PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145855 View Pathway	drug action Rilpivirine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:49 Last Updated: October 07, 2023 at 16:49
PW124609 View Pathway	drug action Rilpivirine Mechanism of Action Homo sapiens Rilpivirine is an oral non- nucleoside reverse transcriptase inhibitor used to treat HIV-1. When HIV infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid containing its RNA and reverse transcriptase into the cytosol of the cell. The reverse transcriptase converts the viral RNA into viral DNA. The viral DNA goes through the process of transcription and translation to produce viral proteins. These viral proteins are assembled and new HIV viruses buds from the cell. Nevirapine enters the cell through the solute carrier family 22 member 1 transporter and binds to and inhibits reverse transcriptase, preventing the formation of viral DNA from viral RNA. Since less viral DNA is formed, less of this DNA is available in the nucleus to undergo transcription and translation, consequently, less viral proteins are formed. This reduces the formation of new viruses since there are fewer viral proteins. Rilpivirine is only effective against HIV-1, and not against HIV-2. Signs and symptoms of HIV such as Chronic fatigue, rapid weight loss, nausea, vomiting, coughing and shortness of breath, recurring fever/chills, rashes/ sores may be relieved from taking rilpivirine. The internal conformational flexibility of rilpivirine and the plasticity of the binding site causes this drug to have high potency and reduces the chance of resistance compared to other NNRTI's. Side effects of nevirapine include rash, nausea, fever, fatigue, headache, stevens-johnson syndrome, liver injury, jaundice, joint ache, edema and blisters. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: March 28, 2021 at 22:02 Last Updated: March 28, 2021 at 22:02
PW126925 View Pathway	metabolic Rilpivirine Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: May 15, 2022 at 22:27 Last Updated: May 15, 2022 at 22:27
PW144851 View Pathway	drug action Riluzole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:33 Last Updated: October 07, 2023 at 14:33
PW176289 View Pathway	metabolic Riluzole Predicted Metabolism Pathway Homo sapiens Metabolites of Riluzole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:43 Last Updated: December 04, 2023 at 14:43
PW127553 View Pathway	drug action Rimantadine Action Pathway Homo sapiens Rimantadine is an RNA synthesis inhibitor used to prevent influenza A infection.The mechanism of action of rimantadine is not fully understood. Rimantadine appears to exert its inhibitory effect early in the viral replicative cycle, possibly inhibiting the uncoating of the virus. It may play a role in the inhibition of the matrix protein 2 protein which is required for the uncoating of the protein. The inhibition of matrix protein 2 prevents the virus from replicating and further infecting cells. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 02, 2023 at 10:15 Last Updated: May 02, 2023 at 10:15
PW132468 View Pathway	metabolic Rimantadine Drug Metabolism Homo sapiens Rimantadine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Rimantadine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:55 Last Updated: September 21, 2023 at 21:55
PW144600 View Pathway	drug action Rimantadine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:59 Last Updated: October 07, 2023 at 13:59
PW146528 View Pathway	drug action Rimegepant Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:25 Last Updated: October 07, 2023 at 18:25
PW127841 View Pathway	drug action Rimexolone Action Pathway Homo sapiens Rimexolone, also known as Vexol, is a glucocorticoid used to treat inflammation of the eye. It is available as a 1% eye drop solution. Rimexolone is a glucocorticoid receptor agonist. As this drug is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) of influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Rimexolone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 08, 2023 at 09:29 Last Updated: June 08, 2023 at 09:29