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Pathways

PathWhiz ID Pathway Meta Data

PW145668

Pw145668 View Pathway
drug action

Noscapine Drug Metabolism Action Pathway

Homo sapiens

PW064693

Pw064693 View Pathway
signaling

Notch

Homo sapiens

PW124223

Pw124223 View Pathway
signaling

Notch signalling pathway

Homo sapiens

PW064734

Pw064734 View Pathway
signaling

notch1

Homo sapiens

PW145145

Pw145145 View Pathway
drug action

Novobiocin Drug Metabolism Action Pathway

Homo sapiens

PW176424

Pw176424 View Pathway
metabolic

Novobiocin Predicted Metabolism Pathway

Homo sapiens
Metabolites of Novobiocin are predicted with biotransformer.

PW132287

Pw132287 View Pathway
metabolic

Noxytiolin Drug Metabolism

Homo sapiens
Noxytiolin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Noxytiolin passes through the liver and is then excreted from the body mainly through the kidney.

PW146682

Pw146682 View Pathway
drug action

Noxytiolin Drug Metabolism Action Pathway

Homo sapiens

PW122236

Pw122236 View Pathway
signaling

npr 1-1

Arabidopsis thaliana

PW124178

Pw124178 View Pathway
signaling

Nuclear factor kappa-B (NF-κB) Pathway

Homo sapiens
NF-kB protein dimmers as nuclear transcription factor, they need to migrate to the nucleus, combined with DNA to have function. In most types of the normal cells under resting state, NF-KB was inactive and retain in the cytoplasm. They binding to a specific inhibitors called IK-B protein, which could bind to the Rel homology domain (RHD) of NF-kB and interfere with its nuclear localization sequence (NLS) function. These inhibitor proteins, which include IkBa, IkBb and IkBg, contain 6–7 ankyrin repeats that mediate binding to the RHD. These repeats are also present in the C-terminal halves of the NF-kB2/p100 and NF-kB1/p105 precursors, which also function as IkBs and retain their partners, the Rel proteins, in the cytoplasm. In order to activate the NF-kB molecular, the cells first need to separate the NF-kB protein from their inhibitors. There are two major signaling pathways lead to the IK-B protein inhibitor dissociation from NF-kB dimmer and let the translocation of NF-kB dimers from the cytoplasm into the nucleus.