PathWhiz

PathWhiz ID	Pathway	Meta Data
PW124088 View Pathway	drug action Sotalol Mechanism of Action (New) Homo sapiens Sotalol is a potassium channel beta blocker used to treat ventricular arrhythmias and to help maintain normal sinus rhythm in atrial fibrillation and flutter. After being taken orally, it is absorbed into the blood through the GI tract and inhibits the beta 1 adrenergic receptor and the potassium voltage gated channel subfamily H member 2 protein on the cell membranes of cardiomyocytes. The beta 1 adrenergic receptor is responsible for Gs signalling and the production of cyclic adenosine monophosphate (cAMP) which activates the L-type calcium channel. The L-type calcium channel is responsible for the influx of calcium from extracellular environment into the cytosol of cardiomyocytes which activates ryanodine receptors to release calcium from the sarcoplasmic reticulum. Calcium is important for the contraction of heart muscle for myosin to and actin to power-stroke so the slower influx of calcium slows down the contractions of the heart lowering the heart rate. The inhibition of potassium voltage gated channel subfamily H member 2 protein inhibits the efflux of potassium out of the cell during the repolarization phase of an action potential. This lengthens the QT interval of the heartbeat as well as prolonging the repolarization phase of action potentials. This regulates the heart rate and slows down any rapid heartrates. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: August 18, 2020 at 13:04 Last Updated: August 18, 2020 at 13:04
PW176292 View Pathway	metabolic Sotalol Predicted Metabolism Pathway Homo sapiens Metabolites of Sotalol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:47 Last Updated: December 04, 2023 at 14:47
PW146928 View Pathway	drug action Sotorasib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:22 Last Updated: October 07, 2023 at 19:22
PW146753 View Pathway	drug action Soy isoflavones Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:57 Last Updated: October 07, 2023 at 18:57
PW130048 View Pathway	metabolic Soybean Drug Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: September 14, 2023 at 20:32 Last Updated: September 14, 2023 at 20:32
PW145294 View Pathway	drug action Sparfloxacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:29 Last Updated: October 07, 2023 at 15:29
PW000356 View Pathway	drug action Spectinomycin Action Pathway Homo sapiens Spectinomycin (also named Togamycin or Trobicin) is an aminocyclitol antibiotic for the treatment of gonorrhea infections such as penicillin-resistant Neisseria gonorrhoeae (experimental studies shows that spectinomycin equips with bacteriostatic effect against most Neisseria gonorrhoeae strains). It is produced from Streptomyces spectabilis, which is a soil microorganism. Spectinomycin reversibly interferes with the interaction between mRNA and the bacterial 30S ribosomal subunit. It is structurally similar to aminoglycosides, but does not cause misreading of mRNA. It is structurally similar to aminoglycosides, but does not cause misreading of mRNA. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW125964 View Pathway	drug action Spectinomycin Anti-bacterial Action Pathway Homo sapiens Spectinomycin is an aminocyclitol antibiotic used to treat susceptible strains of gram-negative bacteria, Neisseria gonorrhoeae. It is used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis. Spectinomycin is an inhibitor of protein synthesis in the bacterial cell by binding to the 30S ribosomal subunit. As a result, this agent interferes with the initiation of protein synthesis and with proper protein elongation. This eventually leads to bacterial cell death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: May 10, 2021 at 10:23 Last Updated: May 10, 2021 at 10:23
PW132419 View Pathway	metabolic Spectinomycin Drug Metabolism Homo sapiens Spectinomycin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Spectinomycin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:37 Last Updated: September 21, 2023 at 21:37
PW145020 View Pathway	drug action Spectinomycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:56 Last Updated: October 07, 2023 at 14:56