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Showing 126761 - 126770 of 605359 pathways
SMPDB ID Pathway Name and Description Pathway Class Chemical Compounds Proteins

SMP0143136

Pw144804 View Pathway

Phentolamine Drug Metabolism Action Pathway

Drug Action

SMP0143143

Pw144811 View Pathway

Nicergoline Drug Metabolism Action Pathway

Drug Action

SMP0143398

Pw145066 View Pathway

Methyldopa Drug Metabolism Action Pathway

Drug Action

SMP0190661

Missing View Pathway

Cardiolipin Biosynthesis CL(12:0/16:0/17:0/i-21:0)

Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism (Wikipedia). Cardiolipin biosynthesis occurs mainly in the mitochondria, but there also exists an alternative synthesis route for CDP-diacylglycerol that takes place in the endoplasmic reticulum. This second route may supplement this pathway. All membrane-localized enzymes are coloured dark green in the image. First, dihydroxyacetone phosphate (or glycerone phosphate) from glycolysis is used by the cytosolic enzyme glycerol-3-phosphate dehydrogenase [NAD(+)] to synthesize sn-glycerol 3-phosphate. Second, the mitochondrial outer membrane enzyme glycerol-3-phosphate acyltransferase esterifies an acyl-group to the sn-1 position of sn-glycerol 3-phosphate to form 1-acyl-sn-glycerol 3-phosphate (lysophosphatidic acid or LPA). Third, the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (PA or 1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone. PA is then transferred to the inner mitochondrial membrane to continue cardiolipin synthesis. Fourth, magnesium-dependent phosphatidate cytidylyltransferase catalyzes the conversion of PA into CDP-diacylglycerol. Fifth, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase synthesizes phosphatidylglycerophosphate (PGP). Sixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). Last, cardiolipin synthase catalyzes the synthesis of cardiolipin by transferring a phosphatidyl group from a second CDP-diacylglycerol to PG. It requires a divalent metal cation cofactor.
Metabolic

SMP0143417

Pw145085 View Pathway

Cytarabine Drug Metabolism Action Pathway

Drug Action

SMP0143429

Pw145097 View Pathway

Hydrochlorothiazide Drug Metabolism Action Pathway

Drug Action

SMP0143424

Pw145092 View Pathway

Neomycin Drug Metabolism Action Pathway

Drug Action

SMP0143393

Pw145061 View Pathway

Bromfenac Drug Metabolism Action Pathway

Drug Action

SMP0143405

Pw145073 View Pathway

Dipyridamole Drug Metabolism Action Pathway

Drug Action

SMP0143410

Pw145078 View Pathway

Ramelteon Drug Metabolism Action Pathway

Drug Action
Showing 126761 - 126770 of 140991 pathways