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Pathways

PathWhiz ID Pathway Meta Data

PW146369

Pw146369 View Pathway
drug action

Alectinib Drug Metabolism Action Pathway

Homo sapiens

PW122401

Pw122401 View Pathway
physiological

Aldosterone from Steroidogenesis

Homo sapiens
Aldosterone is a hormone produced in the zona glomerulosa of the adrenal cortex. It's function is to act on the distal convoluted tubule and the collecting duct of the nephron to make them more permeable to sodium to allow for its reuptake (in addition to allowing potassium wasting). As a result, water follows the sodium back into the body. The water retention contributes to an increased blood volume. Angiotensin II from the circulation binds to receptors on the zona glomerulosa cell membrane, activating the G protein and triggering a signaling cascade. The end result is the activation of the steroidogenic acute regulatory (StAR) protein that permits cholesterol uptake into the mitochondria. From there, cholesterol undergoes a series of reactions in both the mitochondrion and the smooth endoplasmic reticulum (steroidogenesis) where it finally becomes aldosterone.

PW064538

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signaling

Aldosterone

Homo sapiens

PW146297

Pw146297 View Pathway
drug action

Alcloxa Drug Metabolism Action Pathway

Homo sapiens

PW132210

Pw132210 View Pathway
metabolic

Alcloxa Drug Metabolism

Homo sapiens
Alcloxa is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Alcloxa passes through the liver and is then excreted from the body mainly through the kidney.

PW144369

Pw144369 View Pathway
drug action

Alclometasone Drug Metabolism Action Pathway

Homo sapiens

PW127740

Pw127740 View Pathway
drug action

Alclometasone Action Pathway

Homo sapiens
Alclometasone is a synthetic glucocorticoid steroid for topical use in the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Alclometasone is a selective glucocorticoid receptor agonist. The exact mechanism of the anti-inflammatory action is still unclear. It is likely that by binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Aclometasone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Alclometasone is administered as a topical cream or ointment.

PW175964

Pw175964 View Pathway
metabolic

Alclofenac Predicted Metabolism Pathway new

Homo sapiens
Metabolites of Alclofenac are predicted with biotransformer.

PW146600

Pw146600 View Pathway
drug action

Alclofenac Drug Metabolism Action Pathway

Homo sapiens

PW292657

Pw292657 View Pathway
metabolic

Alcaligin Siderophore Repression (alcABC Operon activation)

Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
The alcABC operon, is involved in the production of alcaligin, a siderophore that helps bacteria acquire iron from the host environment. The operon is made up of 3 genes - alcA, alcB, and alcC. AlcA encodes a protein believed to be involved in the initial steps of alcaligin biosynthesis. alcB encodes a protein also involved in the biosynthesis of alcaligin. AlcC encodes a protein that is similar to IucC, another enzyme involved in siderophore biosynthesis. The operon is regulated by iron availability. It is repressed in the presence of iron. The transcriptional regulator protein Fur (ferric uptake regulator) binds to the promoter region of the operon when iron is abundant, inhibiting transcription, ensuring that the operon is only expressed when iron is scarce.