PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146491 View Pathway	drug action Letermovir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:19 Last Updated: October 07, 2023 at 18:19
PW176335 View Pathway	metabolic Letermovir Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:13 Last Updated: December 07, 2023 at 15:13
PW145104 View Pathway	drug action Letrozole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:05 Last Updated: October 07, 2023 at 15:05
PW000811 View Pathway	metabolic Leucine Biosynthesis Escherichia coli Leucine biosynthesis involves a five-step conversion process starting with the valine precursor 2-keto-isovalerate interacting with acetyl-CoA and water through a 2-isopropylmalate synthase resulting in Coenzyme A, hydrogen Ion and 2-isopropylmalic acid. The latter compound reacts with isopropylmalate isomerase which dehydrates the compound resulting in a Isopropylmaleate. This compound reacts with water through a isopropylmalate isomerase resulting in 3-isopropylmalate. This compound interacts with a NAD-driven D-malate / 3-isopropylmalate dehydrogenase results in 2-isopropyl-3-oxosuccinate. This compound interacts spontaneously with hydrogen resulting in the release of carbon dioxide and ketoleucine. Ketoleucine interacts in a reversible reaction with L-glutamic acid through a branched-chain amino-acid aminotransferase resulting in Oxoglutaric acid and L-leucine. L-leucine can then be exported outside the cytoplasm through a transporter: L-amino acid efflux transporter. In the final step, ketoleucine can be catalyzed to form L-leucine by branched-chain amino-acid aminotransferase (IlvE) and tyrosine aminotransferase (TryB). L-Glutamic acid can also be transformed into oxoglutaric acid by these two enzymes. Tyrosine aminotransferase can be suppressed by lecuine, and inhibited by 2-keto-isovarlerate and its end product, tyrosine. 2-ketoisocaproate can not be introduced if 2-keto-isovarlerate inhibit TyrB and IlvE is absent. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 16, 2015 at 15:51 Last Updated: March 16, 2015 at 15:51
PW122595 View Pathway	metabolic Leucine Biosynthesis Pseudomonas aeruginosa Leucine biosynthesis involves a five-step conversion process starting with the valine precursor 2-keto-isovalerate interacting with acetyl-CoA and water through a 2-isopropylmalate synthase resulting in Coenzyme A, hydrogen Ion and 2-isopropylmalic acid. The latter compound reacts with isopropylmalate isomerase which dehydrates the compound resulting in a Isopropylmaleate. This compound reacts with water through a isopropylmalate isomerase resulting in 3-isopropylmalate. This compound interacts with a NAD-driven D-malate / 3-isopropylmalate dehydrogenase results in 2-isopropyl-3-oxosuccinate. This compound interacts spontaneously with hydrogen resulting in the release of carbon dioxide and ketoleucine. Ketoleucine interacts in a reversible reaction with L-glutamic acid through a branched-chain amino-acid aminotransferase resulting in Oxoglutaric acid and L-leucine. L-leucine can then be exported outside the cytoplasm through a transporter: L-amino acid efflux transporter. In the final step, ketoleucine can be catalyzed to form L-leucine by branched-chain amino-acid aminotransferase (IlvE) and tyrosine aminotransferase (TryB). L-Glutamic acid can also be transformed into oxoglutaric acid by these two enzymes. Tyrosine aminotransferase can be suppressed by lecuine, and inhibited by 2-keto-isovarlerate and its end product, tyrosine. 2-ketoisocaproate can not be introduced if 2-keto-isovarlerate inhibit TyrB and IlvE is absent. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 18:20 Last Updated: August 12, 2019 at 18:20
PW002475 View Pathway	metabolic Leucine Biosynthesis Saccharomyces cerevisiae Leucine biosynthesis involves a five-step conversion process starting with the valine precursor 2-keto-isovalerate interacting with acetyl-CoA and water through a 2-isopropylmalate synthase resulting in Coenzyme A, hydrogen Ion and 2-isopropylmalic acid. The latter compound reacts with isopropylmalate isomerase which dehydrates the compound resulting in a Isopropylmaleate. This compound reacts with water through a isopropylmalate isomerase resulting in 3-isopropylmalate. This compound interacts with a NAD-driven D-malate / 3-isopropylmalate dehydrogenase results in 2-isopropyl-3-oxosuccinate. This compound interacts spontaneously with hydrogen resulting in the release of carbon dioxide and ketoleucine. Ketoleucine interacts in a reversible reaction with L-glutamic acid through a branched-chain amino-acid aminotransferase resulting in Oxoglutaric acid and L-leucine. L-leucine can then be exported outside the cytoplasm through a transporter: L-amino acid efflux transporter. In the final step, ketoleucine can be catalyzed to form L-leucine by branched-chain amino-acid aminotransferase (IlvE) and tyrosine aminotransferase (TryB). L-Glutamic acid can also be transformed into oxoglutaric acid by these two enzymes. Tyrosine aminotransferase can be suppressed by lecuine, and inhibited by 2-keto-isovarlerate and its end product, tyrosine. 2-ketoisocaproate can not be introduced if 2-keto-isovarlerate inhibit TyrB and IlvE is absent. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: February 19, 2016 at 13:35 Last Updated: February 19, 2016 at 13:35
PW002540 View Pathway	metabolic Leucine Biosynthesis Arabidopsis thaliana Leucine biosynthesis involves a five-step conversion process starting with the valine precursor 2-keto-isovalerate interacting with acetyl-CoA and water through a 2-isopropylmalate synthase resulting in Coenzyme A, hydrogen Ion and 2-isopropylmalic acid. The latter compound reacts with isopropylmalate isomerase which dehydrates the compound resulting in a Isopropylmaleate. This compound reacts with water through a isopropylmalate isomerase resulting in 3-isopropylmalate. This compound interacts with a NAD-driven D-malate / 3-isopropylmalate dehydrogenase results in 2-isopropyl-3-oxosuccinate. This compound interacts spontaneously with hydrogen resulting in the release of carbon dioxide and ketoleucine. Ketoleucine interacts in a reversible reaction with L-glutamic acid through a branched-chain amino-acid aminotransferase resulting in Oxoglutaric acid and L-leucine. L-leucine can then be exported outside the cytoplasm through a transporter: L-amino acid efflux transporter. In the final step, ketoleucine can be catalyzed to form L-leucine by branched-chain amino-acid aminotransferase (IlvE) and tyrosine aminotransferase (TryB). L-Glutamic acid can also be transformed into oxoglutaric acid by these two enzymes. Tyrosine aminotransferase can be suppressed by lecuine, and inhibited by 2-keto-isovarlerate and its end product, tyrosine. 2-ketoisocaproate can not be introduced if 2-keto-isovarlerate inhibit TyrB and IlvE is absent. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: May 05, 2016 at 14:53 Last Updated: May 05, 2016 at 14:53
PW002490 View Pathway	metabolic Leucine Degradation Saccharomyces cerevisiae The degradation of L-leucine starts either in the mitochondria or the cytosol. L-leucine reacts with 2-oxoglutarate through a branch-chain amino acid aminotransferase resulting in the release of ketoleucine and glutamate. The latter compound reacts with ketoisocaproate decarboxylase resulting in the release of carbon dioxide and 3-methylbutanal. The latter compound can then be turned into 3-methylbutanol through a alcohol dehydrogenase BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: February 29, 2016 at 14:20 Last Updated: February 29, 2016 at 14:20
PW013301 View Pathway	metabolic Leucine degradation Bacteria I would like to test Pathwhiz BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: April 27, 2017 at 06:57 Last Updated: April 27, 2017 at 06:57
PW002541 View Pathway	metabolic Leucine Degradation Arabidopsis thaliana The degradation of L-leucine starts either in the mitochondria, the cytosol or the chloroplast. L-leucine reacts with 2-oxoglutarate through a branch-chain amino acid aminotransferase resulting in the release of ketoleucine and glutamate. Ketoleucine reacts with coenzyme a through a NAD dependent branched chain keto-acid dehydrogenase complex resulting in the release of NADH, carbon dioxide and isovaleryl-CoA. Isovaleryl-CoA reacts with an oxidized electron flavoprotein resulting in the release of a reduced flavoprotein and a methylcrotonyl-CoA. The latter reacts with ATP and hydrogen carbonate through a 3-methylcrotonyl-CoA carboxylase resulting in the release of phosphate, ADP, hydrogen ion and 3-methylglutaconyl-CoA. The latter compound reacts with water through a methylglutaconyl-CoA hydratase resulting in the release of hydroxy-3-methylglutaryl-CoA. The latter reacts with a hydroxymethylglutaryl-CoA lyase resulting in the release of acetyl-CoA and acetoacetate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: May 05, 2016 at 16:47 Last Updated: May 05, 2016 at 16:47