolism Action Pathway |
Drug Action
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SMP0124607View Pathway |
Tiaprofenic Acid Action Pathway (New)
Tiaprofenic acid is a nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Tiaprofenic acid possess anti-inflammatory, analgesic and antipyretic activity. It targets the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2. The rest of the pathway occurs on the endoplasmic reticulum membrane, where prostaglandin G/H synthase 1 & 2 converts arachidonic acid into prostaglandin H2. Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. COX-2 is an inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to the formation of prostaglandin E2 which is responsible for contributing to the inflammatory response by activating immune cells and for increasing pain sensation by acting on pain fibers. Tiaprofenic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2). The low concentration of prostaglandin E2 attenuates the effect it has on stimulating immune cells and pain fibers, consequently reducing inflammation and pain. Fever is triggered by inflammatory and infectious diseases. Cytokines are produced in the central nervous system (CNS) during an inflammatory response. These cytokines induce COX-2 production that increases the synthesis of prostaglandin, specifically prostaglandin E2 which adjusts hypothalamic temperature control by increasing heat production. Because tiaprofenic acid decreases PGE2 in the CNS, it has an antipyretic effect. Antipyretic effects results in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.
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Drug Action
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SMP0000705View Pathway |
Tiaprofenic Acid Action PathwayTiaprofenic Acid (also named tiaprofensaeure and surgam) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat pain (especially arthritic pain). Tiaprofenic can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Decreased prostaglandin synthesis in many animal model's cell is caused by presence of tiaprofenic.
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Drug Action
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SMP0126590View Pathway |
Tiapride Serotonin Antagonist Action PathwayTiapride is a selective D2 and D3 dopamine receptor blocker indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly.
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Drug Action
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SMP0126581View Pathway |
Tiapride Dopamine Antagonist Action PathwayTiapride is a selective D2 and D3 dopamine receptor blocker indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly.
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Drug Action
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SMP0143339View Pathway |
Tiagabine Drug Metabolism Action Pathway |
Drug Action
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SMP0145322View Pathway |
Thyroxine Drug Metabolism Pathway |
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SMP0129737View Pathway |
Thyrotropin Drug Metabolism |
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SMP0127721View Pathway |
Thyrotropin alfa Drug Metabolism |
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Showing 721 -
730 of 65006 pathways