PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144600 View Pathway	drug action Rimantadine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:59 Last Updated: October 07, 2023 at 13:59
PW146528 View Pathway	drug action Rimegepant Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:25 Last Updated: October 07, 2023 at 18:25
PW127841 View Pathway	drug action Rimexolone Action Pathway Homo sapiens Rimexolone, also known as Vexol, is a glucocorticoid used to treat inflammation of the eye. It is available as a 1% eye drop solution. Rimexolone is a glucocorticoid receptor agonist. As this drug is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) of influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Rimexolone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 08, 2023 at 09:29 Last Updated: June 08, 2023 at 09:29
PW144998 View Pathway	drug action Rimexolone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:53 Last Updated: October 07, 2023 at 14:53
PW132449 View Pathway	metabolic Rimonabant Drug Metabolism Homo sapiens Rimonabant is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Rimonabant passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:50 Last Updated: September 21, 2023 at 21:50
PW145667 View Pathway	drug action Rimonabant Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:20 Last Updated: October 07, 2023 at 16:20
PW145893 View Pathway	drug action Riociguat Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:55 Last Updated: October 07, 2023 at 16:55
PW128527 View Pathway	drug action Ripretinib Action Pathway Homo sapiens Ripretinib is a kinase inhibitor primarily used to treat advanced gastrointestinal stromal tumor (GIST) that has not responded well to other kinase inhibitors like sunitinib and imatinib. Marketed under the name Qinlock, this medication is manufactured by Deciphera Pharmaceuticals and received FDA approval on May 15, 2020. It is notable for being the first drug approved as a fourth-line therapy, specifically for patients who have previously undergone treatment with at least three other kinase inhibitors, including imatinib. Ripretinib's mechanism of action involves inhibiting protein kinases, including both wild type and mutant forms of platelet-derived growth factor receptor A (PDGFRA) and KIT, which are implicated in the majority of gastrointestinal stromal tumors (GIST). This medication has been shown to inhibit other genes like PDGFRB, BRAF, VEGF, and TIE2 in laboratory studies. Its unique dual mechanism involves binding to the kinase switch pocket as well as the activation loop, effectively turning off the kinase and halting its ability to promote uncontrolled cell growth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: September 01, 2023 at 13:26 Last Updated: September 01, 2023 at 13:26
PW146893 View Pathway	drug action Ripretinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:18 Last Updated: October 07, 2023 at 19:18
PW176402 View Pathway	metabolic Ripretinib Predicted Metabolism Pathway Homo sapiens Metabolites of Ripretinib are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:51 Last Updated: December 07, 2023 at 16:51